{"id":2159,"date":"2026-09-18T15:46:00","date_gmt":"2026-09-18T07:46:00","guid":{"rendered":"https:\/\/www.millibuff.com\/?p=2159"},"modified":"2026-09-18T15:48:14","modified_gmt":"2026-09-18T07:48:14","slug":"%e5%b0%8f%e7%89%9b%e6%b4%9e%e5%af%9f-%e8%af%ba%e5%a5%96%e9%a3%8e%e5%90%91%e6%a0%87%e6%8c%87%e5%90%91glp-1%ef%bc%9a%e4%bb%8e%e5%9f%ba%e7%a1%80%e6%bf%80%e7%b4%a0%e5%8f%91%e7%8e%b0%e5%88%b0%e5%8d%83","status":"publish","type":"post","link":"https:\/\/www.millibuff.com\/?p=2159","title":{"rendered":"\u5c0f\u725b\u6d1e\u5bdf | \u8bfa\u5956\u98ce\u5411\u6807\u6307\u5411GLP-1\uff1a\u4ece\u57fa\u7840\u6fc0\u7d20\u53d1\u73b0\u5230\u5343\u4ebf\u5e02\u573a\u7684\u4e34\u5e8a\u5f00\u53d1\u542f\u793a\u2014\u2014 2026\u5e74\u5f15\u6587\u6842\u51a0\u5956\u63ed\u6653\uff0cGLP-1\u7814\u7a76\u83b7\u300c\u8bfa\u5956\u7ea7\u300d\u8ba4\u53ef"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\"><strong>2026 <\/strong><strong>\u5e74\u5ea6\u5f15\u6587\u6842\u51a0\u5956\uff08\u751f\u7406\u5b66\u6216\u533b\u5b66\u9886\u57df\uff09<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u63ed\u6653\u65f6\u95f4\uff5c<\/strong>2026 \u5e74 9 \u6708 17 \u65e5\uff08\u79d1\u777f\u552f\u5b89\uff09<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u83b7\u5956\u4eba\u6570\uff5c<\/strong>\u5168\u7403 22 \u4f4d\uff0c\u5206\u5e03\u4e8e 7 \u4e2a\u56fd\u5bb6\u548c\u5730\u533a<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>GLP-1 <\/strong><strong>\u83b7\u5956\u8005\uff5c<\/strong>Daniel J. Drucker\u3001Jens Juul Holst\u3001Svetlana Mojsov<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u83b7\u5956\u7406\u7531\uff5c<\/strong>\u53d1\u73b0\u5e76\u9274\u5b9a GLP-1\uff0c\u7cfb\u7edf\u9610\u660e\u5176\u751f\u7269\u6d3b\u6027\u673a\u5236<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u5386\u53f2\u547d\u4e2d\u7387\uff5c<\/strong>\u81ea 2002 \u5e74\u8bbe\u7acb\u4ee5\u6765\uff0c\u5df2\u6709 89 \u4f4d\u5f97\u4e3b\u83b7\u8bfa\u8d1d\u5c14\u5956<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5f15\u6587\u6842\u51a0\u5956\u7531\u79d1\u777f\u552f\u5b89\u79d1\u5b66\u4fe1\u606f\u7814\u7a76\u6240\uff08ISI\uff09\u57fa\u4e8e Web of Science \u5f15\u6587\u6570\u636e\u9074\u9009\uff0c\u88ab\u8a89\u4e3a\u300c\u8bfa\u5956\u98ce\u5411\u6807\u300d\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Drucker \u5728\u83b7\u5956\u611f\u8a00\u4e2d\u8868\u793a\uff1a\u300cGLP-1 \u836f\u7269\u7684\u7814\u53d1\u5386\u7a0b\uff0c\u5370\u8bc1\u4e86\u597d\u5947\u5fc3\u9a71\u52a8\u7684\u57fa\u7840\u7814\u7a76\u8574\u85cf\u7684\u5f3a\u5927\u529b\u91cf\u3002\u8fd9\u9879\u7814\u7a76\u59cb\u4e8e\u63a2\u7a76\u80a0\u9053\u6fc0\u7d20\u5982\u4f55\u8c03\u63a7\u4eba\u4f53\u4ee3\u8c22\uff0c\u6700\u7ec8\u8f6c\u5316\u800c\u6210\u7684\u7597\u6cd5\u6539\u5584\u4e86\u5168\u7403\u6570\u767e\u4e07\u4eba\u7684\u751f\u6d3b\u3002\u300d<strong><sup>[1]<\/sup><\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5bf9\u4e8e\u4e34\u5e8a\u5f00\u53d1\u4ece\u4e1a\u8005\u800c\u8a00\uff0c\u8fd9\u4e00\u5956\u9879\u7684\u610f\u4e49\u8fdc\u4e0d\u6b62\u4e8e\u5b66\u672f\u8363\u8a89\u3002\u5b83\u6807\u5fd7\u7740 GLP-1 \u4ece\u4e00\u4e2a\u57fa\u7840\u79d1\u5b66\u53d1\u73b0\u5230\u5168\u7403\u6700\u70ed\u95e8\u4e34\u5e8a\u5f00\u53d1\u9886\u57df\u7684\u5b8c\u6574\u8f6c\u5316\u94fe\u6761\uff0c\u83b7\u5f97\u4e86\u300c\u8bfa\u5956\u7ea7\u300d\u7684\u6743\u5a01\u8ba4\u53ef\u3002<\/p>\n\n\n\n<h5 class=\"wp-block-heading\"><strong>\u4e00\u3001\u4ece\u300c\u80a0\u4fc3\u80f0\u7d20\u6548\u5e94\u300d\u5230\u53d7\u4f53\u6fc0\u52a8\u5242\uff1a\u9776\u70b9\u9a8c\u8bc1\u7684\u6f2b\u957f\u9a6c\u62c9\u677e<\/strong><\/h5>\n\n\n\n<p class=\"wp-block-paragraph\">GLP-1 \u7684\u7814\u7a76\u59cb\u4e8e\u5bf9\u300c\u80a0\u4fc3\u80f0\u7d20\u6548\u5e94\u300d\u7684\u63a2\u7d22\u2014\u2014\u53e3\u670d\u8461\u8404\u7cd6\u6bd4\u9759\u8109\u6ce8\u5c04\u8461\u8404\u7cd6\u66f4\u80fd\u523a\u6fc0\u80f0\u5c9b\u7d20\u5206\u6ccc\u3002\u8fd9\u4e00\u73b0\u8c61\u6700\u65e9\u7531 McIntyre \u7b49\u4e0e Elrick \u7b49\u4e24\u7ec4\u7814\u7a76\u8005\u4e8e 1964 \u5e74\u5206\u522b\u8bc1\u5b9e<strong><sup>[3]<\/sup><\/strong>\u3002GLP-1 \u7684\u5e8f\u5217\u4e8e 1983 \u5e74\u7531 Bell \u7b49\u4ece\u80f0\u9ad8\u8840\u7cd6\u7d20\u524d\u4f53\u57fa\u56e0\uff08proglucagon\uff09\u4e2d\u9274\u5b9a\u5e76\u547d\u540d\uff1b\u800c\u5176\u771f\u6b63\u7684\u751f\u7269\u6d3b\u6027\u5f62\u5f0f\u2014\u2014GLP-1(7-37) \/ GLP-1(7-36) amide\u2014\u2014\u5219\u7531 Mojsov \u4e0e Holst \u7b49\u56e2\u961f\u4e8e 1987 \u5e74\u786e\u8ba4\u4e3a\u80a0\u4fc3\u80f0\u7d20<strong><sup>[4,5]<\/sup><\/strong>\u3002\u4ece 1987 \u5e74\u5230 2005 \u5e74\u9996\u4e2a GLP-1 \u53d7\u4f53\u6fc0\u52a8\u5242\uff08\u827e\u585e\u90a3\u80bd\uff0cExenatide\uff09\u83b7 FDA \u6279\u51c6\uff0c\u8f6c\u5316\u5468\u671f\u7ea6\u5341\u516b\u5e74<strong><sup>[6]<\/sup><\/strong>\uff1b\u6b64\u540e\u53f8\u7f8e\u683c\u9c81\u80bd\u548c\u66ff\u5c14\u6cca\u80bd\u76f8\u7ee7\u6210\u4e3a\u5168\u7403\u91cd\u78c5\u836f\u7269\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>GLP-1 <\/strong><strong>\u4ece\u53d1\u73b0\u5230\u5546\u4e1a\u5316\u7684\u5173\u952e\u8282\u70b9<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>1964 <\/strong><strong>\u5e74\uff5c<\/strong>\u300c\u80a0\u4fc3\u80f0\u7d20\u6548\u5e94\u300d\u88ab\u8bc1\u5b9e\uff1a\u53e3\u670d\u8461\u8404\u7cd6\u7684\u80f0\u5c9b\u7d20\u53cd\u5e94\u5f3a\u4e8e\u9759\u8109\u6ce8\u5c04<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>1983 <\/strong><strong>\u5e74\uff5c<\/strong>Bell \u7b49\u4ece proglucagon \u57fa\u56e0\u4e2d\u9274\u5b9a\u5e76\u547d\u540d GLP-1 \u5e8f\u5217<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>1987 <\/strong><strong>\u5e74\uff5c<\/strong>Mojsov \/ Holst \u7b49\u786e\u8ba4 GLP-1(7-37) \u4e3a\u5177\u80f0\u5c9b\u7d20\u4fc3\u6ccc\u6d3b\u6027\u7684\u80a0\u4fc3\u80f0\u7d20<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>2005 <\/strong><strong>\u5e74<\/strong><strong> 4 <\/strong><strong>\u6708\uff5c<\/strong>FDA \u6279\u51c6\u827e\u585e\u90a3\u80bd\uff08Exenatide \/ Byetta\uff09\uff0c\u9996\u4e2a GLP-1 \u53d7\u4f53\u6fc0\u52a8\u5242<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>2010 <\/strong><strong>\u5e74\uff5c<\/strong>FDA \u6279\u51c6\u5229\u62c9\u9c81\u80bd\uff08Liraglutide\uff09\uff0c\u6bcf\u65e5\u4e00\u6b21\u5242\u578b<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>2017 \/ 2022 <\/strong><strong>\u5e74\uff5c<\/strong>\u53f8\u7f8e\u683c\u9c81\u80bd\u3001\u66ff\u5c14\u6cca\u80bd\u76f8\u7ee7\u83b7\u6279\uff0c\u8fdb\u5165\u51cf\u91cd\u4e0e\u591a\u9002\u5e94\u75c7\u65f6\u4ee3<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e34\u5e8a\u5f00\u53d1\u542f\u793a\uff1aGLP-1 \u7684\u6848\u4f8b\u8868\u660e\uff0c\u57fa\u7840\u79d1\u5b66\u7684\u7a81\u7834\u5f80\u5f80\u9700\u8981\u6570\u5341\u5e74\u624d\u80fd\u8f6c\u5316\u4e3a\u4e34\u5e8a\u7597\u6cd5\u3002\u5bf9\u4e8e\u4e34\u5e8a\u7814\u7a76\u670d\u52a1\u65b9\u800c\u8a00\uff0c\u8fd9\u610f\u5473\u7740\u5728\u8bc4\u4f30\u65e9\u671f\u9879\u76ee\u65f6\uff0c\u9700\u8981\u5177\u5907\u957f\u5468\u671f\u89c6\u89d2\u2014\u2014\u4e00\u4e2a\u9776\u70b9\u7684\u79d1\u5b66\u4ef7\u503c\uff0c\u4e0d\u5e94\u4ec5\u4ee5\u77ed\u671f\u7684\u4e34\u5e8a\u8fdb\u5c55\u901f\u5ea6\u6765\u8861\u91cf\u3002\u540c\u65f6\uff0cGLP-1 \u4ece\u7cd6\u5c3f\u75c5\u5230\u80a5\u80d6\u75c7\u3001\u518d\u5230 NASH\u3001\u5fc3\u8870\u3001\u6162\u6027\u80be\u75c5\u7684\u9002\u5e94\u75c7\u62d3\u5c55\u8def\u5f84\uff0c\u5c55\u793a\u4e86\u300c\u6838\u5fc3\u9776\u70b9 + \u591a\u9002\u5e94\u75c7\u5ef6\u4f38\u300d\u7684\u4e34\u5e8a\u5f00\u53d1\u7b56\u7565\u4ef7\u503c\u3002<\/p>\n\n\n\n<h5 class=\"wp-block-heading\"><strong>\u4e8c\u3001\u5fc3\u8840\u7ba1\u7ed3\u5c40\u8bd5\u9a8c\uff08<\/strong><strong>CVOT<\/strong><strong>\uff09\uff1a\u4ece\u300c\u964d\u7cd6\u300d\u5230\u300c\u964d\u98ce\u9669\u300d\u7684\u8bc1\u636e\u5347\u7ea7<\/strong><\/h5>\n\n\n\n<p class=\"wp-block-paragraph\">GLP-1 \u53d7\u4f53\u6fc0\u52a8\u5242\u7684\u4e34\u5e8a\u5f00\u53d1\u5386\u7a0b\u4e2d\uff0c\u5fc3\u8840\u7ba1\u7ed3\u5c40\u8bd5\u9a8c\uff08CVOT\uff09\u662f\u5173\u952e\u7684\u8f6c\u6298\u70b9\u30022007 \u5e74\u7f57\u683c\u5217\u916e\u5fc3\u808c\u6897\u6b7b\u98ce\u9669\u4e89\u8bae\u5f15\u53d1\u56fd\u4f1a\u8c03\u67e5\u540e\uff0cFDA \u4e8e 2008 \u5e74 12 \u6708\u53d1\u5e03\u6307\u5357\uff0c\u5efa\u8bae\u6240\u6709\u65b0\u578b\u964d\u7cd6\u836f\u5728\u4e0a\u5e02\u524d\u6392\u9664\u4e0d\u53ef\u63a5\u53d7\u7684\u5fc3\u8840\u7ba1\u98ce\u9669\uff08\u4ee5 95% \u7f6e\u4fe1\u533a\u95f4\u4e0a\u9650\u6392\u9664\u98ce\u9669\u6bd4 1.8 \u4e3a\u754c\uff0c\u4e0a\u5e02\u540e\u9700\u6392\u9664 1.3\uff09<strong><sup>[7]<\/sup><\/strong>\u3002\u6307\u5357\u539f\u6587\u7528\u7684\u662f\u300cshould\u300d\uff08\u5efa\u8bae\uff09\uff0c\u5e76\u5141\u8bb8\u4ee5 2\/3 \u671f\u8bd5\u9a8c\u7684 meta \u5206\u6790\u4f5c\u4e3a\u9ed8\u8ba4\u8def\u5f84\uff1b\u4f46\u5728\u5b9e\u8df5\u4e2d\uff0c2008 \u5e74\u4e4b\u540e\u83b7\u6279\u7684\u6bcf\u4e00\u4e2a\u65b0\u578b\u964d\u7cd6\u836f\u51e0\u4e4e\u90fd\u5f00\u5c55\u4e86\u4e13\u95e8\u7684\u5fc3\u8840\u7ba1\u7ed3\u5c40\u8bd5\u9a8c<strong><sup>[8]<\/sup><\/strong>\u3002\u8fd9\u4e00\u76d1\u7ba1\u8981\u6c42\uff0c\u610f\u5916\u5730\u6210\u4e3a\u4e86 GLP-1 \u7c7b\u836f\u7269\u5c55\u793a\u5fc3\u8840\u7ba1\u83b7\u76ca\u7684\u5e73\u53f0\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">CVOT \u7684\u8bbe\u8ba1\u548c\u6267\u884c\u662f\u5927\u89c4\u6a21\u3001\u957f\u5468\u671f\u3001\u9ad8\u6210\u672c\u7684\u4e34\u5e8a\u7814\u7a76\u5de5\u7a0b\u3002\u5bf9\u4e8e\u8ba1\u5212\u8fdb\u5165\u4ee3\u8c22\u75be\u75c5\u9886\u57df\u7684\u7533\u529e\u65b9\uff0c\u5fc3\u8840\u7ba1\u7ec8\u70b9\u4e8b\u4ef6\u7684 adjudication \u6d41\u7a0b\u3001\u4e2d\u5fc3\u5b9e\u9a8c\u5ba4\u7684\u6807\u51c6\u5316\u3001\u4ee5\u53ca\u957f\u671f\u968f\u8bbf\u7684\u60a3\u8005\u4fdd\u7559\u7b56\u7565\uff0c\u662f\u4e34\u5e8a\u8fd0\u8425\u7684\u6838\u5fc3\u6311\u6218\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">CVOT \u7684\u8bbe\u8ba1\u9700\u8981\u4e0e\u76d1\u7ba1\u673a\u6784\u5728 III \u671f\u542f\u52a8\u524d\u5c31\u7ec8\u70b9\u9009\u62e9\u548c\u7edf\u8ba1\u5047\u8bbe\u8fbe\u6210\u4e00\u81f4\uff0c\u5426\u5219\u53ef\u80fd\u5bfc\u81f4\u8bd5\u9a8c\u65e0\u6cd5\u652f\u6301\u6807\u7b7e\u6269\u5c55\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">FDA \u6307\u5357\u5bf9\u4e0a\u5e02\u524d \/ \u4e0a\u5e02\u540e\u7684\u98ce\u9669\u6bd4\u6392\u9664\u9608\u503c\uff081.8 \/ 1.3\uff09\u6709\u660e\u786e\u533a\u5206\uff0c\u65b9\u6848\u8bbe\u8ba1\u65f6\u5e94\u5c06\u8fd9\u4e00\u5206\u5c42\u8981\u6c42\u524d\u7f6e\u5230\u7edf\u8ba1\u5047\u8bbe\u4e2d\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">LEADER\uff08\u5229\u62c9\u9c81\u80bd\uff09\u3001SUSTAIN-6\uff08\u53f8\u7f8e\u683c\u9c81\u80bd\u76ae\u4e0b\u6ce8\u5c04\uff09\u3001REWIND\uff08\u5ea6\u62c9\u7cd6\u80bd\uff09\u7b49\u8bd5\u9a8c\u76f8\u7ee7\u8bc1\u5b9e\u4e86 GLP-1 \u53d7\u4f53\u6fc0\u52a8\u5242\u5728\u964d\u4f4e\u4e3b\u8981\u5fc3\u8840\u7ba1\u4e0d\u826f\u4e8b\u4ef6\uff08<a><\/a><a>3-point MACE<\/a>\uff0c\u5373\u5fc3\u8840\u7ba1\u6b7b\u4ea1\u3001\u975e\u81f4\u6b7b\u6027\u5fc3\u808c\u6897\u6b7b\u3001\u975e\u81f4\u6b7b\u6027\u5352\u4e2d\uff09\u65b9\u9762\u7684\u83b7\u76ca\uff0c\u98ce\u9669\u6bd4\u5206\u522b\u4e3a 0.87\u30010.74 \u548c 0.88<strong><sup>[9]<\/sup><\/strong>\u3002\u540e\u7eed\u7684 Harmony Outcomes\uff08albiglutide\uff09\u548c SOUL\uff08\u53e3\u670d semaglutide\uff09\u7b49 CVOT \u8fdb\u4e00\u6b65\u4e30\u5bcc\u4e86 GLP-1 \u7684\u5fc3\u8840\u7ba1\u8bc1\u636e\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u4e0d\u540c\u5206\u5b50\u7684\u83b7\u76ca\u9a71\u52a8\u56e0\u7d20\u5e76\u4e0d\u4e00\u81f4\u2014\u2014<a><\/a><a>REWIND <\/a>\u7684\u83b7\u76ca\u4e3b\u8981\u7531\u5352\u4e2d\u9a71\u52a8\uff0c\u800c Harmony \u4e0e SOUL \u5219\u4e3b\u8981\u7531\u5fc3\u808c\u6897\u6b7b\u9a71\u52a8<strong><sup>[10]<\/sup><\/strong>\u3002\u8fd9\u4e00\u5dee\u5f02\u76ee\u524d\u4ecd\u5c5e\u4e8e\u8bd5\u9a8c\u5c42\u9762\u7684\u89c2\u5bdf\uff0c\u5c1a\u4e0d\u80fd\u76f4\u63a5\u63a8\u5bfc\u4e3a\u836f\u7269\u7c7b\u6548\u5e94\u5dee\u5f02\u3002<\/p>\n\n\n\n<h5 class=\"wp-block-heading\"><strong>\u4e09\u3001\u80a5\u80d6\u75c7\u4e34\u5e8a\u8bd5\u9a8c\u7684\u7ec8\u70b9\u6807\u51c6\u5316\uff1a\u4ece<\/strong><strong> BMI <\/strong><strong>\u5230\u751f\u6d3b\u8d28\u91cf<\/strong><\/h5>\n\n\n\n<p class=\"wp-block-paragraph\">GLP-1 \u7c7b\u836f\u7269\u5728\u80a5\u80d6\u75c7\u9886\u57df\u7684\u6210\u529f\uff0c\u63a8\u52a8\u4e86\u80a5\u80d6\u75c7\u4e34\u5e8a\u8bd5\u9a8c\u7ec8\u70b9\u4f53\u7cfb\u7684\u6f14\u53d8\u3002\u4ece\u65e9\u671f\u7684\u4f53\u91cd\u767e\u5206\u6bd4\u53d8\u5316\uff0c\u5230 BMI \u5206\u7c7b\u6539\u5584\uff0c\u518d\u5230\u60a3\u8005\u62a5\u544a\u7ed3\u5c40\uff08PRO\uff09\u5982\u751f\u6d3b\u8d28\u91cf\u3001\u8eab\u4f53\u529f\u80fd\u3001\u5fc3\u7406\u5065\u5eb7\u7b49\u7ef4\u5ea6\u7684\u7eb3\u5165\uff0c\u80a5\u80d6\u75c7\u8bd5\u9a8c\u7684\u7ec8\u70b9\u8bbe\u8ba1\u6b63\u5728\u53d8\u5f97\u66f4\u52a0\u4ee5\u60a3\u8005\u4e3a\u4e2d\u5fc3\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u4e3b\u8981\u80a5\u80d6\u75c7\u8bd5\u9a8c\u7ec8\u70b9\u6f14\u8fdb<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u5171\u540c\u4e3b\u8981\u7ec8\u70b9\uff5c<\/strong>\u4f53\u91cd\u81ea\u57fa\u7ebf\u53d8\u5316\u767e\u5206\u6bd4 + \u51cf\u91cd \u22655% \u7684\u53d7\u8bd5\u8005\u6bd4\u4f8b<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u5173\u952e\u6b21\u8981\u7ec8\u70b9\uff5c<\/strong>\u51cf\u91cd \u226510% \/ \u226515% \/ \u226520% \u7684\u53d7\u8bd5\u8005\u6bd4\u4f8b\u3001\u8170\u56f4\u53d8\u5316<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>PRO <\/strong><strong>\u91cf\u8868\uff5c<\/strong>IWQOL-Lite-CT \u8eab\u4f53\u529f\u80fd\u590d\u5408\u8bc4\u5206\u3001SF-36v2 \u8eab\u4f53\u529f\u80fd\u57df<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u5b89\u5168\u6027\u7ec8\u70b9\uff5c<\/strong>TEAE\u3001\u56e0\u4e0d\u826f\u4e8b\u4ef6\u505c\u836f\u7387<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u957f\u671f\u6027\u8981\u6c42\uff5c<\/strong>FDA \u6307\u5357\u8349\u6848\u8981\u6c42\u8bc1\u660e\u5728\u7ef4\u6301\u5242\u91cf\u671f\u95f4\u81f3\u5c11 1 \u5e74\u7684\u6301\u7eed\u51cf\u91cd<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">SURMOUNT-1 \u540c\u65f6\u91c7\u96c6 IWQOL-Lite-CT \u4e0e SF-36v2 \u4f5c\u4e3a\u6b21\u8981\u7ec8\u70b9\uff0c\u88ab\u8ba4\u4e3a\u662f\u5f53\u524d\u4e3b\u6d41\u8bbe\u8ba1\u7684\u4ee3\u8868\u4e4b\u4e00\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u80a5\u80d6\u75c7\u8bd5\u9a8c\u7684 PRO \u8bbe\u8ba1\u9700\u8981\u4e0e\u652f\u4ed8\u65b9\u7684\u4ef7\u503c\u5224\u65ad\u5bf9\u9f50\u3002\u5982\u679c\u4e00\u6b3e\u51cf\u80a5\u836f\u7269\u53ea\u80fd\u5c55\u793a\u4f53\u91cd\u4e0b\u964d\uff0c\u4f46\u65e0\u6cd5\u8bc1\u660e\u751f\u6d3b\u8d28\u91cf\u7684\u6539\u5584\u6216\u5e76\u53d1\u75c7\u7684\u51cf\u5c11\uff0c\u5176\u62a5\u9500\u524d\u666f\u5c06\u53d7\u5230\u9650\u5236\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">SF-36\u3001IWQOL-Lite \u7b49\u6807\u51c6\u5316\u91cf\u8868\u7684\u9009\u62e9\uff0c\u4ee5\u53ca PRO \u6570\u636e\u5728\u6ce8\u518c\u7533\u62a5\u4e2d\u7684\u5b9a\u4f4d\uff0c\u9700\u8981\u5728\u65b9\u6848\u8bbe\u8ba1\u9636\u6bb5\u5c31\u660e\u786e\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">FDA \u8fd1\u5e74\u5bf9\u80a5\u80d6\u75c7\u8bd5\u9a8c\u7684\u5efa\u8bae\u5df2\u6269\u5c55\u5230\u8eab\u4f53\u529f\u80fd\u4e0e\u795e\u7ecf\u7cbe\u795e\u7ed3\u5c40\uff08\u5982 PHQ-9\u3001C-SSRS\uff09\uff0c\u7533\u529e\u65b9\u5e94\u4e3b\u52a8\u5c06 COA \u9009\u62e9\u4e0e\u76d1\u7ba1\u9884\u671f\u5bf9\u9f50\u3002<\/p>\n\n\n\n<h5 class=\"wp-block-heading\"><strong>\u56db\u3001\u53e3\u670d<\/strong><strong> GLP-1 <\/strong><strong>\u7684\u4e34\u5e8a\u5f00\u53d1\u6311\u6218\uff1a\u751f\u7269\u5229\u7528\u5ea6\u4e0e\u5b89\u5168\u6027\u76d1\u6d4b<\/strong><\/h5>\n\n\n\n<p class=\"wp-block-paragraph\">\u4ece\u6ce8\u5c04\u5242\u5230\u53e3\u670d\u5236\u5242\uff0cGLP-1 \u7c7b\u836f\u7269\u7684\u4e34\u5e8a\u5f00\u53d1\u9762\u4e34\u751f\u7269\u5229\u7528\u5ea6\u4f4e\u3001\u80c3\u80a0\u9053\u526f\u4f5c\u7528\u7ba1\u7406\u3001\u4ee5\u53ca\u60a3\u8005\u4f9d\u4ece\u6027\u7b49\u72ec\u7279\u6311\u6218\u3002\u53e3\u670d\u53f8\u7f8e\u683c\u9c81\u80bd\uff08Rybelsus\uff09\u4e8e 2019 \u5e74 9 \u6708 20 \u65e5\u83b7 FDA \u6279\u51c6\uff0c\u6210\u4e3a\u9996\u4e2a\u53e3\u670d GLP-1 \u53d7\u4f53\u6fc0\u52a8\u5242<strong><sup>[11]<\/sup><\/strong>\uff0c\u5176\u91c7\u7528 SNAC \u5438\u6536\u4fc3\u8fdb\u5242\u5b9e\u73b0\u80c3\u9ecf\u819c\u5438\u6536\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a><\/a><a><strong>\u53e3\u670d\u53f8\u7f8e\u683c\u9c81\u80bd\uff08<\/strong><\/a><strong>Rybelsus<\/strong><strong>\uff09\u5173\u952e\u53c2\u6570<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u6279\u51c6\u65f6\u95f4\uff5c<\/strong>2019 \u5e74 9 \u6708 20 \u65e5\uff08FDA\uff09<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u7edd\u5bf9\u751f\u7269\u5229\u7528\u5ea6\uff5c<\/strong>\u7ea6 0.4% \u2013 1%<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u7ed9\u836f\u8981\u6c42\uff5c<\/strong>\u7a7a\u8179\u3001\u6bcf\u65e5\u9996\u6b21\u8fdb\u98df\u524d\u81f3\u5c11 30 \u5206\u949f\u3001\u4e0d\u8d85\u8fc7 4 \u76ce\u53f8\u6e05\u6c34\uff08\u7ea6\u5408120 mL\uff0c\u8d85\u51fa\u4f1a\u663e\u8457\u964d\u4f4e\u5438\u6536\uff09<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u5242\u91cf\u9012\u589e\uff5c<\/strong>3 mg\uff081 \u4e2a\u6708\uff09\u2192 7 mg \u2192 14 mg\uff0c\u9010\u7ea7\u9012\u589e<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u5438\u6536\u4fc3\u8fdb\u5242\uff5c<\/strong>SNAC\uff08salcaprozate sodium\uff09<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e25\u683c\u7684\u7a7a\u8179\u670d\u836f\u8981\u6c42\u548c\u5242\u91cf\u9012\u589e\u65b9\u6848\uff0c\u53cd\u6620\u4e86\u591a\u80bd\u7c7b\u836f\u7269\u53e3\u670d\u9012\u9001\u7684\u5de5\u7a0b\u96be\u5ea6\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a><\/a><a>\u53e3\u670d<\/a> GLP-1 \u8bd5\u9a8c\u7684\u8bbe\u8ba1\u9700\u8981\u7279\u522b\u5173\u6ce8\u7ed9\u836f\u65b9\u6848\u7684\u4f9d\u4ece\u6027\u76d1\u6d4b\u3001\u80c3\u80a0\u9053\u4e0d\u826f\u4e8b\u4ef6\u7684\u7ba1\u7406\u7b56\u7565\u3001\u4ee5\u53ca\u98df\u7269-\u836f\u7269\u76f8\u4e92\u4f5c\u7528\u7684\u8bc4\u4f30\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u53e3\u670d\u5236\u5242\u7684\u836f\u4ee3\u52a8\u529b\u5b66\u53d8\u5f02\u6027\u53ef\u80fd\u6bd4\u6ce8\u5c04\u5242\u66f4\u5927\uff08\u66b4\u9732\u91cf\u968f\u4f53\u91cd\u5347\u9ad8\u800c\u4e0b\u964d\uff09\uff0c\u9700\u8981\u5728\u65e9\u671f\u4e34\u5e8a\u9636\u6bb5\u8fdb\u884c\u5145\u5206\u7684\u5242\u91cf\u63a2\u7d22\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u975e\u80bd\u7c7b\u5c0f\u5206\u5b50\u53e3\u670d GLP-1\uff08\u5982 <a><\/a><a>orforglipron<\/a>\uff1a\u4e2d\u6587\u540d\u5965\u683c\u5217\u9686\uff0c\u5546\u54c1\u540dFoundayo\uff0c2026\u5e744\u6708\u83b7FDA\u6279\u51c6\uff09\u5df2\u4e0d\u518d\u9700\u8981\u7a7a\u8179\u670d\u7528\u9650\u5236\uff0c\u8fd9\u4e00\u6280\u672f\u8def\u7ebf\u7684\u8fed\u4ee3\u6b63\u5728\u91cd\u5851\u540e\u7eed\u8bd5\u9a8c\u7684\u8bbe\u8ba1\u5047\u8bbe\u3002<\/p>\n\n\n\n<h5 class=\"wp-block-heading\"><strong>\u884c\u4e1a\u5f71\u54cd\u5206\u6790\uff1a<\/strong><strong>GLP-1 <\/strong><strong>\u83b7\u5956\u5bf9\u4e34\u5e8a\u5f00\u53d1\u683c\u5c40\u7684\u4e09\u4e2a\u4fe1\u53f7<\/strong><\/h5>\n\n\n\n<p class=\"wp-block-paragraph\">\u4fe1\u53f7\u4e00\uff1a\u4ee3\u8c22\u75be\u75c5\u9886\u57df\u7684\u4e34\u5e8a\u5f00\u53d1\u7ade\u4e89\u5c06\u8fdb\u4e00\u6b65\u52a0\u5267\u3002\u5f15\u6587\u6842\u51a0\u5956\u7684\u8ba4\u53ef\uff0c\u5c06\u8fdb\u4e00\u6b65\u63d0\u5347 GLP-1 \u9886\u57df\u7684\u8d44\u672c\u5173\u6ce8\u5ea6\u548c\u4e34\u5e8a\u5f00\u53d1\u70ed\u5ea6\u3002\u76ee\u524d\uff0c\u5168\u7403\u5df2\u6709\u6570\u5341\u4e2a GLP-1 \u76f8\u5173\u5019\u9009\u836f\u7269\u5904\u4e8e\u4e34\u5e8a\u9636\u6bb5\uff0c\u8986\u76d6\u53e3\u670d\u5c0f\u5206\u5b50\u3001\u53cc\u9776\u70b9 \/ \u4e09\u9776\u70b9\u6fc0\u52a8\u5242\u3001\u4ee5\u53ca\u4e0e\u80f0\u5c9b\u7d20 \/ \u80f0\u6dc0\u7d20\u7684\u8054\u5408\u7597\u6cd5\u3002\u5bf9\u4e8e\u4e34\u5e8a\u7814\u7a76\u670d\u52a1\u65b9\u800c\u8a00\uff0c\u8fd9\u610f\u5473\u7740\u4ee3\u8c22\u75be\u75c5\u9886\u57df\u7684\u4e2d\u5fc3\u8d44\u6e90\u7ade\u4e89\u5c06\u66f4\u52a0\u6fc0\u70c8\uff0c\u5177\u5907 GLP-1 \u8bd5\u9a8c\u7ecf\u9a8c\u7684\u4e34\u5e8a\u4e2d\u5fc3\u548c\u7814\u7a76\u8005\u5c06\u6210\u4e3a\u7a00\u7f3a\u8d44\u6e90\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4fe1\u53f7\u4e8c\uff1aGLP-1 \u7684\u9002\u5e94\u75c7\u62d3\u5c55\u5c06\u63a8\u52a8\u66f4\u591a\u300c\u7bee\u5b50\u8bd5\u9a8c\u300d\u8bbe\u8ba1\u3002\u4ece\u7cd6\u5c3f\u75c5\u5230\u80a5\u80d6\u75c7\uff0c\u518d\u5230 MASH\u3001\u5fc3\u8870\u3001\u6162\u6027\u80be\u75c5\u3001\u963b\u585e\u6027\u7761\u7720\u547c\u5438\u6682\u505c\uff0cGLP-1 \u7684\u9002\u5e94\u75c7\u63a2\u7d22\u6b63\u5728\u52a0\u901f\u3002\u8fd9\u79cd\u300c\u540c\u4e00\u9776\u70b9\u3001\u591a\u75be\u75c5\u9886\u57df\u300d\u7684\u5f00\u53d1\u6a21\u5f0f\uff0c\u9700\u8981\u7bee\u5b50\u8bd5\u9a8c\uff08Basket Trial\uff0c\u540c\u4e00\u9776\u70b9\/\u836f\u7269\uff0c\u6d4b\u8bd5\u591a\u4e2a\u4e0d\u540c\u75be\u75c5\uff08\u5982GLP-1\u5728\u7cd6\u5c3f\u75c5\u3001\u80a5\u80d6\u3001MASH\u3001\u5fc3\u8870\u4e2d\u7684\u5e76\u884c\u63a2\u7d22\uff09\uff09\u7684\u8bbe\u8ba1\u80fd\u529b\uff0c\u4ee5\u9ad8\u6548\u8bc4\u4f30\u836f\u7269\u5728\u591a\u4e2a\u9002\u5e94\u75c7\u4e2d\u7684\u6f5c\u5728\u83b7\u76ca\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4fe1\u53f7\u4e09\uff1a\u57fa\u7840\u79d1\u5b66\u4e0e\u4e34\u5e8a\u5f00\u53d1\u7684\u300c\u8f6c\u5316\u9e3f\u6c9f\u300d\u9700\u8981\u66f4\u7cfb\u7edf\u7684\u6865\u63a5\u3002GLP-1 \u4ece 1987 \u5e74\u786e\u8ba4\u751f\u7269\u6d3b\u6027\u5230 2005 \u5e74\u9996\u4e2a\u836f\u7269\u83b7\u6279\uff0c\u7528\u65f6\u7ea6\u5341\u516b\u5e74\uff0c\u5176\u4e2d\u57fa\u7840\u7814\u7a76\u4e0e\u4e34\u5e8a\u5f00\u53d1\u4e4b\u95f4\u7684\u8f6c\u5316\u6548\u7387\u662f\u6838\u5fc3\u74f6\u9888\u3002\u5bf9\u4e8e\u4e34\u5e8a\u7814\u7a76\u670d\u52a1\u65b9\u800c\u8a00\uff0c\u8fd9\u610f\u5473\u7740\u65e9\u671f\u4e34\u5e8a\u9636\u6bb5\u7684\u79d1\u5b66\u4e25\u8c28\u6027\u548c\u8f6c\u5316\u533b\u5b66\u80fd\u529b\u6b63\u5728\u6210\u4e3a\u5dee\u5f02\u5316\u7ade\u4e89\u7684\u5173\u952e\u2014\u2014\u4e0d\u4ec5\u4ec5\u662f\u6267\u884c\u8bd5\u9a8c\uff0c\u66f4\u662f\u5e2e\u52a9\u7533\u529e\u65b9\u8bbe\u8ba1\u6b63\u786e\u7684\u65e9\u671f\u8bd5\u9a8c\u6765\u9a8c\u8bc1\u9776\u70b9\u5047\u8bbe\u3002<\/p>\n\n\n\n<h5 class=\"wp-block-heading\"><strong>\u7efc\u5408\u89c2\u5bdf\uff1a\u57fa\u7840\u79d1\u5b66\u7684\u300c\u8bfa\u5956\u7ea7\u300d\u8ba4\u53ef\uff0c\u6700\u7ec8\u8981\u5728\u4e34\u5e8a\u5f00\u53d1\u4e2d\u5151\u73b0<\/strong><\/h5>\n\n\n\n<p class=\"wp-block-paragraph\">\u5f15\u6587\u6842\u51a0\u5956\u7684\u8868\u5f70\uff0c\u662f\u5bf9 GLP-1 \u57fa\u7840\u79d1\u5b66\u4ef7\u503c\u7684\u786e\u8ba4\u3002\u4f46\u8fd9\u79cd\u529b\u91cf\u7684\u6700\u7ec8\u5151\u73b0\uff0c\u53d6\u51b3\u4e8e\u4e34\u5e8a\u5f00\u53d1\u80fd\u5426\u5c06\u57fa\u7840\u79d1\u5b66\u7684\u53d1\u73b0\u8f6c\u5316\u4e3a\u53ef\u6ce8\u518c\u3001\u53ef\u62a5\u9500\u3001\u53ef\u53ca\u7684\u6cbb\u7597\u65b9\u6848\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5bf9\u4e8e\u4e34\u5e8a\u7814\u7a76\u670d\u52a1\u65b9\u800c\u8a00\uff0cGLP-1 \u7684\u6545\u4e8b\u63d0\u4f9b\u4e86\u4e00\u4e2a\u91cd\u8981\u7684\u542f\u793a\uff1a\u4e00\u4e2a\u9776\u70b9\u7684\u6210\u529f\uff0c\u4e0d\u4ec5\u662f\u79d1\u5b66\u95ee\u9898\uff0c\u66f4\u662f\u4e34\u5e8a\u7b56\u7565\u3001\u76d1\u7ba1\u8def\u5f84\u3001\u652f\u4ed8\u65b9\u8bc1\u636e\u548c\u4f9b\u5e94\u94fe\u80fd\u529b\u7684\u7cfb\u7edf\u5de5\u7a0b\u3002\u4ece CVOT \u7684\u8bbe\u8ba1\u5230 PRO \u7684\u6807\u51c6\u5316\uff0c\u4ece\u53e3\u670d\u5236\u5242\u7684\u751f\u7269\u5229\u7528\u5ea6\u6311\u6218\u5230\u591a\u9002\u5e94\u75c7\u7684\u7bee\u5b50\u8bd5\u9a8c\uff0c\u6bcf\u4e00\u4e2a\u73af\u8282\u90fd\u9700\u8981\u4e13\u4e1a\u7684\u4e34\u5e8a\u5f00\u53d1\u80fd\u529b\u6765\u652f\u6491\u3002<\/p>\n\n\n\n<h5 class=\"wp-block-heading\"><strong>\u4e00\u53e5\u8bdd\u603b\u7ed3<\/strong><\/h5>\n\n\n\n<p class=\"wp-block-paragraph\">\u79d1\u5b66\u521b\u610f\u53ea\u662f\u8d77\u70b9\uff0c\u5c06\u521b\u610f\u8f6c\u5316\u4e3a\u53ef\u6ce8\u518c\u3001\u53ef\u5546\u4e1a\u5316\u6570\u636e\u7684\u4e34\u5e8a\u6267\u884c\u80fd\u529b\uff0c\u624d\u662f\u7a7f\u8d8a\u5468\u671f\u7684\u6838\u5fc3\u7ade\u4e89\u529b\u3002<\/p>\n\n\n\n<h5 class=\"wp-block-heading\"><strong>\u9644\uff1a<\/strong><strong>2026 <\/strong><strong>\u5e74\u5ea6\u5f15\u6587\u6842\u51a0\u5956\u83b7\u5956\u5168\u540d\u5355<\/strong><\/h5>\n\n\n\n<p class=\"wp-block-paragraph\">2026 \u5e74\u5ea6\u5f15\u6587\u6842\u51a0\u5956\u5171 22 \u4f4d\u5f97\u4e3b\uff0c\u6765\u81ea 7 \u4e2a\u56fd\u5bb6\u548c\u5730\u533a\uff0c\u5176\u4e2d 16 \u4f4d\u4efb\u804c\u4e8e\u7f8e\u56fd\uff0c\u52a0\u62ff\u5927\u3001\u4e39\u9ea6\u3001\u4ee5\u8272\u5217\u3001\u65e5\u672c\u3001\u4e2d\u56fd\u5185\u5730\u3001\u745e\u58eb\u5404 1 \u4f4d<strong><sup>[1]<\/sup><\/strong>\u3002\u4ee5\u4e0b\u6309\u5956\u9879\u6240\u5c5e\u9886\u57df\u5206\u7ec4\u5217\u793a\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u751f\u7406\u5b66\u6216\u533b\u5b66\u9886\u57df\uff08<\/strong><strong>7 <\/strong><strong>\u4f4d\uff09<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>GLP-1<\/strong><strong>\uff5c<\/strong>Daniel J. Drucker\uff08\u52a0\u62ff\u5927 \u00b7 \u591a\u4f26\u591a\u5927\u5b66 \/ \u897f\u5948\u5065\u5eb7\u4e2d\u5fc3 Lunenfeld-Tanenbaum \u7814\u7a76\u6240\uff09<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>GLP-1<\/strong><strong>\uff5c<\/strong>Jens Juul Holst\uff08\u4e39\u9ea6 \u00b7 \u54e5\u672c\u54c8\u6839\u5927\u5b66\u5e15\u52aa\u59c6\u7814\u7a76\u6240\uff09<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>GLP-1<\/strong><strong>\uff5c<\/strong>Svetlana Mojsov\uff08\u7f8e\u56fd \u00b7 \u6d1b\u514b\u83f2\u52d2\u5927\u5b66\uff09<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u5149\u5b66\u76f8\u5e72\u65ad\u5c42\u626b\u63cf\uff5c<\/strong>James G. Fujimoto\uff08\u7f8e\u56fd \u00b7 \u9ebb\u7701\u7406\u5de5\u5b66\u9662\uff09<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u5149\u5b66\u76f8\u5e72\u65ad\u5c42\u626b\u63cf\uff5c<\/strong>David Huang\uff08\u7f8e\u56fd \u00b7 \u4fc4\u52d2\u5188\u5065\u5eb7\u4e0e\u79d1\u5b66\u5927\u5b66\u51ef\u897f\u773c\u79d1\u7814\u7a76\u6240\uff09<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u5149\u5b66\u76f8\u5e72\u65ad\u5c42\u626b\u63cf\uff5c<\/strong>Eric A. Swanson\uff08\u7f8e\u56fd \u00b7 \u9ebb\u7701\u7406\u5de5\u5b66\u9662\uff09<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u514d\u75ab\u9ecf\u9644\u53d7\u4f53\uff5c<\/strong>Timothy A. Springer\uff08\u7f8e\u56fd \u00b7 \u6ce2\u58eb\u987f\u513f\u7ae5\u533b\u9662 \/ \u54c8\u4f5b\u533b\u5b66\u9662\uff09<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u83b7\u5956\u7406\u7531\uff1a\u2460 \u53d1\u73b0\u5e76\u9274\u5b9a GLP-1\uff0c\u7cfb\u7edf\u9610\u660e\u5176\u751f\u7269\u6d3b\u6027\u673a\u5236\uff1b\u2461 \u7814\u53d1\u5149\u5b66\u76f8\u5e72\u65ad\u5c42\u626b\u63cf\uff08OCT\uff09\u6210\u50cf\u6280\u672f\uff1b\u2462 \u53d1\u73b0\u514d\u75ab\u7cfb\u7edf\u5173\u952e\u9ecf\u9644\u53d7\u4f53\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u7269\u7406\u5b66\u9886\u57df\uff08<\/strong><strong>5 <\/strong><strong>\u4f4d\uff09<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u6709\u673a\u53d1\u5149\u4e8c\u6781\u7ba1\uff5c<\/strong>\u5b89\u8fbe\u5343\u6ce2\u77e2 Chihaya Adachi\uff08\u65e5\u672c \u00b7 \u4e5d\u5dde\u5927\u5b66 OPERA \u7814\u7a76\u4e2d\u5fc3\uff09<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u6709\u673a\u53d1\u5149\u4e8c\u6781\u7ba1\uff5c<\/strong>Stephen R. Forrest\uff08\u7f8e\u56fd \u00b7 \u5bc6\u6b47\u6839\u5927\u5b66\uff09<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u6709\u673a\u53d1\u5149\u4e8c\u6781\u7ba1\uff5c<\/strong>Mark E. Thompson\uff08\u7f8e\u56fd \u00b7 \u5357\u52a0\u5dde\u5927\u5b66\uff09<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u78c1\u7535\u591a\u94c1\u6027\u6750\u6599\uff5c<\/strong>Nicola A. Spaldin\uff08\u745e\u58eb \u00b7 \u82cf\u9ece\u4e16\u8054\u90a6\u7406\u5de5\u5b66\u9662\uff09<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u91cf\u5b50\u53cd\u5e38\u970d\u5c14\u6548\u5e94\uff5c<\/strong>\u859b\u5176\u5764\uff08\u4e2d\u56fd\u5185\u5730 \u00b7 \u4e2d\u56fd\u79d1\u5b66\u9662\u9662\u58eb\u3001\u5357\u65b9\u79d1\u6280\u5927\u5b66\u6821\u957f\u3001\u6e05\u534e\u5927\u5b66\u6559\u6388\uff09<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u83b7\u5956\u7406\u7531\uff1a\u2460 \u78f7\u5149\u6709\u673a\u53d1\u5149\u4e8c\u6781\u7ba1\uff08PHOLED\uff09\u4e0e\u70ed\u6fc0\u6d3b\u5ef6\u8fdf\u8367\u5149\uff08TADF\uff09\u7684\u5f00\u521b\u6027\u7814\u7a76\uff1b\u2461 \u5ba4\u6e29\u78c1\u7535\u591a\u94c1\u6027\u6750\u6599\u7684\u57fa\u7840\u7406\u8bba\u7a81\u7834\uff1b\u2462 \u91cf\u5b50\u53cd\u5e38\u970d\u5c14\u6548\u5e94\u7684\u5b9e\u9a8c\u89c2\u6d4b\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u5316\u5b66\u9886\u57df\uff08<\/strong><strong>6 <\/strong><strong>\u4f4d\uff09<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u81ea\u7ec4\u88c5\u5355\u5206\u5b50\u5c42\uff5c<\/strong>David L. Allara\uff08\u7f8e\u56fd \u00b7 \u5bbe\u5915\u6cd5\u5c3c\u4e9a\u5dde\u7acb\u5927\u5b66\u6750\u6599\u7814\u7a76\u6240\uff09<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u81ea\u7ec4\u88c5\u5355\u5206\u5b50\u5c42\uff5c<\/strong>Ralph G. Nuzzo\uff08\u7f8e\u56fd \u00b7 \u4f0a\u5229\u8bfa\u4f0a\u5927\u5b66\u5384\u5df4\u7eb3-\u9999\u69df\u5206\u6821\uff09<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u81ea\u7ec4\u88c5\u5355\u5206\u5b50\u5c42\uff5c<\/strong>Jacob Sagiv\uff08\u4ee5\u8272\u5217 \u00b7 \u9b4f\u8328\u66fc\u79d1\u5b66\u7814\u7a76\u6240\uff09<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u86cb\u767d\u8d28\u957f\u7a0b\u7535\u5b50\u8f6c\u79fb\uff5c<\/strong>Harry B. Gray\uff08\u7f8e\u56fd \u00b7 \u52a0\u5dde\u7406\u5de5\u5b66\u9662\uff09<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u86cb\u767d\u8d28\u957f\u7a0b\u7535\u5b50\u8f6c\u79fb\uff5c<\/strong>Jay R. Winkler\uff08\u7f8e\u56fd \u00b7 \u52a0\u5dde\u7406\u5de5\u5b66\u9662\u8d1d\u514b\u66fc\u7814\u7a76\u6240\uff09<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u7cbe\u51c6\u57fa\u56e0\u7f16\u8f91\uff5c<\/strong>David R. Liu \u5218\u5982\u8c26\uff08\u7f8e\u56fd \u00b7 \u54c8\u4f5b\u5927\u5b66 \/ \u5e03\u7f57\u5fb7\u7814\u7a76\u6240 \/ \u970d\u534e\u5fb7\u00b7\u4f11\u65af\u533b\u5b66\u7814\u7a76\u6240\uff09<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u83b7\u5956\u7406\u7531\uff1a\u2460 \u81ea\u7ec4\u88c5\u5355\u5206\u5b50\u5c42\uff08SAMs\uff09\u6280\u672f\uff1b\u2461 \u6df1\u5316\u5bf9\u86cb\u767d\u8d28\u957f\u7a0b\u7535\u5b50\u8f6c\u79fb\u673a\u5236\u7684\u8ba4\u77e5\uff1b\u2462 \u5f00\u53d1\u78b1\u57fa\u7f16\u8f91\u4e0e\u5148\u5bfc\u7f16\u8f91\u7b49\u7cbe\u51c6\u57fa\u56e0\u7f16\u8f91\u6280\u672f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u7ecf\u6d4e\u5b66\u9886\u57df\uff08<\/strong><strong>4 <\/strong><strong>\u4f4d\uff09<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u4fe1\u606f\u6280\u672f\u7684\u7ecf\u6d4e\u5b66\uff5c<\/strong>Susan C. Athey\uff08\u7f8e\u56fd \u00b7 \u65af\u5766\u798f\u5927\u5b66\u5546\u5b66\u9662\uff09<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u4fe1\u606f\u6280\u672f\u7684\u7ecf\u6d4e\u5b66\uff5c<\/strong>Hal R. Varian\uff08\u7f8e\u56fd \u00b7 \u52a0\u5dde\u5927\u5b66\u4f2f\u514b\u5229\u5206\u6821\u54c8\u65af\u5546\u5b66\u9662\u8363\u4f11\u6559\u6388\uff0c\u8c37\u6b4c\u524d\u9996\u5e2d\u7ecf\u6d4e\u5b66\u5bb6\uff09<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u8d27\u5e01\u653f\u7b56\uff5c<\/strong>Michael D. Woodford\uff08\u7f8e\u56fd \u00b7 \u54e5\u4f26\u6bd4\u4e9a\u5927\u5b66\uff09<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u7ecf\u6d4e\u52a8\u6001\u4e0e\u7ec4\u7ec7\u884c\u4e3a\uff5c<\/strong>Sidney G. Winter\uff08\u7f8e\u56fd \u00b7 \u5bbe\u5915\u6cd5\u5c3c\u4e9a\u5927\u5b66\u6c83\u987f\u5546\u5b66\u9662\uff09<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u83b7\u5956\u7406\u7531\uff1a\u2460 \u4fe1\u606f\u6280\u672f\u7ecf\u6d4e\u5b66\u7684\u5f00\u521b\u6027\u5206\u6790\uff1b\u2461 \u8d27\u5e01\u653f\u7b56\u7406\u8bba\u4e0e\u5b9e\u8df5\u8d21\u732e\uff1b\u2462 \u53d7\u6f14\u5316\u7406\u8bba\u542f\u53d1\u7814\u7a76\u7ecf\u6d4e\u52a8\u6001\u4e0e\u7ec4\u7ec7\u884c\u4e3a\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u9700\u8981\u8bf4\u660e\u7684\u662f\uff0c\u5f15\u6587\u6842\u51a0\u5956\u7684\u8bbe\u7acb\u76ee\u7684\u5e76\u975e\u9884\u6d4b\u7279\u5b9a\u5e74\u4efd\u7684\u8bfa\u8d1d\u5c14\u5956\u5f97\u4e3b\uff0c\u800c\u662f\u8868\u5f70\u7814\u7a76\u5de5\u4f5c\u8fbe\u5230\u8bfa\u5956\u6c34\u51c6\u3001\u503c\u5f97\u5168\u7403\u8ba4\u53ef\u7684\u79d1\u5b66\u5bb6\u30022026 \u5e74\u8bfa\u8d1d\u5c14\u5956\u5c06\u4e8e 10 \u6708 5 \u65e5\u81f3 12 \u65e5\u9646\u7eed\u63ed\u6653\u3002<\/p>\n\n\n\n<h5 class=\"wp-block-heading\"><strong>\u53c2\u8003\u6587\u732e<\/strong><\/h5>\n\n\n\n<p class=\"wp-block-paragraph\">[1] Clarivate. Clarivate Reveals Citation Laureates 2026 Recognizing Transformative Scientific Breakthroughs. Press release. September 17, 2026.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">[2] Clarivate. Citation Laureates 2026 in Physiology or Medicine. 2026.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">[3] McIntyre N, Holdsworth CD, Turner DS. New interpretation of oral glucose tolerance. <em>Lancet<\/em>. 1964;2(7349):20-21. \u53c2\u89c1 Elrick H, Stimmler L, Hlad CJ Jr, Arai Y. Plasma insulin response to oral and intravenous glucose administration. <em>J Clin Endocrinol Metab<\/em>. 1964;24:1076-1082.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">[4] Bell GI, Santerre RF, Mullenbach GT. Hamster preproglucagon contains the sequence of glucagon and two related peptides. <em>Nature<\/em>. 1983;302(5910):716-718.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">[5] Mojsov S, Weir GC, Habener JF. Insulinotropin: glucagon-like peptide I (7-37) co-encoded in the glucagon gene is a potent stimulator of insulin release in the perfused rat pancreas. <em>J Clin Invest<\/em>. 1987;79(2):616-619.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">[6] U.S. Food and Drug Administration. Exenatide (Byetta) approval. April 2005.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">[7] U.S. Food and Drug Administration, Center for Drug Evaluation and Research. Guidance for Industry: Diabetes Mellitus \u2014 Evaluating Cardiovascular Risk in New Antidiabetic Therapies to Treat Type 2 Diabetes. December 2008.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">[8] Cefalu WT, Kaul S, Gerstein HC, et al. Cardiovascular Outcomes Trials in Type 2 Diabetes: Where Do We Go From Here? <em>Diabetes Care<\/em>. 2018;41(1):14-31.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">[9] Marso SP, Daniels GH, Brown-Frandsen K, et al. Liraglutide and Cardiovascular Outcomes in Type 2 Diabetes (LEADER). <em>N Engl J Med<\/em>. 2016;375(4):311-322. \u53c2\u89c1 Marso SP, Bain SC, Consoli A, et al. Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes (SUSTAIN-6). <em>N Engl J Med<\/em>. 2016;375(19):1834-1844. \u53ca Gerstein HC, Colhoun HM, Dagenais GR, et al. Dulaglutide and cardiovascular outcomes in type 2 diabetes (REWIND). <em>Lancet<\/em>. 2019;394(10193):121-130.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">[10] Bhandari M, Srivastava K, Shama N. Harmonized Meta-Analysis of GLP-1 Receptor Agonist Cardiovascular Outcome Trials: Consistent Reduction in 3-Point MACE. <em>J Am Coll Cardiol<\/em>. 2026;87(13_Supplement):A275.\uff08\u4f1a\u8bae\u6458\u8981\uff09<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">[11] U.S. Food and Drug Administration. Rybelsus (semaglutide) tablets, for oral use \u2014 FDA-approved labeling and Clinical Pharmacology Review (NDA 213051). September 2019.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">[12] Novo Nordisk. EVOKE and EVOKE+ phase 3 trials of oral semaglutide in early Alzheimer&#8217;s disease: primary endpoint not met. 2026.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u64b0\u6587\uff1a\u90d1\u53f6\u654f<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u79d1\u777f\u552f\u5b89\uff08Clarivate\uff09\u4e8e 2026 \u5e74 9 \u6708 17 \u65e5\u63ed\u6653 2026 \u5e74\u5ea6\u5f15\u6587\u6842\u51a0\u5956\uff08Citation Laureates\uff09\uff0c22 \u4f4d\u79d1\u5b66\u5bb6\u83b7\u5956[1]\u3002\u5176\u4e2d\uff0cDaniel J. Drucker\uff08\u591a\u4f26\u591a\u5927\u5b66 \/ \u897f\u5948\u5065\u5eb7\u4e2d\u5fc3 Lunenfeld-Tanenbaum \u7814\u7a76\u6240\uff09\u3001Jens Juul Holst\uff08\u54e5\u672c\u54c8\u6839\u5927\u5b66\uff09\u548c Svetlana Mojsov\uff08\u6d1b\u514b\u83f2\u52d2\u5927\u5b66\uff09\u4e09\u4f4d\u79d1\u5b66\u5bb6\uff0c\u56e0\u300c\u53d1\u73b0\u5e76\u9274\u5b9a\u80f0\u9ad8\u8840\u7cd6\u7d20\u6837\u80bd-1\uff08GLP-1\uff09\uff0c\u7cfb\u7edf\u9610\u660e\u5176\u751f\u7269\u6d3b\u6027\u673a\u5236\u300d\u800c\u83b7\u5956[2]\u3002<\/p>\n","protected":false},"author":1,"featured_media":2160,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[147],"tags":[86,15,32,29],"class_list":["post-2159","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-147","tag-86","tag-15","tag-32","tag-29"],"_links":{"self":[{"href":"https:\/\/www.millibuff.com\/index.php?rest_route=\/wp\/v2\/posts\/2159","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.millibuff.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.millibuff.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.millibuff.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.millibuff.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2159"}],"version-history":[{"count":2,"href":"https:\/\/www.millibuff.com\/index.php?rest_route=\/wp\/v2\/posts\/2159\/revisions"}],"predecessor-version":[{"id":2162,"href":"https:\/\/www.millibuff.com\/index.php?rest_route=\/wp\/v2\/posts\/2159\/revisions\/2162"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.millibuff.com\/index.php?rest_route=\/wp\/v2\/media\/2160"}],"wp:attachment":[{"href":"https:\/\/www.millibuff.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2159"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.millibuff.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2159"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.millibuff.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2159"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}