{"id":2085,"date":"2026-08-20T14:08:17","date_gmt":"2026-08-20T06:08:17","guid":{"rendered":"https:\/\/www.millibuff.com\/?p=2085"},"modified":"2026-08-20T14:25:57","modified_gmt":"2026-08-20T06:25:57","slug":"%e5%ae%9e%e4%bd%93%e7%98%a4%e6%8a%97%e7%99%8c%e6%96%b0%e5%88%a9%e5%99%a8%ef%bd%9c%e4%b8%80%e6%96%87%e8%af%bb%e6%87%82til%e7%bb%86%e8%83%9e%e7%96%97%e6%b3%95%ef%bc%9a","status":"publish","type":"post","link":"https:\/\/www.millibuff.com\/?p=2085","title":{"rendered":"\u5c0f\u725b\u6d1e\u5bdf | \u5b9e\u4f53\u7624\u6297\u764c\u65b0\u5229\u5668\uff5c\u4e00\u6587\u8bfb\u61c2TIL\u7ec6\u80de\u7597\u6cd5\uff1a\u53d6\u4e4b\u4e8e\u7624\u3001\u7528\u4e4b\u4e8e\u8eab\uff0c\u665a\u671f\u764c\u75c7\u60a3\u8005\u7684\u5168\u65b0\u751f\u673a"},"content":{"rendered":"\n<p class=\"has-medium-font-size wp-block-paragraph\"><strong>\u4e00\u3001\u4ec0\u4e48\u662f<\/strong><strong>TIL<\/strong><strong>\uff1f\u80bf\u7624\u91cc\u81ea\u5e26\u7684\u6297\u764c\u201c\u5148\u9063\u5175\u201d<\/strong><strong><sup>[1]<\/sup><\/strong><strong><\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u80bf\u7624\u6d78\u6da6\u6dcb\u5df4\u7ec6\u80de\uff08Tumor Infiltrating Lymphocytes\uff0cTIL\uff09\u5b9a\u4e49\uff1a\u764c\u7ec6\u80de\u5728\u4f53\u5185\u75af\u72c2\u589e\u6b96\u65f6\uff0c\u4eba\u4f53\u514d\u75ab\u7cfb\u7edf\u4f1a\u81ea\u53d1\u6d3e\u51faT\u7ec6\u80de\u51b2\u8fdb\u80bf\u7624\u5185\u90e8\u56f4\u527f\uff0c\u8fd9\u4e9b\u624e\u6839\u5728\u80bf\u7624\u7ec4\u7ec7\u91cc\u3001\u5929\u7136\u80fd\u8bc6\u522b\u764c\u7ec6\u80de\u7684\u514d\u75ab\u7ec6\u80de\uff0c\u5c31\u662fTIL\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img fetchpriority=\"high\" decoding=\"async\" width=\"865\" height=\"495\" src=\"https:\/\/www.millibuff.com\/wp-content\/uploads\/2026\/08\/e8f7504f22022e0d86882ea109c5e335.png\" alt=\"\" class=\"wp-image-2087\" srcset=\"https:\/\/www.millibuff.com\/wp-content\/uploads\/2026\/08\/e8f7504f22022e0d86882ea109c5e335.png 865w, https:\/\/www.millibuff.com\/wp-content\/uploads\/2026\/08\/e8f7504f22022e0d86882ea109c5e335-300x172.png 300w, https:\/\/www.millibuff.com\/wp-content\/uploads\/2026\/08\/e8f7504f22022e0d86882ea109c5e335-768x439.png 768w\" sizes=\"(max-width: 865px) 100vw, 865px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">\u4f46\u7edd\u5927\u591a\u6570\u665a\u671f\u60a3\u8005\u4f53\u5185\uff0cTIL\u90fd\u4f1a\u9677\u5165\u4e09\u5927\u56f0\u5883\uff1a<\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li style=\"line-height:2.3\">\u5175\u529b\u592a\u5c11\uff1a\u80bf\u7624\u5fae\u73af\u5883\u4f1a\u6301\u7eed\u538b\u5236\u514d\u75ab\u7ec6\u80de\uff0c\u6297\u764cT\u7ec6\u80de\u6570\u91cf\u5be5\u5be5\u65e0\u51e0\uff0c\u5be1\u4e0d\u654c\u4f17\uff1b<\/li>\n\n\n\n<li style=\"line-height:2.3\">\u6218\u6597\u529b\u88ab\u5c01\u5370\uff1a\u764c\u7ec6\u80de\u91ca\u653e\u6291\u5236\u56e0\u5b50\uff0c\u8ba9T\u7ec6\u80de\u5931\u53bb\u6740\u4f24\u80fd\u529b\uff0c\u9677\u5165\u201c\u8017\u7aed\u201d\uff1b<\/li>\n\n\n\n<li style=\"line-height:2.3\">\u8bc6\u522b\u9776\u70b9\u5355\u4e00\uff1a\u5c11\u91cf\u5b58\u6d3bT\u7ec6\u80de\u4ec5\u80fd\u8bc6\u522b\u90e8\u5206\u764c\u7ec6\u80de\uff0c\u80bf\u7624\u6781\u6613\u9003\u9038\u3002<\/li>\n<\/ol>\n\n\n\n<p class=\"wp-block-paragraph\">\u90a3\u4e48\uff0cTIL\u7597\u6cd5\u7684\u6838\u5fc3\u601d\u8def\u4e3a\u628a\u80bf\u7624\u91cc\u5944\u5944\u4e00\u606f\u7684\u6297\u764c\u7cbe\u5175\u53d6\u51fa\u4f53\u5916\uff0c\u6279\u91cf\u6269\u519b\u3001\u7b5b\u9009\u6700\u5f3a\u6740\u4f24\u90e8\u961f\uff0c\u518d\u9001\u56de\u60a3\u8005\u4f53\u5185\u5168\u9762\u6e05\u527f\u5168\u8eab\u80bf\u7624\u3002<\/p>\n\n\n\n<p class=\"has-medium-font-size wp-block-paragraph\"><strong>\u4e8c\u3001<\/strong><strong>TIL<\/strong><strong>\u7597\u6cd5\u5b8c\u6574\u8fc7\u7a0b<\/strong><strong><sup>[2]<\/sup><\/strong><strong><\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4f20\u7edfTIL\u7597\u6cd5\u6574\u5957\u5236\u5907\u5468\u671f\u7ea66~8\u5468\uff0c\u5c5e\u4e8e\u9ad8\u5ea6\u4e2a\u4f53\u5316\u5b9a\u5236\u7597\u6cd5\uff1a<strong><\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u7b2c\u4e00\u6b65\uff1a\u83b7\u53d6\u80bf\u7624\u7ec4\u7ec7\uff08\u6d3b\u68c0<\/strong><strong>\/<\/strong><strong>\u5fae\u521b\u624b\u672f\u53d6\u6837\uff09\uff1a<\/strong>\u901a\u8fc7\u7a7f\u523a\u6d3b\u68c0\u6216\u5c0f\u578b\u624b\u672f\uff0c\u622a\u53d6\u4e00\u5c0f\u5757\u6d3b\u6027\u80bf\u7624\u7ec4\u7ec7\uff0c\u662f\u6574\u5957\u7597\u6cd5\u7684\u539f\u6599\u57fa\u7840\u3002\uff08\u5173\u952e\u70b9\uff1a\u5fc5\u987b\u6709\u53ef\u53d6\u6837\u7684\u5b9e\u4f53\u75c5\u7076\uff0c\u5b8c\u5168\u65e0\u80bf\u7624\u75c5\u7076\u7684\u60a3\u8005\u65e0\u6cd5\u5f00\u5c55TIL\u5236\u5907\u3002\uff09<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u7b2c\u4e8c\u6b65\uff1a\u5206\u79bb<\/strong><strong>+<\/strong><strong>\u521d\u57f9\uff0c\u63d0\u53d6\u539f\u751f<\/strong><strong>TIL<\/strong><strong>\u7ec6\u80de\uff1a<\/strong>\u5b9e\u9a8c\u5ba4\u5c06\u80bf\u7624\u7ec4\u7ec7\u7c89\u788e\u3001\u9176\u89e3\uff0c\u628a\u6df7\u6742\u5728\u764c\u7ec6\u80de\u4e2d\u7684T\u6dcb\u5df4\u7ec6\u80de\u5206\u79bb\u51fa\u6765\uff0c\u52a0\u5165\u767d\u4ecb\u7d202\uff08IL-2\uff09\u523a\u6fc0\u7ec6\u80de\u521d\u6b65\u6d3b\u5316\u6269\u589e\uff0c\u7b5b\u9009\u5b58\u6d3b\u7684\u6297\u80bf\u7624T\u7ec6\u80de\u7fa4\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u7b2c\u4e09\u6b65\uff1a\u7cbe\u51c6\u7b5b\u9009\uff0c\u6dd8\u6c70\u65e0\u6548\u7ec6\u80de\uff1a<\/strong>\u5c06\u6269\u589e\u540e\u7684TIL\u4e0e\u60a3\u8005\u81ea\u8eab\u764c\u7ec6\u80de\u5171\u57f9\u517b\uff0c\u53ea\u4fdd\u7559\u80fd\u7cbe\u51c6\u6740\u4f24\u80bf\u7624\u3001\u8bc6\u522b\u80bf\u7624\u7279\u5f02\u6027\u7a81\u53d8\u6297\u539f\uff08\u65b0\u751f\u6297\u539f\uff09\u7684\u7ec6\u80de\u514b\u9686\uff0c\u65e0\u6740\u7624\u80fd\u529b\u7684\u7ec6\u80de\u76f4\u63a5\u820d\u5f03\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u7b2c\u56db\u6b65\uff1a\u5feb\u901f\u6269\u589e\uff1a<\/strong>\u91c7\u7528OKT3\u6297\u4f53+\u9ad8\u6d53\u5ea6IL-2+\u6ecb\u517b\u7ec6\u80de\u4f53\u7cfb\uff08\u5feb\u901f\u6269\u589e\u5de5\u827a\uff09\uff0c\u77ed\u77ed\u4e24\u5468\u5185\u5c06\u6709\u6548T\u7ec6\u80de\u6269\u589e\u81f3\u4e0a\u767e\u4ebf\u7ea7\u522b\uff0c\u5f62\u6210\u4e00\u652f\u89c4\u6a21\u5e9e\u5927\u3001\u9776\u5411\u7cbe\u51c6\u7684\u514d\u75ab\u90e8\u961f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u7b2c\u4e94\u6b65\uff1a\u6e05\u9ad3\u9884\u5904\u7406<\/strong><strong>+<\/strong><strong>\u7ec6\u80de\u56de\u8f93<\/strong><strong>+<\/strong><strong>\u672f\u540e\u652f\u6301<\/strong><strong><\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">1. \u9884\u5904\u7406\uff1a\u56de\u8f93\u524d\u77ed\u671f\u9ad8\/\u4f4e\u5242\u91cf\u6e05\u6dcb\u5316\u7597\uff08\u73af\u78f7\u9170\u80fa+\u6c1f\u8fbe\u62c9\u6ee8\uff09\uff0c\u6e05\u9664\u4f53\u5185\u5185\u6e90\u6027\u6dcb\u5df4\u7ec6\u80de\uff0c\u51cf\u5c11\u7ec6\u80de\u56e0\u5b50\u7ade\u4e89\u3001\u6d88\u9664\u5916\u5468\u514d\u75ab\u6291\u5236\u5fae\u73af\u5883\uff0c\u964d\u4f4e\u56de\u8f93 TIL \u88ab\u81ea\u4f53\u6dcb\u5df4\u7ec6\u80de\u7ade\u4e89\u6027\u6291\u5236\uff1b<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">2. \u9759\u8109\u56de\u8f93\uff1a\u7eaf\u5316\u540e\u7684TIL\u7ec6\u80de\u50cf\u8f93\u6db2\u4e00\u6837\u56de\u8f93\u60a3\u8005\u4f53\u5185\uff1b<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">3. \u672f\u540e\u8f85\u52a9\uff1a\u77ed\u671f\u6ce8\u5c04IL-2\uff0c\u7ef4\u6301\u56de\u8f93T\u7ec6\u80de\u5728\u4f53\u5185\u5b58\u6d3b\u3001\u6301\u7eed\u6740\u4f24\u5168\u8eab\u8f6c\u79fb\u75c5\u7076\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img decoding=\"async\" width=\"865\" height=\"489\" src=\"https:\/\/www.millibuff.com\/wp-content\/uploads\/2026\/08\/a928f106b51b63bf24d7babe0ee54857.png\" alt=\"\" class=\"wp-image-2088\" srcset=\"https:\/\/www.millibuff.com\/wp-content\/uploads\/2026\/08\/a928f106b51b63bf24d7babe0ee54857.png 865w, https:\/\/www.millibuff.com\/wp-content\/uploads\/2026\/08\/a928f106b51b63bf24d7babe0ee54857-300x170.png 300w, https:\/\/www.millibuff.com\/wp-content\/uploads\/2026\/08\/a928f106b51b63bf24d7babe0ee54857-768x434.png 768w\" sizes=\"(max-width: 865px) 100vw, 865px\" \/><\/figure>\n\n\n\n<p class=\"has-medium-font-size wp-block-paragraph\"><strong>\u4e09\u3001TIL vs CAR-T\uff1a\u5b9e\u4f53\u7624\u8d5b\u9053\uff0cTIL\u5929\u7136\u4f18\u52bf\u7a81\u51fa<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">CAR-T \u7ec6\u80de\u7597\u6cd5\u4f5c\u4e3a\u7ec6\u80de\u6cbb\u7597\u9886\u57df\u7684\u660e\u661f\u65b9\u6848\uff0c\u5df2\u7ecf\u5728\u8840\u6db2\u80bf\u7624\u4e2d\u53d6\u5f97\u5de8\u5927\u6210\u529f\uff0c\u4f46\u5728\u5b9e\u4f53\u7624\u6cbb\u7597\u4e2d\u6301\u7eed\u906d\u9047\u74f6\u9888\uff1b\u4e0e\u4e4b\u76f8\u6bd4\uff0cTIL \u7597\u6cd5\u4ece\u7ec6\u80de\u6765\u6e90\u4e0a\u5c31\u5177\u5907\u9002\u914d\u5b9e\u4f53\u7624\u7684\u5148\u5929\u4f18\u52bf\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-full is-resized\"><img decoding=\"async\" width=\"554\" height=\"369\" src=\"https:\/\/www.millibuff.com\/wp-content\/uploads\/2026\/08\/d058726ca1edd174f0ab9c70b5233dec.png\" alt=\"\" class=\"wp-image-2089\" style=\"width:768px;height:auto\" srcset=\"https:\/\/www.millibuff.com\/wp-content\/uploads\/2026\/08\/d058726ca1edd174f0ab9c70b5233dec.png 554w, https:\/\/www.millibuff.com\/wp-content\/uploads\/2026\/08\/d058726ca1edd174f0ab9c70b5233dec-300x200.png 300w\" sizes=\"(max-width: 554px) 100vw, 554px\" \/><\/figure>\n\n\n\n<p class=\"has-medium-font-size wp-block-paragraph\"><strong>\u56db\u3001<\/strong><strong>TIL<\/strong><strong>\u7597\u6cd5\u56db\u5927\u6838\u5fc3\u4f18\u52bf\uff0c\u4e3a\u4f55\u6210\u4e3a\u884c\u4e1a\u7814\u53d1\u98ce\u53e3<\/strong><strong><\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>1. <\/strong><strong>\u5e7f\u8c31\u6297\u764c\uff0c\u8986\u76d6\u7edd\u5927\u591a\u6570\u5b9e\u4f53\u7624<\/strong><strong><\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u76ee\u524d\u591a\u9879 I\/II \u671f\u4e34\u5e8a\u7814\u7a76\u8bc1\u5b9e\uff0cTIL \u7597\u6cd5\u5728\u665a\u671f\u9ed1\u8272\u7d20\u7624\u3001\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u3001\u809d\u764c\u3001\u5bab\u9888\u764c\u3001\u5375\u5de2\u764c\u3001\u80c6\u7ba1\u764c\u3001\u80c3\u764c\u3001\u80f0\u817a\u764c\u3001\u5934\u9888\u90e8\u80bf\u7624\u7b49\u5b9e\u4f53\u7624\u4e2d\u5747\u5c55\u73b0\u6297\u80bf\u7624\u6d3b\u6027\uff0c\u5c24\u5176\u9002\u5408\u7ecf\u5316\u7597\u3001\u9776\u5411\u3001PD-1 \u514d\u75ab\u6cbb\u7597\u591a\u91cd\u8010\u836f\u540e\u7684\u665a\u671f\u5b9e\u4f53\u7624\u60a3\u8005\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5168\u7403\u9996\u6b3e\u83b7\u6279 TIL \u836f\u7269 Amtagvi\uff08lifileucel\uff09\u83b7\u6279\u9002\u5e94\u75c7\u4e3a\u4e3b\u8981\u9488\u5bf9\u65e2\u5f80\u63a5\u53d7\u8fc7 PD-1 \u6291\u5236\u5242\u6cbb\u7597\u540e\u8fdb\u5c55\uff0c\u6216\u643a\u5e26 BRAF V600 \u7a81\u53d8\u4e14\u63a5\u53d7\u8fc7 BRAF \u6291\u5236\u5242\u6cbb\u7597\u8fdb\u5c55\u7684\u4e0d\u53ef\u5207\u9664\u6216\u8f6c\u79fb\u6027\u9ed1\u8272\u7d20\u7624\u30022026 \u5e74 ASTCT \u5e74\u4f1a\u516c\u5e03\u7684\u5546\u4e1a\u5316<strong>\u771f\u5b9e\u4e16\u754c\u56de\u987e\u7814\u7a76\u663e\u793a\uff0c\u8be5\u836f\u7269\u5ba2\u89c2\u7f13\u89e3\u7387\u8fbe<\/strong><strong> 44%<\/strong><strong>\uff0c<\/strong><strong>73% <\/strong><strong>\u60a3\u8005\u5b9e\u73b0\u80bf\u7624\u7a33\u5b9a\u63a7\u5236<\/strong><strong><sup>[3]<\/sup><\/strong><strong>\u3002<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>2. <\/strong><strong>\u7597\u6548\u6301\u4e45\uff0c\u6709\u671b\u5b9e\u73b0\u957f\u671f\u65e0\u7624\u751f\u5b58\u3001\u8fbe\u5230\u4e34\u5e8a\u6cbb\u6108<\/strong><strong><\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">TIL\u9776\u5411\u80bf\u7624\u72ec\u6709\u65b0\u751f\u6297\u539f\uff0c\u56de\u8f93\u540e\u53ef\u5728\u4f53\u5185\u957f\u671f\u5b58\u6d3b\uff0c\u5f62\u6210\u514d\u75ab\u8bb0\u5fc6\u3002\u652f\u6301 Amtagvi\uff08lifileucel\uff09\u83b7\u6279\u7684\u5173\u952e II \u671f C-144-01 \u7814\u7a76 5 \u5e74\u968f\u8bbf\u6570\u636e\u8bc1\u5b9e\uff0c\u7ecf PD-1\u3001\u9776\u5411\u836f\u591a\u91cd\u8010\u836f\u7684\u665a\u671f\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u63a5\u53d7 TIL \u5355\u6b21\u56de\u8f93\u540e\u53ef\u83b7\u5f97\u6301\u4e45\u6297\u80bf\u7624\u5e94\u7b54\uff0c\u4e2d\u4f4d\u7f13\u89e3\u6301\u7eed\u65f6\u95f4\u8fbe 36.5 \u4e2a\u6708\uff08\u8d85 3 \u5e74\uff09\uff1b\u591a\u540d\u53d7\u8bd5\u8005\u5b9e\u73b0\u80bf\u7624\u5b8c\u5168\u6d88\u9000\uff0c31.3% \u4ea7\u751f\u5ba2\u89c2\u7f13\u89e3\u7684\u60a3\u8005\u5728 5 \u5e74\u968f\u8bbf\u8282\u70b9\u4ecd\u7ef4\u6301\u6301\u7eed\u7f13\u89e3\uff0c5\u5e74\u751f\u5b58\u7387\u4e3a19.7%\uff0c\u90e8\u5206\u60a3\u8005\u5728\u6cbb\u7597 1 \u5e74\u540e\u751a\u81f3\u66f4\u4e45\u51fa\u73b0\u80bf\u7624\u8fdb\u4e00\u6b65\u7f29\u5c0f\u3001\u90e8\u5206\u7f13\u89e3\u8f6c\u4e3a\u5b8c\u5168\u7f13\u89e3\u7684\u6df1\u5ea6\u83b7\u76ca\u73b0\u8c61<sup>[4]<\/sup>\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"864\" height=\"444\" src=\"https:\/\/www.millibuff.com\/wp-content\/uploads\/2026\/08\/a16e359f4c099b00fa7c7d0571311f21.png\" alt=\"\" class=\"wp-image-2090\" srcset=\"https:\/\/www.millibuff.com\/wp-content\/uploads\/2026\/08\/a16e359f4c099b00fa7c7d0571311f21.png 864w, https:\/\/www.millibuff.com\/wp-content\/uploads\/2026\/08\/a16e359f4c099b00fa7c7d0571311f21-300x154.png 300w, https:\/\/www.millibuff.com\/wp-content\/uploads\/2026\/08\/a16e359f4c099b00fa7c7d0571311f21-768x395.png 768w\" sizes=\"(max-width: 864px) 100vw, 864px\" \/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"865\" height=\"804\" src=\"https:\/\/www.millibuff.com\/wp-content\/uploads\/2026\/08\/f3fcdec6e022e6767940692bed3df222.png\" alt=\"\" class=\"wp-image-2091\" srcset=\"https:\/\/www.millibuff.com\/wp-content\/uploads\/2026\/08\/f3fcdec6e022e6767940692bed3df222.png 865w, https:\/\/www.millibuff.com\/wp-content\/uploads\/2026\/08\/f3fcdec6e022e6767940692bed3df222-300x279.png 300w, https:\/\/www.millibuff.com\/wp-content\/uploads\/2026\/08\/f3fcdec6e022e6767940692bed3df222-768x714.png 768w\" sizes=\"(max-width: 865px) 100vw, 865px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>3. <\/strong><strong>\u81ea\u4f53\u7ec6\u80de\u5b89\u5168\u6027\u9ad8\uff0c\u65e0\u6392\u5f02\u98ce\u9669<\/strong><strong><\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u7ec6\u80de\u5168\u90e8\u53d6\u81ea\u60a3\u8005\u81ea\u8eab\uff0c\u4e0d\u5b58\u5728\u5f02\u4f53\u79fb\u690dGVHD\uff08\u79fb\u690d\u7269\u6297\u5bbf\u4e3b\u75c5\uff09\uff1b\u65e0\u5916\u6e90\u57fa\u56e0\u63d2\u5165\uff0c\u65e0\u8131\u9776\u3001\u57fa\u56e0\u6574\u5408\u7a81\u53d8\u9690\u60a3\uff0c\u76f8\u6bd4\u57fa\u56e0\u7f16\u8f91\u7c7b\u7ec6\u80de\u7597\u6cd5\u98ce\u9669\u66f4\u4f4e\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>4. <\/strong><strong>\u53ef\u4e0e<\/strong><strong>PD-1<\/strong><strong>\u3001\u9776\u5411\u836f\u8054\u7528\uff0c\u7597\u6548\u500d\u589e<\/strong><strong><\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">TIL \u56de\u8f93\u540e\u8054\u5408 PD-1 \u6291\u5236\u5242\u80fd\u591f\u53cc\u91cd\u89e3\u9664\u80bf\u7624\u5fae\u73af\u5883\u7684\u514d\u75ab\u6291\u5236\u3002\u76ee\u524d\u5df2\u6709\u591a\u6b3e TIL \u4ea7\u54c1\u5e03\u5c40\u8054\u5408\u65b9\u6848\u7814\u7a76\uff0c\u4f8b\u5982\u5df2\u5728\u7f8e\u56fd\u4e0a\u5e02\u7684 Lifileucel\u63a2\u7d22\u4e0e PD-1 \u6291\u5236\u5242\u8054\u7528\u6cbb\u7597\u665a\u671f\u9ed1\u8272\u7d20\u7624\uff1b\u56fd\u4ea7 GC101 \u5728\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u961f\u5217\u5f00\u5c55 TIL \u8054\u5408 PD-1 \u7684\u4e34\u5e8a\u63a2\u7d22\u3002TIL \u8054\u5408 PD-1 \u6291\u5236\u5242\uff0c\u662f\u5f53\u524d\u665a\u671f\u5b9e\u4f53\u7624\u3001\u5c24\u5176\u9ed1\u8272\u7d20\u7624\u548c\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u6cbb\u7597\u9886\u57df\u7684\u4e3b\u6d41\u7814\u53d1\u65b9\u5411\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">2024\u5e74ASCO\u5927\u4f1a\u4e0a\uff0cIovance\u516c\u53f8\u5c55\u793a\u4e86&nbsp;IOV-COM-202\u4e34\u5e8a\u8bd5\u9a8c1A\u961f\u5217\u7684\u7ed3\u679c\uff0c\u63a2\u7d22\u4e86Lifileucel\u8054\u5408Pembrolizumab\u5728\u665a\u671f\u9ed1\u8272\u7d20\u7624\u4e00\u7ebf\u6cbb\u7597\u4e2d\u7684\u7597\u6548\u548c\u5b89\u5168\u6027\u3002<strong>\u7597\u6548\u65b9\u9762\u786e\u8ba4\u7684<\/strong><strong>ORR<\/strong><strong>\u8fbe<\/strong><strong>65.2%<\/strong><strong>\uff08<\/strong><strong>15\/23<\/strong><strong>\uff09\uff0c\u5305\u62ec<\/strong><strong>CR 7<\/strong><strong>\u4f8b\uff08<\/strong><strong>30.4%<\/strong><strong>\uff09\u548c<\/strong><strong>PR 8<\/strong><strong>\u4f8b\uff08<\/strong><strong>34.8%<\/strong><strong>\uff09\uff0c\u8fd8\u6709<\/strong><strong>6<\/strong><strong>\u4f8b<\/strong><strong>SD<\/strong><strong>\uff08<\/strong><strong>26.1%<\/strong><strong>\uff09\u3002<\/strong>\u4e2d\u4f4d\u6cbb\u7597\u54cd\u5e94\u65f6\u95f42.6\u4e2a\u6708\uff0c\u6240\u6709\u60a3\u8005\u9776\u75c5\u7076\u5747\u51fa\u73b0\u7f29\u5c0f<sup>[5]<\/sup>\u3002\u76ee\u524d\uff0cIovance\u516c\u53f8\u5df2\u7ecf\u5f00\u542fLifileucel + \u5e15\u535a\u5229\u73e0\u5355\u6297\u8054\u7528\u7684III \u671f\u786e\u8bc1\u6ce8\u518c\u8bd5\u9a8c\uff08TILVANCE-301\uff09\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"864\" height=\"405\" src=\"https:\/\/www.millibuff.com\/wp-content\/uploads\/2026\/08\/76cec54eb579cb9b2b48bed8391a00f7.png\" alt=\"\" class=\"wp-image-2092\" srcset=\"https:\/\/www.millibuff.com\/wp-content\/uploads\/2026\/08\/76cec54eb579cb9b2b48bed8391a00f7.png 864w, https:\/\/www.millibuff.com\/wp-content\/uploads\/2026\/08\/76cec54eb579cb9b2b48bed8391a00f7-300x141.png 300w, https:\/\/www.millibuff.com\/wp-content\/uploads\/2026\/08\/76cec54eb579cb9b2b48bed8391a00f7-768x360.png 768w\" sizes=\"(max-width: 864px) 100vw, 864px\" \/><\/figure>\n\n\n\n<p class=\"has-medium-font-size wp-block-paragraph\"><strong>\u4e94\u3001\u5f53\u524d\u5c40\u9650\uff1a<\/strong><strong>TIL<\/strong><strong>\u7597\u6cd5\u8fd8\u9762\u4e34\u54ea\u4e9b\u5f85\u7a81\u7834\u96be\u9898<\/strong><strong><\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5ba2\u89c2\u770b\u5f85\u6280\u672f\u73b0\u72b6\uff0cTIL \u7597\u6cd5\u5927\u89c4\u6a21\u666e\u53ca\u4ecd\u5b58\u5728\u4e09\u5927\u75db\u70b9\uff1a<\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li><strong>\u5236\u5907\u95e8\u69db\u9ad8\u3001\u5468\u671f\u957f\uff1a<\/strong>\u4f20\u7edf\u65b9\u6848\u4f9d\u8d56\u6210\u719f REP \u6269\u589e\u5de5\u827a\uff0c\u5b9e\u9a8c\u5ba4\u8d28\u63a7\u6807\u51c6\u4e25\u82db\uff0c\u7ecf\u5178\u5236\u5907\u5468\u671f\u957f\u8fbe 6\uff5e8 \u5468\uff0c\u96be\u4ee5\u9002\u914d\u80bf\u7624\u8fdb\u5c55\u8fc5\u901f\u3001\u9884\u671f\u751f\u5b58\u671f\u6781\u77ed\u7684\u7ec8\u672b\u671f\u60a3\u8005\uff1b\u76ee\u524d\u591a\u6b3e\u65b0\u4e00\u4ee3\u6539\u826f TIL \u6280\u672f\u6b63\u5728\u5c1d\u8bd5\u7f29\u77ed\u5236\u5907\u65f6\u957f\u3002<\/li>\n\n\n\n<li><strong>\u4f9d\u8d56\u80bf\u7624\u75c5\u7076\u53d6\u6837\uff1a<\/strong>\u6cbb\u7597\u524d\u9700\u8981\u6709\u53ef\u5b89\u5168\u7a7f\u523a\u6216\u624b\u672f\u83b7\u53d6\u7684\u80bf\u7624\u75c5\u7076\u7528\u4e8e\u5206\u79bb TIL\uff1b\u7f3a\u4e4f\u53ef\u53d6\u6837\u75c5\u7076\u3001\u4ec5\u5b58\u5728\u5f71\u50cf\u5b66\u65e0\u6cd5\u68c0\u51fa\u5fae\u5c0f\u8f6c\u79fb\u7076\u7684\u60a3\u8005\uff0c\u65e0\u6cd5\u5f00\u5c55\u8be5\u7597\u6cd5\u3002<\/li>\n\n\n\n<li><strong>\u6cbb\u7597\u6210\u672c\u504f\u9ad8\uff0c\u56fd\u5185\u6682\u65e0\u5546\u4e1a\u5316\u4ea7\u54c1\uff1a<\/strong>\u5168\u7403\u4ec5 Lifileucel\uff08Amtagvi\uff09\u5728\u7f8e\u56fd\u83b7\u6279\u4e0a\u5e02\uff0c\u5c1a\u672a\u5728\u4e2d\u56fd\u83b7\u6279\uff1b\u56fd\u5185\u5728\u7814\u7ba1\u7ebf\u5927\u591a\u5904\u4e8e I \u671f\u3001\u5173\u952e II \u671f\u4e34\u5e8a\u8bd5\u9a8c\u9636\u6bb5\uff0c\u8ddd\u79bb\u5546\u4e1a\u5316\u843d\u5730\u4ecd\u9700\u4e00\u5b9a\u65f6\u95f4\u3002<\/li>\n<\/ol>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u603b\u7ed3<\/strong><strong><\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5b9e\u4f53\u7624\u4e00\u76f4\u662f\u514d\u75ab\u6cbb\u7597\u96be\u4ee5\u653b\u514b\u7684\u6838\u5fc3\u96be\u70b9\uff0cTIL \u7597\u6cd5\u51ed\u501f\u539f\u751f\u80bf\u7624\u9776\u5411\u514d\u75ab\u7ec6\u80de\u3001\u591a\u65b0\u751f\u6297\u539f\u8bc6\u522b\u3001\u5929\u7136\u5b9e\u4f53\u7624\u6d78\u6da6\u4e09\u5927\u6838\u5fc3\u4f18\u52bf\uff0c\u8865\u9f50\u4e86\u5b9e\u4f53\u7624\u514d\u75ab\u6cbb\u7597\u7684\u56fa\u6709\u77ed\u677f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5f53\u524d\u5168\u7403 TIL \u7814\u53d1\u8d5b\u9053\u5168\u9762\u63d0\u901f\u3002\u6d77\u5916\u9664\u5df2\u5546\u4e1a\u5316\u7684 Lifileucel \u5916\uff0cObsidian OBX-115 \u7b49\u57fa\u56e0\u5de5\u7a0b\u6539\u826f TIL \u5904\u4e8e I\/IIa \u65e9\u671f\u4e34\u5e8a\u63a2\u7d22\uff0c\u4e3b\u8981\u9488\u5bf9\u9ed1\u8272\u7d20\u7624\u3001\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u5f00\u5c55\u8bc4\u4f30\uff1b\u56fd\u5185\u6c99\u783e\u751f\u7269 GT101\u3001\u541b\u8d5b\u751f\u7269 GC101\u3001\u534e\u8d5b\u4f2f\u66fc HS-IT101 \u4e09\u6b3e\u6838\u5fc3\u7ba1\u7ebf\u5df2\u8fc8\u5165\u5173\u952e\u6ce8\u518c II \u671f\uff0c\u4e3b\u8981\u8986\u76d6\u9ed1\u8272\u7d20\u7624\u3001\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u3001\u5bab\u9888\u764c\u7b49\u9ad8\u53d1\u5b9e\u4f53\u7624\u3002\u9884\u8ba1\u541b\u8d5b\u751f\u7269GC101 \u8ba1\u5212 2026 \u5e74\u9012\u4ea4\u4e0a\u5e02\u7533\u8bf7\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u884c\u4e1a\u6b63\u6301\u7eed\u7b80\u5316\u5236\u5907\u5de5\u827a\u3001\u964d\u4f4e\u6cbb\u7597\u6210\u672c\uff0c\u5e76\u5927\u529b\u5f00\u53d1 TIL \u8054\u5408 PD-1\u3001\u9776\u5411\u836f\u7684\u534f\u540c\u65b9\u6848\u3002\u4f34\u968f\u6280\u672f\u8fed\u4ee3\u4e0e\u591a\u9002\u5e94\u75c7\u4e34\u5e8a\u843d\u5730\uff0cTIL \u6709\u671b\u91cd\u5851\u665a\u671f\u5b9e\u4f53\u7624\u6cbb\u7597\u683c\u5c40\uff0c\u4e3a\u591a\u7ebf\u8010\u836f\u665a\u671f\u60a3\u8005\u5e26\u6765\u957f\u671f\u751f\u5b58\u65b0\u9009\u62e9\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u53c2\u8003\u6587\u732e\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Skok K, Maccio U, Martin SD, Br\u00e4utigam K. Tumor-Infiltrating Lymphocytes in Breast and Female Genital Tract Cancers: Overlooked Potential and Unexplored Frontiers. Cancer Med. 2025 Jul;14(13):e71023. doi: 10.1002\/cam4.71023. PMID: 40621806; PMCID: PMC12230770.<\/li>\n\n\n\n<li>Zhao, Y.; et al. Tumor Infiltrating Lymphocyte (TIL) Therapy for Solid Tumor Treatment: Progressions and Challenges. Cancers 2022, 14, 4160.<\/li>\n\n\n\n<li>Karapetyan L, Kuriakose J, DiMaggio E, et al. Real-world, evidence-based, retrospective study of patients infused with commercially released lifileucel for advanced melanoma. Presented at: 2026 ASTCT &amp; CIBMTR Tandem Meetings; February 4\u20137, 2026; Salt Lake City, UT. Abstract 48. <a href=\"https:\/\/www.iovance.com\/uploads\/MRA_2026_Lifi_RWE_Poster_FINAL-3224-publication.pdf\">https:\/\/www.iovance.com\/uploads\/MRA_2026_Lifi_RWE_Poster_FINAL-3224-publication.pdf<\/a><\/li>\n\n\n\n<li>Medina TM, Hamid O, Goff SL, et al. Long-Term Efficacy and Safety of Lifileucel Tumor-Infiltrating Lymphocyte Cell Therapy in Patients With Advanced Melanoma: A 5-Year Analysis of the C-144-01 Study. J Clin Oncol. 2025;43(31):3422-3432. doi:10.1200\/JCO-25-00765. <a href=\"https:\/\/ascopubs.org\/doi\/10.1200\/JCO-25-00765\">https:\/\/ascopubs.org\/doi\/10.1200\/JCO-25-00765<\/a><\/li>\n\n\n\n<li>Sarnaik A, Hamid O, Medina T, et al. Lifileucel TIL therapy in combination with pembrolizumab demonstrates deep, durable responses in frontline advanced melanoma (IOV-202). Oral presentation at: 2024 ASCO Annual Meeting; May 31\u2013June 4, 2024; Chicago, IL, USA. Abstract #9502.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u64b0\u6587\uff1a\u5bab\u96ea<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5ba1\u6838\uff1a\u79e6\u96e8<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u63d0\u8d77\u7ec6\u80de\u514d\u75ab\u6cbb\u7597\uff0c\u591a\u6570\u4eba\u6700\u5148\u60f3\u5230\u9488\u5bf9\u8840\u6db2\u80bf\u7624\u7684 CAR-T \u7597\u6cd5\u3002\u4f46\u80ba\u764c\u3001\u809d\u764c\u3001\u5bab\u9888\u764c\u3001\u80f0\u817a\u764c\u7b49\u5b9e\u4f53\u7624\uff0c\u59cb\u7ec8\u662f\u7ec6\u80de\u6cbb\u7597\u9886\u57df\u96be\u4ee5\u7a81\u7834\u7684\u74f6\u9888\u3002<br \/>\n2024 \u5e74 FDA \u6279\u51c6\u5168\u7403\u9996\u6b3e TIL \u7ec6\u80de\u836f\u7269 Amtagvi\uff0c\u6b63\u5f0f\u5f00\u542f\u5b9e\u4f53\u7624\u7ec6\u80de\u6cbb\u7597\u65b0\u65f6\u4ee3\uff1b\u4e0d\u5c11\u665a\u671f\u5b9e\u4f53\u7624\u60a3\u8005\u4f9d\u6258\u8fd9\u5957 \u201c\u81ea\u4f53\u514d\u75ab\u7cbe\u5175\u6218\u672f\u201d \u5b9e\u73b0\u6df1\u5ea6\u80bf\u7624\u7f13\u89e3\uff0c\u90e8\u5206\u4eba\u590d\u67e5\u672a\u89c1\u53ef\u89c1\u75c5\u7076\u3001\u957f\u671f\u7ef4\u6301\u65e0\u7624\u72b6\u6001\u3002\u672c\u6587\u4ee5\u901a\u4fd7\u79d1\u666e\u7684\u5f62\u5f0f\uff0c\u62c6\u89e3 TIL \u7597\u6cd5\u5e95\u5c42\u4f5c\u7528\u903b\u8f91\u3001\u5b8c\u6574\u6cbb\u7597\u6d41\u7a0b\u3001\u6838\u5fc3\u4f18\u52bf\u3001\u9002\u7528\u764c\u79cd\u4ee5\u53ca\u56fd\u5185\u5916\u6700\u65b0\u7814\u53d1\u8fdb\u5c55\u3002<\/p>\n","protected":false},"author":1,"featured_media":2086,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[147],"tags":[86,15,32,34],"class_list":["post-2085","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-147","tag-86","tag-15","tag-32","tag-34"],"_links":{"self":[{"href":"https:\/\/www.millibuff.com\/index.php?rest_route=\/wp\/v2\/posts\/2085","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.millibuff.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.millibuff.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.millibuff.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.millibuff.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2085"}],"version-history":[{"count":7,"href":"https:\/\/www.millibuff.com\/index.php?rest_route=\/wp\/v2\/posts\/2085\/revisions"}],"predecessor-version":[{"id":2099,"href":"https:\/\/www.millibuff.com\/index.php?rest_route=\/wp\/v2\/posts\/2085\/revisions\/2099"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.millibuff.com\/index.php?rest_route=\/wp\/v2\/media\/2086"}],"wp:attachment":[{"href":"https:\/\/www.millibuff.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2085"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.millibuff.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2085"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.millibuff.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2085"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}