{"id":1669,"date":"2026-02-02T17:07:40","date_gmt":"2026-02-02T09:07:40","guid":{"rendered":"https:\/\/www.millibuff.com\/?p=1669"},"modified":"2026-02-02T17:07:40","modified_gmt":"2026-02-02T09:07:40","slug":"%e5%b0%8f%e7%89%9b%e6%b4%9e%e5%af%9f-%e4%b8%b4%e5%ba%8a%e8%af%95%e9%aa%8c%e5%a6%82%e4%bd%95%e7%a0%b4%e8%a7%a3%e7%a7%8d%e6%97%8f%e5%b7%ae%e5%bc%82%e5%9b%b0%e5%b1%80%ef%bc%9f%e7%b2%be%e5%87%86","status":"publish","type":"post","link":"https:\/\/www.millibuff.com\/?p=1669","title":{"rendered":"\u5c0f\u725b\u6d1e\u5bdf | \u4e34\u5e8a\u8bd5\u9a8c\u5982\u4f55\u7834\u89e3\u79cd\u65cf\u5dee\u5f02\u56f0\u5c40\uff1f\u7cbe\u51c6\u7528\u836f\u80cc\u540e\u7684\u5bc6\u7801\u4e0e\u4e34\u5e8a\u4ef7\u503c\u8f6c\u6362"},"content":{"rendered":"\n

PART 01
\u4e34\u5e8a\u8bd5\u9a8c\u6570\u636e\uff1a<\/strong>\u4e0d\u5bb9\u5ffd\u89c6\u7684\u79cd\u65cf\u7528\u836f\u5dee\u5f02<\/strong><\/h2>\n\n\n\n

\u79cd\u65cf\u5dee\u5f02\u5e26\u6765\u7684\u836f\u7269\u53cd\u5e94\u5206\u5316\uff0c\u5728\u4e34\u5e8a\u5b9e\u8df5\u4e0e\u7814\u53d1\u6570\u636e\u4e2d\u65e9\u5df2\u660e\u786e\u663e\u73b0\uff0c\u4e14\u8986\u76d6\u591a\u4e2a\u6cbb\u7597\u9886\u57df\uff1a<\/p>\n\n\n\n

1.\u5242\u91cf\u5dee\u5f02\uff1a\u4e1c\u4e9a\u4eba\u79cd\u4f7f\u7528\u5bf9\u4e59\u9170\u6c28\u57fa\u915a\u65f6\uff0c\u836f\u7269\u66b4\u9732\u91cf\u666e\u904d\u9ad8\u4e8e\u9ad8\u52a0\u7d22\u4eba\u79cd\u3002\u4e0d\u540c\u56fd\u5bb6\u7684\u6bcf\u65e5\u6700\u5927\u63a8\u8350\u5242\u91cf\u5b58\u5728\u663e\u8457\u5dee\u5f02\uff08\u4e2d\u56fd\u5efa\u8bae\u4e0d\u8d85\u8fc72g\/\u5929\uff0c\u65e5\u672c\u548c\u7f8e\u56fd\u5141\u8bb8\u6bcf\u65e54g\uff09\uff0c\u4f46\u7814\u7a76\u663e\u793a\u4e1c\u4e9a\u4eba\u79cd\u5728\u6bcf\u65e54g\u5242\u91cf\u4e0b\u809d\u635f\u4f24\u98ce\u9669\u8f83\u4f4e\uff0c\u4e14\u8be5\u5242\u91cf\u80fd\u66f4\u663e\u8457\u7f13\u89e3\u75bc\u75db\u3001\u6539\u5584\u4e34\u5e8a\u9547\u75db\u7ec8\u70b9\u6307\u6807\uff0c\u9700\u7ed3\u5408\u4e2a\u4f53\u4f53\u91cd\u4e0e\u809d\u80be\u529f\u80fd\u7b49\u5173\u952e\u56e0\u7d20\u8fdb\u884c\u8c03\u6574[1]<\/sup>\u3002<\/p>\n\n\n\n


2.\u7597\u6548\u5dee\u5f02\uff1a\u7f8e\u56fd\u9ed1\u4eba\u548c\u767d\u4eba\u5438\u70df\u8005\u4f7f\u7528\u4f10\u5c3c\u514b\u5170\uff08\u6212\u70df\u836f\uff09\u7684\u7597\u6548\u5b58\u5728\u663e\u8457\u79cd\u65cf\u5206\u5316\u3002\u5728\u7eb3\u5165 8144 \u540d\u5438\u70df\u8005\u7684\u5168\u7403\u6212\u70df\u7814\u7a76\uff08EAGLES\uff09\u4e2d\uff0c\u767d\u4eba\u5438\u70df\u8005\u4f7f\u7528\u4f10\u5c3c\u514b\u5170\u3001\u5b89\u975e\u4ed6\u916e\u3001\u5c3c\u53e4\u4e01\u8d34\u7247\u7684\u7b2c 9-24 \u5468\u8fde\u7eed\u6212\u70df\u7387\uff08CAR\uff09\u5747\u663e\u8457\u9ad8\u4e8e\u5b89\u6170\u5242\uff1b\u4f46\u9ed1\u4eba\u5438\u70df\u8005\u4ec5\u4f10\u5c3c\u514b\u5170\u7597\u6548\u4f18\u4e8e\u5b89\u6170\u5242\uff0c\u5b89\u975e\u4ed6\u916e\u4e0e\u5c3c\u53e4\u4e01\u8d34\u7247\u5747\u65e0\u663e\u8457\u6548\u679c\uff0c\u4e14\u8c03\u6574\u540e\u9ed1\u4eba\u53c2\u4e0e\u8005\u7684 CAR \u6bd4\u767d\u4eba\u4f4e 49%[2]<\/sup>\u3002<\/p>\n\n\n\n


3.\u6bd2\u6027\u5dee\u5f02\uff1a\u4e9a\u88d4\u4eba\u7fa4\u4f7f\u7528\u5361\u9a6c\u897f\u5e73\u65f6\uff0c\u53d1\u751f\u4e2d\u6bd2\u6027\u8868\u76ae\u574f\u6b7b\u677e\u89e3\u75c7\uff08TEN\uff09\u3001\u53f2\u8482\u6587\u65af – \u7ea6\u7ff0\u900a\u7efc\u5408\u5f81\uff08SJS\uff09\u7b49\u4e25\u91cd\u76ae\u80a4\u4e0d\u826f\u53cd\u5e94\u7684\u98ce\u9669\u7ea6\u662f\u9ad8\u52a0\u7d22\u4eba\u7684 10 \u500d[3]<\/sup>\u3002\u8fd9\u4e00\u5dee\u5f02\u7684\u5173\u952e\u673a\u5236\u662f\u4e9a\u88d4\u4e2d HLA-B15:02 \u7b49\u4f4d\u57fa\u56e0\u643a\u5e26\u7387\u9ad8\u8fbe10%-15%\uff0c\u800c\u8be5\u57fa\u56e0\u4e0e\u5361\u9a6c\u897f\u5e73\u8bf1\u5bfc\u7684\u4e25\u91cd\u76ae\u80a4\u53cd\u5e94\u5448\u5f3a\u5173\u8054\u3002<\/p>\n\n\n\n


\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u5e76\u975e\u6240\u6709\u836f\u7269\u90fd\u5b58\u5728\u663e\u8457\u79cd\u65cf\u5dee\u5f02\uff0c\u5982\u6297 HIV \u836f\u7269\u5229\u5339\u97e6\u6797\u7684 PK \u7279\u5f81\u5728\u4e0d\u540c\u79cd\u65cf\u4e2d\u65e0\u4e34\u5e8a\u76f8\u5173\u5dee\u5f02<\/strong>[4]<\/strong><\/sup>\uff0c\u65e0\u9700\u5242\u91cf\u8c03\u6574\uff0c\u8fd9\u4e5f\u63d0\u793a\u79cd\u65cf\u5dee\u5f02\u7684\u590d\u6742\u6027\u4e0e\u836f\u7269\u7279\u5f02\u6027\u3002<\/strong><\/p>\n\n\n\n

PART 02
\u4e09\u5c42\u673a\u5236<\/strong>\u62c6\u89e3\u5dee\u5f02\u6839\u6e90<\/strong><\/h2>\n\n\n\n

\u79cd\u65cf\u5dee\u5f02\u5bf9 PK\/PD \u7684\u5f71\u54cd\u5e76\u975e\u5355\u4e00\u56e0\u7d20\u5bfc\u81f4\uff0c\u800c\u662f\u9057\u4f20\u591a\u6001\u6027\u3001\u751f\u7406\u7279\u5f81\u3001\u73af\u5883\u4e0e\u751f\u6d3b\u65b9\u5f0f\u4e09\u5c42\u673a\u5236\u4ea4\u7ec7\u4f5c\u7528<\/strong>\u7684\u7ed3\u679c\uff0c\u4e14\u6838\u5fc3\u805a\u7126\u4e8e\u836f\u7269 ADME\u00a0\uff08Absorption\uff08\u5438\u6536\uff09\u3001Distribution\uff08\u5206\u5e03\uff09\u3001Metabolism\uff08\u4ee3\u8c22\uff09\u3001Excretion\uff08\u6392\u6cc4\uff09\uff09\u8fc7\u7a0b\u4e0e\u9776\u70b9\u76f8\u4e92\u4f5c\u7528\u7684\u5173\u952e\u73af\u8282\u3002<\/p>\n\n\n\n


1.\u9057\u4f20\u591a\u6001\u6027\uff1a\u6838\u5fc3\u9a71\u52a8\u56e0\u7d20\u57fa\u56e0\u53d8\u5f02\u7684\u79cd\u65cf\u5206\u5e03\u5dee\u5f02\u662f\u5bfc\u81f4 PK\/PD \u5206\u5316\u7684\u6839\u672c\u539f\u56e0\uff0c\u5c24\u5176\u4f53\u73b0\u5728\u836f\u7269\u4ee3\u8c22\u9176\u3001\u8f6c\u8fd0\u4f53\u4e0e\u9776\u70b9\u57fa\u56e0\u4e0a\uff1a<\/p>\n\n\n\n

\u2460\u4ee3\u8c22\u9176\u591a\u6001\u6027\uff1a<\/strong>CYP450 \u5bb6\u65cf\u662f\u6700\u5177\u79cd\u65cf\u5dee\u5f02\u7684\u4ee3\u8c22\u9176\u7cfb\u7edf\uff0c\u4e1c\u4e9a\u4eba\u7fa4\u4e2dCYP2C19\u5f31\u4ee3\u8c22\u8005\u7684\u6bd4\u4f8b\u663e\u8457\u9ad8\u4e8e\u6b27\u6d32\u88d4\u4eba\u7fa4\uff0c\u8fd9\u76f4\u63a5\u5f71\u54cd\u4e86\u5bf9\u6c2f\u5421\u683c\u96f7\u7b49\u836f\u7269\u7684\u53cd\u5e94\uff1bCYP2D6\u7684\u8d85\u5feb\u4ee3\u8c22\u8868\u578b\u5728\u5317\u975e\u4eba\u7fa4\u4e2d\u66f4\u4e3a\u5e38\u89c1\uff0c\u800c\u8be5\u57fa\u56e0\u7684\u65e0\u6548\u7b49\u4f4d\u57fa\u56e0\u5728\u4e1c\u4e9a\u4eba\u7fa4\u4e2d\u9891\u7387\u8f83\u9ad8\u3002UGT\u3001SULT \u7b49 \u2161 \u76f8\u4ee3\u8c22\u9176\u7684\u79cd\u65cf\u5dee\u5f02\uff0c\u8fdb\u4e00\u6b65\u653e\u5927\u4e86\u836f\u7269\u4ee3\u8c22\u7684\u79cd\u7fa4\u5206\u5316[5]<\/sup>\u3002<\/p>\n\n\n\n

\u2461\u8f6c\u8fd0\u4f53\u4e0e\u9776\u70b9\u57fa\u56e0\u591a\u6001\u6027\uff1a<\/strong>OATP1B1\u548c OATP1B3\u4f5c\u4e3a\u809d\u810f\u5173\u952e\u6444\u53d6\u578b\u8f6c\u8fd0\u4f53\uff0c\u5176\u5355\u6838\u82f7\u9178\u591a\u6001\u6027\u5b58\u5728\u663e\u8457\u79cd\u65cf\u5206\u5316\uff0c\u76f4\u63a5\u5bfc\u81f4\u4e0d\u540c\u79cd\u65cf\u5bf9\u4ed6\u6c40\u7c7b\u3001\u5316\u7597\u836f\u7269\u7b49\u5e95\u7269\u7684\u8f6c\u8fd0\u529f\u80fd\u5dee\u5f02\uff0c\u8fdb\u800c\u5f71\u54cd\u836f\u7269\u4ee3\u8c22\u52a8\u529b\u5b66\u4e0e\u4e34\u5e8a\u7528\u836f\u5b89\u5168\u6027\u3002OATP1B1\u548c OATP1B3 \u4e3b\u8981\u7684\u57fa\u56e0\u591a\u6001\u6027\u5728\u4e0d\u540c\u79cd\u65cf\u95f4\u7684\u53d1\u751f\u9891\u7387\u8be6\u89c1\u8868 1[6]<\/sup>\u3002<\/p>\n\n\n\n

\u8868 1 \u4e0d\u540c\u79cd\u65cf\u95f4 SLCO1B1 \u548c SLCO1B3 \u7684\u57fa\u56e0\u591a\u6001\u6027\u53ca\u5176\u53d1\u751f\u9891\u7387\u8868<\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

2.\u751f\u7406\u7279\u5f81\uff1a\u5148\u5929\u57fa\u7840\u5dee\u5f02<\/strong>\u4e0d\u540c\u79cd\u65cf\u5728\u89e3\u5256\u7ed3\u6784\u4e0e\u751f\u7406\u529f\u80fd\u4e0a\u7684\u56fa\u6709\u5dee\u5f02\uff0c\u4e3a\u836f\u7269\u53cd\u5e94\u5206\u5316\u63d0\u4f9b\u4e86\u5148\u5929\u6761\u4ef6\uff1a<\/p>\n\n\n\n

\u2460\u8eab\u4f53\u7ec4\u6210\uff1a<\/strong>\u4e1c\u4e9a\u4eba\u7fa4\u5e73\u5747\u4f53\u91cd\u3001\u4f53\u8102\u6bd4\u4f8b\u5e38\u4f4e\u4e8e\u9ad8\u52a0\u7d22\u4eba\u7fa4\uff0c\u8fd9\u610f\u5473\u7740\u4ee5\u4f53\u91cd\u4e3a\u6807\u51c6\u8ba1\u7b97\u7684\u836f\u7269\u5242\u91cf\uff0c\u53ef\u80fd\u5bfc\u81f4\u524d\u8005\u4f53\u5185\u836f\u7269\u6d53\u5ea6\u66f4\u9ad8\u3001\u5206\u5e03\u5bb9\u79ef\u66f4\u5c0f\u3002<\/p>\n\n\n\n

\u2461\u5668\u5b98\u529f\u80fd\uff1a<\/strong>\u975e\u6d32\u88d4\u7f8e\u56fd\u4eba\u7684\u808c\u9150\u6e05\u9664\u7387\u666e\u904d\u8f83\u9ad8\uff0c\u4f7f\u9752\u9709\u7d20\u7b49\u7ecf\u80be\u6392\u6cc4\u7684\u836f\u7269\u6e05\u9664\u52a0\u5feb\uff0c\u9700\u589e\u52a0\u5242\u91cf\u4ee5\u7ef4\u6301\u7597\u6548\u3002<\/p>\n\n\n\n

\u2462\u80c3\u80a0\u9053\u529f\u80fd\uff1a<\/strong>\u4e0d\u540c\u79cd\u65cf\u7684\u80c3\u6392\u7a7a\u7387\u3001\u80a0\u9053\u8840\u6d41\u4e0e\u7d27\u5bc6\u8fde\u63a5\u529f\u80fd\u5dee\u5f02\uff0c\u4e5f\u4f1a\u5f71\u54cd\u836f\u7269\u5438\u6536\u6548\u7387\u3002<\/p>\n\n\n\n


3.\u73af\u5883\u4e0e\u751f\u6d3b\u65b9\u5f0f\uff1a\u540e\u5929\u8c03\u8282\u56e0\u7d20<\/strong>\u9057\u4f20\u51b3\u5b9a\u7684\u5dee\u5f02\u4f1a\u88ab\u73af\u5883\u56e0\u7d20\u8fdb\u4e00\u6b65\u653e\u5927\uff0c\u5f62\u6210\u79cd\u65cf\u7279\u5f02\u6027\u7684\u836f\u7269\u53cd\u5e94\u6a21\u5f0f\uff1a<\/p>\n\n\n\n

\u2460\u996e\u98df\u4e60\u60ef\uff1a<\/strong>\u9ad8\u8102\u80aa\u996e\u98df\u4f1a\u589e\u52a0\u8102\u6eb6\u6027\u836f\u7269\u5438\u6536\u3001\u5347\u9ad8\u8840\u836f\u6d53\u5ea6\uff0c\u9ad8\u81b3\u98df\u7ea4\u7ef4\u996e\u98df\u5219\u901a\u8fc7\u8c03\u8282\u80a0\u9053\u83cc\u7fa4\u53ca\u4ee3\u8c22\u9176\u6d3b\u6027\u5f71\u54cd\u836f\u7269\u4ee3\u8c22\uff0c\u4e8c\u8005\u5747\u4e0e\u79cd\u65cf\u56fa\u6709\u9057\u4f20\u7279\u5f81\u53e0\u52a0\uff0c\u5f62\u6210\u79cd\u65cf\u7279\u5f02\u6027\u836f\u7269\u53cd\u5e94\u6a21\u5f0f\u3002<\/p>\n\n\n\n

\u2461\u6587\u5316\u4e0e\u4f9d\u4ece\u6027\uff1a<\/strong>\u4e0d\u540c\u79cd\u65cf\u7684\u533b\u7597\u8ba4\u77e5\u3001\u7528\u836f\u4f9d\u4ece\u6027\u5b58\u5728\u5dee\u5f02\uff0c\u5982\u90e8\u5206\u79cd\u65cf\u5bf9\u957f\u671f\u7528\u836f\u7684\u63a5\u53d7\u5ea6\u8f83\u4f4e\uff0c\u53ef\u80fd\u5bfc\u81f4\u836f\u7269\u6d53\u5ea6\u6ce2\u52a8\uff0c\u95f4\u63a5\u5f71\u54cd PK\/PD \u8868\u73b0\u3002<\/p>\n\n\n\n

\u2462\u5408\u5e76\u7528\u836f\uff1a<\/strong>\u79cd\u65cf\u95f4\u75be\u75c5\u5dee\u5f02\uff08\u5982\u9ad8\u8840\u538b\u3001\u7cd6\u5c3f\u75c5\u53d1\u75c5\u7387\uff09\u4e0e\u5408\u5e76\u7528\u836f\u4e60\u60ef\u4e0d\u540c\uff0c\u53ef\u80fd\u901a\u8fc7\u836f\u7269\u76f8\u4e92\u4f5c\u7528\u6539\u53d8\u76ee\u6807\u836f\u7269\u7684\u4ee3\u8c22\u4e0e\u6548\u5e94\u3002<\/p>\n\n\n\n

PART 03
\u4ece\u5b9e\u9a8c\u5ba4\u5230\u4e34\u5e8a\u7684<\/strong>\u4ef7\u503c\u8f6c\u6362<\/strong><\/h2>\n\n\n\n

\u5c06\u79cd\u65cf\u76f8\u5173\u9057\u4f20\u591a\u6001\u6027\uff08\u4ee3\u8c22\u9176\u3001\u8f6c\u8fd0\u4f53\u3001\u9776\u70b9\u57fa\u56e0\uff09\u7684\u5b9e\u9a8c\u5ba4\u7814\u7a76\u53d1\u73b0\u8f6c\u5316\u4e3a\u4e34\u5e8a\u5b9e\u8df5\u4ef7\u503c\uff0c\u6838\u5fc3\u5728\u4e8e\u642d\u5efa \u201c\u57fa\u56e0\u68c0\u6d4b – \u4e2a\u4f53\u5316\u65b9\u6848 – \u7ed3\u5c40\u4f18\u5316\u201d \u7684\u95ed\u73af<\/strong>\uff1a\u901a\u8fc7\u6574\u5408 CYP450 \u5bb6\u65cf\u3001OATP1B3\u3001VKORC1 \u7b49\u57fa\u56e0\u7684\u79cd\u65cf\u5206\u5e03\u6570\u636e\uff0c\u5c06\u5b9e\u9a8c\u5ba4\u5c42\u9762\u7684\u9176\u6d3b\u6027\u5dee\u5f02\u3001\u8f6c\u8fd0\u4f53\u8868\u8fbe\u5206\u5316\u3001\u9776\u70b9\u654f\u611f\u6027\u53d8\u5f02\uff0c\u8f6c\u5316\u4e3a\u4e34\u5e8a\u53ef\u64cd\u4f5c\u7684\u7528\u836f\u6307\u5bfc\u3002<\/p>\n\n\n\n

\u540c\u65f6\uff0c\u8fd9\u7c7b\u8f6c\u5316\u80fd\u63a8\u52a8\u533b\u7597\u8d44\u6e90\u5411\u7cbe\u51c6\u5316\u503e\u659c\uff0c\u901a\u8fc7\u9884\u5224\u4e0d\u540c\u79cd\u65cf\u7684\u836f\u7269\u53cd\u5e94\u5dee\u5f02\uff0c\u964d\u4f4e\u65e0\u6548\u6cbb\u7597\u4e0e\u4e0d\u826f\u53cd\u5e94\u5bfc\u81f4\u7684\u533b\u7597\u8d1f\u62c5\uff0c\u6700\u7ec8\u7f29\u5c0f\u79cd\u65cf\u95f4\u7684\u5065\u5eb7\u8bca\u7597\u5dee\u8ddd\uff0c\u8ba9\u5b9e\u9a8c\u5ba4\u7684\u5206\u5b50\u5c42\u9762\u53d1\u73b0\u771f\u6b63\u843d\u5730\u4e3a\u6539\u5584\u60a3\u8005\u9884\u540e\u3001\u63d0\u5347\u4e34\u5e8a\u7528\u836f\u5b89\u5168\u6027\u4e0e\u6709\u6548\u6027\u7684\u5b9e\u9645\u4ef7\u503c\u3002<\/p>\n\n\n\n

\u7528\u836f\u65e0\u5c0f\u4e8b\uff0c\u4e2a\u4f53\u5316\u6cbb\u7597\u4e0d\u4ec5\u662f\u8d8b\u52bf\uff0c\u66f4\u662f\u79d1\u5b66\u5065\u5eb7\u7b56\u7565\u3002<\/p>\n\n\n\n

PART 04
\u53c2\u8003\u6587\u732e<\/strong><\/h2>\n\n\n\n


[1]\u5f20\u5a77, \u6768\u52b2. \u5bf9\u4e59\u9170\u6c28\u57fa\u915a\u79cd\u65cf\u5dee\u5f02\u7814\u7a76[J]. \u836f\u5b66\u8fdb\u5c55, 2019, 43(03): 194-201.<\/p>\n\n\n\n

[2]Nollen N L, Ahluwalia J S, Sanderson Cox L, et al. Assessment of Racial Differences in Pharmacotherapy Efficacy for Smoking Cessation: Secondary Analysis of the EAGLES Randomized Clinical Trial[J]. JAMA Network Open, 2021, 4(1): e2032053.<\/p>\n\n\n\n

[3]FDA. EQUETRO (carbamazepine) Extended-Release Capsules Label [S]. 2022.<\/p>\n\n\n\n

[4]Aouri M, Barcelo C, Guidi M, et al. Population Pharmacokinetics and Pharmacogenetics Analysis of Rilpivirine in HIV-1-Infected Individuals[J]. Antimicrobial Agents and Chemotherapy, 2017, 61(1): e00899-16.<\/p>\n\n\n\n

[5]Gaibar M, Novillo A, Romero-Lorca A, et al. Pharmacogenetics of ugt genes in North African populations[J]. The pharmacogenomics journal,2018,18(5): 609-612.[6]\u5b59\u6653\u7433, \u8d75\u5a23, \u674e\u519b\u8896, \u7b49. \u6709\u673a\u9634\u79bb\u5b50\u8f6c\u8fd0\u591a\u80bdOATP1B1\u3001OATP1B3\u7684\u57fa\u56e0\u591a\u6001\u6027\u53ca\u5176\u4ecb\u5bfc\u7684\u836f\u7269\u76f8\u4e92\u4f5c\u7528\u7814\u7a76\u8fdb\u5c55[J]. \u4e2d\u56fd\u4e34\u5e8a\u836f\u7406\u5b66\u4e0e\u6cbb\u7597\u5b66, 2015, 20(11): 1296-1301.<\/p>\n\n\n\n

<\/div>\n\n\n\n

\u64b0\u7a3f\u4eba\uff1a\u8042\u8339\u4f73
\u5ba1\u6838\uff1a\u9648\u4e9a\u7ea2
\u6da6\u8272\u6392\u7248\uff1a\u5468\u5b89\u6960<\/p>\n","protected":false},"excerpt":{"rendered":"

\u5728\u7cbe\u51c6\u533b\u7597\u65f6\u4ee3\uff0c\u201c\u4e00\u628a\u94a5\u5319\u5f00\u6240\u6709\u9501\u201d\u7684\u7528\u836f\u6a21\u5f0f\u65e9\u5df2\u6210\u4e3a\u8fc7\u53bb\u3002\u4e0d\u540c\u79cd\u65cf\u4eba\u7fa4\u5bf9\u540c\u4e00\u79cd\u836f\u7269\u7684\u7597\u6548\u3001\u6bd2\u6027\u53cd\u5e94\u5f80\u5f80\u5b58\u5728\u663e\u8457\u5dee\u5f02\u3002\u8fd9\u4e9b\u5dee\u5f02\u5e76\u975e\u5076\u7136\uff0c\u800c\u662f\u79cd\u65cf\u80cc\u540e\u9057\u4f20\u3001\u751f\u7406\u3001\u73af\u5883\u7b49\u591a\u91cd\u56e0\u7d20\u5171\u540c\u4f5c\u7528\u4e8e\u836f\u7269\u4ee3\u8c22\uff08PK\uff0cPharmacokinetics\uff09\u4e0e\u836f\u6548\uff08PD\uff0cPharmacodynamics\uff09\u8fc7\u7a0b\u7684\u5fc5\u7136\u7ed3\u679c\u3002<\/p>\n","protected":false},"author":1,"featured_media":1670,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[17],"tags":[100,35,15,32,98,99],"class_list":["post-1669","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-17","tag-100","tag-35","tag-15","tag-32","tag-98","tag-99"],"_links":{"self":[{"href":"https:\/\/www.millibuff.com\/index.php?rest_route=\/wp\/v2\/posts\/1669","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.millibuff.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.millibuff.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.millibuff.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.millibuff.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1669"}],"version-history":[{"count":1,"href":"https:\/\/www.millibuff.com\/index.php?rest_route=\/wp\/v2\/posts\/1669\/revisions"}],"predecessor-version":[{"id":1672,"href":"https:\/\/www.millibuff.com\/index.php?rest_route=\/wp\/v2\/posts\/1669\/revisions\/1672"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.millibuff.com\/index.php?rest_route=\/wp\/v2\/media\/1670"}],"wp:attachment":[{"href":"https:\/\/www.millibuff.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1669"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.millibuff.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1669"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.millibuff.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1669"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}