{"id":1405,"date":"2024-09-19T10:13:00","date_gmt":"2024-09-19T02:13:00","guid":{"rendered":"https:\/\/www.millibuff.com\/?p=1405"},"modified":"2025-09-04T10:29:37","modified_gmt":"2025-09-04T02:29:37","slug":"%e6%8e%a2%e8%ae%a8%e8%82%9d%e5%8a%9f%e8%83%bd%e4%b8%8d%e5%85%a8%e6%82%a3%e8%80%85%e7%9a%84%e8%8d%af%e4%bb%a3%e5%8a%a8%e5%8a%9b%e5%ad%a6%e7%a0%94%e7%a9%b6","status":"publish","type":"post","link":"https:\/\/www.millibuff.com\/?p=1405","title":{"rendered":"\u63a2\u8ba8\u809d\u529f\u80fd\u4e0d\u5168\u60a3\u8005\u7684\u836f\u4ee3\u52a8\u529b\u5b66\u7814\u7a76"},"content":{"rendered":"\n<p><\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img fetchpriority=\"high\" decoding=\"async\" width=\"1080\" height=\"370\" src=\"https:\/\/www.millibuff.com\/wp-content\/uploads\/2024\/09\/1-1024x351.png\" alt=\"\" class=\"wp-image-1408\" srcset=\"https:\/\/www.millibuff.com\/wp-content\/uploads\/2024\/09\/1-1024x351.png 1024w, https:\/\/www.millibuff.com\/wp-content\/uploads\/2024\/09\/1-300x103.png 300w, https:\/\/www.millibuff.com\/wp-content\/uploads\/2024\/09\/1-768x263.png 768w, https:\/\/www.millibuff.com\/wp-content\/uploads\/2024\/09\/1.png 1080w\" sizes=\"(max-width: 1080px) 100vw, 1080px\" \/><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u524d\u8a00<\/strong><\/h2>\n\n\n\n<p>\u521b\u65b0\u836f\u7269\u7684\u7814\u53d1\u4e0e\u4e34\u5e8a\u7814\u7a76\u4e2d\u5e38\u5e38\u4f1a\u9762\u4e34\u4e00\u4e2a\u95ee\u9898\uff1a\u5373\u9488\u5bf9\u7279\u6b8a\u4eba\u7fa4\u7684\u4e34\u5e8a\u7528\u836f\u8be5\u5982\u4f55\u628a\u63e1\u5242\u91cf\u4e0e\u4f7f\u7528\u9891\u6b21\u3002\u4e0a\u56fe\u4e3a\u622a\u53d6FDA\u6279\u51c6\u7684\u67d0\u4e00\u65b0\u836f\u7684\u836f\u54c1\u8bf4\u660e\u4e66\u90e8\u5206\u76ee\u5f55\u5185\u5bb9\uff0c\u5176\u4e2d\u7b2c8\u6761\u5bf9\u4e8e\u7279\u6b8a\u4eba\u7fa4\uff1a\u598a\u5a20\/\u54fa\u4e73\u671f\u5973\u6027\u3001\u513f\u7ae5\u7528\u836f\u3001\u8001\u5e74\u4eba\u7528\u836f\u4ee5\u53ca\u809d\/\u80be\u635f\u4f24\u60a3\u8005\u7684\u7528\u836f\u5747\u6709\u63cf\u8ff0\uff0c\u56e0\u7279\u6b8a\u4eba\u7fa4\u7684\u673a\u4f53\u7ec4\u6210\u548c\u751f\u7406\u529f\u80fd\u6709\u666e\u901a\u4eba\u7fa4\u6709\u8bb8\u591a\u7684\u533a\u522b\uff0c\u8fd9\u4e9b\u7279\u70b9\u80fd\u5f71\u54cd\u836f\u7269\u5728\u4f53\u5185\u7684\u5438\u6536\u3001\u5206\u5e03\u3001\u4ee3\u8c22\u548c\u6392\u6cc4\u8fc7\u7a0b\uff0c\u56e0\u6b64\u9700\u8981\u683c\u5916\u5173\u6ce8\u6b64\u7c7b\u4eba\u7fa4\u7684\u7528\u836f\u65b9\u6848\u3002<\/p>\n\n\n\n<p><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u4e3a\u4ec0\u4e48\u9700\u8981\u8fdb\u884c\u809d\u529f\u80fd\u635f\u5bb3\u60a3\u8005\u7684\u836f\u4ee3\u52a8\u529b\u5b66\u7814\u7a76\uff1f<\/h2>\n\n\n\n<figure class=\"wp-block-image size-large is-resized\"><img decoding=\"async\" width=\"1024\" height=\"808\" src=\"https:\/\/www.millibuff.com\/wp-content\/uploads\/2024\/09\/2-1024x808.jpg\" alt=\"\" class=\"wp-image-1410\" style=\"width:300px\" srcset=\"https:\/\/www.millibuff.com\/wp-content\/uploads\/2024\/09\/2-1024x808.jpg 1024w, https:\/\/www.millibuff.com\/wp-content\/uploads\/2024\/09\/2-300x237.jpg 300w, https:\/\/www.millibuff.com\/wp-content\/uploads\/2024\/09\/2-768x606.jpg 768w, https:\/\/www.millibuff.com\/wp-content\/uploads\/2024\/09\/2.jpg 1080w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" 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project\uff0c\u57282010\u5e74\uff0c\u6709200\u591a\u4e07\u4eba\u6b7b\u4e8e\u5305\u62ec\u6025\u6027\u809d\u708e\u3001\u809d\u786c\u5316\u548c\u809d\u764c\u7b49\u91cd\u5927\u809d\u75c5\uff0c\u7ea6\u5360\u5168\u7403\u6240\u6709\u6b7b\u4ea1\u4eba\u6570\u76844%\u3002\u636e\u4f30\u8ba1\uff0c\u4e2d\u56fd\u8d85\u8fc7\u4e94\u5206\u4e4b\u4e00\u7684\u4eba\u53e3\u53d7\u5230\u809d\u810f\u75be\u75c5\u7684\u5f71\u54cd\uff0c\u5305\u62ec\u4e59\u578b\u809d\u708e\u75c5\u6bd2\uff08HBV\uff09\u548c\u4e19\u578b\u809d\u708e\u75c5\u6bd2\uff08HCV\uff09\u611f\u67d3\u3001\u809d\u786c\u5316\u3001\u809d\u764c\u3001\u975e\u9152\u7cbe\u6027\u8102\u80aa\u6027\u809d\u75c5\uff08NAFLD\uff09\u3001\u9152\u7cbe\u76f8\u5173\u809d\u75c5\uff08ALD\uff09\u548c\u836f\u7269\u6027\u809d\u635f\u4f24\uff08DILI\uff09\u7b49\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image is-resized\"><img decoding=\"async\" src=\"https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/licmiaH6k5mRodibEKPpGXDib4iaC2uFq6CGD7fFVKCzaz55gNzUqFicMD49XkSBORCDjJ9MHDnficrf8mN70ROkUAEhA\/640?wx_fmt=png&amp;from=appmsg&amp;tp=wxpic&amp;wxfrom=5&amp;wx_lazy=1#imgIndex=2\" alt=\"\u809d\u529f\u80fd\u53d7\u635f\" style=\"width:600px\"\/><\/figure>\n\n\n\n<p>\u53c2\u80032012\u5e74CDE\u9881\u5e03\u300a\u809d\u529f\u80fd\u635f\u5bb3\u60a3\u8005\u7684\u836f\u4ee3\u52a8\u529b\u5b66\u7814\u7a76\u6280\u672f\u6307\u5bfc\u539f\u5219\u300b\uff0c\u901a\u8fc7\u591a\u79cd\u6c27\u5316\u548c\u7ed3\u5408\u4ee3\u8c22\u9014\u5f84\uff0c\u4ee5\u53ca\u836f\u7269\u539f\u578b\u6216\u4ee3\u8c22\u4ea7\u7269\u901a\u8fc7\u80c6\u6c41\u6392\u6cc4\uff0c\u809d\u810f\u53c2\u4e0e\u8bb8\u591a\u836f\u7269\u7684\u6e05\u9664\u3002\u809d\u529f\u80fd\u635f\u5bb3\u5f15\u8d77\u7684\u836f\u7269\u6392\u6cc4\u548c\u4ee3\u8c22\u6d3b\u52a8\u7684\u6539\u53d8\uff0c\u53ef\u80fd\u5bfc\u81f4\u836f\u7269\u84c4\u79ef\uff0c\u6216\u5728\u5c11\u6570\u60c5\u51b5\u4e0b\u65e0\u6cd5\u5f62\u6210\u6d3b\u6027\u4ee3\u8c22\u7269\u3002\u809d\u810f\u4f5c\u4e3a\u4eba\u4f53\u5185\u836f\u7269\u4ee3\u8c22\u7684\u4e3b\u8981\u5668\u5b98\uff0c\u8868\u8fbe\u591a\u79cd\u4ee3\u8c22\u9176\u4e0e\u8f6c\u8fd0\u4f53\u3002\u5927\u91cf\u6587\u732e\u8bc1\u5b9e\uff0c\u809d\u810f\u75be\u75c5\u53ef\u4ee5\u6539\u53d8\u836f\u7269\u5438\u6536\u548c\u5206\u5e03\u8fc7\u7a0b\uff0c\u8fdb\u800c\u6539\u53d8\u836f\u7269\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u3002\u5373\u4fbf\u5728\u809d\u810f\u5e76\u975e\u4e3b\u8981\u8d1f\u8d23\u67d0\u836f\u7269\u6e05\u9664\u7684\u5668\u5b98\u65f6\uff0c\u809d\u810f\u75be\u75c5\u540c\u6837\u53ef\u80fd\u4f1a\u6539\u53d8\u80be\u810f\u529f\u80fd\uff0c\u5e76\u4e14\u8be5\u5f71\u54cd\u662f\u4e0d\u786e\u5b9a\u7684\uff0c\u5c24\u5176\u662f\u5bf9\u836f\u7269\u7684\u836f\u4ee3\u52a8\u529b\u5b66\uff08PK\uff09\u548c\u836f\u6548\u52a8\u529b\u5b66\uff08PD\uff09\u7684\u5f71\u54cd\u3002<\/p>\n\n\n\n<p>\u603b\u7684\u6765\u8bf4\uff0c\u4e34\u5e8a\u4e0a\u5c1a\u6ca1\u6709\u6709\u6548\u5730\u9884\u6d4b\u836f\u7269PK\u548cPD\u7684\u809d\u529f\u80fd\u6307\u6807\u3002\u4f46\u662f\uff0c\u5728\u836f\u7269\u5f00\u53d1\u671f\u95f4\uff0c\u5728\u809d\u529f\u80fd\u53d7\u635f\u60a3\u8005\u4e2d\u8fdb\u884c\u7684\u4e34\u5e8a\u7814\u7a76\u53ef\u63d0\u4f9b\u76f8\u5173\u4fe1\u606f\uff0c\u6709\u52a9\u4e8e\u786e\u5b9a\u8fd9\u4e9b\u60a3\u8005\u7684\u4e34\u5e8a\u7528\u836f\u8d77\u59cb\u65b9\u6848\u3002<\/p>\n\n\n\n<p><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u54ea\u4e9b\u60c5\u51b5\u4e0b\u9700\u8981\u8fdb\u884c\u809d\u529f\u80fd\u635f\u5bb3\u60a3\u8005\u7684\u836f\u4ee3\u52a8\u529b\u5b66\u7814\u7a76\uff1f<\/h2>\n\n\n\n<p>1\u3001\u9700\u8981\u8fdb\u884c\u809d\u810f\u635f\u5bb3\u60a3\u8005\u7684PK\u7814\u7a76\uff1a<\/p>\n\n\n\n<p>1\uff09\u5982\u679c\u809d\u810f\u4ee3\u8c22\u548c\/\u6216\u6392\u6cc4\u7684\u91cf\u5360\u539f\u578b\u836f\u7269\u6216\u6d3b\u6027\u4ee3\u8c22\u4ea7\u7269\u6e05\u9664\u91cf\u7684\u76f8\u5f53\u5927\u90e8\u5206\uff08\u5927\u4e8e\u6240\u5438\u6536\u836f\u7269\u768420%\uff09\uff0c\u63a8\u8350\u5728\u809d\u529f\u80fd\u635f\u5bb3\u60a3\u8005\u4e2d\u8fdb\u884c PK \u7814\u7a76\u3002<\/p>\n\n\n\n<p>2\uff09\u5982\u679c\u836f\u54c1\u8bf4\u660e\u4e66\u6216\u6587\u732e\u8d44\u6599\u63d0\u793a\u8be5\u836f\u4e3a\u4e00\u79cd\u6cbb\u7597\u8303\u56f4\u7a84\u7684\u836f\u7269\u65f6\uff0c\u5373\u4fbf\u8be5\u836f\u7269\u548c\/\u6216\u6d3b\u6027\u4ee3\u8c22\u4ea7\u7269\u7ecf\u809d\u810f\u6d88\u9664\u7684\u91cf\u8f83\u5c11\uff08\uff1c20\uff05\uff09\uff0c\u4e5f\u5efa\u8bae\u8fdb\u884c\u809d\u810f\u635f\u5bb3\u60a3\u8005\u7684 PK \u7814\u7a76\u3002<\/p>\n\n\n\n<p>2\u3001\u4e00\u822c\u4e0d\u9700\u8981\u8fdb\u884c\u809d\u810f\u635f\u5bb3\u60a3\u8005\u7684PK\u7814\u7a76\uff1a<\/p>\n\n\n\n<p>1\uff09\u836f\u7269\u5b8c\u5168\u901a\u8fc7\u80be\u810f\u6e05\u9664\u9014\u5f84\u6392\u6cc4\uff0c\u4e0d\u6d89\u53ca\u5230\u809d\u810f\u3002<\/p>\n\n\n\n<p>2\uff09\u5c0f\u90e8\u5206\u836f\u7269\uff08\uff1c20\uff05\uff09\u5728\u809d\u810f\u4ee3\u8c22\uff0c\u5e76\u4e14\u836f\u7269\u6cbb\u7597\u8303\u56f4\u5bbd\uff0c\u56e0\u6b64\uff0c\u809d\u810f\u6e05\u9664\u80fd\u529b\u7684\u8f7b\u5ea6\u635f\u5bb3\u4e0d\u4f1a\u76f4\u63a5\u6216\u901a\u8fc7\u589e\u52a0\u4e0e\u5176\u4ed6\u836f\u7269\u7684\u76f8\u4e92\u4f5c\u7528\u800c\u4ea7\u751f\u836f\u7269\u6bd2\u6027\u3002<\/p>\n\n\n\n<p>3\uff09\u836f\u7269\u4e3a\u6c14\u6001\u6216\u6325\u53d1\u6027\u7684\uff0c\u5e76\u4e14\u836f\u7269\u53ca\u5176\u6d3b\u6027\u4ee3\u8c22\u4ea7\u7269\u4e3b\u8981\u901a\u8fc7\u80ba\u90e8\u6e05\u9664\u3002<\/p>\n\n\n\n<p>4\uff09\u5bf9\u4e8e\u4ec5\u5355\u5242\u91cf\u4f7f\u7528\u7684\u836f\u7269\uff0c\u4e00\u822c\u4e0d\u9700\u8981\u8fdb\u884c\u809d\u810f\u635f\u5bb3\u60a3\u8005\u7684\u836f\u4ee3\u52a8\u529b\u5b66\u7814\u7a76\u3002<\/p>\n\n\n\n<p><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u809d\u529f\u80fd\u635f\u5bb3\u60a3\u8005PK\u7814\u7a76\u7684\u4e34\u5e8a\u8bd5\u9a8c\u8bbe\u8ba1<\/h2>\n\n\n\n<p>1\u3001\u53d7\u8bd5\u8005\u7684\u9009\u62e9<\/p>\n\n\n\n<p>\u809d\u529f\u80fd\u6b63\u5e38\u5bf9\u7167\u7ec4\u7684\u53d7\u8bd5\u8005\u5e94\u6765\u81ea\u4e8e\u76ee\u6807\u6cbb\u7597\u60a3\u8005\uff0c\u800c\u975e\u5065\u5eb7\u5fd7\u613f\u8005\u30022003\u5e74\uff0cFDA\u9881\u5e03\u6307\u5bfc\u539f\u5219\u300aPharmacokinetics in Patients with Impaired Hepatic Function: Study Design, Data Analysis, and Impact on Dosing and Labeling\u300b\uff0c\u63d0\u51fa\u4e3a\u4e86\u5728\u6574\u4e2a\u809d\u635f\u4f24\u8303\u56f4\u5185\u5236\u5b9a\u7279\u5b9a\u7684\u5242\u91cf\u5efa\u8bae\uff0c\u5e94\u8be5\u5728\u4e09\u7c7bChild-Pugh\u5206\u7ea7\uff1a\u8f7b\u5ea6\u3001\u4e2d\u5ea6\u548c\u91cd\u5ea6\u4ee5\u53ca\u5bf9\u7167\u7ec4\u7684\u60a3\u8005\u4e2d\u8fdb\u884c\u7814\u7a76\uff08\u5982\u88681\u6240\u793a\uff09\u3002<\/p>\n\n\n\n<p>\u5e94\u7528\u8be5\u5206\u7ea7\u65b9\u6cd5\uff0c\u5c06\u6839\u636e\u4e24\u79cd\u4e34\u5e8a\u7279\u5f81\uff08\u8111\u75c5\u548c\u8179\u6c34\uff09\u548c\u4e09\u79cd\u5b9e\u9a8c\u5ba4\u6307\u6807\uff08\u8840\u6e05\u767d\u86cb\u767d\u3001\u8840\u6e05\u80c6\u7ea2\u7d20\u548c\u51dd\u8840\u9176\u539f\u65f6\u95f4\uff09\u5bf9\u53d7\u8bd5\u8005\u8fdb\u884c\u5206\u7ec4\u3002\u5c06\u809d\u810f\u673a\u80fd\u969c\u788d\u5206\u4e3aA\u3001B\u548cC\u7ec4\uff0c\u6216\u5bf9\u5e94\u4e8e5\uff5e6 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src=\"https:\/\/www.millibuff.com\/wp-content\/uploads\/2024\/09\/5-1024x581.png\" alt=\"Case\uff1a\u67d0\u533b\u9662\u809d\u635f\u60a3\u8005Child Pugh\u5206\u7ea7\" class=\"wp-image-1413\" srcset=\"https:\/\/www.millibuff.com\/wp-content\/uploads\/2024\/09\/5-1024x581.png 1024w, https:\/\/www.millibuff.com\/wp-content\/uploads\/2024\/09\/5-300x170.png 300w, https:\/\/www.millibuff.com\/wp-content\/uploads\/2024\/09\/5-768x436.png 768w, https:\/\/www.millibuff.com\/wp-content\/uploads\/2024\/09\/5.png 1080w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u4f46Child-Pugh\u5206\u7ea7\u6807\u51c6\u4e5f\u5177\u6709\u4e00\u5b9a\u5c40\u9650\u6027\uff0c\u4f8b\u5982\uff1aChild-Pugh 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