{"id":2128,"date":"2026-09-02T14:33:12","date_gmt":"2026-09-02T06:33:12","guid":{"rendered":"https:\/\/www.millibuff.com\/?p=2128"},"modified":"2026-09-02T14:36:13","modified_gmt":"2026-09-02T06:36:13","slug":"%e5%b0%8f%e7%89%9b%e6%b4%9e%e5%af%9f-%e7%bb%93%e7%9b%b4%e8%82%a0%e7%99%8c%e7%a7%91%e6%99%ae%ef%bd%9c%e9%ab%98%e5%8f%91%e6%b6%88%e5%8c%96%e9%81%93%e6%81%b6%e6%80%a7%e8%82%bf%e7%98%a4%ef%bc%8c","status":"publish","type":"post","link":"https:\/\/www.millibuff.com\/?p=2128","title":{"rendered":"\u5c0f\u725b\u6d1e\u5bdf | \u7ed3\u76f4\u80a0\u764c\u79d1\u666e\uff5c\u9ad8\u53d1\u6d88\u5316\u9053\u6076\u6027\u80bf\u7624\uff0c\u4e00\u6587\u770b\u61c2\u7b5b\u67e5\u3001\u8bca\u65ad\u4e0e\u5168\u6d41\u7a0b\u6cbb\u7597"},"content":{"rendered":"\n<h4 class=\"wp-block-heading\"><strong>\u4e00\u3001\u7ed3\u76f4\u80a0\u764c\u6d41\u884c\u75c5\u5b66\u7279\u5f81<\/strong><\/h4>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>1. <\/strong><strong>\u5168\u7403\u53d1\u75c5\u4e0e\u6b7b\u4ea1\u60c5\u51b5<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u7ed3\u76f4\u80a0\u764c\uff08Colorectal Cancer, CRC\uff09\u662f\u5168\u7403\u7b2c\u4e09\u5927\u5e38\u89c1\u6076\u6027\u80bf\u7624\uff0c\u4e5f\u662f\u7b2c\u4e8c\u5927\u764c\u75c7\u6b7b\u4ea1\u539f\u56e0\u3002\u6839\u636e\u56fd\u9645\u764c\u75c7\u7814\u7a76\u673a\u6784\uff08IARC\uff09\u53d1\u5e03\u7684GLOBOCAN 2022\u6570\u636e\uff0c2022\u5e74\u5168\u7403\u65b0\u53d1\u7ed3\u76f4\u80a0\u764c\u7ea6192.6\u4e07\u4f8b\uff0c\u5360\u5168\u90e8\u6076\u6027\u80bf\u7624\u53d1\u75c5\u76849.6%\uff1b\u6b7b\u4ea1\u7ea690.4\u4e07\u4f8b\uff0c\u5360\u5168\u90e8\u6076\u6027\u80bf\u7624\u6b7b\u4ea1\u76849.3%<sup>[1]<\/sup>\u3002\u7ed3\u76f4\u80a0\u764c\u4e5f\u662f\u7ec8\u8eab\u53d1\u75c5\u98ce\u9669\u6700\u9ad8\u7684\u80c3\u80a0\u9053\u6076\u6027\u80bf\u7624<sup>[14]<\/sup>\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>2. <\/strong><strong>\u4e2d\u56fd\u6d41\u884c\u75c5\u5b66\u73b0\u72b6<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5728\u6211\u56fd\uff0c\u7ed3\u76f4\u80a0\u764c\u7684\u75be\u75c5\u8d1f\u62c5\u540c\u6837\u6c89\u91cd\u3002\u6839\u636e\u56fd\u5bb6\u764c\u75c7\u4e2d\u5fc3\u53d1\u5e03\u7684\u6700\u65b0\u6570\u636e<sup>[2]<\/sup>\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u53d1\u75c5\u60c5\u51b5<\/strong>\uff1a2024\u5e74\u6211\u56fd\u7ed3\u76f4\u80a0\u764c\u65b0\u53d1\u75c5\u4f8b\u7ea656.2\u4e07\u4f8b\uff0c\u5360\u5168\u90e8\u6076\u6027\u80bf\u7624\u65b0\u53d1\u75c5\u4f8b\u7684\u8fd111%\uff0c\u53d1\u75c5\u6570\u4ec5\u6b21\u4e8e\u80ba\u764c\u548c\u7532\u72b6\u817a\u764c\uff0c\u4f4d\u5c45\u5168\u56fd\u7b2c\u4e09\u4f4d\u3002<\/li>\n\n\n\n<li><strong>\u6b7b\u4ea1\u60c5\u51b5<\/strong>\uff1a\u540c\u5e74\u7ed3\u76f4\u80a0\u764c\u6b7b\u4ea1\u75c5\u4f8b\u7ea625.6\u4e07\u4f8b\uff0c\u5728\u6211\u56fd\u764c\u75c7\u6b7b\u56e0\u4e2d\u6392\u7b2c\u4e09\u4f4d\uff0c\u4ec5\u6b21\u4e8e\u80ba\u764c\u548c\u809d\u764c\u3002<\/li>\n\n\n\n<li><strong>\u6027\u522b\u5dee\u5f02<\/strong>\uff1a\u7537\u6027\u53d1\u75c5\u7387\u548c\u6b7b\u4ea1\u7387\u5747\u9ad8\u4e8e\u5973\u6027\uff0c\u7537\u5973\u53d1\u75c5\u6bd4\u7ea6\u4e3a1.5:1\uff0c\u7537\u5973\u6b7b\u4ea1\u6bd4\u7ea6\u4e3a1.5:1\u3002<\/li>\n\n\n\n<li><strong>\u5e74\u9f84\u5206\u5e03<\/strong>\uff1a\u7ed3\u76f4\u80a0\u764c\u597d\u53d1\u4e8e50\u5c81\u4ee5\u4e0a\u4eba\u7fa4\uff0c\u4f46\u8fd1\u5e74\u6765\u5e74\u8f7b\u5316\u8d8b\u52bf\u660e\u663e\uff0c40~49\u5c81\u5e74\u9f84\u6bb5\u53d1\u75c5\u7387\u5448\u4e0a\u5347\u6001\u52bf<sup>[3]<\/sup>\u3002<\/li>\n<\/ul>\n\n\n\n<figure class=\"wp-block-image aligncenter size-full is-resized\"><img fetchpriority=\"high\" decoding=\"async\" width=\"419\" height=\"933\" src=\"https:\/\/www.millibuff.com\/wp-content\/uploads\/2026\/09\/image.png\" alt=\"\" class=\"wp-image-2129\" style=\"width:431px;height:auto\" srcset=\"https:\/\/www.millibuff.com\/wp-content\/uploads\/2026\/09\/image.png 419w, https:\/\/www.millibuff.com\/wp-content\/uploads\/2026\/09\/image-135x300.png 135w\" sizes=\"(max-width: 419px) 100vw, 419px\" \/><\/figure>\n\n\n\n<p class=\"has-text-align-center wp-block-paragraph\">\u56fe1.&nbsp;2024\u5e74\u4e2d\u56fd\u764c\u75c7\u4e3b\u8981\u8d1f\u62c5\u5206\u5e03<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>3. <\/strong><strong>\u53d1\u75c5\u90e8\u4f4d\u4e0e\u5371\u9669\u56e0\u7d20<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u597d\u53d1\u90e8\u4f4d<\/strong>\uff1a\u7ed3\u76f4\u80a0\u764c\u53ef\u53d1\u751f\u4e8e\u7ed3\u76f4\u80a0\u4efb\u4f55\u90e8\u4f4d\u3002\u6211\u56fd\u4eba\u7fa4\u4e2d\u76f4\u80a0\u764c\u7684\u53d1\u75c5\u6bd4\u4f8b\u76f8\u5bf9\u8f83\u9ad8\uff0c\u4e14\u4ee5\u4f4e\u4f4d\u76f4\u80a0\u764c\u591a\u89c1\uff1b\u7ed3\u80a0\u764c\u4e2d\u4ee5\u4e59\u72b6\u7ed3\u80a0\u764c\u76f8\u5bf9\u5e38\u89c1\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u4e3b\u8981\u5371\u9669\u56e0\u7d20<\/strong>\uff1a\u5305\u62ec\u9ad8\u9f84\u3001\u80a5\u80d6\u3001\u5438\u70df\u3001\u8fc7\u91cf\u996e\u9152\u3001\u7ea2\u8089\u548c\u52a0\u5de5\u8089\u7c7b\u6444\u5165\u8fc7\u591a\u3001\u81b3\u98df\u7ea4\u7ef4\u6444\u5165\u4e0d\u8db3\u3001\u7f3a\u4e4f\u4f53\u529b\u6d3b\u52a8\u30012\u578b\u7cd6\u5c3f\u75c5\u3001\u708e\u75c7\u6027\u80a0\u75c5\uff08\u6e83\u75a1\u6027\u7ed3\u80a0\u708e\u3001\u514b\u7f57\u6069\u75c5\uff09\u3001\u9057\u4f20\u56e0\u7d20\uff08\u5bb6\u65cf\u6027\u817a\u7624\u6027\u606f\u8089\u75c5FAP\u3001Lynch\u7efc\u5408\u5f81\uff09\u7b49<sup>[4]<\/sup>\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u4fdd\u62a4\u56e0\u7d20<\/strong>\uff1a\u589e\u52a0\u81b3\u98df\u7ea4\u7ef4\u6444\u5165\u3001\u89c4\u5f8b\u8fd0\u52a8\u3001\u7ef4\u6301\u5065\u5eb7\u4f53\u91cd\u3001\u6212\u70df\u9650\u9152\u3001\u5b9a\u671f\u7b5b\u67e5\u7b49\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>\u4e8c\u3001\u7ed3\u76f4\u80a0\u764c\u7b5b\u67e5\u4e0e\u65e9\u671f\u8bca\u65ad<\/strong><\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">\u7ed3\u76f4\u80a0\u764c\u662f\u6700\u9002\u5408\u7b5b\u67e5\u7684\u6076\u6027\u80bf\u7624\u4e4b\u4e00\u3002\u7edd\u5927\u591a\u6570\u7ed3\u76f4\u80a0\u764c\u7531\u817a\u7624\u6027\u606f\u8089\u6f14\u53d8\u800c\u6765\uff0c\u8fd9\u4e00\u8fc7\u7a0b\u901a\u5e38\u9700\u89815~10\u5e74\uff0c\u4e3a\u65e9\u671f\u53d1\u73b0\u548c\u5e72\u9884\u63d0\u4f9b\u4e86\u5145\u8db3\u7684\u65f6\u95f4\u7a97\u53e3\u3002\u7814\u7a76\u663e\u793a\uff0c\u901a\u8fc7\u7b5b\u67e5\u53d1\u73b0\u7684\u65e9\u671f\u7ed3\u76f4\u80a0\u764c5\u5e74\u751f\u5b58\u7387\u53ef\u8fbe90%\u4ee5\u4e0a\uff0c\u800c\u53d1\u751f\u8fdc\u5904\u8f6c\u79fb\u7684\u60a3\u80055\u5e74\u751f\u5b58\u7387\u4ec5\u7ea615%<sup>[5]<\/sup>\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>1. <\/strong><strong>\u7b5b\u67e5\u76ee\u6807\u4eba\u7fa4<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u6839\u636e\u56fd\u5bb6\u536b\u751f\u5065\u5eb7\u59d4\u5458\u4f1a\u300a\u7ed3\u76f4\u80a0\u764c\u7b5b\u67e5\u4e0e\u65e9\u8bca\u65e9\u6cbb\u65b9\u6848\uff082024\u5e74\u7248\uff09\u300b<sup>[5]<\/sup>\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u6563\u53d1\u6027\u7ed3\u76f4\u80a0\u764c\u9ad8\u98ce\u9669\u4eba\u7fa4<\/strong>\uff1a\u65b9\u6848\u5bf9\u6563\u53d1\u6027\u7ed3\u76f4\u80a0\u764c\u6309\u5e74\u9f84\uff0850~59\u5c811\u5206\u3001\u226560\u5c812\u5206\uff09\u3001\u6027\u522b\uff08\u7537\u60271\u5206\uff09\u3001\u5438\u70df\u53f2\uff081\u5206\uff09\u3001\u4f53\u91cd\u6307\u6570\uff08BMI\u226523 kg\/m\u00b2\u4e3a1\u5206\uff09\u3001\u4e00\u7ea7\u4eb2\u5c5e\u7ed3\u76f4\u80a0\u764c\u5bb6\u65cf\u53f2\uff081~4\u5206\uff09\u8fdb\u884c\u98ce\u9669\u8bc4\u5206\uff0c\u7d2f\u8ba1\u8bc4\u5206\u22654\u5206\u8005\u8ba4\u5b9a\u4e3a\u9ad8\u98ce\u9669\u4eba\u7fa4\uff1b\u63a8\u8350\u7b5b\u67e5\u8d77\u6b62\u5e74\u9f84\u4e3a40~74\u5c81\u3002\u82e51\u4e2a\u4e00\u7ea7\u4eb2\u5c5e\u572860\u5c81\u524d\u786e\u8bca\u7ed3\u76f4\u80a0\u764c\uff0c\u6216\u67092\u4e2a\u53ca\u4ee5\u4e0a\u4e00\u7ea7\u4eb2\u5c5e\u786e\u8bca\uff0c\u63a8\u8350\u4ece\u6bd4\u5bb6\u65cf\u4e2d\u6700\u65e9\u786e\u8bca\u8005\u7684\u8bca\u65ad\u5e74\u9f84\u63d0\u524d10\u5c81\u5f00\u59cb\u7b5b\u67e5\uff0c\u4e0d\u5bf9\u7b5b\u67e5\u8d77\u59cb\u5e74\u9f84\u4f5c\u9650\u5236\u3002<\/li>\n\n\n\n<li><strong>\u9057\u4f20\u6027\u7ed3\u76f4\u80a0\u764c\u9ad8\u98ce\u9669\u4eba\u7fa4<\/strong>\uff1a\u6797\u5947\u7efc\u5408\u5f81\u53ca\u5bb6\u65cf\u6027\u817a\u7624\u6027\u606f\u8089\u75c5\uff08FAP\uff09\u5bb6\u7cfb\u6210\u5458\u3002MLH1\/MSH2\u7a81\u53d8\u643a\u5e26\u8005\u7ed3\u80a0\u955c\u7b5b\u67e5\u8d77\u59cb\u5e74\u9f84\u4e3a20~25\u5c81\uff08\u6216\u6bd4\u5bb6\u65cf\u4e2d\u6700\u5e74\u8f7b\u60a3\u8005\u53d1\u75c5\u5e74\u9f84\u63d0\u524d2\uff5e5\u5e74\uff09\uff0cMSH6\/PMS2\u7a81\u53d8\u643a\u5e26\u8005\u4e3a30~35\u5c81\uff08\u6216\u6bd4\u5bb6\u65cf\u4e2d\u6700\u5e74\u8f7b\u60a3\u8005\u53d1\u75c5\u5e74\u9f84\u63d0\u524d2~5\u5e74\uff09\uff1bFAP\u5bb6\u7cfb\u6210\u5458\u81ea10\u5c81\u8d77\u6bcf\u5e74\u884c1\u6b21\u7ed3\u80a0\u955c\u7b5b\u67e5\uff0c\u6301\u7eed\u7ec8\u751f\u3002<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>2. <\/strong><strong>\u5e38\u7528\u7b5b\u67e5\u65b9\u6cd5<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><tbody><tr><td>\u7b5b\u67e5\u65b9\u6cd5<\/td><td>\u7279\u70b9<\/td><td>\u63a8\u8350\u9891\u7387<\/td><\/tr><tr><td><strong>\u7ed3\u80a0\u955c<\/strong><\/td><td>\u91d1\u6807\u51c6\uff0c\u53ef\u540c\u65f6\u5b8c\u6210\u8bca\u65ad\u548c\u6cbb\u7597\uff08\u606f\u8089\u5207\u9664\uff09<\/td><td>\u6bcf5~10\u5e741\u6b21<\/td><\/tr><tr><td><strong>\u5927\u4fbf\u6f5c\u8840\u68c0\u6d4b<\/strong><\/td><td>\u65e0\u521b\u3001\u4fbf\u6377\u3001\u4f9d\u4ece\u6027\u597d<\/td><td>\u6bcf\u5e741\u6b21<\/td><\/tr><tr><td><strong>\u591a\u9776\u70b9<\/strong><strong>\u7caa\u4fbf<\/strong><strong>DNA<\/strong><strong>\u68c0\u6d4b<\/strong><\/td><td>\u68c0\u6d4b\u7caa\u4fbf\u4e2d\u80bf\u7624\u76f8\u5173DNA\u6807\u5fd7\u7269<\/td><td>\u6bcf3\u5e741\u6b21<\/td><\/tr><tr><td><strong>\u7ed3\u80a0<\/strong><strong>CT<\/strong><strong>\u6210\u50cf<\/strong><\/td><td>\u65e0\u521b\u5f71\u50cf\u5b66\u68c0\u67e5\uff0c\u5bf9\u8f83\u5927\u606f\u8089\u654f\u611f\u6027\u9ad8<\/td><td>\u6bcf5\u5e741\u6b21<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">\u7ed3\u80a0\u955c\u662f\u76ee\u524d\u7ed3\u76f4\u80a0\u764c\u7b5b\u67e5\u7684\u9996\u9009\u65b9\u6cd5\uff0c\u4e5f\u662f\u91d1\u6807\u51c6\u3002\u5b83\u4e0d\u4ec5\u80fd\u76f4\u63a5\u89c2\u5bdf\u80a0\u9053\u9ecf\u819c\u75c5\u53d8\uff0c\u8fd8\u80fd\u5728\u53d1\u73b0\u606f\u8089\u65f6\u76f4\u63a5\u5207\u9664\uff0c\u5b9e\u73b0\u201c\u7b5b\u67e5+\u6cbb\u7597\u201d\u4e00\u4f53\u5316\u3002\u300a\u65b9\u6848\u300b\u9488\u5bf9\u6563\u53d1\u6027\u7ed3\u76f4\u80a0\u764c\u9ad8\u98ce\u9669\u4eba\u7fa4\u63a8\u8350\u7b5b\u67e5\u8d77\u6b62\u5e74\u9f84\u4e3a40~74\u5c81\uff1b\u5bf9\u4e8e\u4e0d\u8010\u53d7\u6216\u4e0d\u4f9d\u4ece\u7ed3\u80a0\u955c\u68c0\u67e5\u8005\uff0c\u53ef\u9009\u62e9\u514d\u75ab\u6cd5\u6216\u5316\u5b66\u6cd5\u7684\u5927\u4fbf\u6f5c\u8840\u68c0\u6d4b\u3001\u4e59\u72b6\u7ed3\u80a0\u955c\u3001\u7ed3\u80a0CT\u6210\u50cf\u3001\u591a\u9776\u70b9\u7caa\u4fbfDNA\u68c0\u6d4b\u7b49\u66ff\u4ee3\u65b9\u6cd5<sup>[5]<\/sup>\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>3. <\/strong><strong>\u65e9\u671f\u8bca\u65ad\u7684\u91cd\u8981\u6027<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u6211\u56fd\u7ed3\u76f4\u80a0\u764c\u65e9\u671f\u8bca\u65ad\u7387\u4e0d\u8db310%\uff0c\u4e0e\u65e5\u672c\u3001\u97e9\u56fd\u7b49\u53d1\u8fbe\u56fd\u5bb6\u76f8\u6bd4\u4ecd\u6709\u8f83\u5927\u5dee\u8ddd<sup>[5]<\/sup>\u3002\u63d0\u9ad8\u516c\u4f17\u7b5b\u67e5\u610f\u8bc6\u3001\u6269\u5927\u7b5b\u67e5\u8986\u76d6\u9762\u662f\u964d\u4f4e\u7ed3\u76f4\u80a0\u764c\u6b7b\u4ea1\u7387\u7684\u5173\u952e\u3002\u4ee5\u4e0b\u75c7\u72b6\u9700\u8b66\u60d5\u7ed3\u76f4\u80a0\u764c\u53ef\u80fd\uff0c\u5e94\u53ca\u65f6\u5c31\u533b\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u6392\u4fbf\u4e60\u60ef\u6539\u53d8\uff08\u4fbf\u79d8\u3001\u8179\u6cfb\u6216\u4e24\u8005\u4ea4\u66ff\uff09<\/li>\n\n\n\n<li>\u5927\u4fbf\u6027\u72b6\u6539\u53d8\uff08\u53d8\u7ec6\u3001\u5e26\u8840\u3001\u9ecf\u6db2\uff09<\/li>\n\n\n\n<li>\u8179\u75db\u3001\u8179\u80c0\u3001\u8179\u90e8\u4e0d\u9002<\/li>\n\n\n\n<li>\u4e0d\u660e\u539f\u56e0\u7684\u4f53\u91cd\u4e0b\u964d\u3001\u8d2b\u8840<\/li>\n\n\n\n<li>\u8179\u90e8\u80bf\u5757<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>\u4e09\u3001\u7ed3\u76f4\u80a0\u764c\u6807\u51c6\u5316\u8bca\u65ad\u4f53\u7cfb<\/strong><\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">\u7ed3\u76f4\u80a0\u764c\u7684\u8bca\u65ad\u9075\u5faa&#8221;\u4e34\u5e8a-\u5f71\u50cf-\u75c5\u7406&#8221;\u4e09\u7ed3\u5408\u7684\u539f\u5219\uff0c\u5f3a\u8c03\u591a\u5b66\u79d1\u534f\u4f5c\uff08MDT\uff09\u6a21\u5f0f\u3002\u5b8c\u6574\u7684\u8bca\u65ad\u6d41\u7a0b\u5305\u62ec\uff1a\u4e34\u5e8a\u8bc4\u4f30\u2192\u5185\u955c\u68c0\u67e5\u4e0e\u6d3b\u68c0\u2192\u5f71\u50cf\u5b66\u5206\u671f\u2192\u5206\u5b50\u75c5\u7406\u68c0\u6d4b<sup>[3][4]<\/sup>\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>1. <\/strong><strong>\u4e34\u5e8a\u8bc4\u4f30\u4e0e\u5185\u955c\u68c0\u67e5<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u4e34\u5e8a\u8868\u73b0<\/strong>\uff1a\u65e9\u671f\u7ed3\u76f4\u80a0\u764c\u5e38\u65e0\u660e\u663e\u75c7\u72b6\uff0c\u968f\u75c5\u60c5\u8fdb\u5c55\u53ef\u51fa\u73b0\u4fbf\u8840\u3001\u6392\u4fbf\u4e60\u60ef\u6539\u53d8\u3001\u8179\u75db\u3001\u8179\u90e8\u80bf\u5757\u3001\u80a0\u6897\u963b\u3001\u8d2b\u8840\u3001\u4f53\u91cd\u4e0b\u964d\u7b49\u3002<\/li>\n\n\n\n<li><strong>\u76f4\u80a0\u6307\u68c0<\/strong>\uff1a\u7b80\u5355\u3001\u7ecf\u6d4e\u3001\u65e0\u521b\uff0c\u53ef\u53d1\u73b0\u7ea670%\u7684\u76f4\u80a0\u764c\uff0c\u662f\u76f4\u80a0\u764c\u521d\u7b5b\u7684\u91cd\u8981\u624b\u6bb5\u3002<\/li>\n\n\n\n<li><strong>\u7ed3\u80a0\u955c\u68c0\u67e5<\/strong><strong>+<\/strong><strong>\u6d3b\u68c0<\/strong>\uff1a\u662f\u7ed3\u76f4\u80a0\u764c\u8bca\u65ad\u7684\u91d1\u6807\u51c6\u3002\u901a\u8fc7\u7ed3\u80a0\u955c\u53ef\u76f4\u63a5\u89c2\u5bdf\u80bf\u7624\u5f62\u6001\u3001\u90e8\u4f4d\u3001\u5927\u5c0f\uff0c\u5e76\u53d6\u7ec4\u7ec7\u8fdb\u884c\u75c5\u7406\u786e\u8bca\u3002<\/li>\n\n\n\n<li><strong>\u75c5\u7406\u8bca\u65ad<\/strong>\uff1a\u7ec4\u7ec7\u75c5\u7406\u5b66\u68c0\u67e5\u662f\u786e\u8bca\u7ed3\u76f4\u80a0\u764c\u7684\u6700\u7ec8\u4f9d\u636e\uff0c\u9700\u660e\u786e\u80bf\u7624\u7ec4\u7ec7\u5b66\u7c7b\u578b\u3001\u5206\u5316\u7a0b\u5ea6\u3001\u6d78\u6da6\u6df1\u5ea6\u3001\u8109\u7ba1\u4fb5\u72af\u3001\u795e\u7ecf\u4fb5\u72af\u7b49\u3002<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>2. <\/strong><strong>\u5f71\u50cf\u5b66\u5206\u671f\u8bc4\u4f30<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u786e\u8bca\u540e\u9700\u8fdb\u884c\u5168\u9762\u7684\u5f71\u50cf\u5b66\u8bc4\u4f30\u4ee5\u660e\u786e\u4e34\u5e8a\u5206\u671f\uff0c\u6307\u5bfc\u6cbb\u7597\u65b9\u6848\u5236\u5b9a\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u80f8\u8179\u90e8\u589e\u5f3a<\/strong><strong>CT<\/strong>\uff1a\u8bc4\u4f30\u539f\u53d1\u80bf\u7624\u3001\u533a\u57df\u6dcb\u5df4\u7ed3\u548c\u8fdc\u5904\u8f6c\u79fb\uff08\u809d\u3001\u80ba\u3001\u8179\u819c\u7b49\uff09<\/li>\n\n\n\n<li><strong>\u76c6\u8154\u9ad8\u5206\u8fa8\u7387<\/strong><strong>MRI<\/strong>\uff1a\u76f4\u80a0\u764c\u672f\u524d\u5206\u671f\u7684\u9996\u9009\u65b9\u6cd5\uff0c\u53ef\u51c6\u786e\u8bc4\u4f30\u80bf\u7624\u6d78\u6da6\u6df1\u5ea6\u3001\u7cfb\u819c\u7b4b\u819c\u53d7\u7d2f\u3001\u6dcb\u5df4\u7ed3\u8f6c\u79fb\u7b49<\/li>\n\n\n\n<li><strong>\u809d\u810f\u589e\u5f3a<\/strong><strong>MRI<\/strong>\uff1a\u8bc4\u4f30\u809d\u8f6c\u79fb\u7684\u9996\u9009\u65b9\u6cd5\uff0c2025\u7248CSCO\u6307\u5357\u5c06\u809d\u810f\u7ec6\u80de\u7279\u5f02\u6027\u9020\u5f71\u5242\u589e\u5f3aMRI\u63d0\u5347\u4e3aI\u7ea7\u63a8\u8350<sup>[15]<\/sup><\/li>\n\n\n\n<li><strong>PET\/CT<\/strong>\uff1a\u7528\u4e8e\u7591\u4f3c\u8fdc\u5904\u8f6c\u79fb\u6216\u5168\u8eab\u8bc4\u4f30\u7684\u8865\u5145\u68c0\u67e5<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>3. <\/strong><strong>\u5206\u5b50\u75c5\u7406\u68c0\u6d4b<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5206\u5b50\u75c5\u7406\u68c0\u6d4b\u5bf9\u7ed3\u76f4\u80a0\u764c\u7684\u7cbe\u51c6\u6cbb\u7597\u81f3\u5173\u91cd\u8981\uff0c\u5df2\u6210\u4e3a\u6807\u51c6\u8bca\u7597\u7684\u5fc5\u8981\u73af\u8282\u30022026\u7248CSCO\u6307\u5357\u63a8\u8350\u7684\u68c0\u6d4b\u9879\u76ee\u5305\u62ec<sup>[3]<\/sup>\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>RAS<\/strong><strong>\u57fa\u56e0\uff08<\/strong><strong>KRAS\/NRAS<\/strong><strong>\uff09\u7a81\u53d8\u68c0\u6d4b<\/strong>\uff1a\u53ef\u6307\u5bfcEGFR\/VEGF\u5355\u6297\u7528\u836f<\/li>\n\n\n\n<li><strong>BRAF V600E<\/strong><strong>\u7a81\u53d8\u68c0\u6d4b<\/strong>\uff1a\u9884\u540e\u5224\u65ad\u53ca\u9776\u5411\u6cbb\u7597\u9009\u62e9<\/li>\n\n\n\n<li><strong>HER2<\/strong><strong>\u68c0\u6d4b<\/strong>\uff1aHER2\u6269\u589e\u60a3\u8005\u53ef\u8003\u8651\u6297HER2\u6cbb\u7597<\/li>\n\n\n\n<li><strong>RET<\/strong><strong>\u878d\u5408\u68c0\u6d4b<\/strong>\uff1a\u9633\u6027\u60a3\u8005\u53ef\u8003\u8651RET\u6291\u5236\u5242\u6cbb\u7597<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>\u56db\u3001\u7ed3\u76f4\u80a0\u764c\u89c4\u8303\u5316\u7efc\u5408\u6cbb\u7597\u65b9\u6848<\/strong><sup><strong>[3]<\/strong><\/sup><\/h4>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u6574\u4f53\u6cbb\u7597\u539f\u5219<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u7ed3\u76f4\u80a0\u764c\u7684\u6cbb\u7597\u4ee5\u624b\u672f\u4e3a\u6838\u5fc3\uff0c\u6839\u636e\u80bf\u7624\u90e8\u4f4d\u3001\u5206\u671f\u3001\u5206\u5b50\u5206\u578b\u548c\u60a3\u8005\u4e00\u822c\u72b6\u51b5\uff0c\u91c7\u53d6\u591a\u5b66\u79d1\u7efc\u5408\u6cbb\u7597\u6a21\u5f0f\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u65e9\u671f\uff08<\/strong><strong>I<\/strong><strong>\u671f\uff09<\/strong>\uff1a\u6839\u6cbb\u6027\u624b\u672f\u5207\u9664\uff0c\u672f\u540e\u4e00\u822c\u65e0\u9700\u8f85\u52a9\u5316\u7597<\/li>\n\n\n\n<li><strong>\u4e2d\u671f\uff08<\/strong><strong>II~III<\/strong><strong>\u671f\uff09<\/strong>\uff1a\u6839\u6cbb\u6027\u624b\u672f+\u672f\u540e\u8f85\u52a9\u5316\u7597\uff1b\u90e8\u5206\u9ad8\u5371\u60a3\u8005\u53ef\u8003\u8651\u8054\u5408\u65b9\u6848\u5316\u7597<\/li>\n\n\n\n<li><strong>\u5c40\u90e8\u665a\u671f\u76f4\u80a0\u764c<\/strong>\uff1a\u65b0\u8f85\u52a9\u653e\u5316\u7597+\u6839\u6cbb\u6027\u624b\u672f+\u8f85\u52a9\u5316\u7597\uff08\u201c\u4e09\u660e\u6cbb\u201d\u6a21\u5f0f\uff09<\/li>\n\n\n\n<li><strong>\u665a\u671f<\/strong><strong>\/<\/strong><strong>\u8f6c\u79fb\u6027<\/strong>\uff1a\u4ee5\u7cfb\u7edf\u6cbb\u7597\uff08\u5316\u7597+\u9776\u5411+\u514d\u75ab\uff09\u4e3a\u4e3b\uff0c\u914d\u5408\u5c40\u90e8\u6cbb\u7597\uff08\u624b\u672f\u3001\u6d88\u878d\u3001\u653e\u7597\u7b49\uff09\uff0c\u90e8\u5206\u53ef\u5207\u9664\u8f6c\u79fb\u7076\u60a3\u8005\u4ecd\u6709\u6cbb\u6108\u53ef\u80fd<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>1. <\/strong><strong>\u5916\u79d1\u624b\u672f\u6cbb\u7597<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u624b\u672f\u662f\u7ed3\u76f4\u80a0\u764c\u552f\u4e00\u53ef\u80fd\u6cbb\u6108\u7684\u624b\u6bb5\u3002\u624b\u672f\u65b9\u5f0f\u6839\u636e\u80bf\u7624\u90e8\u4f4d\u3001\u5206\u671f\u548c\u60a3\u8005\u60c5\u51b5\u9009\u62e9\uff1a<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u7ed3\u80a0\u764c\u624b\u672f<\/strong>\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u53f3\u534a\u7ed3\u80a0\u764c\uff1a\u53f3\u534a\u7ed3\u80a0\u5207\u9664\u672f<\/li>\n\n\n\n<li>\u6a2a\u7ed3\u80a0\u764c\uff1a\u6a2a\u7ed3\u80a0\u5207\u9664\u672f<\/li>\n\n\n\n<li>\u5de6\u534a\u7ed3\u80a0\u764c\uff1a\u5de6\u534a\u7ed3\u80a0\u5207\u9664\u672f<\/li>\n\n\n\n<li>\u4e59\u72b6\u7ed3\u80a0\u764c\uff1a\u4e59\u72b6\u7ed3\u80a0\u5207\u9664\u672f<\/li>\n\n\n\n<li>\u624b\u672f\u539f\u5219\uff1a\u5b8c\u6574\u5207\u9664\u80bf\u7624\u6240\u5728\u80a0\u6bb5+\u533a\u57df\u6dcb\u5df4\u7ed3\u6e05\u626b\uff08D3\u6839\u6cbb\u672f\uff09\uff0c\u786e\u4fdd\u5207\u7f18\u9634\u6027<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u76f4\u80a0\u764c\u624b\u672f<\/strong>\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u4f4e\u4f4d\u524d\u5207\u9664\u672f\uff08LAR\uff09\uff1a\u9002\u7528\u4e8e\u4e2d\u9ad8\u4f4d\u76f4\u80a0\u764c\uff0c\u53ef\u4fdd\u7559\u809b\u95e8<\/li>\n\n\n\n<li>\u8179\u4f1a\u9634\u8054\u5408\u5207\u9664\u672f\uff08Miles\u624b\u672f\uff09\uff1a\u9002\u7528\u4e8e\u6781\u4f4e\u4f4d\u76f4\u80a0\u764c\uff0c\u65e0\u6cd5\u4fdd\u7559\u809b\u95e8<\/li>\n\n\n\n<li>\u5168\u76f4\u80a0\u7cfb\u819c\u5207\u9664\u672f\uff08TME\uff09\uff1a\u76f4\u80a0\u764c\u624b\u672f\u7684\u91d1\u6807\u51c6\uff0c\u53ef\u663e\u8457\u964d\u4f4e\u5c40\u90e8\u590d\u53d1\u7387<\/li>\n\n\n\n<li>\u5fae\u521b\u624b\u672f\uff08\u8179\u8154\u955c\/\u673a\u5668\u4eba\uff09\uff1a\u521b\u4f24\u5c0f\u3001\u6062\u590d\u5feb\uff0c\u80bf\u7624\u5b66\u6548\u679c\u4e0e\u5f00\u8179\u624b\u672f\u76f8\u5f53<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u8f6c\u79fb\u7076\u624b\u672f<\/strong>\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u809d\u8f6c\u79fb\uff1a\u5bf9\u4e8e\u53ef\u5207\u9664\u7684\u809d\u8f6c\u79fb\u7076\uff0c\u624b\u672f\u5207\u9664\u53ef\u4f7f\u90e8\u5206\u60a3\u8005\u83b7\u5f97\u957f\u671f\u751f\u5b58\uff0c5\u5e74\u751f\u5b58\u7387\u53ef\u8fbe30%~50%<sup>[4]<\/sup><\/li>\n\n\n\n<li>\u80ba\u8f6c\u79fb\uff1a\u5b64\u7acb\u6027\u80ba\u8f6c\u79fb\u4e5f\u53ef\u8003\u8651\u624b\u672f\u5207\u9664<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>2. <\/strong><strong>\u65b0\u8f85\u52a9\u6cbb\u7597<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u65b0\u8f85\u52a9\u6cbb\u7597\u662f\u6307\u5728\u624b\u672f\u524d\u8fdb\u884c\u7684\u5316\u7597\u3001\u653e\u7597\u6216\u514d\u75ab\u6cbb\u7597\uff0c\u76ee\u7684\u662f\u7f29\u5c0f\u80bf\u7624\u3001\u964d\u4f4e\u5206\u671f\u3001\u63d0\u9ad8\u624b\u672f\u5207\u9664\u7387\u548c\u4fdd\u809b\u7387<sup>[7]<\/sup>\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u5c40\u90e8\u665a\u671f\u76f4\u80a0\u764c\u65b0\u8f85\u52a9\u653e\u5316\u7597<\/strong>\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u6807\u51c6\u65b9\u6848\uff1a\u672f\u524d\u540c\u6b65\u653e\u5316\u7597\uff08\u957f\u7a0b\u653e\u5316\u7597\u6216\u77ed\u7a0b\u653e\u7597\uff09+ \u624b\u672f + \u8f85\u52a9\u5316\u7597<\/li>\n\n\n\n<li>\u957f\u7a0b\u653e\u5316\u7597\uff1a50Gy\/25\u6b21\u540c\u6b65\u5361\u57f9\u4ed6\u6ee8\u5316\u7597<\/li>\n\n\n\n<li>\u77ed\u7a0b\u653e\u7597\uff1a25Gy\/5\u6b21\uff0c\u7136\u540e\u7acb\u5373\u6216\u5ef6\u8fdf\u624b\u672f<\/li>\n\n\n\n<li>\u5168\u7a0b\u65b0\u8f85\u52a9\u6cbb\u7597\uff08TNT\uff09\uff1a\u5c06\u5316\u7597\u5168\u90e8\u79fb\u81f3\u672f\u524d\uff0c\u53ef\u63d0\u9ad8\u6cbb\u7597\u5b8c\u6210\u7387\u548c\u80bf\u7624\u53cd\u5e94\u7387<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>MSI-H<\/strong><strong>\/<\/strong><strong>dMMR<\/strong><strong>\u7ed3\u76f4\u80a0\u764c\u65b0\u8f85\u52a9\u514d\u75ab\u6cbb\u7597<\/strong><sup><strong>[16]<\/strong><\/sup>\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>NeoShot-1b \u7814\u7a76\u663e\u793a\uff0cIBI310\uff08\u6297 CTLA-4 \u5355\u6297\uff09\u8054\u5408\u4fe1\u8fea\u5229\u5355\u6297\uff08\u6297 PD-1 \u5355\u6297\uff09\u5bf9\u6bd4\u4fe1\u8fea\u5229\u5355\u6297\u5355\u836f\u7528\u4e8e\u5c40\u90e8\u8fdb\u5c55\u671f MSI-H\/dMMR \u7ed3\u80a0\u764c\u65b0\u8f85\u52a9\u6cbb\u7597\uff0c\u53cc\u514d\u75ab\u8054\u5408\u7ec4 pCR \u7387\u663e\u8457\u9ad8\u4e8e\u5355\u836f\u7ec4\uff0878.4% vs 46.7%\uff09\u3002<\/li>\n\n\n\n<li>NICHE-1 \u7814\u7a76\u5f00\u521b\u6027\u63a2\u7d22\u65e9\u671f dMMR \u7ed3\u80a0\u764c\u53cc\u514d\u75ab\u65b0\u8f85\u52a9\u53ef\u884c\u6027\uff0c\u7ed3\u679c\u663e\u793a60% \u60a3\u8005\u8fbe\u5230 pCR\uff1bNICHE-2 \u7814\u7a76\u6269\u5927\u6837\u672c\u518d\u6b21\u9a8c\u8bc1\u8be5\u65b9\u6848\u7597\u6548\u4e0e\u5b89\u5168\u6027\uff1bNICHE-3 \u7814\u7a76\u63a2\u7d22\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u8054\u5408\u745e\u62c9\u5229\u5355\u6297\u5728 dMMR \u7ed3\u80a0\u764c\u4e2d\u7684\u5e7f\u9614\u5e94\u7528\u3002NICHE\u7cfb\u5217\u7814\u7a76\u5171\u540c\u8bc1\u5b9e\uff1a\u53cc\u514d\u75ab\u65b0\u8f85\u52a9\u662f dMMR \u7ed3\u76f4\u80a0\u764c\u9ad8\u6548\u6cbb\u7597\u65b9\u6848\uff0c\u75c5\u7406\u7f13\u89e3\u7387\u8fdc\u4f18\u4e8e\u4f20\u7edf\u65b0\u8f85\u52a9\u5316\u7597\uff08FOxTROT \u7814\u7a76\u5355\u7eaf\u5316\u7597 pCR \u7387\u4ec5 7%\uff09\uff0c\u6709\u671b\u66ff\u4ee3\u672f\u540e\u8f85\u52a9\u5316\u7597\u3002<\/li>\n\n\n\n<li>2026\u7248CSCO\u6307\u5357\u66f4\u65b0\uff1a\u5c06\u65e0\u9700\u6025\u8bca\u624b\u672f\u7684\u975e\u8f6c\u79fb\u6027 MSI-H\/dMMR \u7ed3\u80a0\u764c\u72ec\u7acb\u6210\u7ae0\uff0c\u9488\u5bf9\u4e34\u5e8a T4 \u5206\u671f\uff08cT<sub>4<\/sub>\uff09\u6216\u6dcb\u5df4\u7ed3\u9633\u6027\uff08N<sub>+<\/sub>\uff09\u60a3\u8005\uff0c\u5c06<strong>\u4fe1\u8fea\u5229\u5355\u6297<\/strong><strong>\uff08<\/strong><strong>PD-1<\/strong><strong>\u5355\u6297\uff09<\/strong><strong>\u8054\u5408<\/strong><strong>\u4f0a\u5339\u6728\u5355\u6297<\/strong><strong> N01<\/strong><strong>\uff08<\/strong><strong>CTLA-4<\/strong><strong>\u5355\u6297\uff09<\/strong>\u672f\u524d\u65b9\u6848\u5217\u4e3a 1 \u7c7b\u63a8\u8350\u3002\u9488\u5bf9cT<sub>4b<\/sub>\u60a3\u8005\uff0c\u7ed3\u5408 NICHE \u7cfb\u5217\u53ca\u5176\u4ed6\u65b0\u8f85\u52a9\u7814\u7a76\u7597\u6548\u6570\u636e\uff0c\u6307\u5357\u4fdd\u7559 2 \u7c7b\u63a8\u8350\uff1a\u672f\u524d\u91c7\u7528\u7eb3\u6b66\u5229\u5c24\u5355\u6297 + \u4f0a\u5339\u6728\u5355\u6297\u53cc\u514d\u75ab\uff0c\u6216 PD-1 \u5355\u836f\u514d\u75ab\u6cbb\u7597\u3002<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>3. <\/strong><strong>\u672f\u540e\u8f85\u52a9\u5316\u7597<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u8f85\u52a9\u5316\u7597\u7684\u76ee\u7684\u662f\u6740\u706d\u672f\u540e\u53ef\u80fd\u6b8b\u7559\u7684\u5fae\u5c0f\u8f6c\u79fb\u7076\uff0c\u964d\u4f4e\u590d\u53d1\u98ce\u9669\uff0c\u63d0\u9ad8\u751f\u5b58\u7387<sup>[6]<\/sup>\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>II<\/strong><strong>\u671f<\/strong><strong>\u7ed3\u80a0\u764c<\/strong>\uff1a\u5747\u5e94\u8fdb\u884c\u9519\u914d\u4fee\u590d\u86cb\u767d\uff08MMR\uff09\u68c0\u6d4b\uff0cMSI-H\/dMMR\u7684\u60a3\u8005\u53ef\u80fd\u9884\u540e\u8f83\u597d\uff0c\u4e14\u4e0d\u4f1a\u4ece\u6c1f\u5c3f\u5627\u5576\u7c7b\u836f\u7269\u5355\u836f\u8f85\u52a9\u5316\u7597\u4e2d\u83b7\u76ca\u3002DYANMIC\u7814\u7a76\u8868\u660e\uff0c\u57fa\u4e8ectDNA\u68c0\u6d4b\u7684\u5fae\u5c0f\u6b8b\u7559\u75c5\u7076\uff08MRD\uff09\u72b6\u6001\u53ef\u80fd\u4f1a\u6539\u53d8\u90e8\u5206II\u671f\u7ed3\u80a0\u764c\u7684\u672f\u540e\u8f85\u52a9\u5316\u7597\u7b56\u7565\u3002\u800c\u5f53\u524dMRD\u7684\u68c0\u6d4b\u6280\u672f\u7684\u6807\u51c6\u5316\u5c1a\u6709\u7559\u767d\u3002<\/li>\n\n\n\n<li><strong>II<\/strong><strong>I<\/strong><strong>\u671f<\/strong><strong>\u7ed3\u80a0\u764c<\/strong>\uff1a\u63a8\u8350\u8fdb\u884c\u8054\u5408\u5316\u7597\u65b9\u6848\u672f\u540e\u8f85\u52a9\u6cbb\u7597\u3002ATOMIC\u7814\u7a76\u8868\u660e\uff0c\u9488\u5bf9\u63a5\u53d7\u8fc7\u6839\u6cbb\u6027\u624b\u672f\u540e\u7684MSI-H\/dMMR III\u671f\u60a3\u8005\uff0cFOLFOX\uff085-\u6c1f\u5c3f\u5627\u5576+\u4e9a\u53f6\u9178\u9499+\u5965\u6c99\u5229\u94c2\uff09\u8054\u5408\u963f\u66ff\u5229\u73e0\u5355\u6297\u5bf9\u6bd4FOLFOX\uff0c3\u5e74\u65e0\u75c5\u751f\u5b58\u7387\u663e\u8457\u63d0\u9ad8\uff0c\u7136\u800c\u963f\u66ff\u5229\u73e0\u5355\u6297\u5728\u56fd\u5185\u5c1a\u672a\u83b7\u6279\u80a0\u764c\u9002\u5e94\u75c7\u3002<\/li>\n\n\n\n<li><strong>\u76f4\u80a0\u764c<\/strong>\uff1a\u65b0\u8f85\u52a9\u653e\u5316\u7597\u540e\u63a5\u53d7\u6839\u6cbb\u6027\u624b\u672f\u7684\u60a3\u8005\uff0c\u672f\u540e\u8f85\u52a9\u5316\u7597\u53ef\u8fdb\u4e00\u6b65\u964d\u4f4e\u8fdc\u5904\u8f6c\u79fb\u98ce\u9669\u3002<\/li>\n\n\n\n<li><strong>\u6807\u51c6\u8f85\u52a9\u5316\u7597\u65b9\u6848<\/strong>\u4e3aXELOX\uff08\u5361\u57f9\u4ed6\u6ee8+\u5965\u6c99\u5229\u94c2\uff09\u6216mFOLFOX6\uff085-\u6c1f\u5c3f\u5627\u5576+\u4e9a\u53f6\u9178\u9499+\u5965\u6c99\u5229\u94c2\uff09\uff0c\u7597\u7a0b6\u4e2a\u6708\u3002\u57fa\u4e8eIDEA\u7814\u7a76\u7ed3\u679c\uff0c\u9ad8\u5371II\u671f\u53ca\u4f4e\u5371III\u671f\u60a3\u8005\uff08T<sub>1-3<\/sub>N<sub>1<\/sub>\uff09\u53ef\u8003\u86513\u4e2a\u6708XELOX\u65b9\u6848\u8f85\u52a9\u5316\u7597\u3002<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>4. <\/strong><strong>\u665a\u671f<\/strong><strong>\/<\/strong><strong>\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\u7cfb\u7edf\u6cbb\u7597<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u665a\u671f\/\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\uff08mCRC\uff09\u7684\u6cbb\u7597\u4ee5\u7cfb\u7edf\u6cbb\u7597\u4e3a\u4e3b\uff0c\u76ee\u6807\u662f\u5ef6\u957f\u751f\u5b58\u3001\u6539\u5584\u751f\u6d3b\u8d28\u91cf\u3002\u6cbb\u7597\u65b9\u6848\u7684\u9009\u62e9\u9700\u7efc\u5408\u8003\u8651\u5206\u5b50\u5206\u578b\u3001\u80bf\u7624\u90e8\u4f4d\u3001\u60a3\u8005\u4f53\u529b\u72b6\u51b5\u548c\u6cbb\u7597\u76ee\u6807<sup>[8][9]<\/sup>\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u4e00\u7ebf\u6cbb\u7597<\/strong>\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>RAS\/BRAF<\/strong><strong>\u91ce\u751f\u578b\u5de6\u534a\u7ed3\u80a0\u764c<\/strong>\uff1a\u5316\u7597+EGFR\u5355\u6297\uff08\u897f\u59a5\u6614\u5355\u6297\/\u5e15\u5c3c\u5355\u6297\uff09\u4e3a\u9996\u9009<\/li>\n\n\n\n<li><strong>RAS<\/strong><strong>\u7a81\u53d8\u6216\u53f3\u534a\u7ed3\u80a0\u764c<\/strong>\uff1a\u5316\u7597+VEGF\u5355\u6297\uff08\u8d1d\u4f10\u73e0\u5355\u6297\uff09\u4e3a\u9996\u9009<\/li>\n\n\n\n<li><strong>MSI-H\/dMMR<\/strong><strong>\u60a3\u8005<\/strong>\uff1a\u514d\u75ab\u6cbb\u7597\u4e3a\u4e00\u7ebf\u9996\u9009\uff0cPD-1\u5355\u836f\u6216PD-1\u00b1CTLA-4<\/li>\n\n\n\n<li>\u5e38\u7528\u5316\u7597\u65b9\u6848\uff1aFOLFOX\/CAPOX\uff08\u5965\u6c99\u5229\u94c2+\u6c1f\u5c3f\u5627\u5576\u7c7b\uff09\u3001FOLFIRI\uff08\u4f0a\u7acb\u66ff\u5eb7+\u6c1f\u5c3f\u5627\u5576\u7c7b\uff09\u3001FOLFOXIRI\uff08\u4e09\u836f\u8054\u5408\uff09<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u4e8c\u7ebf\u53ca\u540e\u7ebf\u6cbb\u7597<\/strong>\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u6839\u636e\u4e00\u7ebf\u6cbb\u7597\u65b9\u6848\u4ea4\u53c9\u9009\u62e9\u5316\u7597\u836f\u7269<\/li>\n\n\n\n<li>\u7ee7\u7eed\u6216\u66f4\u6362\u9776\u5411\u836f\u7269<\/li>\n\n\n\n<li>\u745e\u6208\u975e\u5c3c\u3001\u544b\u55b9\u66ff\u5c3c\u7b49\u591a\u9776\u70b9\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242<\/li>\n\n\n\n<li>TAS-102\uff08\u66f2\u6c1f\u5c3f\u82f7\u66ff\u5339\u5627\u5576\uff09<\/li>\n\n\n\n<li>HER2\u6269\u589e\u60a3\u8005\uff1a\u6297HER2\u6cbb\u7597\uff08\u66f2\u59a5\u73e0\u5355\u6297+\u5e15\u59a5\u73e0\u5355\u6297\u7b49\uff09<\/li>\n\n\n\n<li>BRAF V600E\u7a81\u53d8\u60a3\u8005\uff1aBRAF\u6291\u5236\u5242+EGFR\u5355\u6297\u8054\u5408\u65b9\u6848<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u8f6c\u5316\u6cbb\u7597<\/strong>\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u5bf9\u4e8e\u521d\u59cb\u4e0d\u53ef\u5207\u9664\u4f46\u6709\u6f5c\u5728\u5207\u9664\u53ef\u80fd\u7684\u809d\/\u80ba\u8f6c\u79fb\u60a3\u8005\uff0c\u901a\u8fc7\u9ad8\u5f3a\u5ea6\u5316\u7597+\u9776\u5411\u6cbb\u7597\u4f7f\u80bf\u7624\u7f29\u5c0f\uff0c\u4e89\u53d6\u624b\u672f\u673a\u4f1a<\/li>\n\n\n\n<li>\u8f6c\u5316\u6210\u529f\u540e\u884c\u624b\u672f\u5207\u9664\uff0c\u90e8\u5206\u60a3\u8005\u53ef\u83b7\u5f97\u957f\u671f\u751f\u5b58<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>5. <\/strong><strong>\u9776\u5411<\/strong><strong>\u6cbb\u7597<\/strong><sup><strong>[16]<\/strong><\/sup><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">BRAF V600E\u7a81\u53d8\u3001HER2\u8fc7\u8868\u8fbe\/\u6269\u589e&nbsp;\u665a\u671f\/\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\u4eba\u7fa4\u6709\u4e86\u65b0\u9009\u62e9\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>BREAKWATER<\/strong><strong>\u7814\u7a76<\/strong>\uff1a\u5bf9\u4e8e\u521d\u6cbb\u4e0d\u53ef\u5207\u9664\u3001\u6f5c\u5728\u53ef\u5207\u9664\u8f6c\u79fb\u6027BRAF V600E\u7a81\u53d8\u7ed3\u76f4\u80a0\u764c\uff0c\u6069\u8003\u82ac\u5c3c+\u897f\u59a5\u6614\u5355\u6297\u8054\u5408mFOLFOX6\uff08EC&nbsp;+&nbsp;mFOLFOX6\uff09\u65b9\u6848\u7597\u6548\u663e\u8457\u4f18\u4e8e\u6807\u51c6\u5316\u7597\u00b1\u8d1d\u4f10\u73e0\u5355\u6297\uff08\u6807\u51c6\u6cbb\u7597SOC\uff09<\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li>\u5ba2\u89c2\u7f13\u89e3\u7387\uff08ORR\uff09\uff1a60.9% VS 40.0%\uff08HR=2.443\uff0cP=0.0008\uff09\uff1b<\/li>\n\n\n\n<li>\u4e2d\u4f4d\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08mPFS\uff09\uff1a12.8\u4e2a\u6708 vs 7.1\u4e2a\u6708\uff08HR=0.53\uff0cP\uff1c0.0001\uff09\u3002<\/li>\n\n\n\n<li>\u5173\u952e\u6b21\u8981\u7ec8\u70b9OS\u4e2d\u671f\u5206\u6790\uff1aEC+mFOLFOX6 \u7ec4\u4e2d\u4f4dOS\uff1a30.3\u4e2a\u6708\uff0c\u63a5\u8fd1 SOC\u7ec4\uff0815.1\u4e2a\u6708\uff09\u7684\u4e24\u500d\uff08HR=0.49\uff0cP\uff1c0.0001\uff09\u3002<\/li>\n<\/ol>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>NAUTICAL<\/strong><strong>\u7814\u7a76<\/strong>\uff1a\u5bf9\u4e8e\u6807\u51c6\u6cbb\u7597\u5931\u8d25\u7684BRAF V600E\u7a81\u53d8\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\uff0c\u6069\u8003\u82ac\u5c3c\uff08BRAF\uff09+&nbsp;\u897f\u59a5\u6614\u5355\u6297\uff08EGFR\uff09\u53cc\u836f\u65b9\u6848\u5bf9\u6bd4\u4f0a\u5229\u66ff\u5eb7\/FOLFIRI + \u897f\u59a5\u6614\u5355\u6297<\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li>mPFS\uff1a4.2\u4e2a\u6708 vs 2.5\u4e2a\u6708\uff08HR=0.37\uff0cP=0.0004\uff09<\/li>\n\n\n\n<li>\u4e2d\u4f4dOS\uff1a11.6\u4e2a\u6708 vs 8.2\u4e2a\u6708\uff08HR=0.55\uff09<\/li>\n\n\n\n<li>ORR\uff1a24.6% vs 6.3%<\/li>\n<\/ol>\n\n\n\n<p class=\"wp-block-paragraph\">2026\u7248CSCO\u6307\u5357\u5c06\u6069\u8003\u82ac\u5c3c\u8054\u5408EGFR\u5355\u6297\u4f5c\u4e3aBRAF V600E\u7a81\u53d8\u60a3\u8005\u4e8c\u3001\u4e09\u7ebfI\u7ea7\u63a8\u8350\uff081A\u7c7b\u8bc1\u636e\uff09\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>HORIZON-CRC01<\/strong><strong>\u7814\u7a76<\/strong>\uff1a\u5bf9\u4e8e\u5316\u7597\u8010\u836f\u3001HER2\u9633\u6027\u3001RAS\/BRAF\u91ce\u751f\u578b\u665a\u671f\u7ed3\u76f4\u80a0\u764c\uff0c\u7ef4\u8fea\u897f\u59a5\u5355\u6297\u5bf9\u6bd4\u6807\u51c6\u540e\u7ebf\u65b9\u6848\uff08TAS-102\u3001\u544b\u55b9\u66ff\u5c3c\u3001\u745e\u6208\u975e\u5c3c\uff09<\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li>mPFS\uff1a5.5\u4e2a\u6708\u00a0vs\u00a02.8\u4e2a\u6708\uff08HR=0.33\uff09<\/li>\n\n\n\n<li>ORR\uff1a40.7%\u00a0vs\u00a04.5%<\/li>\n<\/ol>\n\n\n\n<p class=\"wp-block-paragraph\">\u57fa\u4e8e\u8be5\u7814\u7a76\u7ed3\u679c\u53ca2025\u5e74\u7ef4\u8fea\u897f\u59a5\u5355\u6297\u56fd\u5185\u65b0\u83b7\u6279\u9002\u5e94\u75c7\uff0c2026\u7248CSCO\u6307\u5357\u5c06\u7ef4\u8fea\u897f\u59a5\u5355\u6297\u5217\u4e3aIII\u7c7b\u63a8\u8350\uff08\u8bc1\u636e\u7b49\u7ea71B\uff09\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>EGFR<\/strong><strong>\u5355\u6297<\/strong>\uff1a\u897f\u59a5\u6614\u5355\u62972005\u5e74\u5728\u56fd\u5185\u83b7\u6279\uff0c\u957f\u671f\u662f\u6211\u56fd\u7ed3\u76f4\u80a0\u764c\u4e34\u5e8a\u552f\u4e00\u53ef\u7528\u6297EGFR\u5355\u6297\uff1b2024\u5e74\u897f\u59a5\u6614\u5355\u6297\u03b2\u83b7\u6279\u4e0a\u5e02\uff0c2026\u5e74\u53c8\u6709\u4e24\u6b3e\u65b0\u578b\u6297EGFR\u5355\u6297\u9646\u7eed\u56fd\u5185\u83b7\u6279\uff0c\u6781\u5927\u4e30\u5bcc\u8be5\u7c7b\u836f\u7269\u9009\u62e9\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>\u4e94\u3001\u8bca\u7597\u603b\u7ed3<\/strong><\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">\u7ed3\u76f4\u80a0\u764c\u4f5c\u4e3a\u6211\u56fd\u53d1\u75c5\u7387\u548c\u6b7b\u4ea1\u7387\u5747\u5c45\u524d\u5217\u7684\u9ad8\u53d1\u6076\u6027\u80bf\u7624\uff0c\u5176\u9632\u6cbb\u5f62\u52bf\u4e25\u5cfb\u3002\u4f46\u503c\u5f97\u6b23\u6170\u7684\u662f\uff0c\u7ed3\u76f4\u80a0\u764c\u4e5f\u662f\u6700\u53ef\u9632\u53ef\u6cbb\u7684\u764c\u79cd\u4e4b\u4e00\uff1a<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u65e9\u7b5b\u65e9\u8bca\u662f\u5173\u952e<\/strong>\u3002\u4ece\u817a\u7624\u6027\u606f\u8089\u53d1\u5c55\u4e3a\u817a\u764c\u901a\u5e38\u9700\u89815~10\u5e74\uff0c\u9ad8\u98ce\u9669\u4eba\u7fa4\u81ea40\u5c81\u8d77\u5b9a\u671f\u63a5\u53d7\u7b5b\u67e5\u53ef\u6709\u6548\u964d\u4f4e\u7ed3\u76f4\u80a0\u764c\u53d1\u75c5\u7387\u548c\u6b7b\u4ea1\u7387\u3002\u65e9\u671f\u7ed3\u76f4\u80a0\u764c5\u5e74\u751f\u5b58\u7387\u53ef\u8fbe90%\u4ee5\u4e0a\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u7cbe\u51c6\u6cbb\u7597\u662f\u65b9\u5411<\/strong>\u3002\u5206\u5b50\u5206\u578b\u6307\u5bfc\u4e0b\u7684\u4e2a\u4f53\u5316\u6cbb\u7597\u5df2\u6210\u4e3a\u7ed3\u76f4\u80a0\u764c\u6cbb\u7597\u7684\u6807\u51c6\u6a21\u5f0f\u3002RAS\u3001BRAF\u3001HER2\u3001RET\u7b49\u751f\u7269\u6807\u5fd7\u7269\u7684\u68c0\u6d4b\uff0c\u4e3a\u9776\u5411\u6cbb\u7597\u548c\u514d\u75ab\u6cbb\u7597\u7684\u7cbe\u51c6\u9009\u62e9\u63d0\u4f9b\u4e86\u4f9d\u636e\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u514d\u75ab\u6cbb\u7597\u5e26\u6765\u7a81\u7834<\/strong>\u3002MSI-H\/dMMR\u4e9a\u578b\u60a3\u8005\u4ece\u514d\u75ab\u6cbb\u7597\u4e2d\u83b7\u76ca\u663e\u8457\uff0c\u4e00\u7ebf\u514d\u75ab\u6cbb\u7597\u5df2\u6210\u4e3a\u6807\u51c6\uff0c\u65b0\u8f85\u52a9\u514d\u75ab\u6cbb\u7597\u4e5f\u5c55\u73b0\u51fa\u4ee4\u4eba\u632f\u594b\u7684\u7597\u6548\uff0c\u90e8\u5206\u60a3\u8005\u751a\u81f3\u53ef\u80fd\u5b9e\u73b0\u201c\u53bb\u624b\u672f\u201d\u6cbb\u7597\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u591a\u5b66\u79d1\u534f\u4f5c\u662f\u4fdd\u969c<\/strong>\u3002MDT\u6a21\u5f0f\u8d2f\u7a7f\u7ed3\u76f4\u80a0\u764c\u8bca\u7597\u5168\u7a0b\uff0c\u5916\u79d1\u3001\u5185\u79d1\u3001\u653e\u7597\u79d1\u3001\u5f71\u50cf\u79d1\u3001\u75c5\u7406\u79d1\u7b49\u591a\u5b66\u79d1\u534f\u4f5c\uff0c\u4e3a\u60a3\u8005\u5236\u5b9a\u6700\u4f73\u4e2a\u4f53\u5316\u6cbb\u7597\u65b9\u6848\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u79d1\u5b66\u7b5b\u67e5\u3001\u89c4\u8303\u8bca\u7597\u3001\u5168\u7a0b\u7ba1\u7406\uff0c\u662f\u5bf9\u6297\u7ed3\u76f4\u80a0\u764c\u6700\u6709\u529b\u7684\u6b66\u5668\u3002\u968f\u7740\u533b\u5b66\u7684\u4e0d\u65ad\u8fdb\u6b65\uff0c\u8d8a\u6765\u8d8a\u591a\u7684\u6cbb\u7597\u624b\u6bb5\u548c\u836f\u7269\u6b63\u5728\u6d8c\u73b0\uff0c\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\u7684\u751f\u5b58\u65f6\u95f4\u548c\u751f\u6d3b\u8d28\u91cf\u5fc5\u5c06\u6301\u7eed\u6539\u5584\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u53c2\u8003\u6587\u732e<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">[1] Bray F, Laversanne M, Sung H, et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2024.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">[2] Xia C, Li H, Wu C, Chen W. Cancer burden and control in China: landscape, trends and challenges. Nat Rev Clin Oncol. 2026 Jun 19. doi: 10.1038\/s41571-026-01165-8. Epub ahead of print. PMID: 42321391.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">[3] \u4e2d\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a\u6307\u5357\u5de5\u4f5c\u59d4\u5458\u4f1a. \u4e2d\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a(CSCO)\u7ed3\u76f4\u80a0\u764c\u8bca\u7597\u6307\u53572026[M]. \u5317\u4eac: \u4eba\u6c11\u536b\u751f\u51fa\u7248\u793e, 2026.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">[4] Abedizadeh R, Majidi F, Khorasani HR, et al. Colorectal cancer: a comprehensive review of carcinogenesis, diagnosis, and novel strategies for classified treatments. Cancer Metastasis Rev. 2024;43(2):729-753.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">[5] \u56fd\u5bb6\u536b\u751f\u5065\u5eb7\u59d4\u5458\u4f1a. \u7ed3\u76f4\u80a0\u764c\u7b5b\u67e5\u4e0e\u65e9\u8bca\u65e9\u6cbb\u65b9\u6848(2024\u5e74\u7248). 2024.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">[6] Andr\u00e9 T, Boni C, Mounedji-Boudiaf L, et al. Oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment for colon cancer. N Engl J Med. 2004;350(23):2343-2351.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">[7] Castria TB, Lenz G, Valagni G, et al. Role of neoadjuvant therapies in locally advanced colon cancer. Chin Med J. 2025;138(17):2091-2101.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">[8] Steup C, Kennel K, Neurath MF, Fichtner-Feigl S. Current and emerging concepts for systemic treatment of metastatic colorectal cancer. Gut. 2025;74(12):2070-2095.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">[9] Leowattana W, Leowattana P, Leowattana T. Systemic treatment for metastatic colorectal cancer. World J Gastroenterol. 2023;29(10):1569-1588.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">[10] Diaz LA Jr, Shiu KK, Kim TW, et al. Pembrolizumab versus chemotherapy for microsatellite instability-high or mismatch repair-deficient metastatic colorectal cancer (KEYNOTE-177): final analysis of a randomised, open-label, phase 3 study. Lancet Oncol. 2022;23(5):659-670.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">[11] Andr\u00e9 T, Shiu KK, Kim TW, et al. Pembrolizumab Versus chemotherapy in microsatellite instability-high or mismatch repair-deficient metastatic colorectal cancer: 5-year follow-up from the randomized phase 3 KEYNOTE-177 study. Ann Oncol. 2025;36(3):277-284.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">[12] Andr\u00e9 T, Elez E, Lenz HJ, et al. Nivolumab plus ipilimumab versus nivolumab in microsatellite instability-high metastatic colorectal cancer (CheckMate 8HW): a randomised, open-label, phase 3 trial. Lancet. 2025;405(10476):383-395.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">[13] Andr\u00e9 T, Elez E, Lenz HJ, et al. Nivolumab plus Ipilimumab in Microsatellite-Instability-High Metastatic Colorectal Cancer. N Engl J Med. 2024;391(21):2014-2026.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">[14] Wang S, Zheng R, Li J, et al. Global, regional, and national lifetime risks of developing and dying from gastrointestinal cancers in 185 countries: a population-based systematic analysis of GLOBOCAN. Lancet Gastroenterol Hepatol. 2024;9(3):229-237.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">[15]&nbsp;Lu D, Dong C, Wang K, et al. Updates of CSCO guidelines for colorectal cancer version 2025. Chin J Cancer Res. 2025;37(3):297-302. doi:10.21147\/j.issn.1000-9604.2025.03.01.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">[16]&nbsp;Zhong X, Chen J, Zhang Y, Hu H,&nbsp;Weng S, Zhang S, Yuan Y. Updates of CSCO guidelines for&nbsp;colorectal cancer version 2026. Chin J Cancer Res&nbsp;2026;38(3):329-335. doi: 10.21147\/j.issn.1000-9604.2026.03.10<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><em>\u514d\u8d23\u58f0\u660e\uff1a\u672c\u6587\u5185\u5bb9\u4ec5\u4f9b\u533b\u5b66\u79d1\u666e\u548c\u5b66\u4e60\u53c2\u8003\uff0c\u4e0d\u6784\u6210\u4efb\u4f55\u8bca\u7597\u5efa\u8bae\u3002\u5177\u4f53\u8bca\u7597\u65b9\u6848\u8bf7\u54a8\u8be2\u4e13\u4e1a\u533b\u5e08\uff0c\u5e76\u4ee5\u6743\u5a01\u6307\u5357\u548c\u4e34\u5e8a\u5224\u65ad\u4e3a\u51c6\u3002\u6587\u4e2d\u5f15\u7528\u6587\u732e\u4ec5\u4f9b\u53c2\u8003\uff0c\u5176\u89c2\u70b9\u4e0d\u4ee3\u8868\u672c\u516c\u4f17\u53f7\u7acb\u573a\u3002<\/em><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u64b0\u6587\uff1a\u9648\u4f73\u73b2<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5ba1\u6838\uff1a\u5bab\u96ea<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u7ed3\u76f4\u80a0\u764c\u662f\u5168\u7403\u53ca\u6211\u56fd\u53d1\u75c5\u7387\u548c\u6b7b\u4ea1\u7387\u5747\u5c45\u524d\u5217\u7684\u9ad8\u53d1\u6076\u6027\u80bf\u7624\uff0c\u8fd1\u5e74\u6765\u5448\u73b0\u5e74\u8f7b\u5316\u3001\u53d1\u75c5\u7387\u6301\u7eed\u4e0a\u5347\u7684\u8d8b\u52bf\u3002\u4f5c\u4e3a\u4e00\u79cd&#8221;\u6c89\u9ed8\u7684\u6740\u624b&#8221;\uff0c\u7ed3\u76f4\u80a0\u764c\u65e9\u671f\u75c7\u72b6\u9690\u533f\uff0c\u591a\u6570\u60a3\u8005\u786e\u8bca\u65f6\u5df2\u5904\u4e8e\u4e2d\u665a\u671f\u3002\u7136\u800c\uff0c\u7ed3\u76f4\u80a0\u764c\u4e5f\u662f\u6700\u9002\u5408\u7b5b\u67e5\u7684\u764c\u79cd\u4e4b\u4e00\u2014\u2014\u4ece\u817a\u7624\u6027\u606f\u8089\u53d1\u5c55\u4e3a\u817a\u764c\u901a\u5e38\u9700\u89815~10\u5e74\u65f6\u95f4\uff0c\u65e9\u671f\u53d1\u73b0\u5e76\u5e72\u9884\u53ef\u663e\u8457\u964d\u4f4e\u6b7b\u4ea1\u7387\u3002\u672c\u6587\u4f9d\u6258\u300aCSCO\u7ed3\u76f4\u80a0\u764c\u8bca\u7597\u6307\u5357\uff082026\u7248\uff09\u300b\u53ca\u591a\u9879\u56fd\u9645\u6743\u5a01\u7814\u7a76\uff0c\u7cfb\u7edf\u68b3\u7406\u7ed3\u76f4\u80a0\u764c\u6d41\u884c\u75c5\u5b66\u7279\u5f81\u3001\u7b5b\u67e5\u7b56\u7565\u3001&#8221;\u4e34\u5e8a-\u5f71\u50cf-\u75c5\u7406&#8221;\u4e09\u4f4d\u4e00\u4f53\u8bca\u65ad\u4f53\u7cfb\uff0c\u4ee5\u53ca\u624b\u672f\u3001\u5316\u7597\u3001\u9776\u5411\u3001\u514d\u75ab\u5168\u6d41\u7a0b\u6cbb\u7597\u65b9\u6848\uff0c\u4e3a\u5927\u4f17\u4e0e\u4e34\u5e8a\u5de5\u4f5c\u8005\u63d0\u4f9b\u5b8c\u6574\u6613\u61c2\u7684\u8bca\u7597\u79d1\u666e\u53c2\u8003\u3002<\/p>\n","protected":false},"author":1,"featured_media":2130,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[147],"tags":[35,86,15,32,29],"class_list":["post-2128","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-147","tag-35","tag-86","tag-15","tag-32","tag-29"],"_links":{"self":[{"href":"https:\/\/www.millibuff.com\/index.php?rest_route=\/wp\/v2\/posts\/2128","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.millibuff.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.millibuff.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.millibuff.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.millibuff.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2128"}],"version-history":[{"count":4,"href":"https:\/\/www.millibuff.com\/index.php?rest_route=\/wp\/v2\/posts\/2128\/revisions"}],"predecessor-version":[{"id":2134,"href":"https:\/\/www.millibuff.com\/index.php?rest_route=\/wp\/v2\/posts\/2128\/revisions\/2134"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.millibuff.com\/index.php?rest_route=\/wp\/v2\/media\/2130"}],"wp:attachment":[{"href":"https:\/\/www.millibuff.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2128"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.millibuff.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2128"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.millibuff.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2128"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}