{"id":1694,"date":"2026-02-28T14:06:36","date_gmt":"2026-02-28T06:06:36","guid":{"rendered":"https:\/\/www.millibuff.com\/?p=1694"},"modified":"2026-02-28T14:06:36","modified_gmt":"2026-02-28T06:06:36","slug":"%e5%b0%8f%e7%89%9b%e6%b4%9e%e5%af%9f-%e4%bb%8e%e7%bb%b4%e9%80%82%e5%b9%b3%e8%8e%b7%e6%89%b9%ef%bc%8c%e7%9c%8b%e6%ba%83%e7%96%a1%e6%80%a7%e7%bb%93%e8%82%a0%e7%82%8e%ef%bc%88uc%ef%bc%89%e7%96%be","status":"publish","type":"post","link":"https:\/\/www.millibuff.com\/?p=1694","title":{"rendered":"\u5c0f\u725b\u6d1e\u5bdf | \u4ece\u7ef4\u9002\u5e73\u83b7\u6279\uff0c\u770b\u6e83\u75a1\u6027\u7ed3\u80a0\u708e\uff08UC\uff09\u75be\u75c5\u8d1f\u62c5\u4e0e\u8bca\u7597\u683c\u5c40\u6f14\u53d8"},"content":{"rendered":"\n

\u5728\u8fd1\u671f\u7ef4\u9002\u5e73\u00ae\uff08\u7cbe\u6c28\u9178\u827e\u66f2\u83ab\u5fb7\u7247\uff0cVELSIPITY\u00ae\uff09\u83b7 NMPA \u6279\u51c6\u7684\u80cc\u666f\u4e0b\uff0c\u672c\u6587\u805a\u7126\u4e09\u4e2a\u95ee\u9898\uff1a<\/p>\n\n\n\n

    \n
  1. \u6e83\u75a1\u6027\u7ed3\u80a0\u708e\uff08ulcerative\u00a0colitis,\u00a0UC\uff09\u7684\u75be\u75c5\u8d1f\u62c5\u6b63\u5728\u53d1\u751f\u4ec0\u4e48\u53d8\u5316\uff1f\u4ece\u6d41\u884c\u75c5\u5b66\u8d8b\u52bf\u5230\u53d1\u75c5\u673a\u5236\uff0c\u6211\u4eec\u5bf9\u8fd9\u79cd\u75be\u75c5\u4e86\u89e3\u4e86\u591a\u5c11\uff1f<\/li>\n\n\n\n
  2. UC\u00a0\u7684\u5178\u578b\u4e34\u5e8a\u8868\u73b0\u548c\u81ea\u7136\u75c5\u7a0b\u6709\u54ea\u4e9b\u7279\u5f81\uff1f\u4e3a\u4ec0\u4e48\u5b83\u88ab\u79f0\u4e3a”\u7ec8\u8eab\u6027\u75be\u75c5”\uff1f<\/li>\n\n\n\n
  3. \u5728\u00a0Treat-to-Target\u00a0\u6210\u4e3a\u5171\u8bc6\u7684\u80cc\u666f\u4e0b\uff0cUC\u00a0\u7684\u8bca\u65ad\u5206\u5c42\u4e0e\u9636\u68af\u6cbb\u7597\u5e94\u5982\u4f55\u7406\u89e3\uff1f<\/li>\n<\/ol>\n\n\n\n
    \"\u5c0f\u725b\u6d1e\u5bdf<\/figure>\n\n\n\n

    2026 \u5e74 2 \u6708 6 \u65e5\uff0c\u4e2d\u56fd\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u6279\u51c6\u7cbe\u6c28\u9178\u827e\u66f2\u83ab\u5fb7\u7247\uff08\u5546\u54c1\u540d\uff1a\u7ef4\u9002\u5e73\u00ae\uff0c\u82f1\u6587\u540d\uff1aVELSIPITY\u00ae\uff09\u7684\u65b0\u836f\u4e0a\u5e02\u8bb8\u53ef\u7533\u8bf7\uff08NDA\uff09\uff0c\u7531\u4e91\u9876\u65b0\u8000\u5f15\u8fdb\u5e76\u5728\u4e2d\u56fd\u5546\u4e1a\u5316\uff0c\u7528\u4e8e\u6cbb\u7597\u5bf9\u4f20\u7edf\u6cbb\u7597\u6216\u751f\u7269\u5236\u5242\u5e94\u7b54\u4e0d\u5145\u5206\u3001\u5931\u5e94\u7b54\u6216\u4e0d\u8010\u53d7\u7684\u4e2d\u5ea6\u81f3\u91cd\u5ea6\u6d3b\u52a8\u6027\u6e83\u75a1\u6027\u7ed3\u80a0\u708e\uff08ulcerative colitis, UC\uff09\u6210\u4eba\u60a3\u8005[1]<\/sup>\u3002<\/p>\n\n\n\n

    \u7ef4\u9002\u5e73\u00ae\u7684\u83b7\u6279\uff0c\u662f\u8fd1\u5e74\u521b\u65b0\u836f\u7269\u52a0\u901f\u8fdb\u5165 UC \u9886\u57df\u7684\u4e00\u4e2a\u7f29\u5f71\u3002\u4ece\u76d1\u7ba1\u89c6\u89d2\u770b\uff0c\u65e0\u8bba\u662f FDA \u7684\u52a0\u901f\u5ba1\u6279\u901a\u9053\uff0c\u8fd8\u662f NMPA \u8fd1\u5e74\u6765\u5bf9\u4e25\u91cd\u75be\u75c5\u521b\u65b0\u836f\u5b9e\u65bd\u7684\u9644\u6761\u4ef6\u6279\u51c6\u548c\u4f18\u5148\u5ba1\u8bc4\uff0c\u5747\u663e\u8457\u7f29\u77ed\u4e86 UC \u7b49\u514d\u75ab\u75be\u75c5\u65b0\u836f\u4ece\u4e34\u5e8a\u8bd5\u9a8c\u5230\u4e0a\u5e02\u7684\u5468\u671f\uff0c\u4e5f\u5728\u5ba2\u89c2\u4e0a\u63a8\u52a8\u4e86\u66f4\u591a\u57fa\u4e8e\u66ff\u4ee3\u7ec8\u70b9\u548c\u591a\u533a\u57df\u4e34\u5e8a\u8bd5\u9a8c\uff08MRCT\uff09\u7684 UC \u65b0\u836f\u4e34\u5e8a\u5f00\u53d1\u9879\u76ee\u5bc6\u96c6\u843d\u5730\u4e2d\u56fd[2, 3]<\/sup>\u3002<\/p>\n\n\n\n

    \u4e00\u3001UC \u836f\u7269\u5e02\u573a\u4e0e\u75be\u75c5\u8d1f\u62c5\uff1a\u4e3a\u4ec0\u4e48\u503c\u5f97\u5173\u6ce8\uff1f<\/h1>\n\n\n\n

    \u8fd9\u4e00\u8d8b\u52bf\u7684\u80cc\u540e\uff0c\u662f\u6301\u7eed\u6269\u5bb9\u7684\u5168\u7403 UC \u836f\u7269\u5e02\u573a\u2014\u2014\u636e IMARC Group \u9884\u8ba1\uff0c2024 \u5e74\u5e02\u573a\u89c4\u6a21\u5df2\u8fbe\u7ea6 80 \u4ebf\u7f8e\u5143\uff0c\u672a\u6765\u5341\u5e74\u4ecd\u5c06\u4fdd\u6301\u6e29\u548c\u589e\u957f\uff08\u9884\u4f30\u590d\u5408\u5e74\u589e\u957f\u7387\u4e3a 4.82%\uff09[4]<\/sup>\u3002<\/p>\n\n\n\n

    \u5bf9\u836f\u4f01\u800c\u8a00\uff0c\u8fd9\u610f\u5473\u7740 UC \u4e0d\u518d\u53ea\u662f”\u76f8\u5bf9\u5c0f\u4f17\u7684\u514d\u75ab\u75be\u75c5”\uff0c\u800c\u662f\u4e00\u4e2a\u5df2\u8d85\u8fc7 80 \u4ebf\u7f8e\u5143\u3001\u5e76\u5c06\u6301\u7eed\u4ee5\u7ea6 5% \u901f\u5ea6\u589e\u957f\u7684\u6210\u719f\u7ec6\u5206\u5e02\u573a<\/strong>\u3002<\/p>\n\n\n\n

    \u4e0e\u6b64\u76f8\u5e94\uff0c\u5168\u7403 UC \u836f\u7269\u7ba1\u7ebf\u4e5f\u5728\u6301\u7eed\u6269\u5bb9\u2014\u2014\u4ec5\u5728 7 \u5927\u5e02\u573a\u8303\u56f4\u5185\uff0c\u5df2\u6709\u6570\u5341\u4e2a\u9488\u5bf9 UC \u7684\u65b0\u5206\u5b50\u5b9e\u4f53\u5904\u4e8e II\/III \u671f\u4e34\u5e8a\u5f00\u53d1\u9636\u6bb5\uff0c\u6db5\u76d6 JAK \u6291\u5236\u5242\u3001S1P \u53d7\u4f53\u8c03\u8282\u5242\u3001IL\u001e23 \u901a\u8def\u3001\u5fae\u751f\u7269\u7ec4\u6cbb\u7597\u7b49\u591a\u4e2a\u9776\u70b9\uff0cUC \u65b0\u836f\u7814\u53d1\u7684\u5bc6\u5ea6\u548c\u4e34\u5e8a\u8bd5\u9a8c\u7ade\u4e89\u7a0b\u5ea6\u90fd\u5728\u5feb\u901f\u4e0a\u5347[5]<\/sup>\u3002\u5728\u5e02\u573a\u89c4\u6a21\u4e0e\u7ba1\u7ebf\u5bc6\u5ea6\u7684\u53cc\u91cd\u9a71\u52a8\u4e0b\uff0cUC \u5df2\u6210\u4e3a\u5168\u7403\u708e\u75c7\u6027\u80a0\u75c5\uff08inflammatory bowel disease\uff0cIBD\uff09\u4e34\u5e8a\u5f00\u53d1\u4e0e BD \u53ca\u5e76\u8d2d\u5e03\u5c40\u6700\u6d3b\u8dc3\u7684\u6cbb\u7597\u9886\u57df\u4e4b\u4e00\u3002<\/p>\n\n\n\n

    \u63a8\u52a8\u8fd9\u4e00\u8d8b\u52bf\u7684\u6838\u5fc3\u56e0\u7d20\u6709\u4e09\uff1aUC \u60a3\u8005\u4eba\u6570\u6301\u7eed\u589e\u52a0\u3001\u75be\u75c5\u957f\u671f\u590d\u53d1\u8fc1\u5ef6\u5e26\u6765\u7684\u7d2f\u79ef\u8d1f\u62c5\uff08\u6bcf\u4e00\u6b21\u590d\u53d1\u90fd\u610f\u5473\u7740\u65b0\u4e00\u8f6e\u7684\u6cbb\u7597\u6295\u5165\u548c\u751f\u6d3b\u8d28\u91cf\u635f\u8017\uff09\uff0c\u4ee5\u53ca\u9ad8\u7ea7\u6cbb\u7597\u6e17\u900f\u7387\u7684\u9010\u6b65\u63d0\u5347\u3002\u4e09\u8005\u5171\u540c\u91cd\u5851\u7740 UC \u7684”\u75be\u75c5\u8d1f\u62c5”\uff08\u5373\u60a3\u8005\u6570\u91cf\u3001\u533b\u7597\u652f\u51fa\u4e0e\u751f\u6d3b\u8d28\u91cf\u5f71\u54cd\u7684\u7efc\u5408\u4f53\u73b0\uff09\u4e0e”\u8bca\u7597\u683c\u5c40”\u3002<\/p>\n\n\n\n

    \u5728\u8fd9\u6837\u7684\u80cc\u666f\u4e0b\uff0c\u672c\u6587\u4ece UC \u7684\u57fa\u7840\u4e8b\u5b9e\u51fa\u53d1\u2014\u2014\u68b3\u7406\u75be\u75c5\u6982\u8ff0\u3001\u6d41\u884c\u75c5\u5b66\u73b0\u72b6\u3001\u5178\u578b\u4e34\u5e8a\u8868\u73b0\uff0c\u4ee5\u53ca\u73b0\u4ee3\u8bca\u65ad\u4e0e\u98ce\u9669\u5206\u5c42\u6846\u67b6\uff0c\u4e3a\u7406\u89e3\u5f53\u524d UC \u9886\u57df\u7684\u4e34\u5e8a\u9700\u6c42\u4e0e\u6cbb\u7597\u6f14\u8fdb\u63d0\u4f9b\u57fa\u7840\u6846\u67b6\u3002<\/p>\n\n\n\n

    \u4e8c\u3001\u75be\u75c5\u6982\u8ff0\u4e0e\u6d41\u884c\u75c5\u5b66<\/h1>\n\n\n\n

    \u6e83\u75a1\u6027\u7ed3\u80a0\u708e\uff08ulcerative colitis\uff0cUC\uff09\u662f\u708e\u75c7\u6027\u80a0\u75c5\uff08inflammatory bowel disease\uff0cIBD\uff09\u7684\u4e00\u4e2a\u4e9a\u578b\uff0c\u7279\u5f81\u662f\u4ece\u76f4\u80a0\u5411\u8fd1\u7aef\u8fde\u7eed\u7d2f\u53ca\u7ed3\u80a0\u9ecf\u819c\u7684\u6162\u6027\u975e\u7279\u5f02\u6027\u708e\u75c7\uff0c\u53ef\u53cd\u590d\u53d1\u4f5c\u3001\u8fc1\u5ef6\u4e0d\u6108\uff0c\u662f\u5178\u578b\u7684\u7ec8\u8eab\u6027\u514d\u75ab\u4ecb\u5bfc\u75be\u75c5[6]<\/sup>\u3002\u5176\u53d1\u75c5\u7387\u548c\u60a3\u75c5\u7387\u5728\u5168\u7403\u8303\u56f4\u5185\u5448\u4e0a\u5347\u8d8b\u52bf[7]<\/sup>\u3002<\/p>\n\n\n\n

    \u6839\u636e2025\u5e74\u7f8e\u56fd\u80c3\u80a0\u75c5\u534f\u4f1a\uff08AGA\uff09\u4e34\u5e8a\u6307\u5357\u66f4\u65b0\u5f15\u7528\u7684\u6570\u636e\uff0c\u708e\u75c7\u6027\u80a0\u75c5\uff08IBD\uff0c\u5305\u62ec\u6e83\u75a1\u6027\u7ed3\u80a0\u708e\u548c\u514b\u7f57\u6069\u75c5\uff09\u7684\u5168\u7403\u60a3\u75c5\u4eba\u6570\u4f30\u8ba1\u5df2\u8d85\u8fc7800\u4e07[7]<\/sup>\u3002\u4f5c\u4e3a IBD \u7684\u4e3b\u8981\u4e9a\u578b\uff0cUC \u60a3\u8005\u6784\u6210\u4e86\u8fd9\u4e00\u5de8\u5927\u75be\u75c5\u8d1f\u62c5\u7684\u91cd\u8981\u90e8\u5206\u3002\u5728\u5317\u7f8e\u7b49\u9ad8\u53d1\u75c5\u7387\u5730\u533a\uff0cUC \u7684\u60a3\u75c5\u7387\u5df2\u8d85\u8fc7\u6bcf 10 \u4e07\u4eba 400 \u4f8b\uff0c\u610f\u5473\u7740\u7ea6 0.4% \u7684\u4eba\u53e3\u53d7\u7d2f[6]<\/sup>\u3002\u540c\u65f6\uff0c\u5728\u4e9a\u6d32\u3001\u62c9\u4e01\u7f8e\u6d32\u7b49\u65e2\u5f80\u7684\u4f4e\u53d1\u75c5\u7387\u5730\u533a\uff0cUC \u7684\u53d1\u75c5\u7387\u548c\u60a3\u75c5\u7387\u6b63\u5728\u8fc5\u901f\u4e0a\u5347[6, 9, 10]\u3002\u53d1\u75c5\u9ad8\u5cf0\u591a\u5728\u9752\u58ee\u5e74\uff0820\u201340 \u5c81\uff09\uff0c\u4f46\u513f\u7ae5\u548c\u8001\u5e74\u4eba\u53d1\u75c5\u4e5f\u5728\u589e\u52a0\uff0c\u513f\u7ae5\u9752\u5c11\u5e74 UC \u7684\u53d1\u75c5\u7387\u5728\u5168\u7403\u591a\u5730\u533a\u5448\u6301\u7eed\u4e0a\u5347\u8d8b\u52bf[6]<\/sup>\u3002<\/p>\n\n\n\n

    \u4e2d\u56fd\u8fc7\u53bb\u88ab\u89c6\u4e3a\u4f4e\u53d1\u533a\uff0c\u4f46\u6700\u65b0 2023 \u7248\u4e2d\u56fd UC \u8bca\u6cbb\u6307\u5357\u7279\u522b\u5f3a\u8c03\uff0cUC \u6b63\u5728\u6210\u4e3a\u6211\u56fd\u91cd\u8981\u7684\u6162\u6027\u6d88\u5316\u75c5\u8d1f\u62c5[11]<\/sup>\u3002\u8fd9\u79cd”\u60a3\u8005\u8d8a\u6765\u8d8a\u591a\u3001\u75c5\u7a0b\u7ec8\u8eab\u6027\u3001\u5e76\u53d1\u75c7\u4e0e\u764c\u53d8\u98ce\u9669\u5e76\u5b58”\u7684\u7279\u70b9\uff0c\u4e5f\u6b63\u5728\u9a71\u52a8\u4e34\u5e8a\u5b9e\u8df5\u548c\u536b\u751f\u8d44\u6e90\u914d\u7f6e\u7684\u6301\u7eed\u8c03\u6574\u3002<\/p>\n\n\n\n

    \u4e09\u3001\u53d1\u75c5\u673a\u5236\u4e0e\u75c5\u7406\u751f\u7406<\/h1>\n\n\n\n

    UC \u7684\u786e\u5207\u75c5\u56e0\u5c1a\u4e0d\u6e05\u695a\uff0c\u4f46\u4e3b\u6d41\u5171\u8bc6\u8ba4\u4e3a\uff1a\u9057\u4f20\u6613\u611f\u4e2a\u4f53\u5728\u7279\u5b9a\u73af\u5883\u66b4\u9732\u4e0b\uff0c\u80a0\u9053\u5c4f\u969c\u3001\u5fae\u751f\u7269\u7fa4\u548c\u9ecf\u819c\u514d\u75ab\u5931\u8861\u5171\u540c\u4f5c\u7528\uff0c\u6700\u7ec8\u5bfc\u81f4\u75be\u75c5\u53d1\u751f[6]<\/sup>\u3002<\/p>\n\n\n\n

      \n
    • \u9057\u4f20\u56e0\u7d20<\/strong>\uff1a\u4e0e\u514b\u7f57\u6069\u75c5\uff08CD\uff09\u76f8\u6bd4\uff0cUC\u00a0\u7684\u5355\u4e2a\u9ad8\u5371\u57fa\u56e0\u6548\u5e94\u7565\u5f31\uff0c\u4f46\u591a\u57fa\u56e0\u98ce\u9669\u3001\u591a\u57fa\u56e0-\u73af\u5883\u4ea4\u4e92\u66f4\u4e3a\u91cd\u8981[17]<\/sup>\u3002<\/li>\n\n\n\n
    • \u9ecf\u819c\u5c4f\u969c\u53d7\u635f<\/strong>\uff1a\u4e0a\u76ae\u7d27\u5bc6\u8fde\u63a5\u548c\u9ecf\u6db2\u5c42\u53d7\u635f\uff0c\u4f7f\u7ec6\u83cc\u4ea7\u7269\u66f4\u6613\u8fdb\u5165\u9ecf\u819c\u4e0b\u5c42\uff0c\u89e6\u53d1\u514d\u75ab\u53cd\u5e94[18]<\/sup>\u3002<\/li>\n\n\n\n
    • \u80a0\u9053\u83cc\u7fa4\u5931\u8c03<\/strong>\uff1a\u591a\u9879\u7814\u7a76\u663e\u793a\uff0cUC\u00a0\u60a3\u8005\u80a0\u9053\u5fae\u751f\u7269\u591a\u6837\u6027\u4e0b\u964d\u3001\u4fdd\u62a4\u6027\u83cc\u7fa4\u51cf\u5c11\u3001\u81f4\u708e\u83cc\u589e\u591a\uff0c\u5fae\u751f\u7269\u7ec4\u6210\u4e3a\u91cd\u8981\u521b\u65b0\u6cbb\u7597\u9776\u70b9[12]<\/sup>\u3002<\/li>\n\n\n\n
    • \u514d\u75ab\u5931\u8861<\/strong>\uff1a\u6d89\u53ca\u591a\u79cd\u708e\u75c7\u901a\u8def\uff0c\u5305\u62ec\u80bf\u7624\u574f\u6b7b\u56e0\u5b50-\u03b1\uff08TNF-\u03b1\uff09\u3001\u767d\u7ec6\u80de\u4ecb\u7d20-12\/23\uff08IL-12\/23\uff09\u3001Janus\u00a0\u6fc0\u9176-\u4fe1\u53f7\u8f6c\u5bfc\u548c\u8f6c\u5f55\u6fc0\u6d3b\u56e0\u5b50\uff08JAK-STAT\uff09\u3001\u9798\u6c28\u9187-1-\u78f7\u9178\uff08S1P\uff09\u7b49\u5173\u952e\u4fe1\u53f7\u901a\u8def\u7684\u5f02\u5e38\u6fc0\u6d3b[6,\u00a013]\u3002<\/li>\n<\/ul>\n\n\n\n

      \u75c5\u7406\u4e0a\uff0cUC \u5178\u578b\u8868\u73b0\u4e3a\u76f4\u80a0\u8d77\u59cb\u7684\u8fde\u7eed\u6027\u9ecf\u819c\u708e\u3002\u91cd\u8005\u53ef\u89c1\u9ecf\u819c\u7cdc\u70c2\u3001\u6e83\u75a1\u3001\u8113\u6027\u6e17\u51fa\uff1b\u6162\u6027\u671f\u53ef\u89c1\u9ecf\u819c\u840e\u7f29\u3001\u5047\u606f\u8089\u3002\u7d2f\u53ca\u8303\u56f4\u4e0e\u4e25\u91cd\u7a0b\u5ea6\u76f4\u63a5\u5bf9\u5e94\u4e34\u5e8a\u5206\u578b\u548c\u6cbb\u7597\u7b56\u7565\u3002<\/p>\n\n\n\n

      \"\"<\/figure>\n\n\n\n

      \u56fe1. \u6e83\u75a1\u6027\u7ed3\u80a0\u708e\u7684\u4e0d\u540c\u4e34\u5e8a\u8868\u578b\u3002\u6839\u636e\u9ecf\u819c\u53d7\u7d2f\u8303\u56f4\uff0c\u4f20\u7edf\u4e0a\u53ef\u5c06\u75be\u75c5\u5206\u4e3a\u5b64\u7acb\u6027\u76f4\u80a0\u708e\uff08a\uff09\u3001\u76f4\u80a0\u4e59\u72b6\u7ed3\u80a0\u708e\uff08b\uff09\u3001\u5de6\u4fa7\u7ed3\u80a0\u708e\uff08c\uff09\u3001\u5e7f\u6cdb\u6027\u7ed3\u80a0\u708e\uff08d\uff09\u548c\u5168\u7ed3\u80a0\u708e\uff08e\uff09\uff08\u8fc7\u53bb\u901a\u8fc7\u94a1\u9910\u9020\u5f71\u6216\u5185\u955c\u68c0\u67e5\u5224\u65ad\uff0c\u8fd1\u5e74\u5219\u4f9d\u9760\u7ec4\u7ec7\u5b66\u68c0\u67e5\u7ed3\u679c\u786e\u5b9a\uff09\u3002\u539f\u53d1\u6027\u786c\u5316\u6027\u80c6\u7ba1\u708e\u8868\u73b0\u4e3a\u76f8\u5bf9\u6216\u5b8c\u5168\u7684\u76f4\u80a0\u4e0d\u53d7\u7d2f\uff08f\uff09\uff0c\u867d\u5c5e\u4e8e\u4f20\u7edf\u5206\u7c7b\u4e2d\u7684\u7279\u6b8a\u7c7b\u578b\uff0c\u4f46\u5176\u6cbb\u7597\u65b9\u6848\u4e0e\u5176\u5b83\u7c7b\u578b\u76f8\u4f3c\u3002\u9611\u5c3e\u5468\u56f4\u6216\u76f2\u80a0\u533a\u57df\u7684\u75c5\u53d8\uff08g\uff09\u5e38\u89c1\u4e8e\u8fdc\u7aef\u7ed3\u80a0\u708e\u60a3\u8005\uff0c\u5176\u5904\u7406\u65b9\u5f0f\u4e5f\u4e0e\u4e4b\u76f8\u540c[7]<\/sup>\u3002<\/p>\n\n\n\n

      \u56db\u3001\u4e34\u5e8a\u8868\u73b0\u4e0e\u81ea\u7136\u75c5\u7a0b<\/h1>\n\n\n\n

      \u5178\u578b UC \u8868\u73b0\u5305\u62ec[6]<\/sup>\uff1a<\/p>\n\n\n\n

        \n
      • \u80a0\u9053\u75c7\u72b6<\/strong>\uff1a\u53cd\u590d\u53d1\u4f5c\u7684\u9ecf\u6db2\u8113\u8840\u4fbf\u3001\u8179\u6cfb\uff08\u8f7b\u8005\u6bcf\u65e5\u00a03\u20134\u00a0\u6b21\uff0c\u91cd\u8005\u53ef\u00a0>10\u00a0\u6b21\uff09\u3001\u91cc\u6025\u540e\u91cd\u3001\u8179\u75db\u3002<\/li>\n\n\n\n
      • \u5168\u8eab\u75c7\u72b6<\/strong>\uff1a\u4e4f\u529b\u3001\u4f53\u91cd\u4e0b\u964d\u3001\u98df\u6b32\u5dee\u3002\u91cd\u5ea6\u6216\u6025\u6027\u91cd\u75c7\u53ef\u51fa\u73b0\u53d1\u70ed\u3001\u5fc3\u52a8\u8fc7\u901f\u3001\u8d2b\u8840\u3001\u4f4e\u767d\u86cb\u767d\u8840\u75c7\u3002<\/li>\n\n\n\n
      • \u80a0\u5916\u8868\u73b0<\/strong>\uff1a\u5173\u8282\u708e\u6216\u5173\u8282\u75db\u3001\u7ed3\u8282\u6027\u7ea2\u6591\u3001\u574f\u75bd\u6027\u8113\u76ae\u75c5\u3001\u8461\u8404\u819c\u708e\u3001\u539f\u53d1\u6027\u786c\u5316\u6027\u80c6\u7ba1\u708e\uff08PSC\uff09\u7b49\u3002<\/li>\n<\/ul>\n\n\n\n

        \u81ea\u7136\u75c5\u7a0b\u591a\u4e3a”\u53d1\u4f5c\u2013\u7f13\u89e3\u2013\u518d\u53d1\u4f5c”\u3002\u6025\u6027\u91cd\u75c7\u6e83\u75a1\u6027\u7ed3\u80a0\u708e\uff08acute severe ulcerative colitis\uff0cASUC\uff09\u662f UC \u7684\u4e00\u79cd\u5371\u91cd\u72b6\u6001\uff0c\u636e\u4f30\u8ba1\u7ea6 25% \u7684 UC \u60a3\u8005\u5728\u5176\u75c5\u7a0b\u4e2d\u81f3\u5c11\u4f1a\u7ecf\u5386\u4e00\u6b21 ASUC \u53d1\u4f5c[12]<\/sup>\u3002\u6bcf\u6b21\u53d1\u4f5c\u90fd\u4f34\u968f\u7ed3\u80a0\u5207\u9664\u672f\u548c\u6b7b\u4ea1\u98ce\u9669\uff0c\u9700\u8981\u7d27\u6025\u5904\u7406\u3002<\/p>\n\n\n\n

        \u6b64\u5916\uff0c\u7531\u4e8e\u957f\u671f\u6162\u6027\u708e\u75c7\u53cd\u590d\u635f\u4f24\u80a0\u9053\u9ecf\u819c\uff0cUC \u60a3\u8005\u7684\u7ed3\u76f4\u80a0\u764c\uff08colorectal cancer, CRC\uff09\u98ce\u9669\u8f83\u4e00\u822c\u4eba\u7fa4\u5347\u9ad8\u3002\u4e0d\u8fc7\uff0c\u968f\u7740\u8fbe\u6807\u6cbb\u7597\u63a8\u52a8\u9ecf\u819c\u6108\u5408\u7387\u63d0\u5347\u3001\u4ee5\u53ca\u7ed3\u80a0\u955c\u76d1\u6d4b\u7684\u89c4\u8303\u5316\u666e\u53ca\uff0c\u8fd1\u5e74\u6765 UC \u76f8\u5173 CRC \u7684\u5e74\u53d1\u75c5\u7387\u5df2\u5448\u660e\u663e\u4e0b\u964d\u8d8b\u52bf[11]<\/sup>\u3002<\/p>\n\n\n\n

        \u4e94\u3001\u8bca\u65ad\uff1a\u4ece”\u6392\u9664\u5176\u4ed6\u75be\u75c5”\u5230”\u6d3b\u52a8\u5ea6\u4e0e\u98ce\u9669\u5206\u5c42”<\/h1>\n\n\n\n

        \u968f\u7740 UC \u75be\u75c5\u8d1f\u62c5\u9010\u6b65\u52a0\u91cd\uff0c\u8bca\u7597\u7406\u5ff5\u4e5f\u4ece\u8fc7\u53bb\u7684”\u80fd\u6392\u9664\u5176\u4ed6\u75be\u75c5\u5373\u53ef”\u8f6c\u5411”\u901a\u8fc7\u7cbe\u51c6\u5206\u5c42\u652f\u6491\u8fbe\u6807\u6cbb\u7597”\u3002\u8bca\u65ad\u73af\u8282\u6b63\u5728\u4ece\u5355\u7eaf\u786e\u8bca\uff0c\u5347\u7ea7\u4e3a\u8d2f\u7a7f\u5168\u7a0b\u7ba1\u7406\u7684\u8d77\u70b9\u3002<\/p>\n\n\n\n

        1\uff09\u8bca\u65ad\u6d41\u7a0b\uff1a\u4ece\u6392\u9664\u6027\u8bca\u65ad\u5230\u89c4\u8303\u5316\u786e\u8bca<\/h2>\n\n\n\n

        \u56fd\u9645\u4e0e\u4e2d\u56fd\u6307\u5357\u57fa\u672c\u4e00\u81f4\uff1a\u8bca\u65ad UC \u9700\u8981\u7efc\u5408\u4e34\u5e8a\u8868\u73b0\u3001\u5185\u955c\u68c0\u67e5\u3001\u7ec4\u7ec7\u75c5\u7406\u5b66\u548c\u5b9e\u9a8c\u5ba4\u68c0\u67e5\u7b49\u591a\u7ef4\u5ea6\u4fe1\u606f\uff0c\u5e76\u7cfb\u7edf\u6392\u9664\u611f\u67d3\u6027\u7ed3\u80a0\u708e\u7b49\u5176\u4ed6\u53ef\u80fd\u75c5\u56e0[6, 7, 11]<\/sup>\u3002<\/p>\n\n\n\n

          \n
        • \u75c5\u53f2\u4e0e\u4f53\u68c0<\/strong>\uff1a\u91cd\u70b9\u8be2\u95ee\u662f\u5426\u5b58\u5728\u6301\u7eed\u6216\u53cd\u590d\u8840\u4fbf\u3001\u8179\u6cfb\u3001\u91cc\u6025\u540e\u91cd\u7b49\u5178\u578b\u75c7\u72b6\uff0c\u540c\u65f6\u4e86\u89e3\u7528\u836f\u53f2\uff08NSAIDs\u3001\u6297\u751f\u7d20\uff09\u3001\u611f\u67d3\u63a5\u89e6\u53f2\u53ca\u5bb6\u65cf\u53f2\u3002<\/li>\n\n\n\n
        • \u5b9e\u9a8c\u5ba4\u4e0e\u7caa\u4fbf\u68c0\u67e5<\/strong>\uff1a\u5e38\u89c4\u68c0\u6d4b\u5305\u62ec\u8840\u5e38\u89c4\u3001CRP\u00a0\u6216\u00a0ESR\u3001\u809d\u80be\u529f\u80fd\u53ca\u7535\u89e3\u8d28\u30022025\u00a0\u5e74\u00a0ACG\u00a0\u6307\u5357\u5f3a\u70c8\u63a8\u8350\u5bf9\u7591\u4f3c\u00a0UC\u00a0\u60a3\u8005\u8fdb\u884c\u7caa\u4fbf\u68c0\u6d4b\u4ee5\u6392\u9664\u8270\u96be\u68ad\u83cc\uff08C.\u00a0difficile\uff09\u611f\u67d3<\/strong>\uff0c\u540c\u65f6\u53cd\u5bf9\u4f7f\u7528\u8840\u6e05\u5b66\u6297\u4f53\u68c0\u6d4b\u6765\u5efa\u7acb\u6216\u6392\u9664\u00a0UC\u00a0\u8bca\u65ad\u6216\u5224\u65ad\u9884\u540e<\/strong>[7]<\/sup>\u3002<\/li>\n\n\n\n
        • \u5185\u955c\u4e0e\u6d3b\u68c0<\/strong>\uff1a\u7ed3\u80a0\u955c\u68c0\u67e5\u662f\u786e\u8bca\u00a0UC\u00a0\u7684\u5173\u952e\uff0c\u5e94\u5c1d\u8bd5\u8fdb\u5165\u56de\u80a0\u672b\u7aef\uff0c\u5e76\u5bf9\u53d7\u7d2f\u53ca\u672a\u53d7\u7d2f\u533a\u57df\u5747\u8fdb\u884c\u6d3b\u68c0\u3002\u75c5\u53d8\u8303\u56f4\u5e94\u6309\u8499\u7279\u5229\u5c14\uff08Montreal\uff09\u5206\u7c7b\u660e\u786e\uff1a\u76f4\u80a0\u708e\uff08E1\uff09\u3001\u5de6\u534a\u7ed3\u80a0\u708e\uff08E2\uff09\u3001\u5e7f\u6cdb\u7ed3\u80a0\u708e\uff08E3\uff09[7,\u00a011]\u3002<\/li>\n\n\n\n
        • \u5f71\u50cf<\/strong>\uff1a\u5f53\u6000\u7591\u5b58\u5728\u7a7f\u5b54\u3001\u91cd\u5ea6\u6269\u5f20\u7b49\u5e76\u53d1\u75c7\uff0c\u6216\u9700\u4e0e\u514b\u7f57\u6069\u75c5\u8fdb\u884c\u9274\u522b\u65f6\uff0cCT\u3001MR\u00a0\u6216\u80a0\u9053\u8d85\u58f0\u53ef\u63d0\u4f9b\u8f85\u52a9\u4fe1\u606f\u3002<\/li>\n<\/ul>\n\n\n\n

          2\uff09\u8bc4\u4f30\u75be\u75c5\u8303\u56f4\u4e0e\u6d3b\u52a8\u5ea6\uff1a\u4e3a\u98ce\u9669\u5206\u5c42\u548c\u8fbe\u6807\u6cbb\u7597\u63d0\u4f9b\u57fa\u7ebf<\/h2>\n\n\n\n

          \u786e\u8bca UC \u540e\uff0c\u9700\u8fdb\u4e00\u6b65\u8bc4\u4f30\u75be\u75c5\u8303\u56f4\u4e0e\u6d3b\u52a8\u5ea6\u30022025 \u5e74 ACG \u6307\u5357\u4e3b\u8981\u4ece\u4ee5\u4e0b\u4e24\u4e2a\u7ef4\u5ea6\u8fdb\u884c\u5206\u578b\u4e0e\u8bc4\u4f30[7]<\/sup>\uff1a<\/p>\n\n\n\n

            \n
          • \u75c5\u53d8\u8303\u56f4\uff08Montreal\u00a0\u5206\u7c7b\uff09<\/strong>\uff1a
            • E1\uff08\u76f4\u80a0\u708e\uff0cproctitis\uff09<\/strong>\uff1a\u708e\u75c7\u8303\u56f4\u901a\u5e38\u00a0\u226415\u00a0cm<\/li><\/ul>
              • E2\uff08\u5de6\u4fa7\u7ed3\u80a0\u708e\uff09<\/strong>\uff1a\u708e\u75c7\u8d85\u8fc7\u76f4\u80a0\u708e\u8303\u56f4\uff0c\u4f46\u6b62\u4e8e\u813e\u66f2\u6216\u813e\u66f2\u4ee5\u8fdc<\/li><\/ul>
                • E3\uff08\u5e7f\u6cdb\u6027\u7ed3\u80a0\u708e\uff09<\/strong>\uff1a\u708e\u75c7\u5ef6\u4f38\u81f3\u813e\u66f2\u4ee5\u8fdc\uff1b\u82e5\u6574\u4e2a\u76f4\u80a0\u3001\u7ed3\u80a0\u53ca\u76f2\u80a0\u5747\u53d7\u7d2f\uff0c\u5219\u79f0\u4e3a\u5168\u7ed3\u80a0\u708e\uff08pancolitis\uff09<\/li><\/ul>\n
                    \n
                  • \u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u5373\u4f7f\u5185\u955c\u4e0b\u770b\u8d77\u6765\u6b63\u5e38\u7684\u8fd1\u7aef\u7ed3\u80a0\u4e5f\u53ef\u80fd\u5b58\u5728\u7ec4\u7ec7\u5b66\u75c5\u53d8\uff0c\u56e0\u6b64\u5e94\u5bf9\u5185\u955c\u4e0b\u672a\u89c1\u708e\u75c7\u7684\u8fd1\u7aef\u533a\u57df\u5355\u72ec\u53d6\u6d3b\u68c0\uff0c\u4ee5\u51c6\u786e\u786e\u5b9a\u75be\u75c5\u8303\u56f4\u53ca\u540e\u7eed\u76d1\u6d4b\u95f4\u9694\u3002\u540c\u7406\uff0c\u5373\u4f7f\u76f4\u80a0\u5185\u955c\u4e0b\u8868\u73b0\u6b63\u5e38\uff0c\u4e5f\u5e94\u5355\u72ec\u53d6\u6d3b\u68c0\u3002<\/li>\n<\/ul>\n<\/li>\n\n\n\n
                  • \u6d3b\u52a8\u5ea6<\/strong>\uff1a\u786e\u8bca\u540e\u9700\u7acb\u5373\u5e76\u6301\u7eed\u8bc4\u4f30\u75be\u75c5\u6d3b\u52a8\u5ea6\uff0c\u4ee5\u6307\u5bfc\u6cbb\u7597\u51b3\u7b56\u548c\u540e\u7eed\u76d1\u6d4b\uff1a<\/li>\n\n\n\n
                  • \u4e34\u5e8a\u6d3b\u52a8\u5ea6<\/strong>\uff1a\u5e38\u7528\u6539\u826f\u00a0Mayo\u00a0\u8bc4\u5206<\/strong>\uff08\u4ea6\u79f0\u90e8\u5206\u00a0Mayo\u00a0\u8bc4\u5206\uff0c\u542b\u6392\u4fbf\u9891\u7387\u3001\u4fbf\u8840\u3001\u533b\u5e08\u603b\u4f53\u8bc4\u4ef7\uff09\u6216\u7b80\u5355\u4e34\u5e8a\u7ed3\u80a0\u708e\u6d3b\u52a8\u6307\u6570\uff08SCCAI\uff09<\/strong>\u8bc4\u4f30\u75c7\u72b6\u3002Truelove\u00a0&\u00a0Witts\u00a0\u6807\u51c6<\/strong>\u662f\u5b9a\u4e49\u6025\u6027\u91cd\u75c7\u00a0UC\uff08ASUC\uff09<\/strong>\u7684\u7ecf\u5178\u4f9d\u636e\u3002<\/li>\n\n\n\n
                  • \u5185\u955c\u4e25\u91cd\u7a0b\u5ea6<\/strong>\uff1a\u5fc5\u987b\u91c7\u7528\u7ecf\u8fc7\u9a8c\u8bc1\u7684\u91cf\u8868\u8fdb\u884c\u5ba2\u89c2\u8bc4\u4f30\u3002Mayo\u00a0\u5185\u955c\u8bc4\u5206\uff08MES\uff09<\/strong>\u662f\u4e34\u5e8a\u5b9e\u8df5\u4e2d\u6700\u5e38\u7528\u7684\u5de5\u5177\uff0c\u800cUC\u00a0\u5185\u955c\u4e25\u91cd\u7a0b\u5ea6\u6307\u6570\uff08UCEIS\uff09<\/strong>\u56e0\u5b9a\u4e49\u66f4\u7cbe\u786e\uff0c\u66f4\u5e38\u7528\u4e8e\u4e34\u5e8a\u7814\u7a76\u53ca\u9884\u540e\u9884\u6d4b\u3002<\/li>\n\n\n\n
                  • \u7efc\u5408\u5206\u5c42<\/strong>\uff1a\u57fa\u4e8e\u4e34\u5e8a\u3001\u5185\u955c\u53ca\u708e\u75c7\u6807\u5fd7\u7269\uff08\u5982\u00a0C\u00a0\u53cd\u5e94\u86cb\u767d\u3001\u7caa\u4fbf\u9499\u536b\u86cb\u767d\uff09\uff0cUC\u00a0\u6d3b\u52a8\u5ea6\u901a\u5e38\u5206\u4e3a\uff1a\u7f13\u89e3\u671f<\/strong>\u3001\u8f7b\u5ea6\u6d3b\u52a8<\/strong>\u3001\u4e2d\u5ea6\u81f3\u91cd\u5ea6\u6d3b\u52a8<\/strong>\u3001\u6025\u6027\u91cd\u75c7<\/strong>\u3002\u5176\u4e2d”\u4e2d\u5ea6\u81f3\u91cd\u5ea6”\u5e38\u88ab\u4f5c\u4e3a\u4e00\u4e2a\u6574\u4f53\u6cbb\u7597\u51b3\u7b56\u533a\u95f4\u3002<\/li>\n\n\n\n
                  • \u5173\u952e\u70b9<\/strong>\uff1a\u6cbb\u7597\u9009\u62e9\u4e0d\u4ec5\u53d6\u51b3\u4e8e\u5f53\u524d\u6d3b\u52a8\u5ea6\uff0c\u66f4\u5e94\u7ed3\u5408\u9884\u540e\u56e0\u7d20<\/strong>\uff08\u5982\u53d1\u75c5\u5e74\u9f84\u00a0<40\u00a0\u5c81\u3001\u5e7f\u6cdb\u6027\u7ed3\u80a0\u708e\u3001\u5185\u955c\u4e0b\u6df1\u6e83\u75a1\u3001CRP\u00a0\u663e\u8457\u5347\u9ad8\u3001\u4f4e\u767d\u86cb\u767d\u8840\u75c7\uff09\u3002\u5b58\u5728\u00a0\u22652\u00a0\u4e2a\u9ad8\u5371\u56e0\u7d20\u7684\u60a3\u8005\uff0c\u5373\u4f7f\u4e34\u5e8a\u8868\u73b0\u4e3a\u8f7b\u5ea6\uff0c\u4e5f\u5e94\u6309\u7167\u4e2d\u91cd\u5ea6\u6d3b\u52a8\u5ea6\u7684\u65b9\u6848\u8fdb\u884c\u79ef\u6781\u6cbb\u7597\u3002<\/li>\n<\/ul>\n\n\n\n

                    \u88681. \u6539\u826f Truelove \u548c Witts \u75be\u75c5\u4e25\u91cd\u7a0b\u5ea6\u5206\u578b<\/p>\n\n\n\n

                    \"\"<\/figure>\n\n\n\n

                    \u88682. \u8bc4\u4f30\u6e83\u75a1\u6027\u7ed3\u80a0\u708e\u6d3b\u52a8\u6027\u7684\u6539\u826f Mayo \u8bc4\u5206\u7cfb\u7edf<\/p>\n\n\n\n

                    \"\"<\/figure>\n\n\n\n

                    \u6ce8\uff1aa \u6bcf\u4f4d\u53d7\u8bd5\u8005\u4f5c\u4e3a\u81ea\u8eab\u5bf9\u7167\uff0c\u4ece\u800c\u8bc4\u4ef7\u6392\u4fbf\u6b21\u6570\u7684\u5f02\u5e38\u7a0b\u5ea6\uff1bb \u6bcf\u65e5\u51fa\u8840\u8bc4\u5206\u4ee3\u8868\u4e00\u5929\u4e2d\u6700\u4e25\u91cd\u7684\u51fa\u8840\u60c5\u51b5\uff1bc \u533b\u5e08\u603b\u4f53\u8bc4\u4ef7\u5305\u62ec 3 \u9879\u6807\u51c6\uff0c\u53d7\u8bd5\u8005\u5bf9\u4e8e\u8179\u90e8\u4e0d\u9002\u7684\u56de\u987e\u3001\u603b\u4f53\u5e78\u798f\u611f\u548c\u5176\u4ed6\u8868\u73b0\uff0c\u5982\u4f53\u683c\u68c0\u67e5\u53d1\u73b0\u548c\u53d7\u8bd5\u8005\u8868\u73b0\u72b6\u6001\uff1b\u603b\u8bc4\u5206\u22642 \u5206\u4e14\u65e0\u5355\u4e2a\u5206\u9879\u8bc4\u5206\uff1e1 \u5206\u4e3a\u4e34\u5e8a\u7f13\u89e3\uff0c3 ~ 5 \u5206\u4e3a\u8f7b\u5ea6\u6d3b\u52a8\uff0c6 ~ 10 \u5206\u4e3a\u4e2d\u5ea6\u6d3b\u52a8\uff0c11 ~ 12 \u5206\u4e3a\u91cd\u5ea6\u6d3b\u52a8\uff1b\u6709\u6548\u5b9a\u4e49\u4e3a\u8bc4\u5206\u76f8\u5bf9\u4e8e\u57fa\u7ebf\u503c\u7684\u964d\u5e45\u226530% \u4ee5\u53ca\u8bc4\u5206\u964d\u5e45\u22653 \u5206\uff0c\u800c\u4e14\u4fbf\u8840\u7684\u5206\u9879\u8bc4\u5206\u964d\u5e45\u22651 \u5206\u6216\u8be5\u5206\u9879\u8bc4\u5206\u4e3a 0 \u6216 1 \u5206\u3002<\/p>\n\n\n\n

                    \u88683. \u6e83\u75a1\u6027\u7ed3\u80a0\u708e Mayo \u5185\u955c\u8bc4\u5206<\/p>\n\n\n\n

                    \"\"<\/figure>\n\n\n\n

                    \u88684. \u6e83\u75a1\u6027\u7ed3\u80a0\u708e\u5185\u955c\u4e0b\u4e25\u91cd\u7a0b\u5ea6\u6307\u6570\uff08UCEIS\uff09\u8bc4\u5206\u7cfb\u7edf<\/p>\n\n\n\n

                    \"\"<\/figure>\n\n\n\n

                    \u6ce8\uff1a\u603b\u8bc4\u5206\u4e3a 3 \u4e2a\u6307\u6807\u8bc4\u5206\u4e4b\u548c\uff0c\u6b63\u5e38\uff1a0 \u5206\uff0c\u8f7b\u5ea6\u6d3b\u52a8\uff1a1 ~ 3 \u5206\uff0c\u4e2d\u5ea6\u6d3b\u52a8\uff1a4 ~ 6 \u5206\uff0c\u91cd\u5ea6\u6d3b\u52a8\uff1a7 ~ 8 \u5206<\/p>\n\n\n\n

                    \"\"<\/figure>\n\n\n\n

                    \u56fe2. \u4f7f\u7528Mayo\u5185\u955c\u8bc4\u5206\u7cfb\u7edf\u548c\u6e83\u75a1\u6027\u7ed3\u80a0\u708e\u5185\u955c\u4e25\u91cd\u7a0b\u5ea6\u6307\u6570\uff08UCEIS\uff09\u5bf9\u6e83\u75a1\u6027\u7ed3\u80a0\u708e\u60a3\u8005\u8fdb\u884c\u7684\u5185\u955c\u56fe\u50cf\u6837\u672c[7]<\/sup><\/p>\n\n\n\n

                    2025 \u5e74 ACG \u6307\u5357\u4e0e\u4e2d\u56fd 2023 \u7248\u6307\u5357\u5747\u5f3a\u8c03”\u8fbe\u6807\u6cbb\u7597\uff08treat-to-target\uff09”\u7406\u5ff5<\/strong>[7, 11, 14]<\/sup>\uff1a\u6cbb\u7597\u76ee\u6807\u5e94\u8ffd\u6c42\u5185\u955c\u6539\u5584<\/strong>\uff08\u5b9a\u4e49\u4e3a\u708e\u75c7\u6d88\u9000\uff0cMayo \u5185\u955c\u8bc4\u5206\u4e3a 0 \u6216 1 \u5206\uff09\uff0c\u4ee5\u589e\u52a0\u6301\u7eed\u65e0\u6fc0\u7d20\u7f13\u89e3\u7684\u53ef\u80fd\u6027\uff0c\u5e76\u9884\u9632\u4f4f\u9662\u548c\u624b\u672f\u3002\u75be\u75c5\u8bc4\u4f30\u548c\u76d1\u6d4b\u5e94\u7ed3\u5408\u60a3\u8005\u62a5\u544a\u7ed3\u5c40\u3001\u5185\u955c\u8bc4\u4f30\u4ee5\u53ca\u7caa\u4fbf\u9499\u536b\u86cb\u767d\uff08FC\uff09\u3001C \u53cd\u5e94\u86cb\u767d\uff08CRP\uff09\u7b49\u708e\u75c7\u6807\u5fd7\u7269<\/strong>\u3002<\/p>\n\n\n\n

                    \u516d\u3001\u6cbb\u7597\u7b56\u7565\u6f14\u8fdb\uff1a\u57fa\u4e8e\u4e25\u91cd\u7a0b\u5ea6\u7684\u9636\u68af\u9009\u62e9<\/h1>\n\n\n\n

                    \u73b0\u4ee3 UC \u6cbb\u7597\u7b56\u7565\u9ad8\u5ea6\u4f9d\u8d56\u75be\u75c5\u6d3b\u52a8\u5ea6\u7684\u7cbe\u786e\u5206\u5c42\u3002<\/p>\n\n\n\n

                    UC \u7684\u836f\u7269\u6cbb\u7597\u5206\u4e3a\u4e24\u4e2a\u9636\u6bb5\uff1a<\/p>\n\n\n\n

                      \n
                    • \u8bf1\u5bfc\u7f13\u89e3\uff08induction\u00a0of\u00a0remission\uff09<\/strong>\uff1a\u5373\u901a\u8fc7\u77ed\u671f\u5f3a\u5316\u6cbb\u7597\u63a7\u5236\u6d3b\u52a8\u6027\u708e\u75c7\u3001\u4f7f\u75be\u75c5\u8fdb\u5165\u7f13\u89e3\u72b6\u6001\uff1b<\/li>\n\n\n\n
                    • \u7ef4\u6301\u7f13\u89e3\uff08maintenance\u00a0of\u00a0remission\uff09<\/strong>\uff1a\u5373\u5728\u8fbe\u5230\u7f13\u89e3\u540e\u6301\u7eed\u7528\u836f\u4ee5\u9632\u6b62\u590d\u53d1\u3002\u6cbb\u7597\u65b9\u6848\u7684\u9009\u62e9\u53d6\u51b3\u4e8e\u75be\u75c5\u6d3b\u52a8\u5ea6\u548c\u75c5\u53d8\u8303\u56f4\u3002<\/li>\n<\/ul>\n\n\n\n

                      1\uff09\u8f7b\u4e2d\u5ea6\u6d3b\u52a8\u6027 UC<\/h2>\n\n\n\n

                      \u8f7b\u4e2d\u5ea6\u6d3b\u52a8\u6027 UC \u7684\u6cbb\u7597\u6838\u5fc3\u662f\u4ee5 5-ASA \u4e3a\u57fa\u7840\u7684\u8bf1\u5bfc\u4e0e\u7ef4\u6301\u7b56\u7565\uff0c\u6cbb\u7597\u65b9\u6848\u6839\u636e\u75c5\u53d8\u8303\u56f4\uff08E1\/E2\/E3\uff09\u8fdb\u884c\u5206\u5c42\u3002\u636e 2025 \u5e74 ACG \u6307\u5357[7]<\/sup>\uff1a<\/p>\n\n\n\n

                        \n
                      • \u8bf1\u5bfc\u7f13\u89e3<\/strong>\uff1a
                        • \u76f4\u80a0\u708e\uff08E1\uff09<\/strong>\uff1a\u9996\u9009\u76f4\u80a0\u7528\u00a05-\u6c28\u57fa\u6c34\u6768\u9178\uff085-ASA\uff09\u81f3\u5c11\u00a01\u00a0g\/\u65e5<\/strong>\uff1b\u82e5\u65e0\u6548\uff0c\u53ef\u8003\u8651\u4ed6\u514b\u83ab\u53f8\u6813\u5242\u6216\u500d\u6c2f\u7c73\u677e\u6813\u5242\u3002<\/li><\/ul>
                          • \u5de6\u534a\u7ed3\u80a0\u708e\uff08E2\uff09<\/strong>\uff1a\u63a8\u8350\u76f4\u80a0\u00a05-ASA\uff08\u81f3\u5c11\u00a01\u00a0g\/\u65e5\uff09\u8054\u5408\u53e3\u670d\u00a05-ASA\uff08\u81f3\u5c11\u00a02.0\u00a0g\/\u65e5\uff09<\/strong>\uff0c\u8054\u5408\u7528\u836f\u4f18\u4e8e\u5355\u7528\u53e3\u670d\u3002<\/li><\/ul>
                            • \u5e7f\u6cdb\u7ed3\u80a0\u708e\uff08E3\uff09<\/strong>\uff1a\u63a8\u8350\u53e3\u670d\u00a05-ASA\u00a0\u81f3\u5c11\u00a02.0\u00a0g\/\u65e5<\/strong>\u3002<\/li><\/ul>\n
                                \n
                              • \u82e5\u53e3\u670d\u4e0e\u76f4\u80a0\u00a05-ASA\u00a0\u8054\u5408\u4f7f\u7528\u4ecd\u65e0\u6548\u6216\u4e0d\u8010\u53d7\uff0c\u63a8\u8350\u52a0\u7528\u53e3\u670d\u5e03\u5730\u5948\u5fb7\u00a0MMX\u00a09\u00a0mg\/\u65e5<\/strong>\u8bf1\u5bfc\u7f13\u89e3\uff1b\u82e5\u00a05-ASA\u00a0\u6cbb\u7597\u6574\u4f53\u5931\u8d25\uff0c\u53ef\u8003\u8651\u53e3\u670d\u5168\u8eab\u6027\u7cd6\u76ae\u8d28\u6fc0\u7d20\u3002<\/li>\n<\/ul>\n<\/li>\n\n\n\n
                              • \u7ef4\u6301\u7f13\u89e3<\/strong>\uff1a\u76f4\u80a0\u708e\u63a8\u8350\u76f4\u80a0\u00a05-ASA\uff081\u00a0g\/\u65e5\uff09<\/strong>\uff1b\u5de6\u534a\u7ed3\u80a0\u708e\u6216\u5e7f\u6cdb\u7ed3\u80a0\u708e\u63a8\u8350\u53e3\u670d\u00a05-ASA\uff08\u81f3\u5c11\u00a01.5\u00a0g\/\u65e5\uff09<\/strong>\u3002\u6307\u5357\u53cd\u5bf9\u4f7f\u7528\u5168\u8eab\u6027\u7cd6\u76ae\u8d28\u6fc0\u7d20\u3001\u5e03\u5730\u5948\u5fb7\u00a0MMX\u00a0\u6216\u5c40\u90e8\u7cd6\u76ae\u8d28\u6fc0\u7d20\u8fdb\u884c\u7ef4\u6301\u6cbb\u7597<\/strong>\u3002<\/li>\n<\/ul>\n\n\n\n

                                2\uff09\u4e2d\u91cd\u5ea6\u6d3b\u52a8\u6027 UC<\/h2>\n\n\n\n

                                \u6cbb\u7597\u76ee\u6807\u662f\u5feb\u901f\u8bf1\u5bfc\u4e34\u5e8a\u4e0e\u5185\u955c\u7f13\u89e3\uff0c\u5e76\u8f6c\u5411\u6709\u6548\u7684\u7ef4\u6301\u6cbb\u7597\uff0c\u907f\u514d\u957f\u671f\u4f7f\u7528\u6fc0\u7d20\u3002<\/p>\n\n\n\n

                                \u636e 2025 \u5e74 ACG \u6307\u5357[7]<\/sup>\uff0c\u8bf1\u5bfc\u7f13\u89e3\u6709\u591a\u79cd\u5f3a\u63a8\u8350\u9009\u62e9\uff1a<\/p>\n\n\n\n

                                  \n
                                • \u8bf1\u5bfc\u7f13\u89e3<\/strong>\uff1a
                                  • \u5bf9\u4e8e\u4e2d\u5ea6\u6d3b\u52a8\u6027<\/strong>\u00a0UC\uff0c\u53ef\u4f7f\u7528\u53e3\u670d\u5e03\u5730\u5948\u5fb7\u00a0MMX<\/strong>\u00a0\u8bf1\u5bfc\u7f13\u89e3\uff08\u5f3a\u63a8\u8350\uff09<\/li><\/ul>
                                    • \u53e3\u670d\u5168\u8eab\u6027\u7cd6\u76ae\u8d28\u6fc0\u7d20<\/li><\/ul>
                                      • S1P\u00a0\u53d7\u4f53\u8c03\u8282\u5242\uff08\u5965\u624e\u83ab\u5fb7\u3001\u827e\u66f2\u83ab\u5fb7\uff09<\/li><\/ul>
                                        • IL-12\/23p40\u00a0\u6297\u4f53\uff08\u4e4c\u53f8\u5974\u5355\u6297\uff09<\/li><\/ul>
                                          • IL-23p19\u00a0\u6291\u5236\u5242\uff08\u53e4\u585e\u5947\u5c24\u5355\u6297\u3001\u7c73\u5229\u5947\u73e0\u5355\u6297\u3001\u745e\u838e\u5947\u73e0\u5355\u6297\uff09<\/li><\/ul>
                                            • \u6297\u6574\u5408\u7d20\u836f\u7269\uff08\u7ef4\u591a\u5229\u73e0\u5355\u6297\uff09<\/li><\/ul>
                                              • \u6297\u00a0TNF\u00a0\u836f\u7269\uff08\u82f1\u592b\u5229\u6614\u5355\u6297\u3001\u963f\u8fbe\u6728\u5355\u6297\u3001\u6208\u5229\u6728\u5355\u6297\uff09<\/li><\/ul>\n
                                                  \n
                                                • JAK\u00a0\u6291\u5236\u5242\uff08\u6258\u6cd5\u66ff\u5e03\u3001\u4e4c\u5e15\u66ff\u5c3c\uff09<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n

                                                  \u6307\u5357\u540c\u65f6\u53cd\u5bf9\u786b\u560c\u5464\u6216\u7532\u6c28\u8776\u5464\u5355\u836f\u7528\u4e8e\u8bf1\u5bfc\u7f13\u89e3<\/strong>\u3002\u5f53\u4f7f\u7528\u82f1\u592b\u5229\u6614\u5355\u6297\u8bf1\u5bfc\u65f6\uff0c\u63a8\u8350\u8054\u5408\u786b\u560c\u5464<\/strong>\u4ee5\u63d0\u9ad8\u7597\u6548\u3002<\/p>\n\n\n\n

                                                    \n
                                                  • \u7ef4\u6301\u7f13\u89e3<\/strong>\uff1a\u539f\u5219\u4e0a\uff0c\u4f7f\u7528\u54ea\u79cd\u836f\u7269\u6210\u529f\u8bf1\u5bfc\u7f13\u89e3\uff0c\u5c31\u5e94\u7ee7\u7eed\u4f7f\u7528\u8be5\u836f\u7269\u8fdb\u884c\u7ef4\u6301\u6cbb\u7597\u3002\u6307\u5357\u5f3a\u70c8\u53cd\u5bf9\u4f7f\u7528\u5168\u8eab\u6027\u7cd6\u76ae\u8d28\u6fc0\u7d20\u7ef4\u6301\u7f13\u89e3<\/strong>\u3002<\/li>\n<\/ul>\n\n\n\n

                                                    3\uff09\u6025\u6027\u91cd\u75c7 UC\uff08ASUC\uff09<\/h2>\n\n\n\n

                                                    \u5c5e\u4e8e\u5185\u79d1\u6025\u75c7\uff0c\u9700\u4f4f\u9662\u6cbb\u7597\u3002<\/p>\n\n\n\n

                                                    \u636e 2025 \u5e74 ACG \u6307\u5357[7]<\/sup>\uff0cASUC \u7684\u7ba1\u7406\u6d41\u7a0b\u5982\u4e0b\uff1a<\/p>\n\n\n\n

                                                      \n
                                                    • \u5165\u9662\u8bc4\u4f30<\/strong>\uff1a\u5f3a\u63a8\u8350\u5bf9\u00a0ASUC\u00a0\u60a3\u8005\u8fdb\u884c\u8270\u96be\u68ad\u83cc\uff08CDI\uff09\u68c0\u6d4b<\/strong>\uff0c\u5e76\u5e94\u8bc4\u4f30\u6709\u65e0\u4e2d\u6bd2\u6027\u5de8\u7ed3\u80a0\u3002\u6240\u6709\u60a3\u8005\u5e94\u5728\u5165\u9662\u540e\u00a072\u00a0\u5c0f\u65f6\u5185\uff08\u6700\u597d\u00a024\u00a0\u5c0f\u65f6\u5185\uff09\u5b8c\u6210\u8f6f\u5f0f\u4e59\u72b6\u7ed3\u80a0\u955c\u68c0\u67e5\uff0c\u8bc4\u4f30\u708e\u75c7\u4e25\u91cd\u7a0b\u5ea6\u5e76\u6392\u67e5\u5de8\u7ec6\u80de\u75c5\u6bd2\uff08CMV\uff09\u7ed3\u80a0\u708e\u3002<\/li>\n\n\n\n
                                                    • \u4e00\u822c\u7ba1\u7406<\/strong>\uff1a\u5f3a\u63a8\u8350\u836f\u7269\u6027\u6df1\u9759\u8109\u8840\u6813\uff08DVT\uff09\u9884\u9632<\/strong>\uff0c\u540c\u65f6\u53cd\u5bf9\u5e38\u89c4\u4f7f\u7528\u5e7f\u8c31\u6297\u751f\u7d20<\/strong>\u3002<\/li>\n\n\n\n
                                                    • \u521d\u59cb\u6cbb\u7597<\/strong>\uff1a\u63a8\u8350\u9759\u8109\u7528\u7cd6\u76ae\u8d28\u6fc0\u7d20<\/strong>\u2014\u2014\u7532\u57fa\u5f3a\u7684\u677e\u9f99\u00a060\u00a0mg\/\u65e5\u6216\u6c22\u5316\u53ef\u7684\u677e\u00a0100\u00a0mg\u00a0\u6bcf\u65e5\u00a03\u20134\u00a0\u6b21\u3002<\/li>\n\n\n\n
                                                    • \u633d\u6551\u6cbb\u7597<\/strong>\uff1a\u82e5\u9759\u8109\u7cd6\u76ae\u8d28\u6fc0\u7d20\u6cbb\u7597\u00a03\u00a0\u5929\u540e\u53cd\u5e94\u4e0d\u4f73\uff0c\u63a8\u8350\u82f1\u592b\u5229\u6614\u5355\u6297\u6216\u73af\u5b62\u7d20<\/strong>\u4f5c\u4e3a\u633d\u6551\u6cbb\u7597\u836f\u7269\u3002<\/li>\n<\/ul>\n\n\n\n

                                                      \u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u968f\u7740\u4e0a\u8ff0\u65b0\u673a\u5236\u836f\u7269\u7ade\u76f8\u8fdb\u5165\u4e34\u5e8a\uff0cUC \u76f8\u5173\u7684\u6ce8\u518c\u6027\u4e34\u5e8a\u8bd5\u9a8c\u6570\u91cf\u5728\u8fc7\u53bb 10\u201315 \u5e74\u5185\u5448\u6301\u7eed\u4e0a\u5347\u8d8b\u52bf\uff0c\u4e14\u4ece\u5355\u81c2\u3001\u5355\u4e00\u7ec8\u70b9\u9010\u6b65\u6f14\u8fdb\u4e3a\u968f\u673a\u3001\u53cc\u76f2\u3001\u591a\u7ec8\u70b9\u8bbe\u8ba1\uff0c\u5bf9\u5185\u955c\u7f13\u89e3\u3001\u7ec4\u7ec7\u5b66\u7f13\u89e3\u7b49”\u786c\u7ec8\u70b9”\u7684\u4f9d\u8d56\u663e\u8457\u589e\u52a0[15]<\/sup>\uff0c\u8fd9\u4e5f\u5ba2\u89c2\u62ac\u9ad8\u4e86 UC \u4e34\u5e8a\u5f00\u53d1\u5bf9\u4e13\u4e1a CRO \u7684\u9700\u6c42\u95e8\u69db\u3002<\/p>\n\n\n\n

                                                      \u4e03\u3001\u5199\u5728\u6700\u540e<\/h1>\n\n\n\n

                                                      \u4f34\u968f\u5168\u7403\u53ca\u4e2d\u56fd UC \u60a3\u8005\u6570\u91cf\u6301\u7eed\u4e0a\u5347\u3001\u53d1\u75c5\u5e74\u9f84\u524d\u79fb\u4ee5\u53ca\u957f\u671f\u590d\u53d1\u8fc1\u5ef6\uff0c\u6e83\u75a1\u6027\u7ed3\u80a0\u708e\u5df2\u7ecf\u4ece\u6559\u79d1\u4e66\u91cc\u7684”\u6d88\u5316\u79d1\u5c0f\u4e13\u75c5”\uff0c\u9010\u6e10\u6f14\u53d8\u4e3a\u9700\u8981\u5168\u7a0b\u7ba1\u7406\u548c\u591a\u5b66\u79d1\u534f\u4f5c\u7684\u6162\u75c5\u8d1f\u62c5\u3002<\/p>\n\n\n\n

                                                      \u4ece\u672c\u6587\u68b3\u7406\u7684\u75be\u75c5\u6982\u8ff0\u3001\u6d41\u884c\u75c5\u5b66\u3001\u4e34\u5e8a\u8868\u73b0\u4ee5\u53ca”\u4ece\u6392\u9664\u8bca\u65ad\u8d70\u5411\u5206\u5c42\u7ba1\u7406”\u7684\u8bca\u65ad\u6846\u67b6\u53ef\u4ee5\u770b\u5230\uff0cUC \u7684\u4e34\u5e8a\u5b9e\u8df5\u6b63\u671d\u7740\u66f4\u65e9\u8bc6\u522b\u9ad8\u5371\u4eba\u7fa4\u3001\u66f4\u7cbe\u7ec6\u5316\u8bc4\u4f30\u75be\u75c5\u6d3b\u52a8\u5ea6\u548c\u98ce\u9669\u7684\u65b9\u5411\u6f14\u8fdb\u30022025 \u5e74 ACG \u6307\u5357\u7684\u66f4\u65b0<\/strong>\uff0c\u8fdb\u4e00\u6b65\u5f3a\u5316\u4e86\u4ee5\u5185\u955c\u6108\u5408<\/strong>\u4e3a\u6838\u5fc3\u7684\u6cbb\u7597\u76ee\u6807\uff0c\u5e76\u4e3a\u8f7b\u3001\u4e2d\u3001\u91cd\u5ea6\u53ca\u6025\u6027\u91cd\u75c7 UC \u63d0\u4f9b\u4e86\u8be6\u5c3d\u7684\u3001\u57fa\u4e8e GRADE \u5206\u7ea7\u7684\u5faa\u8bc1\u6cbb\u7597\u8def\u5f84\u3002<\/p>\n\n\n\n

                                                      \u5728\u8fd9\u6837\u7684\u57fa\u7840\u4e4b\u4e0a\uff0c\u9776\u5411\u751f\u7269\u5236\u5242\u3001\u53e3\u670d\u5c0f\u5206\u5b50\u7b49\u521b\u65b0\u7597\u6cd5\u624d\u6709\u673a\u4f1a\u901a\u8fc7\u5408\u7406\u7684\u5e8f\u8d2f\u4e0e\u7ec4\u5408\u7b56\u7565\u771f\u6b63\u6539\u5584\u7ed3\u5c40\u3002\u7136\u800c\uff0c\u7cfb\u7edf\u7efc\u8ff0\u4ecd\u53cd\u590d\u5f3a\u8c03\uff1a\u5728\u771f\u5b9e\u4e16\u754c\u4e2d\uff0c\u80fd\u957f\u671f\u8fbe\u5230”\u65e0\u6fc0\u7d20\u7f13\u89e3\uff0b\u9ecf\u819c\u6108\u5408”\u7684 UC \u60a3\u8005\u4ecd\u662f\u5c11\u6570\uff0c\u7597\u6548”\u5929\u82b1\u677f”\u3001\u957f\u671f\u5b89\u5168\u6027\u548c\u5e8f\u8d2f\/\u8054\u5408\u7b56\u7565\u4ecd\u5b58\u5728\u663e\u8457\u672a\u6ee1\u8db3\u7684\u4e34\u5e8a\u9700\u6c42\uff08unmet clinical needs\uff09[15, 16]<\/sup>\uff0c\u8fd9\u4e5f\u662f\u5168\u7403 UC \u65b0\u836f\u4e34\u5e8a\u5f00\u53d1\u548c\u9002\u5e94\u75c7\u6269\u5c55\u7684\u6838\u5fc3\u9a71\u52a8\u529b\u3002<\/p>\n\n\n\n

                                                      \u672c\u6587\u68b3\u7406\u4e86 UC \u7684\u75be\u75c5\u57fa\u7840\u4e0e\u8bca\u7597\u73b0\u72b6\uff0c\u4e3a\u7406\u89e3\u8be5\u9886\u57df\u7684\u4e34\u5e8a\u9700\u6c42\u4e0e\u7814\u53d1\u65b9\u5411\u63d0\u4f9b\u4e86\u6846\u67b6\u3002\u968f\u7740\u66f4\u591a\u521b\u65b0\u7597\u6cd5\u8fdb\u5165\u4e34\u5e8a\uff0cUC \u7684\u6cbb\u7597\u683c\u5c40\u4ecd\u503c\u5f97\u6301\u7eed\u5173\u6ce8\u3002<\/p>\n\n\n\n

                                                      \u53c2\u8003\u6587\u732e<\/h1>\n\n\n\n

                                                      [1] \u4e91\u9876\u65b0\u8000. \u4e91\u9876\u65b0\u8000\u7ef4\u9002\u5e73\u00ae\u83b7\u4e2d\u56fd\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u6279\u51c6\u4e0a\u5e02 \u4e3a\u4e2d\u91cd\u5ea6\u6e83\u75a1\u6027\u7ed3\u80a0\u708e\u6cbb\u7597\u63d0\u4f9b\u65b0\u9009\u62e9 [EB\/OL]. (2026-02-06) [2026-02-24].<\/p>\n\n\n\n

                                                      [2] Zheng L, Wang W, Sun Q. Targeted drug approvals in 2023: breakthroughs by the FDA and NMPA.<\/em> Signal Transduct Target Ther. 2024;9:46.\uff08\u7528\u4e8e\u652f\u6301 FDA\/NMPA \u52a0\u901f\u5ba1\u6279\u5728\u514d\u75ab\u75be\u75c5\u9886\u57df\u7684\u5e38\u6001\u5316\u8d8b\u52bf\uff09<\/p>\n\n\n\n

                                                      [3] Sun J, et al. Confirmatory Trials for Drugs Granted Conditional Approval by the Chinese National Medical Products Administration.<\/em> JAMA Health Forum. 2024;5(12):e244469.\uff08\u7528\u4e8e\u652f\u6301 NMPA \u9644\u6761\u4ef6\u6279\u51c6\u653f\u7b56\u53ca\u5176\u5bf9\u521b\u65b0\u836f\u4e0a\u5e02\u5468\u671f\u7684\u5f71\u54cd\uff09<\/p>\n\n\n\n

                                                      [4] IMARC Group. Ulcerative Colitis Market: Global Industry Trends, Share, Size, Growth, Opportunity and Forecast 2025-2033.<\/em> [EB\/OL]. [2026-02-24]. https:\/\/www.imarcgroup.com\/ulcerative-colitis-market[1] \uff08\u7528\u4e8e\u652f\u6301\u5168\u7403 UC \u836f\u7269\u5e02\u573a\u89c4\u6a21\u4e0e\u589e\u957f\u7387\u9884\u6d4b\uff09<\/p>\n\n\n\n

                                                      [5] Zurba Y, Gros B, Shehab M. Exploring the Pipeline of Novel Therapies for Inflammatory Bowel Disease; State of the Art Review.<\/em> Biomedicines. 2023;11(3):747.\uff08\u7528\u4e8e\u652f\u6301\u5168\u7403 UC \u5728\u7814\u7ba1\u7ebf\u6570\u91cf\u3001\u9776\u70b9\u591a\u6837\u6027\u53ca II\/III \u671f\u4e34\u5e8a\u5f00\u53d1\u5bc6\u5ea6\uff09<\/p>\n\n\n\n

                                                      [6] Gros B, Kaplan GG. Ulcerative Colitis in Adults: A Review.<\/em> JAMA. 2023;330(10):951-965.\uff08\u7528\u4e8e\u652f\u6301\u5317\u7f8e\u60a3\u75c5\u7387\u3001\u53d1\u75c5\u7387\u53d8\u5316\u8d8b\u52bf\u3001\u53d1\u75c5\u673a\u5236\u9776\u70b9\u53ca\u6cbb\u7597\u836f\u7269\u5206\u7c7b\uff09<\/p>\n\n\n\n

                                                      [7] Rubin DT, Ananthakrishnan AN, Siegel CA, et al. ACG Clinical Guideline Update: Ulcerative Colitis in Adults.<\/em> Am J Gastroenterol. 2025;120:1187-1224.\uff082025 \u5e74\u7f8e\u56fd\u80c3\u80a0\u75c5\u5b66\u4f1a\uff08ACG\uff09\u6700\u65b0\u4e34\u5e8a\u6307\u5357\uff0c\u63d0\u4f9b\u8bca\u65ad\u3001\u6cbb\u7597\u3001\u76d1\u6d4b\u7684\u5168\u9762\u5faa\u8bc1\u63a8\u8350\uff09<\/p>\n\n\n\n

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                                                      [9] Ng SC, et al. Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies.<\/em> Lancet. 2017;390(10114):2769-2778.\uff08\u7528\u4e8e\u652f\u6301\u5168\u7403\u53d1\u75c5\u7387\u3001\u60a3\u75c5\u7387\u53d8\u5316\u8d8b\u52bf\uff0c\u7279\u522b\u662f\u65b0\u5174\u5de5\u4e1a\u5316\u56fd\u5bb6\u7684\u589e\u957f\uff09<\/p>\n\n\n\n

                                                      [10] Buie MJ, et al. Global Hospitalization Trends for Crohn’s Disease and Ulcerative Colitis in the 21st Century: A Systematic Review with Temporal Analyses.<\/em> Clin Gastroenterol Hepatol. 2023;21(9):2212-2223.e15.\uff08\u7528\u4e8e\u652f\u6301\u4e0d\u540c\u6d41\u884c\u75c5\u5b66\u9636\u6bb5\u5730\u533a\u7684\u4f4f\u9662\u7387\u53d8\u5316\u8d8b\u52bf\uff09<\/p>\n\n\n\n

                                                      [11] \u4e2d\u534e\u533b\u5b66\u4f1a\u6d88\u5316\u75c5\u5b66\u5206\u4f1a\u708e\u75c7\u6027\u80a0\u75c5\u5b66\u7ec4. \u4e2d\u56fd\u6e83\u75a1\u6027\u7ed3\u80a0\u708e\u8bca\u6cbb\u6307\u5357\uff082023 \u5e74\u00b7\u897f\u5b89\uff09<\/em>[J]. \u4e2d\u534e\u708e\u6027\u80a0\u75c5\u6742\u5fd7\uff08\u4e2d\u82f1\u6587\uff09, 2024, 8(1):1-50.\uff08\u7528\u4e8e\u652f\u6301\u4e2d\u56fd\u6307\u5357\u8bca\u65ad\u6807\u51c6\u3001\u8bc4\u4f30\u65b9\u6cd5\u53ca\u6cbb\u7597\u76ee\u6807\uff09<\/p>\n\n\n\n

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                                                      [15] Fanizzi F, Allocca M, Fiorino G, et al. Raising the bar in ulcerative colitis management.<\/em> Therap Adv Gastroenterol. 2024;17:17562848241273066.\uff08\u7528\u4e8e\u652f\u6301 UC \u4e34\u5e8a\u8bd5\u9a8c\u7ec8\u70b9\u4ece\u75c7\u72b6\u5411\u5185\u955c\/\u7ec4\u7ec7\u5b66\u5347\u7ea7\u7684\u8d8b\u52bf\uff0c\u4ee5\u53ca\u6df1\u5ea6\u7f13\u89e3\u7387\u4ecd\u6709\u9650\u7684 unmet need\uff09<\/p>\n\n\n\n

                                                      [16] Irving PM, Hur P, Gautam R, Guo X, Vermeire S. Real-world effectiveness and safety of advanced therapies for the treatment of moderate-to-severe ulcerative colitis: Evidence from a systematic literature review.<\/em> J Manag Care Spec Pharm. 2024;30(9):1026-1040.\uff08\u7528\u4e8e\u652f\u6301\u9ad8\u7ea7\u6cbb\u7597\u5728\u771f\u5b9e\u4e16\u754c\u4e2d\u7684\u7597\u6548\u5c40\u9650\u4e0e\u6570\u636e\u7a7a\u767d\uff09<\/p>\n\n\n\n

                                                      [17] Caron B, Honap S, Peyrin-Biroulet L. Epidemiology of Inflammatory Bowel Disease across the Ages in the Era of Advanced Therapies.<\/em> J Crohns Colitis. 2024;18(Supplement_2):ii3-ii15.\uff08\u7528\u4e8e\u652f\u6301 IBD \u9057\u4f20\u6613\u611f\u6027\u4e2d\u591a\u57fa\u56e0\u98ce\u9669\u4e0e\u57fa\u56e0-\u73af\u5883\u4ea4\u4e92\u7684\u91cd\u8981\u6027\uff09<\/p>\n\n\n\n

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                                                      <\/div>\n\n\n\n

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                                                      \u6392\u7248\uff1a\u5468\u5b89\u6960<\/p>\n\n\n\n

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