{"id":1781,"date":"2026-04-28T11:50:15","date_gmt":"2026-04-28T03:50:15","guid":{"rendered":"https:\/\/www.millibuff.com\/?p=1781"},"modified":"2026-04-28T11:50:15","modified_gmt":"2026-04-28T03:50:15","slug":"%e5%b0%8f%e7%89%9b%e6%b4%9e%e5%af%9f-%e7%96%be%e7%97%85%e8%b4%9f%e6%8b%85%ef%bc%9a%e5%88%9b%e6%96%b0%e8%8d%af%e7%a0%94%e5%8f%91%e7%9a%84%e5%ba%95%e5%b1%82%e5%9d%90%e6%a0%87%ef%bc%88%e4%b8%8b","status":"publish","type":"post","link":"https:\/\/www.millibuff.com\/?p=1781","title":{"rendered":"\u5c0f\u725b\u6d1e\u5bdf | \u75be\u75c5\u8d1f\u62c5\uff1a\u521b\u65b0\u836f\u7814\u53d1\u7684\u5e95\u5c42\u5750\u6807\uff08\u4e0b\u7bc7\uff09\u2014\u2014\u4ece\u6570\u636e\u5230\u7814\u53d1\u51b3\u7b56\u7684\u843d\u5730"},"content":{"rendered":"\n


<\/strong>PART 01
\u4ece\u6570\u636e\u5230\u7814\u53d1\u51b3\u7b56<\/strong><\/h2>\n\n\n\n

\u4e0a\u4e00\u671f<\/a>\uff0c\u6211\u4eec\u4ecb\u7ecd\u4e86\u75be\u75c5\u8d1f\u62c5\uff08Burden of Disease\uff09\u8fd9\u5957\u8bc4\u4f30\u6846\u67b6\u53ca\u5176\u6838\u5fc3\u6307\u6807DALY\uff0c\u5e76\u7528\u5b83\u4ecb\u7ecd\u4e86\u5168\u7403\u548c\u4e2d\u56fd\u7684\u75be\u75c5\u8d1f\u62c5\u60c5\u51b5\uff1aNCDs\uff08\u975e\u4f20\u67d3\u6027\u75be\u75c5\uff09\u4e3b\u5bfc\u5168\u7403\u75be\u75c5\u8d1f\u62c5\uff0c\u4e2d\u56fd\u5728\u80ba\u764c\u3001\u5fc3\u8840\u7ba1\u3001\u7f55\u89c1\u75c5\u7b49\u591a\u4e2a\u9886\u57df\u5904\u4e8e\u8d1f\u62c5\u9ad8\u5730\uff0c\u73b0\u6709\u7597\u6cd5\u4e0e\u672a\u6ee1\u8db3\u9700\u6c42\u4e4b\u95f4\u7684\u7f3a\u53e3\u4f9d\u7136\u5de8\u5927\u3002\u4f46\u6570\u636e\u53ea\u80fd\u544a\u8bc9\u4f60”\u54ea\u91cc\u503c\u5f97\u53bb”\u3002<\/p>\n\n\n\n

\u672c\u7bc7\u901a\u8fc7\u4e00\u4e2a\u5177\u4f53\u6848\u4f8b\uff0c\u770b\u770b\u75be\u75c5\u8d1f\u62c5\u7684\u5206\u6790\u903b\u8f91\u5982\u4f55\u5728\u5b9e\u9645\u7814\u53d1\u51b3\u7b56\u4e2d\u5f97\u5230\u4f53\u73b0\u3002<\/p>\n\n\n\n

PART 02
\u7814\u53d1\u8d44\u6e90\u5e94\u8be5\u5f80\u54ea\u91cc\u6295\uff1f<\/strong><\/h2>\n\n\n\n

\u75be\u75c5\u8d1f\u62c5\u6570\u636e\uff0c\u672c\u8d28\u4e0a\u662f\u5728\u56de\u7b54\u4e00\u4e2a\u95ee\u9898\uff1a\u54ea\u4e9b\u9886\u57df\u7684\u5065\u5eb7\u635f\u5931\u6700\u5927\u3001\u73b0\u6709\u7597\u6cd5\u6700\u4e0d\u591f\u7528\uff1f<\/p>\n\n\n\n

EFPIA\u8054\u5408IQVIA\u5728\u300a2024 Pipeline Review: Innovation for Unmet Need\u300b\u62a5\u544a\u4e2d\u6307\u51fa\uff1a\u8001\u9f84\u5316\u76f8\u5173\u75be\u75c5\u3001\u7cbe\u795e\u5065\u5eb7\u3001\u6297\u83cc\u836f\u7269\u8010\u836f\u6027\u7b49\u9886\u57df\u7684\u75be\u75c5\u8d1f\u62c5\u589e\u901f\uff0c\u660e\u663e\u5feb\u4e8e\u76f8\u5e94\u7ba1\u7ebf\u7684\u6269\u5f20\u901f\u5ea6\u3002<\/p>\n\n\n\n

\u8fd9\u79cd\u75be\u75c5\u8d1f\u62c5\u4e0e\u7814\u53d1\u7ba1\u7ebf\u4e4b\u95f4\u7684\u9519\u914d<\/strong>\uff0c\u6b63\u662f\u75be\u75c5\u8d1f\u62c5\u5206\u6790\u5728\u7acb\u9879\u9636\u6bb5\u7684\u7528\u6b66\u4e4b\u5730\u3002\u5f53\u7136\uff0c\u75be\u75c5\u8d1f\u62c5\u5927\u2260\u7814\u53d1\u56de\u62a5\u9ad8\u3002\u8fdb\u5165\u95e8\u69db\u3001\u7ade\u4e89\u683c\u5c40\u3001\u76d1\u7ba1\u8def\u5f84\u3001\u652f\u4ed8\u4f53\u7cfb\u2014\u2014\u8fd9\u4e9b\u540c\u6837\u662fBD\u548c\u7acb\u9879\u5224\u65ad\u7ed5\u4e0d\u5f00\u7684\u7ef4\u5ea6\u3002\u75be\u75c5\u8d1f\u62c5\u5206\u6790\u63d0\u4f9b\u7684\u662f\u4e00\u5757\u57fa\u7840\u6570\u636e\u5e95\u677f\uff0c\u800c\u975e\u51b3\u7b56\u7684\u5168\u90e8\u3002<\/p>\n\n\n\n

PART 03
\u6848\u4f8b\u62c6\u89e3\uff1a\u82f1\u77fd\u667a\u80fd\u4e0eIPF<\/strong><\/h2>\n\n\n\n

\u6e2f\u80a1”AI\u5236\u836f\u7b2c\u4e00\u80a1”\u82f1\u77fd\u667a\u80fd\uff08Insilico Medicine\uff09\uff0c\u63d0\u4f9b\u4e86\u4e00\u4e2a\u89c2\u5bdf\u8fd9\u79cd\u5224\u65ad\u903b\u8f91\u7684\u5207\u53e3\u3002\u8fd9\u5bb6\u4ee5\u751f\u6210\u5f0fAI\u8986\u76d6\u4ece\u75be\u75c5\u8bc4\u4f30\u3001\u9776\u70b9\u53d1\u73b0\u5230\u5206\u5b50\u8bbe\u8ba1\u5168\u94fe\u6761\u7684\u751f\u7269\u79d1\u6280\u516c\u53f8\uff0c2025\u5e7412\u6708\u5728\u6e2f\u4ea4\u6240\u4e3b\u677f\u4e0a\u5e02\uff08\u80a1\u7968\u4ee3\u78013696\u00b7HK\uff09\uff0c\u5176\u6700\u6838\u5fc3\u7684\u81ea\u7814\u8d44\u4ea7\u9501\u5b9a\u7684\u662f\u7279\u53d1\u6027\u80ba\u7ea4\u7ef4\u5316\uff08IPF\uff09\u3002<\/p>\n\n\n\n

1. \u4e3a\u4ec0\u4e48\u662f\u7279\u53d1\u6027\u80ba\u7ea4\u7ef4\u5316\uff08IPF\uff09<\/strong><\/p>\n\n\n\n

IPF\u4e0d\u662f\u4e00\u4e2a\u4ee5\u60a3\u8005\u4eba\u6570\u53d6\u80dc\u7684\u9002\u5e94\u75c7\u3002\u6839\u636e\u82f1\u77fd\u667a\u80fd\u62db\u80a1\u8bf4\u660e\u4e66\uff0c2023\u5e74\u5168\u7403IPF\u60a3\u75c5\u4eba\u6570\u7ea661.2\u4e07\u4f8b\uff0c\u4e0e\u80ba\u764c\u3001\u5fc3\u8840\u7ba1\u75be\u75c5\u76f8\u6bd4\uff0c\u89c4\u6a21\u76f8\u5dee\u60ac\u6b8a\u3002\u4f46\u75be\u75c5\u8d1f\u62c5\u7684\u903b\u8f91\u4e0d\u53ea\u770b\u4eba\u6570\uff0c\u8fd8\u8981\u770b”\u8d28”\uff1aIPF\u786e\u8bca\u540e\u4e2d\u4f4d\u751f\u5b58\u671f\u4ec53\u81f35\u5e74\uff0c\u75be\u75c5\u8fdb\u5c55\u5feb\u3001\u4e0d\u53ef\u9006\uff0c\u73b0\u6709\u4e24\u6b3e\u83b7\u6279\u539f\u7814\u836f\uff08\u5421\u975e\u5c3c\u916e\u548c\u5c3c\u8fbe\u5c3c\u5e03\uff09\u53ea\u80fd\u5ef6\u7f13\u8fdb\u5c55\u3001\u65e0\u6cd5\u9006\u8f6c\uff0c\u4e14\u8010\u53d7\u6027\u95ee\u9898\u7a81\u51fa\uff08\u6d88\u5316\u9053\u4e0d\u826f\u53cd\u5e94\u548c\u76ae\u80a4\u53cd\u5e94\u662f\u5e38\u89c1\u505c\u836f\u539f\u56e0\uff09\u3002<\/p>\n\n\n\n

\u7528\u4e0a\u7bc7<\/a>\u4ecb\u7ecd\u8fc7\u7684DALY\u6846\u67b6\u6765\u7406\u89e3\uff1aIPF\u7684YLL\uff08\u65e9\u6b7b\u635f\u5931\u5e74\uff09\u6781\u9ad8\u2014\u2014\u5927\u91cf\u60a3\u8005\u5728\u751f\u547d\u4e2d\u6bb5\u5373\u79bb\u4e16\uff1bYLD\uff08\u6b8b\u75be\u635f\u5931\u5e74\uff09\u540c\u6837\u663e\u8457\u2014\u2014\u75be\u75c5\u8fdb\u884c\u6027\u4e0d\u53ef\u9006\uff0c\u60a3\u8005\u957f\u671f\u627f\u53d7\u6301\u7eed\u7684\u529f\u80fd\u4e0b\u964d\u3002\u57fa\u4e8eGBD 2023\u6570\u636e\uff0c\u5168\u7403\u95f4\u8d28\u6027\u80ba\u75c5\uff08ILD\uff09\u7684DALY\u603b\u91cf\u57282023\u5e74\u5df2\u8fbe446\u4e07\uff0c\u8f831990\u5e74\u589e\u957f2.4\u500d\uff0c\u4e14\u9884\u8ba1\u52302050\u5e74\u4ecd\u5c06\u6301\u7eed\u6500\u5347\uff1b\u4e2d\u56fd\u627f\u62c5\u5176\u4e2d\u7ea626.7\u4e07DALY\u3002<\/p>\n\n\n\n

\u503c\u5f97\u8bf4\u660e\u7684\u662f\uff0cGBD\u7814\u7a76\u672a\u5355\u72ec\u7edf\u8ba1IPF\uff0c\u800c\u662f\u5c06ILD\u4f5c\u4e3a\u6574\u4f53\u8fdb\u884c\u75be\u75c5\u8d1f\u62c5\u4f30\u7b97\u3002\u4f46\u6b63\u5982Ma\u7b49\u4eba\u5728\u57fa\u4e8eGBD 2023\u7684\u7cfb\u7edf\u5206\u6790\u4e2d\u6307\u51fa\u7684\uff1aGBD 2023\u6570\u636e\u96c6\u660e\u786e\u6392\u9664\u4e86\u7ed3\u7f14\u7ec4\u7ec7\u75c5\u76f8\u5173ILD\uff08CTD-ILD\uff09\uff0c\u800cCTD-ILD\u662fILD\u4e2d\u9664IPF\u5916\u6700\u5927\u7684\u4e9a\u7c7b\u2014\u2014”this exclusion directly results in the predominance of IPF in the ILD disease spectrum captured by the dataset”\u3002\u6362\u8a00\u4e4b\uff0c\u4e0a\u8ff0ILD\u7684DALY\u6570\u5b57\u5728\u76f8\u5f53\u7a0b\u5ea6\u4e0a\u53cd\u6620\u7684\u5c31\u662fIPF\u7684\u75be\u75c5\u8d1f\u62c5\u3002\u60a3\u75c5\u89c4\u6a21\u4e0d\u5927\uff0c\u4f46\u4eba\u5747\u5065\u5eb7\u635f\u5931\u6781\u9ad8\uff0c\u672a\u6ee1\u8db3\u9700\u6c42\u7684\u5bc6\u5ea6\u8fdc\u6bd4\u7edd\u5bf9\u6570\u5b57\u6240\u5448\u73b0\u7684\u66f4\u4e3a\u96c6\u4e2d\u3002<\/p>\n\n\n\n

\u6839\u636e\u82f1\u77fd\u667a\u80fd\u62db\u80a1\u4e66\u6570\u636e\uff0cIPF\u5168\u7403\u60a3\u75c5\u4eba\u6570\u5c06\u4ee5\u5e74\u590d\u5408\u589e\u957f\u7387\u7ea66.4%\u7684\u901f\u5ea6\u6269\u5f20\uff0c\u81f32032\u5e74\u8fbe\u5230\u7ea6106.8\u4e07\u4f8b\uff0c\u5e02\u573a\u7a7a\u95f4\u6709\u76f8\u5f53\u7684\u53ef\u53ca\u6027\u3002<\/p>\n\n\n\n

2. \u5019\u9009\u836f\u7269Rentosertib\u7684\u4e34\u5e8a\u9a8c\u8bc1<\/strong><\/p>\n\n\n\n

\u82f1\u77fd\u667a\u80fd\u7684\u5019\u9009\u836f\u7269Rentosertib\uff08ISM001-055\uff09\u662f\u4e00\u6b3eTNIK\u6291\u5236\u5242\uff0c\u5176\u9776\u70b9\u4e0e\u5206\u5b50\u7ed3\u6784\u5747\u7531\u751f\u6210\u5f0fAI\u53d1\u73b0\u4e0e\u8bbe\u8ba1\uff0c\u4ece\u9776\u70b9\u53d1\u73b0\u5230\u5b8c\u6210I\u671f\u4e34\u5e8a\u4ec5\u7528\u4e86\u7ea630\u4e2a\u6708\u3002<\/p>\n\n\n\n

2025\u5e746\u6708\uff0c\u5176IIa\u671f\u968f\u673a\u5bf9\u7167\u8bd5\u9a8c\uff08GENESIS-IPF\uff0cNCT05938920\uff09\u7ed3\u679c\u53d1\u8868\u4e8e\u300a\u81ea\u7136\u00b7\u533b\u5b66\u300b\uff1a\u5728\u4e2d\u56fd22\u4e2a\u4e2d\u5fc3\u5165\u7ec4\u768471\u4f8bIPF\u60a3\u8005\u4e2d\uff0c\u8be5\u8bd5\u9a8c\u4ee5\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u4e3a\u4e3b\u8981\u7ec8\u70b9\uff0c\u4ee5FVC\u53d8\u5316\u4e3a\u6b21\u8981\u7ec8\u70b9\uff0c\u63a5\u53d760mg\u6bcf\u65e5\u4e00\u6b21\u5242\u91cf\u6cbb\u759712\u5468\u540e\uff0cFVC\u8f83\u57fa\u7ebf\u6539\u558498.4 mL\uff0895% CI 10.9\u2013185.9\uff09\uff0c\u800c\u5b89\u6170\u5242\u7ec4\u540c\u671f\u4e0b\u964d20.3 mL\uff0895% CI -116.1\u201375.6\uff09\u3002\u8bd5\u9a8c\u8bbe\u7f6e\u56db\u4e2a\u5242\u91cf\u7ec4\uff0c60mg\u6bcf\u65e5\u4e00\u6b21\u4e3a\u6548\u679c\u6700\u4f18\u7ec4\u3002<\/p>\n\n\n\n

\u5728\u672a\u540c\u65f6\u4f7f\u7528\u6807\u51c6\u6297\u7ea4\u7ef4\u5316\u6cbb\u7597\u7684\u4e9a\u7ec4\u4e2d\uff0cFVC\u6539\u5584\u8fbe187.8 mL\uff0c\u54b3\u55fd\u75c7\u72b6\u8bc4\u5206\u4e5f\u51fa\u73b0\u6709\u4e34\u5e8a\u610f\u4e49\u7684\u6539\u5584\u3002\u300a\u81ea\u7136\u00b7\u533b\u5b66\u300b\u540c\u671f\u8bc4\u8bba\u5c06\u8fd9\u4e00\u7ed3\u679c\u79f0\u4e3a”AI\u836f\u7269\u53d1\u73b0\u9886\u57df\u7684\u91cc\u7a0b\u7891”\u3002<\/p>\n\n\n\n

3. \u6848\u4f8b\u542f\u793a<\/strong><\/p>\n\n\n\n

\u8fd9\u4e2a\u6848\u4f8b\u503c\u5f97\u5173\u6ce8\u7684\uff0c\u4e0d\u53ea\u662fAI\u5e26\u6765\u7684\u7814\u53d1\u63d0\u901f\uff0c\u8fd8\u6709\u9002\u5e94\u75c7\u7684\u5546\u4e1a\u7cbe\u51c6\u5224\u65ad\u7684\u5e95\u5c42\u903b\u8f91\uff1a\u5728\u60a3\u8005\u7edd\u5bf9\u6570\u91cf\u6709\u9650\u3001\u4f46\u4eba\u5747\u75be\u75c5\u8d1f\u62c5\u6781\u9ad8\u3001\u4e14\u73b0\u6709\u7597\u6cd5\u5b58\u5728\u660e\u663e\u7f3a\u53e3\u7684\u9886\u57df\uff0c\u7814\u53d1\u4ef7\u503c\u53ef\u80fd\u88ab\u60a3\u8005\u89c4\u6a21\u7684”\u5c0f”\u6240\u63a9\u76d6\u3002\u6362\u8a00\u4e4b\uff0c\u75be\u75c5\u8d1f\u62c5\u7684”\u8d28”\u6bd4”\u91cf”\u66f4\u80fd\u6307\u793a\u771f\u5b9e\u7684\u7814\u53d1\u673a\u4f1a\u2014\u2014\u8fd9\u4e5f\u662f\u75be\u75c5\u8d1f\u62c5\u5206\u6790\u5728\u7acb\u9879\u9636\u6bb5\u7684\u6838\u5fc3\u4ef7\u503c\u3002<\/p>\n\n\n\n

\u800c\u82f1\u77fd\u667a\u80fd\u7684AI\u5e73\u53f0\u8986\u76d6\u4e86\u4ece\u9002\u5e94\u75c7\u8bc4\u4f30\u3001\u9776\u70b9\u53d1\u73b0\u5230\u5206\u5b50\u8bbe\u8ba1\u7684\u7814\u53d1\u5168\u94fe\u6761\uff0c\u4f7f\u5f97\u4e0a\u8ff0\u5224\u65ad\u903b\u8f91\u80fd\u591f\u66f4\u5feb\u5730\u8fdb\u5165\u4e34\u5e8a\u9a8c\u8bc1\u73af\u8282\u3002\u81f3\u4e8e\u8fd9\u5957\u903b\u8f91\u6700\u7ec8\u80fd\u5426\u7ecf\u53d7\u4f4f\u66f4\u5927\u89c4\u6a21\u4e34\u5e8a\u6570\u636e\u7684\u68c0\u9a8c\uff0c\u4ecd\u9700\u540e\u7eed\u8bd5\u9a8c\u7ed9\u51fa\u7b54\u6848\u3002\u9700\u8981\u8bf4\u660e\u7684\u662f\uff0c\u76ee\u524d\u516c\u5f00\u4fe1\u606f\u4e2d\u5e76\u672a\u663e\u793a\u82f1\u77fd\u667a\u80fd\u5728IPF\u7acb\u9879\u65f6\u76f4\u63a5\u5f15\u7528\u4e86DALY\u6216GBD\u6570\u636e\u3002<\/p>\n\n\n\n

\u8fd9\u4e00\u6848\u4f8b\u4ece\u4fa7\u9762\u5370\u8bc1\u7684\u662f\u75be\u75c5\u8d1f\u62c5\u903b\u8f91\u7684\u9002\u7528\u6027\u2014\u2014\u5373\u4fbf\u4f01\u4e1a\u672a\u5fc5\u4ee5”\u75be\u75c5\u8d1f\u62c5\u5206\u6790”\u4e3a\u540d\uff0c\u5176\u9002\u5e94\u75c7\u9009\u62e9\u80cc\u540e\u7684\u5224\u65ad\u7ef4\u5ea6\uff0c\u4e0e\u75be\u75c5\u8d1f\u62c5\u6846\u67b6\u7684\u6838\u5fc3\u7ef4\u5ea6\u9ad8\u5ea6\u543b\u5408\u3002<\/p>\n\n\n\n

PART 04
\u75be\u75c5\u8d1f\u62c5\u7684\u5730\u7406\u5206\u5e03\u4e0e\u8bd5\u9a8c\u9009\u5740<\/strong><\/h2>\n\n\n\n

\u9002\u5e94\u75c7\u9009\u5b9a\u4e4b\u540e\uff0c\u75be\u75c5\u8d1f\u62c5\u7684\u5730\u7406\u5206\u5e03\u4f1a\u76f4\u63a5\u5f71\u54cd\u4e34\u5e8a\u8bd5\u9a8c\u7684\u9009\u5740\u51b3\u7b56\u2014\u2014\u5c3d\u7ba1\u5b83\u59cb\u7ec8\u662f\u80cc\u666f\u56e0\u7d20\uff0c\u800c\u975e\u51b3\u7b56\u672c\u8eab\u3002\u75be\u75c5\u8d1f\u62c5\u8d8a\u91cd\u7684\u5730\u533a\uff0c\u7b26\u5408\u5165\u7ec4\u6807\u51c6\u7684\u60a3\u8005\u8d8a\u5bc6\u96c6\uff0c\u62db\u52df\u6548\u7387\u8d8a\u9ad8\uff0c\u65f6\u95f4\u548c\u6210\u672c\u8d8a\u4f4e\u3002<\/p>\n\n\n\n

\u6bd4\u5982\u5728\u4e0a\u7bc7\u4ecb\u7ecd\u8fc7\u7684\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u9886\u57df\uff0c\u4e2d\u56fd\u7684\u60a3\u8005\u57fa\u6570\u548c\u62db\u52df\u6548\u7387\u5df2\u7ecf\u6210\u4e3a\u8de8\u56fd\u836f\u4f01\u8bbe\u8ba1\u5168\u7403\u591a\u4e2d\u5fc3\u8bd5\u9a8c\u65f6\u7684\u91cd\u8981\u8003\u91cf\uff0c\u4e0d\u5c11\u516c\u53f8\u628a\u4e2d\u56fd\u5217\u4e3a\u4f18\u5148\u7eb3\u5165\u5730\u533a\u3002<\/p>\n\n\n\n

\u5fc3\u8840\u7ba1\u3001\u4ee3\u8c22\u75be\u75c5\u3001\u90e8\u5206\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u7b49\u9886\u57df\u540c\u6837\u5982\u6b64\u3002\u4f46\u60a3\u8005\u5bc6\u96c6\u2260\u8bd5\u9a8c\u6210\u529f\u3002\u9ad8\u75be\u75c5\u8d1f\u62c5\u5730\u533a\u5728\u63d0\u4f9b\u62db\u52df\u6548\u7387\u7ea2\u5229\u7684\u540c\u65f6\uff0c\u4e5f\u5bf9\u4e34\u5e8a\u8bd5\u9a8c\u6267\u884c\u4f53\u7cfb\u63d0\u51fa\u4e86\u66f4\u9ad8\u8981\u6c42\uff1a\u4e34\u5e8a\u73b0\u573a\u7ba1\u7406\uff08SMO\uff09\u7684\u89c4\u8303\u5316\u6c34\u5e73\u3001\u4e34\u5e8a\u76d1\u67e5\uff08CRA\uff09\u5bf9\u6570\u636e\u8d28\u91cf\u7684\u7ba1\u63a7\u80fd\u529b\u3001\u7814\u7a76\u8005GCP\u610f\u8bc6\u4e0e\u4f9d\u4ece\u6027\uff0c\u6bcf\u4e00\u73af\u90fd\u76f4\u63a5\u5f71\u54cd\u6570\u636e\u7684\u53ef\u4fe1\u5ea6\u548c\u8bd5\u9a8c\u7684\u6700\u7ec8\u6210\u8d25\u3002\u75be\u75c5\u8d1f\u62c5\u5730\u56fe\u6807\u51fa\u4e86\u60a3\u8005\u6700\u5bc6\u96c6\u7684\u533a\u57df\uff0c\u4f46\u80fd\u5426\u5c06\u5bc6\u5ea6\u8f6c\u5316\u4e3a\u9ad8\u8d28\u91cf\u7684\u4e34\u5e8a\u6570\u636e\uff0c\u8fd8\u53d6\u51b3\u4e8e\u9009\u5740\u51b3\u7b56\u662f\u5426\u540c\u65f6\u8003\u91cf\u4e86\u6267\u884c\u4f53\u7cfb\u7684\u6210\u719f\u5ea6\u3002<\/p>\n\n\n\n

PART 05
\u5c0f\u7ed3<\/strong><\/h2>\n\n\n\n

\u4e0a\u7bc7<\/a>\uff0c\u6211\u4eec\u68b3\u7406\u4e86DALY\u8bc4\u4f30\u6846\u67b6\u548c\u5168\u7403\u4e0e\u4e2d\u56fd\u7684\u75be\u75c5\u8d1f\u62c5\u6570\u5b57\u5730\u56fe\u2014\u2014\u5b83\u6807\u51fa\u4e86”\u54ea\u91cc\u503c\u5f97\u53bb”\u3002\u672c\u7bc7\uff0c\u6211\u4eec\u901a\u8fc7\u82f1\u77fd\u667a\u80fdIPF\u6848\u4f8b\u548c\u8bd5\u9a8c\u9009\u5740\u7684\u89c6\u89d2\uff0c\u89c2\u5bdf\u4e86\u75be\u75c5\u8d1f\u62c5\u6570\u636e\u5982\u4f55\u5728\u9002\u5e94\u75c7\u9009\u62e9\u548c\u8bd5\u9a8c\u9009\u5740\u4e2d\u63d0\u4f9b\u53c2\u7167\u3002<\/p>\n\n\n\n

\u75be\u75c5\u8d1f\u62c5\u5206\u6790\u7684\u4ef7\u503c\uff0c\u4e0d\u5728\u4e8e\u5b83\u80fd\u72ec\u7acb\u7ed9\u51fa\u7b54\u6848\uff0c\u800c\u5728\u4e8e\u5b83\u4e3a\u7814\u53d1\u51b3\u7b56\u63d0\u4f9b\u4e86\u4e00\u4e2a\u53ef\u91cf\u5316\u3001\u53ef\u6bd4\u8f83\u7684\u53c2\u7167\u8d77\u70b9\u3002<\/p>\n\n\n\n

<\/p>\n\n\n\n

\u8054\u7cfb\u6211\u4eec<\/h2>\n\n\n\n


\u5982\u679c\u60a8\u5bf9\u75be\u75c5\u8d1f\u62c5\u5206\u6790\u5728\u7814\u53d1\u51b3\u7b56\u4e2d\u7684\u5e94\u7528\u611f\u5174\u8da3\uff0c\u6b22\u8fce\u8054\u7cfb\u5c0f\u725b\u533b\u836f\u56e2\u961f\u4ea4\u6d41\u63a2\u8ba8\uff1a

\ud83d\udca1\u90d1\u603b\u76d1<\/strong><\/p>\n\n\n\n

\u8054\u7cfb\u7535\u8bdd\uff1a13758291914\uff08\u5fae\u4fe1\u540c\u53f7\uff09\u00a0<\/strong><\/p>\n\n\n\n

\u5546\u52a1\u90ae\u7bb1\uff1azym@millibuff.com<\/strong><\/p>\n\n\n\n

<\/p>\n\n\n\n

\u672c\u6587\u53c2\u8003\u8d44\u6599\u00a0<\/h2>\n\n\n\n


[1]\u00a0<\/strong>IQVIA Institute for Human Data Science. 2024 pipeline review: innovation for unmet need[R\/OL]. London: EFPIA, 2024[2026-04-14]. https:\/\/www.efpia.eu\/media\/mezjxddv\/2024-pipeline-review.pdf<\/p>\n\n\n\n

\u6587\u4e2d\u5f15\u7528\uff1a\u5168\u7403\u7814\u53d1\u7ba1\u7ebf\u4e0e\u75be\u75c5\u8d1f\u62c5\u5b58\u5728\u9519\u914d\uff0c\u8001\u9f84\u5316\u3001\u7cbe\u795e\u5065\u5eb7\u3001AMR\u7b49\u9886\u57df\u672a\u6ee1\u8db3\u9700\u6c42\u589e\u901f\u5feb\u4e8e\u7ba1\u7ebf\u6269\u5f20<\/em><\/p>\n\n\n\n

[2]\u00a0<\/strong>Xu Z, Ren F, Wang P, et al. A generative AI-discovered TNIK inhibitor for idiopathic pulmonary fibrosis: a randomized phase 2a trial[J]. Nat Med, 2025, 31(8): 2602-2610. DOI: 10.1038\/s41591-025-03743-2.<\/p>\n\n\n\n

\u6587\u4e2d\u5f15\u7528\uff1aRentosertib\uff08ISM001-055\uff09IIa\u671f\u4e34\u5e8a\u8bd5\u9a8c\u8bbe\u8ba1\u4e0e\u7ed3\u679c\uff08FVC\u6539\u5584\u6570\u636e\u3001\u5b89\u5168\u6027\u6570\u636e\u3001AI\u9776\u70b9\u53d1\u73b0\u4e0e\u7814\u53d1\u5468\u671f\uff09\uff1b\u82f1\u77fd\u667a\u80fd\u4ece\u9776\u70b9\u53d1\u73b0\u5230I\u671f\u4e34\u5e8a\u7ea630\u4e2a\u6708\u7684\u5f00\u53d1\u901f\u5ea6\uff1b\u751f\u6210\u5f0fAI\u836f\u7269\u53d1\u73b0\u4e34\u5e8a\u91cc\u7a0b\u7891\u8bc4\u4ef7<\/em><\/p>\n\n\n\n

[3]\u00a0<\/strong>Insilico Medicine Cayman TopCo. \u5168\u7403\u53d1\u552e[EB\/OL]. Hong Kong: The Stock Exchange of Hong Kong Limited, 2025[2026-04-14]. https:\/\/www1.hkexnews.hk\/listedco\/listconews\/sehk\/2025\/1218\/2025121800032_c.pdf<\/p>\n\n\n\n

\u6587\u4e2d\u5f15\u7528\uff1a\u5168\u7403IPF\u60a3\u75c5\u4eba\u6570\uff082023\u5e74\u7ea6612.4\u5343\u4f8b\u30012032\u5e74\u9884\u8ba1\u7ea61,067.7\u5343\u4f8b\uff09\u3001\u590d\u5408\u5e74\u589e\u957f\u7387\u7ea66.4%\u3001\u73b0\u6709\u83b7\u6279\u539f\u7814\u836f\u7597\u6548\u4e0e\u8010\u53d7\u6027\u8bc4\u4ef7<\/em><\/p>\n\n\n\n

[4]\u00a0<\/strong>Ma X, Zhu L, Xiao H, et al. Global, regional, and national burden of interstitial lung disease and pulmonary sarcoidosis from 1990 to 2023, and projections to 2050: A systematic analysis for the Global Burden of Disease Study 2023[J]. Chin Med J Pulm Crit Care Med, 2025, 3: 300-307. DOI: 10.1016\/j.pccm.2025.11.008.<\/p>\n\n\n\n

\u6587\u4e2d\u5f15\u7528\uff1aIPF\u4e2d\u4f4d\u751f\u5b58\u671f3-5\u5e74\uff1bGBD 2023\u6570\u636e\u96c6\u6392\u9664CTD-ILD\u3001ILD\u75be\u75c5\u8c31\u4ee5IPF\u4e3a\u4e3b\u4f53\uff1b\u5168\u7403ILD DALY\u603b\u91cf446\u4e07\uff082023\u5e74\uff09\u3001\u8f831990\u5e74\u589e\u957f2.4\u500d\uff1b\u4e2d\u56fdILD DALY\u7ea626.7\u4e07\uff1b2050\u5e74\u9884\u6d4bDALY\u7387\u589e60.43%<\/em><\/p>\n\n\n\n

<\/p>\n\n\n\n

\u64b0\u7a3f\u4eba\uff1a\u5468\u5b89\u6960<\/p>\n\n\n\n

\u5ba1\u6838\uff1a\u5bab\u96ea<\/p>\n\n\n\n

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