{"id":1787,"date":"2026-05-11T13:40:50","date_gmt":"2026-05-11T05:40:50","guid":{"rendered":"https:\/\/www.millibuff.com\/?p=1787"},"modified":"2026-05-11T13:45:27","modified_gmt":"2026-05-11T05:45:27","slug":"%e5%b0%8f%e7%89%9b%e6%b4%9e%e5%af%9f-kat%e6%8a%91%e5%88%b6%e5%89%82%e8%b5%9b%e9%81%93%e6%b7%b1%e5%ba%a6%e8%a7%a3%e6%9e%90%ef%bc%9a2026-aacr%e6%95%b0%e6%8d%ae%e6%8f%ad%e6%99%93%ef%bc%8casco%e5%a4%a7","status":"publish","type":"post","link":"https:\/\/www.millibuff.com\/?p=1787","title":{"rendered":"\u5c0f\u725b\u6d1e\u5bdf | KAT\u6291\u5236\u5242\u8d5b\u9053\u6df1\u5ea6\u89e3\u6790\uff1a2026 AACR\u6570\u636e\u63ed\u6653\uff0cASCO\u5927\u4f1a\u770b\u70b9\u524d\u77bb"},"content":{"rendered":"\n<p>\u4ece\u8868\u89c2\u9057\u4f20\u5b66\u5230\u7cbe\u51c6\u533b\u7597\uff0c<a>KAT<\/a>\uff08\u8d56\u6c28\u9178\u4e59\u9170\u8f6c\u79fb\u9176\uff09\u6291\u5236\u5242\u6b63\u6210\u4e3aHR+\u4e73\u817a\u764c\u9886\u57df\u7ee7CDK4\/6\u4e4b\u540e\u6700\u5177\u6f5c\u529b\u7684\u65b0\u9776\u70b9\u3002\u66f4\u503c\u5f97\u5173\u6ce8\u7684\u662f\uff0cKAT6A\u5728\u514d\u75ab\u7ec6\u80de\u5206\u5316\u4e2d\u7684\u5173\u952e\u4f5c\u7528\uff0c\u6b63\u5c06\u5176\u5e94\u7528\u8fb9\u754c\u4ece\u80bf\u7624\u62d3\u5c55\u81f3\u81ea\u8eab\u514d\u75ab\u75be\u75c5<sup>1<\/sup>\u3002\u968f\u77402026\u5e74AACR\u5e74\u4f1a\u7684\u843d\u5e55\u548cASCO\u5e74\u4f1a\u7684\u4e34\u8fd1\uff0c\u8fd9\u4e00\u8d5b\u9053\u8fce\u6765\u4e86\u591a\u9879\u5173\u952e\u6570\u636e\u62ab\u9732\u3002\u672c\u6587\u6df1\u5ea6\u89e3\u6790\u6700\u65b0\u8fdb\u5c55\uff0c\u5e76\u524d\u77bb\u5373\u5c06\u5230\u6765\u7684ASCO\u91cd\u78c5\u62a5\u544a\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u4e00\u3001\u9776\u70b9\u518d\u8ba4\u8bc6\uff1a\u4ece\u80bf\u7624\u5230\u81ea\u8eab\u514d\u75ab\u7684\u8de8\u754c\u6f5c\u529b<\/strong><\/h2>\n\n\n\n<p>KAT6A\/KAT6B\u5c5e\u4e8eMYST\u5bb6\u65cf\u4e59\u9170\u8f6c\u79fb\u9176\uff0c\u901a\u8fc7\u50ac\u5316\u7ec4\u86cb\u767dH3\u7b2c23\u4f4d\u8d56\u6c28\u9178\uff08H3K23\uff09\u7684\u4e59\u9170\u5316\uff0c\u8c03\u63a7\u67d3\u8272\u8d28\u5f00\u653e\u72b6\u6001\u548c\u57fa\u56e0\u8f6c\u5f55\u3002\u5728HR+\u4e73\u817a\u764c\u4e2d\uff0cKAT6A\u662fESR1\u57fa\u56e0\u8f6c\u5f55\u7684\u76f4\u63a5\u8c03\u8282\u56e0\u5b50\uff0c\u5176\u5f02\u5e38\u6d3b\u5316\u4e0e\u5185\u5206\u6ccc\u6cbb\u7597\u8010\u836f\u5bc6\u5207\u76f8\u5173\u3002<\/p>\n\n\n\n<p><strong>\u8de8\u75be\u75c5\u6cbb\u7597\u6f5c\u529b<\/strong>\uff1a\u8fd1\u5e74\u7814\u7a76\u63ed\u793a\uff0cKAT6A\u5728\u514d\u75ab\u7cfb\u7edf\u4e2d\u540c\u6837\u626e\u6f14\u5173\u952e\u89d2\u8272\u3002\u7814\u7a76\u8868\u660e\uff0cKAT6A\u662fCD4+ T\u7ec6\u80de\u4f53\u5916\u589e\u6b96\u548cTh1\/Th17\u5206\u5316\u6240\u5fc5\u9700\u7684<sup>1<\/sup>\uff0c\u8fd9\u4e00\u53d1\u73b0\u5c06KAT6A\u6291\u5236\u5242\u7684\u5e94\u7528\u524d\u666f\u4ece\u80bf\u7624\u62d3\u5c55\u81f3\u81ea\u8eab\u514d\u75ab\u75be\u75c5\u9886\u57df\u3002\u540c\u65f6\uff0cKAT6A\u8fd8\u9a71\u52a8\u5de8\u566c\u7ec6\u80deM1\u6781\u5316\uff0c\u5728\u8113\u6bd2\u75c7\u8bf1\u5bfc\u7684\u6025\u6027\u80ba\u635f\u4f24\u4e2d\u53d1\u6325\u5173\u952e\u4f5c\u7528\uff0c\u6291\u5236KAT6A\u53ef\u51cf\u8f7b\u80ba\u635f\u4f24\u3001\u6539\u5584\u7ec6\u83cc\u6e05\u9664\u5e76\u5ef6\u957f\u751f\u5b58\u671f<sup>2<\/sup>\u3002 \u4ece\u4e34\u5e8a\u8bd5\u9a8c\u8bbe\u8ba1\u7684\u89d2\u5ea6\u6765\u770b\uff0cKAT6\u6291\u5236\u5242\u5f00\u53d1\u8def\u5f84\u5c06\u5448\u73b0\u201c\u80bf\u7624\u4f18\u5148\u3001\u81ea\u514d\u8ddf\u8fdb\u201d\u7684\u53cc\u7ebf\u5e03\u5c40\u2014\u2014\u65e2\u53ef\u901a\u8fc7\u7cbe\u51c6\u60a3\u8005\u7b5b\u9009\uff08\u5982ESR1\u7a81\u53d8\u72b6\u6001\uff09\u63a8\u8fdb\u4e73\u817a\u764c\u6ce8\u518c\u7814\u7a76\uff0c\u4e5f\u53ef\u63a2\u7d22\u5176\u5728Th1\/Th17\u9a71\u52a8\u7684\u81ea\u8eab\u514d\u75ab\u75be\u75c5\uff08\u5982\u94f6\u5c51\u75c5\u3001\u7c7b\u98ce\u6e7f\u5173\u8282\u708e\u3001\u708e\u75c7\u6027\u80a0\u75c5\uff09\u4e2d\u7684\u5e94\u7528\u6f5c\u529b<sup>1<\/sup>\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u4e8c\u3001\u4e2d\u56fd\u529b\u91cf\uff1a\u82f1\u77fd\u667a\u80fdISM5043\u9996\u6b21\u4eba\u4f53\u6570\u636e\u5373\u5c06\u63ed\u6653<\/strong><\/h2>\n\n\n\n<p>\u5728KAT6\u6291\u5236\u5242\u8d5b\u9053\u4e2d\uff0c\u82f1\u77fd\u667a\u80fd\uff08Insilico Medicine\uff09\u7684<strong>ISM5043<\/strong>\u662f\u5907\u53d7\u5173\u6ce8\u7684\u4e2d\u56fd\u529b\u91cf\u4ee3\u8868\u3002\u8be5\u516c\u53f8\u5229\u7528\u751f\u6210\u5f0f\u4eba\u5de5\u667a\u80fd\u5e73\u53f0Pharma AI\u8fdb\u884c\u9776\u70b9\u53d1\u73b0\u548c\u5206\u5b50\u8bbe\u8ba1\uff0c\u5c55\u73b0\u4e86AI\u9a71\u52a8\u836f\u7269\u7814\u53d1\u7684\u72ec\u7279\u8def\u5f84\u3002<\/p>\n\n\n\n<p><strong>\u4e34\u5e8a\u8fdb\u5c55<\/strong>\uff1aISM5043\uff08\u7814\u53d1\u4ee3\u53f7\uff1aMEN2312\uff09\u7684\u9996\u6b21\u4eba\u4f53I\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08NCT06638307\uff09\u5df2\u4e8e2024\u5e7410\u6708\u542f\u52a8\uff0c\u76ee\u524d\u6b63\u5728\u62db\u52df\u665a\u671f\u4e73\u817a\u764c\u60a3\u8005<sup>3<\/sup>\u3002\u8be5\u7814\u7a76\u65e8\u5728\u8bc4\u4f30ISM5043\u5355\u836f\u53ca\u8054\u5408\u65b9\u6848\u5728\u665a\u671f\u4e73\u817a\u764c\u60a3\u8005\u4e2d\u7684\u5b89\u5168\u6027\u3001\u8010\u53d7\u6027\u3001\u836f\u4ee3\u52a8\u529b\u5b66\u548c\u521d\u6b65\u6297\u80bf\u7624\u6d3b\u6027\u3002<\/p>\n\n\n\n<p><strong>\u6280\u672f\u7279\u70b9<\/strong>\uff1a\u4f5c\u4e3a\u4e00\u6b3e\u53e3\u670dKAT6A\u5c0f\u5206\u5b50\u6291\u5236\u5242\uff0cISM5043\u7684\u53d1\u73b0\u5168\u7a0b\u7531AI\u5e73\u53f0\u8d4b\u80fd\uff0c\u4ece\u9776\u70b9\u8bc6\u522b\u5230\u5206\u5b50\u4f18\u5316\u5747\u4f53\u73b0\u4e86\u4eba\u5de5\u667a\u80fd\u5728\u836f\u7269\u65e9\u671f\u53d1\u73b0\u4e2d\u7684\u6f5c\u529b\u3002<strong>\u884c\u4e1a\u610f\u4e49<\/strong>\uff1aISM5043\u662f\u5168\u7403\u8303\u56f4\u5185\u5c11\u6570\u8fdb\u5165\u4e34\u5e8a\u9636\u6bb5\u7684KAT6\u6291\u5236\u5242\u4e4b\u4e00\uff0c\u4e5f\u662f\u4e2d\u56fdAI\u5236\u836f\u4f01\u4e1a\u5728\u8868\u89c2\u9057\u4f20\u5b66\u9776\u70b9\u9886\u57df\u7684\u91cd\u8981\u5e03\u5c40\u3002\u5176\u4e34\u5e8a\u6570\u636e\u7684\u8bfb\u51fa\uff0c\u5c06\u4e3aAI\u8f85\u52a9\u836f\u7269\u53d1\u73b0\u7684\u4ef7\u503c\u63d0\u4f9b\u5173\u952e\u9a8c\u8bc1\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u4e09\u3001AACR 2026\u9ad8\u5149\u65f6\u523b\uff1a\u8f89\u745e\u516c\u5e03ctDNA\u5173\u952e\u6570\u636e<\/strong><\/h2>\n\n\n\n<p>\u4f5c\u4e3a\u8be5\u9886\u57df\u8fdb\u5ea6\u6700\u5feb\u7684\u9886\u8dd1\u8005\uff0c\u8f89\u745e\uff08Pfizer\uff09\u7684<strong>PF-07248144<\/strong><strong>\uff08<\/strong><strong>Prifetrastat<\/strong><strong>\uff09<\/strong>\u57282026\u5e74AACR\u5927\u4f1a\u4e0a\u516c\u5e03\u4e86\u5173\u952e\u7684\u751f\u7269\u6807\u5fd7\u7269\u5206\u6790\u6570\u636e<sup>4<\/sup>\u3002<\/p>\n\n\n\n<p><strong>\u7814\u7a76\u8bbe\u8ba1<\/strong><strong><\/strong><\/p>\n\n\n\n<p>\u8be5\u7814\u7a76\u7eb3\u5165CDK4\/6\u6291\u5236\u5242\u8054\u5408\u5185\u5206\u6ccc\u6cbb\u7597\u540e\u8fdb\u5c55\u7684ER+\/HER2-\u665a\u671f\u4e73\u817a\u764c\u60a3\u8005\uff0c\u8bc4\u4f30\u4e0d\u540c\u5242\u91cfPF-07248144\u5355\u836f\u6216\u8054\u5408\u6c1f\u7ef4\u53f8\u7fa4\u7684\u7597\u6548\u548c\u5b89\u5168\u6027\u3002<\/p>\n\n\n\n<p><strong>\u6838\u5fc3\u53d1\u73b0<\/strong><strong><\/strong><\/p>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><thead><tr><td>\u6307\u6807<\/td><td>5mg QD\u8054\u5408\u7ec4\uff08n=34\uff09<\/td><td>1mg QD\u8054\u5408\u7ec4\uff08n=23\uff09<\/td><td>5mg QD\u5355\u836f\u7ec4\uff08n=24\uff09<\/td><\/tr><\/thead><tbody><tr><td>\u65e9\u671fctDNA\u6e05\u9664\u7387\uff08\u603b\u4f53\uff09<\/td><td><strong>26%<\/strong><\/td><td>9%<\/td><td>4%<\/td><\/tr><tr><td>ESR1\u7a81\u53d8\u60a3\u8005ctDNA\u6e05\u9664\u7387<\/td><td><strong>63%<\/strong><\/td><td>8%<\/td><td>\u2014<\/td><\/tr><tr><td>PIK3CA\/AKT1\/PTEN\u901a\u8def\u7a81\u53d8\u6e05\u9664\u7387<\/td><td>31%<\/td><td>\u2014<\/td><td>\u2014<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p>\u6b64\u5916\uff0c\u6240\u6709\u6cbb\u7597\u7ec4\u5747\u5b9e\u73b0\u4e86H3K23Ac \u226550%\u7684\u964d\u5e45\uff0c\u8bc1\u5b9e\u4e86\u9776\u70b9\u7ed3\u5408\u3002\u8f6c\u5f55\u7ec4\u5206\u6790\u663e\u793a\uff0c5mg QD\u8054\u5408\u6cbb\u7597\u7ec4\u8bf1\u5bfc\u4e86\u6700\u5f3a\u7684\u6291\u764c\u57fa\u56e0\u6fc0\u6d3b\u548c\u7ec6\u80de\u5468\u671f\u57fa\u56e0\u6291\u5236<sup>4<\/sup>\u3002<\/p>\n\n\n\n<p><strong>III<\/strong><strong>\u671f\u4e34\u5e8a\u8fdb\u5c55<\/strong><strong><\/strong><\/p>\n\n\n\n<p>\u8f89\u745e\u5df2\u542f\u52a8\u5168\u7403\u591a\u4e2d\u5fc3III\u671f\u7814\u7a76\uff08NCT06800032\uff09\uff0c\u65e8\u5728\u6bd4\u8f83PF-07248144\u8054\u5408\u6c1f\u7ef4\u53f8\u7fa4\u4e0e\u7814\u7a76\u8005\u9009\u62e9\u65b9\u6848\uff08\u4f9d\u7ef4\u83ab\u53f8\u8054\u5408\u5185\u5206\u6ccc\u6cbb\u7597\uff09\u7684\u7597\u6548\u548c\u5b89\u5168\u6027\u3002\u8fd9\u662fKAT6\u6291\u5236\u5242\u9886\u57df\u9996\u4e2a\u8fdb\u5165III\u671f\u6ce8\u518c\u7814\u7a76\u7684\u836f\u7269\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u56db\u3001ASCO 2026\u524d\u77bb\uff1aOP-3136\u9996\u6b21\u4eba\u4f53\u6570\u636e\u5373\u5c06\u63ed\u6653<\/strong><\/h2>\n\n\n\n<p>2026\u5e74\u7f8e\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a\uff08ASCO\uff09\u5e74\u4f1a\u5c06\u4e8e<strong>5<\/strong><strong>\u6708<\/strong><strong>29<\/strong><strong>\u65e5\u81f3<\/strong><strong>6<\/strong><strong>\u6708<\/strong><strong>2<\/strong><strong>\u65e5<\/strong>\u5728\u829d\u52a0\u54e5\u4e3e\u884c\u3002KAT6\u6291\u5236\u5242\u5c06\u8fce\u6765\u5173\u952e\u9a8c\u8bc1\u8282\u70b9\u3002<\/p>\n\n\n\n<p><strong>\u6700\u503c\u5f97\u5173\u6ce8\u7684\u770b\u70b9\uff1a<\/strong><strong>Olema Oncology OP-3136<\/strong><\/p>\n\n\n\n<p>\u6839\u636e2026\u5e74ASCO\u5927\u4f1a\u65e5\u7a0b\uff0cOlema Oncology\u5c06\u5728\u4f1a\u4e0a\u4ee5\u58c1\u62a5\u5f62\u5f0f\u516c\u5e03OP-3136\u7684I\u671f\u7814\u7a76\u6570\u636e\uff08\u6458\u8981\u53f73088\uff09<sup>5<\/sup>\u3002\u8fd9\u662f\u7ee7\u8f89\u745e\u4e4b\u540e\uff0c\u5168\u7403\u7b2c\u4e8c\u4e2a\u8fdb\u5165\u4e34\u5e8a\u9636\u6bb5\u7684KAT6A\/B\u6291\u5236\u5242\u9996\u6b21\u516c\u5e03\u4eba\u4f53\u6570\u636e\u3002<\/p>\n\n\n\n<p><strong>\u4e34\u5e8a\u524d\u6570\u636e\u4e0e<\/strong><strong>BIC<\/strong><strong>\u5b9a\u4f4d<\/strong>\uff1aOP-3136\u662f\u4e00\u6b3e\u5f3a\u6548\u3001\u9009\u62e9\u6027\u3001\u53e3\u670d\u751f\u7269\u53ef\u5229\u7528\u7684KAT6\u6291\u5236\u5242\u3002\u57282026\u5e74AACR\u5e74\u4f1a\u4e0a\uff0cOlema\u516c\u5e03\u4e86OP-3136\u4e0epalazestrant\uff08\u4e00\u79cd\u5b8c\u5168\u96cc\u6fc0\u7d20\u53d7\u4f53\u62ee\u6297\u5242\uff09\u8054\u5408\u4f7f\u7528\u7684\u4e34\u5e8a\u524d\u6570\u636e\u3002\u7814\u7a76\u53d1\u73b0\uff0cOP-3136\u8054\u5408palazestrant\u53ef\u534f\u540c\u4e0b\u8c03\u7ec6\u80de\u5468\u671f\u548c\u8f6c\u79fb\u76f8\u5173\u57fa\u56e0\u7279\u5f81\uff0c\u6291\u5236MYC\u3001E2F\u548cG2M\u901a\u8def\u7684\u6548\u679c\u663e\u8457\u4f18\u4e8e\u5355\u836f\u6216OP-3136\u8054\u5408\u6c1f\u7ef4\u53f8\u7fa4<sup>6<\/sup>\u3002\u8fd9\u4e9b\u6570\u636e\u4e3a\u5176Best-in-class\u5b9a\u4f4d\u63d0\u4f9b\u4e86\u6709\u529b\u652f\u6301\u3002<\/p>\n\n\n\n<p><strong>\u62a5\u544a\u5185\u5bb9<\/strong>\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>OP-3136\u5355\u836f\u6cbb\u7597\u665a\u671f\u5b9e\u4f53\u7624\u7684\u5b89\u5168\u6027\u3001\u8010\u53d7\u6027\u548c\u836f\u4ee3\u52a8\u529b\u5b66<\/li>\n\n\n\n<li>\u8054\u5408\u5185\u5206\u6ccc\u6cbb\u7597ER+\/HER2-\u665a\u671f\u4e73\u817a\u764c\u7684\u521d\u6b65\u7597\u6548<\/li>\n<\/ul>\n\n\n\n<p><strong>\u884c\u4e1a\u610f\u4e49<\/strong>\uff1a\u6b64\u6b21\u6570\u636e\u5c06\u4e3a\u6574\u4e2aKAT6\u8d5b\u9053\u63d0\u4f9b\u5173\u952e\u9a8c\u8bc1\u3002\u79ef\u6781\u7684\u7ed3\u679c\u5c06\u529b\u8bc1\u9776\u70b9\u6210\u836f\u6027\uff0c\u5e76\u4e3a\u540e\u7eed\u5728\u7814\u9879\u76ee\u63d0\u4f9b\u5242\u91cf\u548c\u5b89\u5168\u6027\u53c2\u8003<sup>5<\/sup>\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u4e94\u3001\u6280\u672f\u8def\u7ebf\u767e\u82b1\u9f50\u653e\uff1a\u53cc\u9776\u70b9\u6291\u5236\u5242\u4e0e\u86cb\u767d\u964d\u89e3\u5242\u767b\u573a<\/strong><\/h2>\n\n\n\n<p>\u5728\u8f89\u745e\u9a8c\u8bc1\u4e86KAT6\u9776\u70b9\u53ef\u884c\u6027\u540e\uff0c\u66f4\u591a\u521b\u65b0\u6280\u672f\u8def\u5f84\u6d8c\u73b0\u3002<\/p>\n\n\n\n<p><strong>1. <\/strong><strong>\u5eb7\u8fb0\u836f\u4e1a\uff1a<\/strong><strong>KAT6\/7<\/strong><strong>\u53cc\u9776\u70b9\u6291\u5236\u5242<\/strong><strong>KC1086<\/strong><\/p>\n\n\n\n<p>\u57282026\u5e74AACR\u5e74\u4f1a\u4e0a\uff0c\u5eb7\u8fb0\u836f\u4e1a\u4ee5\u58c1\u62a5\u5f62\u5f0f\u9996\u6b21\u516c\u5e03\u4e86\u5176\u81ea\u4e3b\u7814\u53d1\u7684KC1086\u7684\u4e34\u5e8a\u524d\u7814\u7a76\u6570\u636e\u3002\u503c\u5f97\u5173\u6ce8\u7684\u662f\uff0cKC1086\u5e76\u975e\u5355\u7eaf\u7684KAT6\u6291\u5236\u5242\uff0c\u800c\u662f\u4e00\u6b3e<strong>KAT6\/7<\/strong><strong>\u53cc\u9776\u70b9\u5c0f\u5206\u5b50\u6291\u5236\u5242<\/strong><sup>7<\/sup>\u3002<\/p>\n\n\n\n<p><strong>\u5173\u952e\u4e34\u5e8a\u524d\u6570\u636e<\/strong>\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>KC1086\u5bf9KAT6A\/B\u53caKAT7\u5747\u5177\u6709\u5f3a\u6548\u6291\u5236\u6d3b\u6027\u4e0e\u9ad8\u9009\u62e9\u6027<\/li>\n\n\n\n<li><strong>\u8054\u5408\u7528\u836f\u4f18\u52bf<\/strong>\uff1a\u4e0e\u54cc\u67cf\u897f\u5229\uff08CDK4\/6\u6291\u5236\u5242\uff09\u8054\u7528\uff0c\u5728ZR-75-1 ER+\u4e73\u817a\u764c\u6a21\u578b\u4e2d\u80bf\u7624\u751f\u957f\u6291\u5236\u7387\u8fbe<strong>101%<\/strong>\uff1b\u4e0e\u6c1f\u7ef4\u53f8\u7fa4\u8054\u7528\uff0c\u5728T47D\u4e73\u817a\u764c\u6a21\u578b\u4e2d\u80bf\u7624\u751f\u957f\u6291\u5236\u7387\u8fbe<strong>83%<\/strong><sup>7<\/sup><\/li>\n\n\n\n<li>\u5c55\u73b0\u51fa\u826f\u597d\u7684\u836f\u4ee3\u52a8\u529b\u5b66\u7279\u5f81\u548c\u5b89\u5168\u7a97\u53e3\uff0c\u5177\u6709\u7ebf\u6027\u836f\u4ee3\u52a8\u529b\u5b66\u7279\u5f81\u3001\u9ad8\u53e3\u670d\u751f\u7269\u5229\u7528\u5ea6\u3001\u4f4e\u836f\u7269\u84c4\u79ef\u7684\u7279\u70b9<\/li>\n<\/ul>\n\n\n\n<p><strong>\u4e34\u5e8a\u8fdb\u5c55<\/strong>\uff1aKC1086\u5df2\u4e8e2025\u5e748\u6708\u542f\u52a8I\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u5e76\u6210\u529f\u83b7\u5f97\u7f8e\u56fdFDA\u7684\u65b0\u836f\u4e34\u5e8a\u7814\u7a76\u9ed8\u793a\u8bb8\u53ef\u3002<\/p>\n\n\n\n<p>\u8fd9\u4e00\u5e03\u5c40\u4e0eIDEAYA\u7684IDE574\uff08\u540c\u4e3aKAT6\/7\u53cc\u9776\u70b9\u6291\u5236\u5242\uff09\u5f62\u6210\u76f4\u63a5\u7ade\u4e89\uff0c\u4f46KC1086\u5728\u8054\u5408\u6cbb\u7597\u4e2d\u7684\u6570\u636e\u66f4\u4e3a\u8be6\u5b9e\uff0c\u4f53\u73b0\u4e86\u4e2d\u56fd\u836f\u4f01\u5728\u8be5\u9886\u57df\u7684\u5dee\u5f02\u5316\u7ade\u4e89\u7b56\u7565\u3002<\/p>\n\n\n\n<p><strong>2. IDEAYA Biosciences<\/strong><strong>\uff1a<\/strong><strong>KAT6\/7<\/strong><strong>\u53cc\u9776\u70b9\u6291\u5236\u5242<\/strong><strong>IDE574<\/strong><\/p>\n\n\n\n<p>IDEAYA\u5f00\u53d1\u4e86\u4e00\u6b3e\u6f5c\u5728\u9996\u521b\u7684KAT6\/7\u7b49\u5f3a\u53cc\u9776\u70b9\u6291\u5236\u5242IDE574\u3002I\u671f\u5242\u91cf\u9012\u589e\u8bd5\u9a8c\u5df2\u4e8e2026\u5e744\u6708\u5b8c\u6210\u9996\u4f8b\u60a3\u8005\u7ed9\u836f<sup>8<\/sup>\u3002\u4e34\u5e8a\u524d\u6570\u636e\u663e\u793a\uff0c\u5176\u5bf9\u65c1\u7cfb\u540c\u6e90\u7269KAT5\/KAT8\u7684\u9009\u62e9\u6027\u9ad8\u8fbe350-2000\u500d\uff0c\u5728\u591a\u79cd\u5b9e\u4f53\u7624\u6a21\u578b\u4e2d\u5c55\u73b0\u51fa\u8d85\u8d8aKAT6\u9009\u62e9\u6027\u6291\u5236\u5242\u7684\u6301\u4e45\u7597\u6548<sup>10<\/sup>\u3002<\/p>\n\n\n\n<p><strong>3. Prelude Therapeutics<\/strong><strong>\uff1a<\/strong><strong>KAT6A<\/strong><strong>\u9009\u62e9\u6027\u964d\u89e3\u5242<\/strong><strong>PRT13722<\/strong><\/p>\n\n\n\n<p>Prelude\u7684<strong>PRT13722<\/strong>\u662f\u4e00\u6b3e\u6f5c\u5728\u9996\u521b\u7684\u53e3\u670dKAT6A\u9009\u62e9\u6027\u964d\u89e3\u5242\uff0c\u901a\u8fc7PROTAC\u6280\u672f\u76f4\u63a5\u6e05\u9664KAT6A\u86cb\u767d\u3002\u4e34\u5e8a\u524d\u6570\u636e\u663e\u793a\uff0c\u8be5\u836f\u7269\u5728HR+\/HER2-\u4e73\u817a\u764c\u6a21\u578b\u4e2d\u5b9e\u73b0\u4e86\u6301\u4e45\u7684\u80bf\u7624\u5b8c\u5168\u6d88\u9000\u3002\u4e0e\u8f89\u745e\u7684PF-07248144\u76f8\u6bd4\uff0cPRT13722\u5728\u4e34\u5e8a\u524d\u6a21\u578b\u4e2d\u5c55\u73b0\u51fa\u6539\u5584\u7684\u8840\u6db2\u5b66\u5b89\u5168\u6027<a><\/a><a><sup>9<\/sup><\/a>\u3002<\/p>\n\n\n\n<p><strong>\u5f00\u53d1\u8ba1\u5212<\/strong>\uff1a\u516c\u53f8\u5df2\u57282026\u5e74AACR\u5e74\u4f1a\u4e0a\u516c\u5e03\u4e86PRT13722\u7684\u4e34\u5e8a\u524d\u6570\u636e\uff0c\u5e76\u6b63\u79ef\u6781\u63a8\u8fdb\u5176\u5411\u4e34\u5e8a\u9636\u6bb5\u8f6c\u5316<sup>9<\/sup>\u3002\u6839\u636e\u516c\u53f8\u5b98\u65b9\u62ab\u9732\uff0cPrelude\u8ba1\u5212\u4e8e2026\u5e74\u4e2d\u63d0\u4ea4IND\u7533\u8bf7\u3002<\/p>\n\n\n\n<p><strong>4. <\/strong><strong>\u82f1\u77fd\u667a\u80fd\uff1a<\/strong><strong>ISM5043<\/strong> \u5982\u524d\u6240\u8ff0\uff0cISM5043\u662f\u82f1\u77fd\u667a\u80fd\u5229\u7528AI\u5e73\u53f0\u53d1\u73b0\u7684KAT6A\u6291\u5236\u5242\uff0c\u5df2\u8fdb\u5165I\u671f\u4e34\u5e8a\uff0c\u662f\u5168\u7403\u5c11\u6570\u7531AI\u8d4b\u80fd\u7684\u8fdb\u5165\u4e34\u5e8a\u9636\u6bb5\u7684KAT6\u6291\u5236\u5242<sup>3<\/sup>\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u516d\u3001\u9002\u5e94\u75c7\u62d3\u5c55\uff1a\u4ece\u80bf\u7624\u5230\u81ea\u8eab\u514d\u75ab\u7684\u8de8\u8d8a<\/strong><\/h2>\n\n\n\n<p>KAT6A\u7684\u751f\u7269\u5b66\u529f\u80fd\u8fdc\u8d85\u80bf\u7624\u9886\u57df\uff0c\u5176\u5728\u514d\u75ab\u7ec6\u80de\u5206\u5316\u4e2d\u7684\u5173\u952e\u4f5c\u7528\u6b63\u5728\u88ab\u9010\u6b65\u63ed\u793a\uff1a<\/p>\n\n\n\n<p><strong>\u81ea\u8eab\u514d\u75ab\u75be\u75c5\u6f5c\u529b<\/strong>\uff1a\u7814\u7a76\u8868\u660e\uff0cKAT6A\u662fCD4+ T\u7ec6\u80de\u4f53\u5916\u589e\u6b96\u548cTh1\/Th17\u5206\u5316\u6240\u5fc5\u9700\u7684<sup>1<\/sup>\u3002Th1\/Th17\u662f\u591a\u79cd\u81ea\u8eab\u514d\u75ab\u75be\u75c5\u7684\u6838\u5fc3\u9a71\u52a8\u7ec6\u80de\uff0c\u5305\u62ec\u7c7b\u98ce\u6e7f\u5173\u8282\u708e\u3001\u94f6\u5c51\u75c5\u3001\u708e\u75c7\u6027\u80a0\u75c5\u548c\u591a\u53d1\u6027\u786c\u5316\u7b49\u3002\u8fd9\u4e00\u53d1\u73b0\u63d0\u793a\uff0cKAT6A\u6291\u5236\u5242\u53ef\u80fd\u901a\u8fc7\u8c03\u8282\u81f4\u75c5\u6027T\u7ec6\u80de\u5206\u5316\uff0c\u5728\u8fd9\u4e9b\u75be\u75c5\u4e2d\u53d1\u6325\u6cbb\u7597\u4f5c\u7528\u3002<\/p>\n\n\n\n<p><strong>\u708e\u75c7\u6027\u75be\u75c5\u6f5c\u529b<\/strong>\uff1a\u6700\u65b0\u7814\u7a76\u8bc1\u5b9e\uff0cKAT6A\u5728\u8113\u6bd2\u75c7\u8bf1\u5bfc\u7684\u6025\u6027\u80ba\u635f\u4f24\u4e2d\u9a71\u52a8\u5de8\u566c\u7ec6\u80deM1\u6781\u5316\u3002\u5728\u76f2\u80a0\u7ed3\u624e\u7a7f\u523a\uff08CLP\uff09\u8bf1\u5bfc\u7684\u8113\u6bd2\u75c7\u6a21\u578b\u4e2d\uff0c\u4f7f\u7528KAT6A\u6291\u5236\u5242WM1119\u53ef\u663e\u8457\u51cf\u8f7b\u80ba\u635f\u4f24\u3001\u6539\u5584\u7ec6\u83cc\u6e05\u9664\u5e76\u5ef6\u957f\u751f\u5b58\u671f<sup>2<\/sup>\u3002\u8fd9\u4e00\u53d1\u73b0\uff0c\u65e2\u8865\u5145\u4e86\u6700\u65b0\u6570\u636e\uff0c\u53c8\u4f53\u73b0\u4e86\u57fa\u7840\u7814\u7a76\u9886\u57df\u7684\u91cd\u8981\u8fdb\u5c55\u3002<strong>\u4e34\u5e8a\u5f00\u53d1\u7b56\u7565\u542f\u793a<\/strong>\uff1aKAT6\u6291\u5236\u5242\u53ef\u91c7\u53d6\u201c\u80bf\u7624\u4f18\u5148\u3001\u81ea\u514d\u8ddf\u8fdb\u201d\u7684\u5f00\u53d1\u7b56\u7565\u3002\u5728\u80bf\u7624\u9886\u57df\u5b8c\u6210\u6982\u5ff5\u9a8c\u8bc1\u540e\uff0c\u5229\u7528\u5176\u5728T\u7ec6\u80de\u548c\u5de8\u566c\u7ec6\u80de\u8c03\u8282\u4e2d\u7684\u4f5c\u7528\u673a\u5236\uff0c\u5411\u81ea\u8eab\u514d\u75ab\u548c\u708e\u75c7\u6027\u75be\u75c5\u62d3\u5c55\u2014\u2014\u8fd9\u4e00\u8def\u5f84\u5df2\u6709\u8bf8\u591a\u6210\u529f\u5148\u4f8b\uff08\u5982JAK\u6291\u5236\u5242\u4ece\u80bf\u7624\u8d70\u5411\u81ea\u514d\uff09\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u4e03\u3001KAT6\u8d5b\u9053\u5168\u666f\u68b3\u7406<\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><thead><tr><td>\u836f\u7269\/\u9879\u76ee<\/td><td>\u7814\u53d1\u673a\u6784<\/td><td>\u6280\u672f\u8def\u7ebf<\/td><td>\u5f53\u524d\u9636\u6bb5<\/td><td>\u6700\u65b0\u91cc\u7a0b\u7891<\/td><\/tr><\/thead><tbody><tr><td><strong>PF-07248144<\/strong><\/td><td>\u8f89\u745e<\/td><td>KAT6A\/B\u6291\u5236\u5242<\/td><td><strong>III<\/strong><strong>\u671f<\/strong><\/td><td>AACR\u516c\u5e03ctDNA\u6570\u636e\uff1b\u5168\u7403III\u671f\u8fdb\u884c\u4e2d<sup>4<\/sup><\/td><\/tr><tr><td><strong>OP-3136<\/strong><\/td><td>Olema<\/td><td>KAT6A\/B\u6291\u5236\u5242<\/td><td><strong>I<\/strong><strong>\u671f<\/strong><\/td><td>ASCO 2026\u516c\u5e03\u9996\u6b21\u4eba\u4f53\u6570\u636e\uff08\u6458\u89813088\uff09<sup>5<\/sup>\uff1bAACR\u516c\u5e03\u8054\u5408palazestrant\u534f\u540c\u6570\u636e<sup>6<\/sup><\/td><\/tr><tr><td><strong>ISM5043<\/strong><\/td><td>\u82f1\u77fd\u667a\u80fd<\/td><td>KAT6A\u6291\u5236\u5242<\/td><td><strong>I<\/strong><strong>\u671f<\/strong><\/td><td>AI\u5e73\u53f0\u53d1\u73b0\uff1b2024\u5e7410\u6708\u542f\u52a8I\u671f\uff08NCT06638307\uff09<sup>3<\/sup><\/td><\/tr><tr><td><strong>KC1086<\/strong><\/td><td>\u5eb7\u8fb0\u836f\u4e1a<\/td><td><strong>KAT6\/7<\/strong><strong>\u53cc\u9776\u70b9<\/strong><\/td><td><strong>I<\/strong><strong>\u671f<\/strong><\/td><td>AACR\u516c\u5e03\u4e34\u5e8a\u524d\u6570\u636e\uff1b\u8054\u5408\u7528\u836f\u6291\u7624\u7387\u8fbe101%\uff1b\u5df2\u83b7FDA IND\u9ed8\u8bb8<sup>7<\/sup><\/td><\/tr><tr><td><strong>IDE574<\/strong><\/td><td>IDEAYA<\/td><td><strong>KAT6\/7<\/strong><strong>\u53cc\u9776\u70b9<\/strong><\/td><td><strong>I<\/strong><strong>\u671f<\/strong><\/td><td>2026\u5e744\u6708\u9996\u4f8b\u7ed9\u836f<sup>8<\/sup>\uff1b\u9009\u62e9\u6027350-2000\u500d<sup>10<\/sup><\/td><\/tr><tr><td><strong>PRT13722<\/strong><\/td><td>Prelude<\/td><td><strong>KAT6A<\/strong><strong>\u964d\u89e3\u5242<\/strong><\/td><td>\u4e34\u5e8a\u524d\u2192IND<\/td><td>AACR\u516c\u5e03\u4e34\u5e8a\u524d\u6570\u636e\uff1b\u6b63\u63a8\u8fdb\u5411\u4e34\u5e8a\u8f6c\u5316<sup>9<\/sup><\/td><\/tr><tr><td><strong>HRS-2189<\/strong><\/td><td>\u6052\u745e\u533b\u836f<\/td><td>KAT6A\/B\u6291\u5236\u5242<\/td><td><strong>Ib\/II<\/strong><strong>\u671f<\/strong><\/td><td>\u4e2d\u56fd\u8fdb\u5ea6\u6700\u5feb<\/td><\/tr><tr><td><strong>HLX97<\/strong><\/td><td>\u590d\u5b8f\u6c49\u9716<\/td><td>KAT6A\/B\u6291\u5236\u5242<\/td><td>I\u671f\u83b7\u6279\uff082026.03\uff09<\/td><td>\u5ba3\u79f0BIC\u6f5c\u529b<\/td><\/tr><tr><td><strong>SYH2095<\/strong><\/td><td>\u82f1\u521b\u533b\u836f\/\u77f3\u836f<\/td><td>KAT6\u6291\u5236\u5242<\/td><td>IND\u53d7\u7406\uff082026.03\uff09<\/td><td>\u5168\u65b0\u7ed3\u6784\u4e13\u5229<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u516b\u3001\u4e34\u5e8a\u5f00\u53d1\u7b56\u7565\u542f\u793a<\/strong><\/h2>\n\n\n\n<p>\u57fa\u4e8e\u5f53\u524d\u6570\u636e\uff0cKAT6\u6291\u5236\u5242\u7684\u4e34\u5e8a\u5f00\u53d1\u9762\u4e34\u4ee5\u4e0b\u51e0\u4e2a\u5173\u952e\u95ee\u9898\uff1a<\/p>\n\n\n\n<p><strong>\u5242\u91cf\u4f18\u5316\u4e0e\u751f\u7269\u6807\u5fd7\u7269\u7b56\u7565<\/strong>\uff1a\u8f89\u745e\u7684ctDNA\u6570\u636e\u8868\u660e\uff0c5mg QD\u8054\u5408\u65b9\u6848\u5728ESR1\u7a81\u53d8\u60a3\u8005\u4e2d\u6e05\u9664\u7387\u9ad8\u8fbe63%\uff0c\u8fd9\u4e3a\u6ce8\u518c\u7814\u7a76\u7684\u4eba\u7fa4\u5bcc\u96c6\u7b56\u7565\u63d0\u4f9b\u4e86\u4f9d\u636e<sup>4<\/sup>\u3002<\/p>\n\n\n\n<p><strong>\u5b89\u5168\u6027\u7ba1\u7406\u7684\u5dee\u5f02\u5316\u7ade\u4e89<\/strong>\uff1a\u8840\u6db2\u5b66\u6bd2\u6027\u662fKAT6\u7c7b\u836f\u7269\u7684\u201c\u7c7b\u6548\u5e94\u201d\u3002 Prelude\u7684\u964d\u89e3\u7b56\u7565\u5728\u4e34\u5e8a\u524d\u6a21\u578b\u4e2d\u5c55\u73b0\u51fa\u6539\u5584\u7684\u8840\u6db2\u5b66\u5b89\u5168\u6027<sup>9<\/sup>\uff1b\u590d\u5b8f\u6c49\u9716\u7684BIC\u5ba3\u79f0\u4e5f\u4ee5\u201c\u66f4\u4f4e\u8840\u6db2\u6bd2\u6027\u201d\u4e3a\u6838\u5fc3\u5356\u70b9\u3002\u5728\u4e34\u5e8a\u7814\u7a76\u4e2d\uff0c\u5b89\u5168\u6027\u7279\u5f81\u7684\u7cbe\u786e\u523b\u753b\u5c06\u6210\u4e3a\u540e\u671f\u6ce8\u518c\u7814\u7a76\u6210\u8d25\u7684\u5173\u952e\u3002<\/p>\n\n\n\n<p><strong>\u8de8\u9002\u5e94\u75c7\u62d3\u5c55\u7b56\u7565<\/strong>\uff1aKAT6A\u5728CD4+ T\u7ec6\u80de\u589e\u6b96\u548cTh1\/Th17\u5206\u5316\u4e2d\u7684\u5173\u952e\u4f5c\u7528<sup>1<\/sup>\uff0c\u4ee5\u53ca\u4e2d\u5c71\u5927\u5b66\u56e2\u961f\u5728\u8113\u6bd2\u75c7\u80ba\u635f\u4f24\u6a21\u578b\u4e2d\u7684\u9a8c\u8bc1<sup>2<\/sup>\uff0c\u4e3a\u8be5\u7c7b\u836f\u7269\u7684\u9002\u5e94\u75c7\u62d3\u5c55\u63d0\u4f9b\u4e86\u660e\u786e\u65b9\u5411\u3002\u53ef\u8003\u8651\u5728\u80bf\u7624\u9886\u57df\u7684I\u671f\/II\u671f\u7814\u7a76\u4e2d\u540c\u6b65\u6536\u96c6\u514d\u75ab\u76f8\u5173\u751f\u7269\u6807\u5fd7\u7269\uff0c\u4e3a\u540e\u7eed\u81ea\u514d\u9886\u57df\u7684\u4e34\u5e8a\u5f00\u53d1\u79ef\u7d2f\u6570\u636e\u3002<\/p>\n\n\n\n<p><strong>\u603b\u7ed3<\/strong><strong><\/strong><\/p>\n\n\n\n<p><strong>\u9776\u70b9\u4ef7\u503c\u83b7\u53cc\u91cd\u9a8c\u8bc1<\/strong>\uff1aKAT6\u4e0d\u4ec5\u5728HR+\u4e73\u817a\u764c\u4e2d\u5c55\u73b0\u51fa\u9006\u8f6c\u5185\u5206\u6ccc\u8010\u836f\u7684\u6f5c\u529b\uff0c\u66f4\u5728\u514d\u75ab\u8c03\u8282\u4e2d\u53d1\u6325\u5173\u952e\u4f5c\u7528\uff0c\u5e94\u7528\u524d\u666f\u6a2a\u8de8\u80bf\u7624\u4e0e\u81ea\u8eab\u514d\u75ab\u4e24\u5927\u9886\u57df<sup>1,2<\/sup>\u3002<\/p>\n\n\n\n<p><strong>\u6280\u672f\u8def\u7ebf\u52a0\u901f\u5206\u5316<\/strong>\uff1a\u4ece\u5355\u9776\u70b9\u6291\u5236\u5242\u2192\u53cc\u9776\u70b9\u6291\u5236\u5242\u2192\u86cb\u767d\u964d\u89e3\u5242\uff0c\u8d5b\u9053\u5feb\u901f\u6f14\u8fdb\u3002\u5eb7\u8fb0\u836f\u4e1aKC1086\u5728\u8054\u5408\u6cbb\u7597\u4e2d101%\u7684\u6291\u7624\u7387\u6570\u636e\u5c24\u4e3a\u4eae\u773c<sup>7<\/sup>\uff0c\u672a\u6765\u7ade\u4e89\u7684\u5173\u952e\u662f\u5728\u4fdd\u8bc1\u7597\u6548\u7684\u540c\u65f6\uff0c\u5982\u4f55\u514b\u670d\u8840\u6db2\u5b66\u6bd2\u6027\u8fd9\u4e00\u201c\u7c7b\u6548\u5e94\u201d\uff0c\u5e76\u5411\u66f4\u5e7f\u6cdb\u7684\u9002\u5e94\u75c7\u62d3\u5c55\u3002<\/p>\n\n\n\n<p><strong>\u4e2d\u56fd\u529b\u91cf\u6301\u7eed\u52a0\u7801<\/strong>\uff1a\u6052\u745e\u3001\u590d\u5b8f\u6c49\u9716\u3001\u5eb7\u8fb0\u3001\u82f1\u77fd\u667a\u80fd\u3001\u82f1\u521b\u7b49\u4f01\u4e1a\u901a\u8fc7\u5feb\u901f\u5e03\u5c40\u548c\u5dee\u5f02\u5316\u8bbe\u8ba1\uff0c\u6709\u671b\u5728\u5168\u7403KAT6\u5e02\u573a\u4e2d\u5360\u636e\u4e00\u5e2d\u4e4b\u5730\u3002<\/p>\n\n\n\n<p><\/p>\n\n\n\n<p><strong>\u53c2\u8003\u6587\u732e<\/strong><\/p>\n\n\n\n<p>[1] Fu JY, Wang YJ, Wang SX, et al. Lysine acetyltransferase 6A maintains CD4+ T cell response via epigenetic reprogramming of glucose metabolism in autoimmunity. Cell Metabolism. 2024;36(3):557-574.e10.<\/p>\n\n\n\n<p>[2] Lysine Acetyltransferase 6A Drives M1 Macrophage Polarization Through Metabolic Reprogramming in Sepsis-Induced Acute Lung Injury. Biomolecules. 2026;16(4):609.<\/p>\n\n\n\n<p>[3] U.S. National Library of Medicine. A Study of ISM5043 in Advanced Breast Cancer (NCT06638307) [Internet]. ClinicalTrials.gov. 2024 [cited 2026 Apr 30]. Available from: <a href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT06638307\">https:\/\/clinicaltrials.gov\/ct2\/show\/NCT06638307<\/a><\/p>\n\n\n\n<p>[4] Liu L, Layman RM, Mu XJ, et al. Unlocking endocrine resistance: Co-targeting KAT6 and ER with prifetrastat (PF-07248144) and fulvestrant drives tumor and ctDNA response in ER+\/HER2\u2212 metastatic breast cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2026; 2026 Apr 17-22; San Diego, CA. Philadelphia (PA): AACR; Cancer Research. 2026;86(8_Suppl):Abstract nr CT174.<\/p>\n\n\n\n<p>[5] Olema Pharmaceuticals. Olema Oncology to Present Initial Clinical Data for OP-3136 at the 2026 ASCO Annual Meeting [news release]. April 21, 2026. Available from: https:\/\/ir.olema.com\/news-releases\/news-release-details\/olema-oncology-present-initial-clinical-data-op-3136-2026-asco<\/p>\n\n\n\n<p>[6] Olema Pharmaceuticals. Olema Oncology Announces Preclinical Data for Palazestrant and OP-3136 at the 2026 AACR Annual Meeting [news release]. April 17, 2026. Available from: https:\/\/www.manilatimes.net\/2026\/04\/18\/tmt-newswire\/globenewswire\/olema-oncology-announces-preclinical-data-for-palazestrant-and-op-3136-at-the-2026-aacr-annual-meeting\/2323055<\/p>\n\n\n\n<p>[7] \u5317\u4eac\u5eb7\u8fb0\u836f\u4e1a\u80a1\u4efd\u6709\u9650\u516c\u53f8. \u5173\u4e8e\u516c\u53f8\u57282026\u5e74AACR\u5e74\u4f1a\u5c55\u793a\u521b\u65b0\u836fKC1086\u548cKC1101\u4e34\u5e8a\u524d\u7814\u7a76\u6570\u636e\u7684\u516c\u544a [\u516c\u544a]. \u8bc1\u5238\u65e5\u62a5. 2026\u5e744\u670824\u65e5. Available from: http:\/\/epaper.zqrb.cn\/html\/2026-04\/24\/content_1235161.htm<\/p>\n\n\n\n<p>[8] IDEAYA Biosciences. IDEAYA Biosciences Announces First-Patient-In for Phase 1 Trial of IDE574, a Potential First-in-Class Dual Inhibitor of KAT6\/7 [news release]. April 6, 2026.<\/p>\n\n\n\n<p>[9] Prelude Therapeutics. Prelude Therapeutics Presents Preclinical Data from Development Candidate, PRT13722, a First-in-Class, Orally Bioavailable, Potent and Highly Selective KAT6A Degrader at American Association for Cancer Research (AACR) Annual Meeting 2026 [news release]. April 20, 2026.<\/p>\n\n\n\n<p>[10] Gupta M, et al. The KAT6\/7 inhibitor IDE574 disrupts tumor lineage identity and drug tolerance to deliver robust antitumor activity in biomarker selected indications [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2026; 2026 Apr 17-22; San Diego, CA. Philadelphia (PA): AACR; Cancer Research. 2026;86(8_Suppl): Abstract nr 4483.<\/p>\n\n\n\n<p>\u64b0\u7a3f\u4eba\uff1a\u90d1\u53f6\u654f<\/p>\n\n\n\n<p>\u5ba1\u6838\uff1a\u5bab\u96ea<\/p>\n\n\n\n<p>\u6da6\u8272\u6392\u7248\uff1a\u5434\u534e\u82b3<\/p>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u4ece\u8868\u89c2\u9057\u4f20\u5b66\u5230\u7cbe\u51c6\u533b\u7597\uff0cKAT\uff08\u8d56\u6c28\u9178\u4e59\u9170\u8f6c\u79fb\u9176\uff09\u6291\u5236\u5242\u6b63\u6210\u4e3aHR+\u4e73\u817a\u764c\u9886\u57df\u7ee7CDK4\/6\u4e4b\u540e\u6700\u5177\u6f5c\u529b\u7684\u65b0\u9776\u70b9\u3002\u66f4\u503c\u5f97\u5173\u6ce8\u7684\u662f\uff0cKAT6A\u5728\u514d\u75ab\u7ec6\u80de\u5206\u5316\u4e2d\u7684\u5173\u952e\u4f5c\u7528\uff0c\u6b63\u5c06\u5176\u5e94\u7528\u8fb9\u754c\u4ece\u80bf\u7624\u62d3\u5c55\u81f3\u81ea\u8eab\u514d\u75ab\u75be\u75c51\u3002\u968f\u77402026\u5e74AACR\u5e74\u4f1a\u7684\u843d\u5e55\u548cASCO\u5e74\u4f1a\u7684\u4e34\u8fd1\uff0c\u8fd9\u4e00\u8d5b\u9053\u8fce\u6765\u4e86\u591a\u9879\u5173\u952e\u6570\u636e\u62ab\u9732\u3002\u672c\u6587\u6df1\u5ea6\u89e3\u6790\u6700\u65b0\u8fdb\u5c55\uff0c\u5e76\u524d\u77bb\u5373\u5c06\u5230\u6765\u7684ASCO\u91cd\u78c5\u62a5\u544a\u3002<\/p>\n","protected":false},"author":1,"featured_media":1788,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[17],"tags":[15,32,34],"class_list":["post-1787","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-17","tag-15","tag-32","tag-34"],"_links":{"self":[{"href":"https:\/\/www.millibuff.com\/index.php?rest_route=\/wp\/v2\/posts\/1787","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.millibuff.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.millibuff.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.millibuff.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.millibuff.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1787"}],"version-history":[{"count":2,"href":"https:\/\/www.millibuff.com\/index.php?rest_route=\/wp\/v2\/posts\/1787\/revisions"}],"predecessor-version":[{"id":1790,"href":"https:\/\/www.millibuff.com\/index.php?rest_route=\/wp\/v2\/posts\/1787\/revisions\/1790"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.millibuff.com\/index.php?rest_route=\/wp\/v2\/media\/1788"}],"wp:attachment":[{"href":"https:\/\/www.millibuff.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1787"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.millibuff.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1787"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.millibuff.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1787"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}