{"id":2169,"date":"2026-09-25T22:26:53","date_gmt":"2026-09-25T14:26:53","guid":{"rendered":"https:\/\/www.millibuff.com\/?p=2169"},"modified":"2026-09-25T22:30:00","modified_gmt":"2026-09-25T14:30:00","slug":"%e5%b0%8f%e7%89%9b%e6%b4%9e%e5%af%9f%ef%bd%9c%e5%89%8d%e5%88%97%e8%85%ba%e7%99%8c%e8%80%90%e8%8d%af%e6%b2%bb%e7%96%97%e7%9a%84%e4%b8%8b%e4%b8%80%e4%b8%aa%e9%9d%b6%e7%82%b9%ef%bc%9asteap1-%e4%bb%8e","status":"publish","type":"post","link":"https:\/\/www.millibuff.com\/?p=2169","title":{"rendered":"\u5c0f\u725b\u6d1e\u5bdf\uff5c\u524d\u5217\u817a\u764c\u8010\u836f\u6cbb\u7597\u7684\u4e0b\u4e00\u4e2a\u9776\u70b9\uff1aSTEAP1 \u4ece\u5355\u9776\u70b9\u5230\u53cc\u9776\u70b9\u7684\u7ade\u901f"},"content":{"rendered":"\n<h5 class=\"wp-block-heading\"><strong>\u5f15\u8a00\uff1a\u4e3a\u4ec0\u4e48\u662f<\/strong><strong> STEAP1<\/strong><strong>\uff1f<\/strong><\/h5>\n\n\n\n<p class=\"wp-block-paragraph\">\u5728\u524d\u5217\u817a\u764c\u9776\u5411\u6cbb\u7597\u9886\u57df\uff0cPSMA \u4ecd\u662f\u6700\u6210\u719f\u7684\u9776\u70b9\u3002\u4f46 PSMA \u5e76\u975e\u5b8c\u7f8e\u2014\u2014\u5b83\u5728\u6b63\u5e38\u7ec4\u7ec7\uff08\u5982\u80be\u810f\u3001\u553e\u6db2\u817a\uff09\u4e2d\u6709\u4e00\u5b9a\u8868\u8fbe\uff0c\u4e14\u90e8\u5206&nbsp;mCRPC&nbsp;\u60a3\u8005\u5728 PSMA \u9776\u5411\u6cbb\u7597\u540e\u51fa\u73b0\u8868\u8fbe\u4e0b\u8c03\u6216\u4e22\u5931\uff0c\u5bfc\u81f4\u6cbb\u7597\u5931\u6548\u3002\u4e00\u9879\u5bf9 114 \u4f8b&nbsp;mCRPC&nbsp;\u7ec4\u7ec7\u7684\u5bf9\u6bd4\u5206\u6790\u663e\u793a\uff0cPSMA \u9633\u6027\u7387\u4ec5 60.5%\uff0c\u800c STEAP1 \u8fbe 87.7%\uff1b28.1% \u7684\u7ec4\u7ec7\u5448 STEAP1 \u9633\u6027 \/ PSMA \u9634\u6027<sup><strong>[1]<\/strong><\/sup>\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">STEAP1\uff08\u516d\u8de8\u819c\u4e0a\u76ae\u524d\u5217\u817a\u6297\u539f 1\uff09\u6b63\u662f\u5728\u8fd9\u79cd\u300c\u8865\u5145\u751a\u81f3\u66ff\u4ee3 PSMA\u300d\u7684\u671f\u5f85\u4e2d\u8d70\u4e0a\u524d\u53f0\u3002\u5176\u6838\u5fc3\u4f18\u52bf\u5728\u4e8e\uff1a\u5728\u8d85\u8fc7 85% \u7684\u524d\u5217\u817a\u80bf\u7624\u4e2d\u9ad8\u8868\u8fbe\uff0c\u5728\u6b63\u5e38\u7ec4\u7ec7\u4e2d\u51e0\u4e4e\u4e0d\u8868\u8fbe\uff0c\u4e14\u5728\u53bb\u52bf\u62b5\u6297\u9636\u6bb5\u4ecd\u7ef4\u6301\u9ad8\u8868\u8fbe<sup><strong>[1]<\/strong><\/sup>\u30022025 \u5e74\u524d\u5217\u817a\u764c\u57fa\u91d1\u4f1a\uff08PCF\uff09\u79d1\u5b66\u5cf0\u4f1a\u4e0a\u62a5\u544a\u7684\u673a\u5236\u7814\u7a76\u8fdb\u4e00\u6b65\u63ed\u793a\uff1aCRISPR \u5e72\u6270\u7b5b\u9009\u53d1\u73b0\uff0c\u6291\u5236 MYC \u6216 SWI\/SNF \u67d3\u8272\u8d28\u91cd\u5851\u590d\u5408\u7269\u57fa\u56e0\u53ef\u4e0a\u8c03 STEAP1 \u8868\u8fbe\uff0c\u800c\u8017\u7aed\u8f6c\u5f55\u56e0\u5b50 ZIC4 \u5219\u663e\u8457\u964d\u4f4e STEAP1 \u6c34\u5e73\u2014\u2014\u6291\u5236 ZIC4 \u51e0\u4e4e\u53ef\u5b8c\u5168\u6d88\u9664 STEAP1 \u7684\u8868\u9762\u8868\u8fbe\uff1bATAC-seq&nbsp;\u5206\u6790\u5728 STEAP1 \u542f\u52a8\u5b50\u533a\u57df\u53d1\u73b0\u6e05\u6670\u7684 ZIC4 \u7ed3\u5408\u8db3\u8ff9\uff0c\u8bc1\u5b9e\u5176\u4e3a\u76f4\u63a5\u8f6c\u5f55\u8c03\u63a7\u56e0\u5b50<sup><strong>[2]<\/strong><\/sup>\u3002\u7814\u7a76\u8005\u540c\u65f6\u9274\u5b9a\u51fa\u53ef\u4e0a\u8c03 STEAP1 \u8868\u8fbe\u7684\u5c0f\u5206\u5b50\u5316\u5408\u7269\uff0c\u4e3a\u300c\u8054\u5408\u7528\u836f\u4e0a\u8c03\u9776\u70b9\u8868\u8fbe\u3001\u589e\u5f3a\u9776\u5411\u6cbb\u7597\u7597\u6548\u300d\u63d0\u4f9b\u4e86\u7406\u8bba\u4f9d\u636e<sup><strong>[2]<\/strong><\/sup>\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4f46 STEAP1 \u5e76\u975e\u6ca1\u6709\u8fb9\u754c\u30022026 \u5e74 5 \u6708\u53d1\u8868\u4e8e Molecular Cancer Research \u7684\u6574\u5408\u5206\u6790\uff08\u4e09\u4e2a\u961f\u5217\u5171 1095 \u4f8b&nbsp;mCRPC&nbsp;\u6837\u672c\uff09\u663e\u793a\uff1aSTEAP1 \u4e0e KLK2 \u7684\u8868\u8fbe\u5747\u5f3a\u70c8\u5bcc\u96c6\u4e8e AR \u9633\u6027\u80bf\u7624\uff0c\u5728\u795e\u7ecf\u5185\u5206\u6ccc\u4e0e\u53cc\u9634\u6027\u8868\u578b\u4e2d\u57fa\u672c\u7f3a\u5931\uff1b\u4e0e KLK2 \u7684\u4e25\u683c AR \u4f9d\u8d56\u4e0d\u540c\uff0cSTEAP1 \u4ec5\u90e8\u5206\u4f9d\u8d56 AR\uff0c\u8fd8\u53d7\u4f4d\u70b9\u7279\u5f02\u6027 DNA \u7532\u57fa\u5316\u8c03\u63a7<sup><strong>[3]<\/strong><\/sup>\u3002\u8fd9\u610f\u5473\u7740 STEAP1 \u9776\u5411\u6cbb\u7597\u5929\u7136\u8986\u76d6 AR \u9633\u6027\u817a\u764c\u8c31\u7cfb\uff0c\u4f46\u795e\u7ecf\u5185\u5206\u6ccc\u8f6c\u5316\u540e\u8868\u8fbe\u663e\u8457\u4e0b\u964d\u2014\u2014\u4e0e KLK2 \u9762\u4e34\u76f8\u4f3c\u7684\u8c31\u7cfb\u53ef\u5851\u6027\u6311\u6218<sup><strong>[3]<\/strong><\/sup>\u3002\u56f4\u7ed5\u8fd9\u4e00\u9776\u70b9\uff0c\u5168\u7403\u521b\u65b0\u836f\u7814\u53d1\u5728 T \u7ec6\u80de\u8854\u63a5\u5668\u3001ADC\u3001CAR-T \u548c\u75ab\u82d7\u56db\u6761\u6280\u672f\u8def\u7ebf\u4e0a\u540c\u65f6\u63a8\u8fdb\uff0c2025 \u81f3 2026 \u5e74\u95f4\u591a\u9879\u5173\u952e\u4e34\u5e8a\u6570\u636e\u9646\u7eed\u516c\u5e03\u3002\u5176\u4e2d\u6700\u5f15\u4eba\u6ce8\u76ee\u7684\u8d8b\u52bf\u662f\uff1aT \u7ec6\u80de\u8854\u63a5\u5668\u5df2\u7387\u5148\u8fdb\u5165\u4ee5\u603b\u751f\u5b58\u671f\uff08OS\uff09\u4e3a\u7ec8\u70b9\u7684 III \u671f\u786e\u8bc1\u9636\u6bb5\uff0c\u800c ADC \u6b63\u5728\u4ece\u5355\u9776\u70b9\u5411 PSMA\u00d7STEAP1 \u53cc\u9776\u70b9\u5feb\u901f\u8fed\u4ee3<\/p>\n\n\n\n<h5 class=\"wp-block-heading\"><strong>\u4e00\u3001<\/strong><strong>T <\/strong><strong>\u7ec6\u80de\u8854\u63a5\u5668\uff1a<\/strong><strong>STEAP1 <\/strong><strong>\u8d5b\u9053\u7684\u9886\u8dd1\u8005<\/strong><\/h5>\n\n\n\n<p class=\"wp-block-paragraph\">T \u7ec6\u80de\u8854\u63a5\u5668\uff08TCE\uff09\u662f\u76ee\u524d STEAP1 \u9776\u70b9\u4e34\u5e8a\u63a8\u8fdb\u6700\u5feb\u7684\u65b9\u5411\uff0c\u5b89\u8fdb\uff08Amgen\uff09\u7684&nbsp;Xaluritamig\uff08AMG 509\uff09\u662f\u8fd9\u4e00\u8d5b\u9053\u7684\u9886\u8dd1\u8005\u3002Xaluritamig&nbsp;\u662f\u4e00\u79cd STEAP1\u00d7CD3\u300cXmAb 2+1\u300dT \u7ec6\u80de\u8854\u63a5\u5668\uff0c\u5177\u6709\u4e24\u4e2a STEAP1 \u7ed3\u5408\u57df\u548c\u4e00\u4e2a CD3 \u7ed3\u5408\u57df\u3002\u5176 I \u671f\u7814\u7a76\uff08NCT04221542\uff09\u5165\u7ec4 97 \u4f8b\u91cd\u5ea6\u9884\u5904\u7406\u7684&nbsp;mCRPC&nbsp;\u60a3\u8005\uff1a\u603b\u4f53 PSA50 \u5e94\u7b54\u7387\u4e3a 49%\uff0c\u5ba2\u89c2\u7f13\u89e3\u7387\uff08ORR\uff09\u4e3a 24%\uff1b\u5728\u76ee\u6807\u5242\u91cf\u7ec4\uff08\u22650.75 mg\uff09\uff0cPSA50 \u5e94\u7b54\u7387\u5347\u81f3 59%\uff0cORR \u8fbe 41%<sup><strong>[4]<\/strong><\/sup>\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Xaluritamig<\/strong><strong> I <\/strong><strong>\u671f\uff08<\/strong><strong>NCT04221542<\/strong><strong>\uff09\u5173\u952e\u6570\u636e<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u5165\u7ec4\u4eba\u7fa4\uff5c<\/strong>97 \u4f8b&nbsp;mCRPC\uff0c\u4e2d\u4f4d\u65e2\u5f80 4 \u7ebf\u6cbb\u7597\uff0c86% \u65e2\u5f80\u63a5\u53d7\u8fc7\u7d2b\u6749\u70f7<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u603b\u4f53\uff08\u6240\u6709\u5242\u91cf\uff09\uff5c<\/strong>PSA50 49% \uff0f ORR 24%<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u76ee\u6807\u5242\u91cf\u7ec4\uff08<\/strong><strong>\u22650.75 mg<\/strong><strong>\uff09\uff5c<\/strong>PSA50 59% \uff0f ORR 41%<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u6700\u5e38\u89c1\u6cbb\u7597\u76f8\u5173\u4e0d\u826f\u4e8b\u4ef6\uff5c<\/strong>CRS 72%\uff08\u591a\u4e3a 1\u20132 \u7ea7\uff0c\u96c6\u4e2d\u4e8e\u7b2c 1 \u5468\u671f\uff09\u3001\u75b2\u4e4f 45%\u3001\u808c\u75db 34%<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u6700\u5927\u8010\u53d7\u5242\u91cf\uff5c<\/strong>1.5 mg \u9759\u8109\u6bcf\u5468\u7ed9\u836f\uff08\u4e09\u6b65\u5242\u91cf\u9012\u589e\uff09<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u57fa\u4e8e\u8fd9\u4e00\u6570\u636e\uff0cXaluritamig&nbsp;\u7684\u4e24\u9879 III \u671f\u8bd5\u9a8c\u5df2\u5168\u9762\u5c55\u5f00\u3002XALute\uff08NCT06691984\uff09\u5728\u5316\u7597\u540e&nbsp;mCRPC&nbsp;\u4e2d\u5bf9\u6bd4&nbsp;Xaluritamig&nbsp;\u4e0e\u5361\u5df4\u4ed6\u8d5b\u6216\u7b2c\u4e8c\u79cd ARDT\uff08\u96c4\u6fc0\u7d20\u53d7\u4f53\u5bfc\u5411\u6cbb\u7597\uff09\uff0c\u8ba1\u5212\u5165\u7ec4 675 \u4f8b\uff082:1 \u968f\u673a\uff09\uff0c\u5b9e\u9645\u5165\u7ec4 707 \u4f8b\uff0c\u62db\u52df\u7ed3\u675f\uff1b\u4e3b\u8981\u7ec8\u70b9\u4e3a\u603b\u751f\u5b58\u671f\uff08OS\uff09\uff0c\u968f\u8bbf\u65f6\u95f4\u7a97\u7ea6 53 \u4e2a\u6708<sup><strong>[5]<\/strong><\/sup>\u3002XALience\uff08NCT07213674\uff09\u5728\u5316\u7597\u524d&nbsp;mCRPC&nbsp;\u4e2d\u8bc4\u4f30&nbsp;Xaluritamig&nbsp;\u8054\u5408\u963f\u6bd4\u7279\u9f99\u5bf9\u6bd4\u7814\u7a76\u8005\u9009\u62e9\u65b9\u6848\uff08\u591a\u897f\u4ed6\u8d5b \/ \u5361\u5df4\u4ed6\u8d5b \/ \u963f\u6bd4\u7279\u9f99\uff09\uff0c\u8ba1\u5212\u5165\u7ec4\u7ea6 750 \u4f8b\uff0c\u4e3b\u8981\u7ec8\u70b9\u540c\u6837\u4e3a OS\uff0c2025 \u5e74 11 \u6708\u542f\u52a8\uff0c\u9884\u8ba1 2030 \u5e74\u521d\u5b8c\u6210\u4e3b\u8981\u968f\u8bbf<sup><strong>[6]<\/strong><\/sup>\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u4e24\u9879<\/strong><strong> III <\/strong><strong>\u671f\u8bd5\u9a8c\u8bbe\u8ba1\u6982\u89c8<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>XALute<\/strong><strong>\uff08<\/strong><strong>NCT06691984<\/strong><strong>\uff09\uff5c<\/strong>\u5316\u7597\u540e&nbsp;mCRPC\uff1bXaluritamig vs \u5361\u5df4\u4ed6\u8d5b\u6216\u7b2c\u4e8c\u79cd ARDT\uff1b\u8ba1\u5212 675 \u4f8b\u3001\u5b9e\u9645\u5165\u7ec4 707 \u4f8b\uff1b\u4e3b\u8981\u7ec8\u70b9 OS\uff08\u7ea6 53 \u4e2a\u6708\uff09<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>XALience<\/strong><strong>\uff08<\/strong><strong>NCT07213674<\/strong><strong>\uff09\uff5c<\/strong>\u5316\u7597\u524d&nbsp;mCRPC\uff1bXaluritamig + \u963f\u6bd4\u7279\u9f99 vs \u7814\u7a76\u8005\u9009\u62e9\uff08\u591a\u897f\u4ed6\u8d5b \/ \u5361\u5df4\u4ed6\u8d5b \/ \u963f\u6bd4\u7279\u9f99\uff09\uff1b\u8ba1\u5212\u7ea6 750 \u4f8b\uff1b\u4e3b\u8981\u7ec8\u70b9 OS\uff0c2025 \u5e74 11 \u6708\u542f\u52a8<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e24\u9879\u8bd5\u9a8c\u5747\u4ee5 OS \u4e3a\u4e3b\u8981\u7ec8\u70b9\uff0c\u6807\u5fd7 STEAP1 \u9776\u5411\u6cbb\u7597\u8fdb\u5165\u786e\u8bc1\u6027\u68c0\u9a8c\u9636\u6bb5[5,6]\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0cXALute\u660e\u786e\u6392\u9664\u4e86\u65e2\u5f80\u63a5\u53d7\u8fc7 STEAP1 \u9776\u5411\u6cbb\u7597\u7684\u60a3\u8005\uff0c\u540c\u65f6\u8981\u6c42\u5165\u7ec4\u8005\u5728\u81f3\u5c11\u4e00\u79cd ARDT\uff08\u6069\u624e\u5362\u80fa\u3001\u963f\u6bd4\u7279\u9f99\u3001\u963f\u5e15\u9c81\u80fa\u6216\u8fbe\u7f57\u4ed6\u80fa\uff09\u6cbb\u7597\u540e\u8fdb\u5c55<sup><strong>[5]<\/strong><\/sup>\u3002\u8fd9\u4e00\u8bbe\u8ba1\u53cd\u6620\u4e86 STEAP1 \u9776\u5411\u6cbb\u7597\u5728 ARDT \u8010\u836f\u4eba\u7fa4\u4e2d\u7684\u5b9a\u4f4d\u2014\u2014\u5176\u6740\u4f24\u673a\u5236\u4e0d\u7ecf\u8fc7 AR \u901a\u8def\uff0c\u4e0e ARDT \u8010\u836f\u673a\u5236\u5f62\u6210\u4e92\u8865\uff0c\u4e3a ARDT \u8010\u836f\u540e\u4eba\u7fa4\u63d0\u4f9b\u4e86\u673a\u5236\u4e0a\u72ec\u7acb\u7684\u6cbb\u7597\u9009\u9879\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e2d\u56fd\u836f\u4f01\u5728\u8fd9\u4e00\u8d5b\u9053\u540c\u6837\u6709\u5e03\u5c40\u3002\u590d\u5b8f\u6c49\u9716\u7684 HLX3902 \u662f\u4e00\u79cd STEAP1\u00d7CD3\u00d7CD28 \u4e09\u7279\u5f02\u6027\u6297\u4f53\u2014\u2014\u5728\u4f20\u7edf TCE \u57fa\u7840\u4e0a\u5f15\u5165 CD28 \u5171\u523a\u6fc0\u4fe1\u53f7\uff0c\u4ee5\u300c\u53cc\u4fe1\u53f7\u6fc0\u6d3b\u300d\u5e94\u5bf9\u524d\u5217\u817a\u764c\u7684\u514d\u75ab\u51b7\u80bf\u7624\u7279\u5f81\u30022026 \u5e74 5 \u6708\uff0cHLX3902 \u83b7\u6fb3\u5927\u5229\u4e9a\u4e34\u5e8a\u8bd5\u9a8c\u8bb8\u53ef\uff08\u4f26\u7406\u59d4\u5458\u4f1a\u6279\u51c6 + TGA \u5907\u6848\uff0c\u4e3a\u5176\u5168\u7403\u9996\u4e2a\u4e34\u5e8a\u8bd5\u9a8c\u8bb8\u53ef\uff09\uff1b\u540c\u5e74 6 \u6708\u53c8\u83b7\u4e2d\u56fd\u4e34\u5e8a\u8bd5\u9a8c\u8bb8\u53ef\uff0cI \u671f\u9996\u6b21\u4eba\u4f53\u8bd5\u9a8c\u5373\u5c06\u542f\u52a8<sup><strong>[7]<\/strong><\/sup>\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5b89\u5168\u6027\u65b9\u9762\uff0cXaluritamig&nbsp;\u7684 CRS \u53d1\u751f\u7387\u53ef\u63a7\u3002\u7814\u7a76\u56e2\u961f\u5728\u5b66\u672f\u8bc4\u8bba\u56de\u5e94\u4e2d\u6307\u51fa\uff0cT \u7ec6\u80de\u8854\u63a5\u5668\u7684 CRS \u4e0e\u6574\u4f53\u75be\u75c5\u8d1f\u8377\u76f8\u5173\uff0c\u968f\u7740&nbsp;Xaluritamig&nbsp;\u5411\u75be\u75c5\u8d1f\u8377\u66f4\u8f7b\u7684\u65e9\u671f\u9636\u6bb5\u63a8\u8fdb\uff0cCRS \u7684\u53d1\u751f\u7387\u548c\u4e25\u91cd\u7a0b\u5ea6\u6709\u671b\u8fdb\u4e00\u6b65\u6539\u5584<sup><strong>[8]<\/strong><\/sup>\u3002\u808c\u8089\u9aa8\u9abc\u708e\u75c7\uff08\u808c\u75db\u3001\u5173\u8282\u75db\uff0c\u7591\u4f3c\u808c\u7b4b\u819c\u708e\uff09\u662f STEAP1 T \u7ec6\u80de\u8854\u63a5\u5668\u7684\u7279\u5f81\u6027\u4e0d\u826f\u4e8b\u4ef6\uff0c\u76ee\u524d\u5176\u673a\u5236\u5c1a\u4e0d\u660e\u786e\u2014\u2014\u8840\u6e05\u808c\u9178\u6fc0\u9176\u4e0d\u9ad8\u3001\u808c\u7ea4\u7ef4 STEAP1 \u8868\u8fbe\u7f3a\u5931\u63d0\u793a\u5e76\u975e\u76f4\u63a5\u808c\u8089\u635f\u4f24\uff0c\u53ef\u80fd\u4e0e\u7ed3\u7f14\u7ec4\u7ec7\u4e0a\u7684\u4f4e\u6c34\u5e73\u8868\u8fbe\u6709\u5173\uff0c\u9700\u5728\u66f4\u5927\u6837\u672c\u4e2d\u8fdb\u4e00\u6b65\u8bc4\u4f30<sup><strong>[4,8]<\/strong><\/sup>\u3002<\/p>\n\n\n\n<h5 class=\"wp-block-heading\"><strong>\u4e8c\u3001<\/strong><strong>ADC<\/strong><strong>\uff1a\u4ece\u5355\u9776\u70b9\u5411\u53cc\u9776\u70b9\u8fed\u4ee3\u7684\u6838\u5fc3\u903b\u8f91<\/strong><\/h5>\n\n\n\n<p class=\"wp-block-paragraph\">STEAP1 ADC \u7684\u5f00\u53d1\u5386\u7a0b\u5e76\u975e\u4e00\u5e06\u98ce\u987a\uff0c\u4f46\u7b2c\u4e00\u4ee3\u4ea7\u54c1\u7684\u7ecf\u9a8c\u6559\u8bad\uff0c\u76f4\u63a5\u63a8\u52a8\u4e86\u7b2c\u4e8c\u4ee3\u53cc\u9776\u70b9 ADC \u7684\u5feb\u901f\u8fed\u4ee3\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u7b2c\u4e00\u4ee3 ADC \u7684\u6559\u8bad\u3002Vandortuzumab&nbsp;vedotin\uff08DSTP3086S\uff09\u662f\u9996\u4e2a\u8fdb\u5165\u4e34\u5e8a\u7684 STEAP1 ADC\uff0c\u5176 I \u671f\u7814\u7a76\u5171\u5165\u7ec4 84 \u4f8b&nbsp;mCRPC&nbsp;\u60a3\u8005\uff0877 \u4f8b\u63a5\u53d7\u6bcf 3 \u5468\u7ed9\u836f\uff09\uff1a\u5728 62 \u4f8b\u63a5\u53d7 \u22652 mg\/kg \u5242\u91cf\u7684\u60a3\u8005\u4e2d\uff0c18% \u8fbe\u5230 PSA50\uff1b36 \u4f8b\u57fa\u7ebf\u53ef\u6d4b\u91cf\u75be\u75c5\u60a3\u8005\u4e2d\u4ec5 2 \u4f8b\uff086%\uff09\u83b7\u5f97\u5f71\u50cf\u5b66\u90e8\u5206\u7f13\u89e3<sup><strong>[9]<\/strong><\/sup>\u3002\u7597\u6548\u6709\u9650\uff0c\u4f46\u8be5\u7814\u7a76\u9a8c\u8bc1\u4e86 STEAP1 ADC \u7684\u53ef\u5f00\u53d1\u6027\uff0c\u4e5f\u66b4\u9732\u4e86\u5355\u9776\u70b9 ADC \u7684\u6838\u5fc3\u95ee\u9898\u2014\u2014STEAP1 \u5728\u80bf\u7624\u5185\u548c\u80bf\u7624\u95f4\u7684\u8868\u8fbe\u5f02\u8d28\u6027\u53ef\u80fd\u9650\u5236\u7597\u6548\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u53cc\u9776\u70b9 ADC \u7684\u8bbe\u8ba1\u903b\u8f91\u30022026 \u5e74\u53d1\u8868\u4e8e Molecular Cancer Research \u7684\u6574\u5408\u5206\u6790\u4e3a\u53cc\u9776\u70b9\u8bbe\u8ba1\u63d0\u4f9b\u4e86\u76f4\u63a5\u7684\u751f\u7269\u5b66\u4f9d\u636e\uff1a\u5728 AR \u9633\u6027\u80bf\u7624\u4e2d\uff0cSTEAP1\u3001KLK2 \u4e0e PSMA \u9ad8\u5ea6\u5171\u8868\u8fbe\uff0c\u8054\u5408\u9776\u5411\u5176\u4e2d\u4efb\u610f\u4e24\u4e2a\u6297\u539f\u53ef\u63d0\u9ad8\u6574\u4f53\u80bf\u7624\u8986\u76d6\u7387<sup><strong>[3]<\/strong><\/sup>\u3002\u6362\u8a00\u4e4b\uff0c\u5373\u4f7f\u90e8\u5206\u80bf\u7624\u7ec6\u80de STEAP1 \u8868\u8fbe\u4e0b\u8c03\uff0cPSMA \u4ecd\u53ef\u80fd\u8868\u8fbe\u2014\u2014\u53cc\u9776\u70b9 ADC \u53ef\u901a\u8fc7\u4e24\u79cd\u6297\u539f\u7684\u534f\u540c\u7ed3\u5408\uff0c\u8986\u76d6\u66f4\u5e7f\u6cdb\u7684\u80bf\u7624\u7ec6\u80de\u7fa4\u4f53\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u8868<\/strong><strong> 1&nbsp; <\/strong><strong>\u5f53\u524d\u5904\u4e8e\u4e34\u5e8a\u9636\u6bb5\u7684\u4e09\u6b3e<\/strong><strong> STEAP1 <\/strong><strong>\u9776\u5411<\/strong><strong> ADC<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><tbody><tr><td><strong>\u836f\u7269\uff08\u5f00\u53d1\u65b9\uff09<\/strong><\/td><td><strong>\u9776\u70b9<\/strong><strong> \/ <\/strong><strong>\u8f7d\u8377<\/strong><\/td><td><strong>\u4e34\u5e8a\u9636\u6bb5<\/strong><\/td><td><strong>\u5173\u952e\u8fdb\u5c55<\/strong><\/td><\/tr><tr><td><strong>ADRX-0405<\/strong><strong>\uff08<\/strong><strong>Adcentrx<\/strong><strong>\uff09<\/strong><\/td><td>STEAP1 \u5355\u9776\u70b9 \/ \u62d3\u6251\u5f02\u6784\u9176 I \u6291\u5236\u5242\uff08DAR 8\uff09<\/td><td>I \u671f 1a\/1b<\/td><td>2026 \u5e74 6 \u6708\u83b7 NMPA IND \u8bb8\u53ef\uff08\u4e2d\u7f8e\u53cc\u4e2d\u5fc3\uff09\uff1b2025 \u5e74 7 \u6708\u83b7 FDA \u80c3\u764c\u5b64\u513f\u836f\u8d44\u683c<\/td><\/tr><tr><td><strong>ABBV-969<\/strong><strong>\uff08<\/strong><strong>AbbVie<\/strong><strong>\uff09<\/strong><\/td><td>PSMA\u00d7STEAP1 \u53cc\u9776\u70b9 \/ \u62d3\u6251\u5f02\u6784\u9176 I \u6291\u5236\u5242<\/td><td>I \u671f<\/td><td>ASCO 2026 \u62a5\u544a\uff1a\u786e\u8ba4 ORR 45%\uff0829 \u4f8b\u53ef\u8bc4\u4f30\uff09\uff0c\u6d3b\u6027\u5242\u91cf PSA50 67%\u3001PSA90 28%\uff0c\u4e2d\u4f4d&nbsp;rPFS 15.3 \u4e2a\u6708<\/td><\/tr><tr><td><strong>DXC-008<\/strong><strong>\uff08\u676d\u5dde\u591a<\/strong><strong>\u79a7<\/strong><strong>\u751f\u7269\uff09<\/strong><\/td><td>PSMA\u00d7STEAP1 \u53cc\u9776\u70b9 \/ tubulysin B \u7c7b\u4f3c\u7269<\/td><td>I \u671f<\/td><td>\u8ba1\u5212\u5165\u7ec4 110 \u4f8b\u524d\u5217\u817a\u764c\u3001\u5c24\u6587\u8089\u7624\u7b49\u5b9e\u4f53\u7624\uff1b\u4eba\u4f53\u7597\u6548\u6570\u636e\u5c1a\u672a\u62ab\u9732<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">\u6ce8\uff1a\u5168\u7403\u5c1a\u65e0 STEAP1 \u9776\u5411\u6216 PSMA\u00d7STEAP1 \u53cc\u9776\u70b9 ADC \u83b7\u6279\u4e0a\u5e02\uff1b\u8bfa\u8bda\u5065\u534e ICP-B381 \u5df2\u4e8e 2026 \u5e74 9 \u6708\u83b7 NMPA \u4e34\u5e8a\u8bb8\u53ef\uff0c\u5c1a\u672a\u542f\u52a8\u7ed9\u836f[10-13]\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">ABBV-969 \u662f\u76ee\u524d\u6570\u636e\u6700\u6210\u719f\u7684 STEAP1 \u53cc\u9776\u70b9 ADC\u3002ASCO 2026 \u516c\u5e03\u7684 I \u671f\u5242\u91cf\u9012\u589e\u6570\u636e\u663e\u793a\uff1a49 \u4f8b\u4e2d\u4f4d 5 \u7ebf\uff081\u20139 \u7ebf\uff09\u65e2\u5f80\u6cbb\u7597\u7684&nbsp;mCRPC&nbsp;\u60a3\u8005\u4e2d\uff0c\u22653 mg\/kg \u5242\u91cf\u7ec4\u786e\u8ba4 PSA50 \u5e94\u7b54\u7387 67%\u3001PSA90 \u5e94\u7b54\u7387 28%\uff1b29 \u4f8b RECIST \u53ef\u8bc4\u4f30\u60a3\u8005\u7684\u786e\u8ba4 ORR \u4e3a 45%\uff0895% CI 26\u201364\uff09\uff0c\u4e2d\u4f4d&nbsp;rPFS&nbsp;\u8fbe 15.3 \u4e2a\u6708\u2014\u2014\u5728 47% \u60a3\u8005\u65e2\u5f80\u63a5\u53d7\u8fc7 \u00b9\u2077\u2077Lu-PSMA \u6cbb\u7597\u7684\u672b\u7ebf\u4eba\u7fa4\u4e2d\uff0c\u8fd9\u4e00\u6570\u636e\u9887\u5177\u7ade\u4e89\u529b<sup><strong>[10]<\/strong><\/sup>\u3002\u5b89\u5168\u6027\u65b9\u9762\uff0c\u22653 \u7ea7 TEAE \u53d1\u751f\u7387 63%\uff0c\u4e3b\u8981\u4e3a 3 \u7ea7\u8d2b\u8840\uff0849%\uff0c24\/49 \u4f8b\uff09\uff1b\u6700\u9ad8\u5242\u91cf 12.5 mg\/kg \u56e0\u51fa\u73b0 2 \u4f8b\u95f4\u8d28\u6027\u80ba\u75c5\uff08\u542b 1 \u4f8b\u6b7b\u4ea1\uff09\u5df2\u505c\u6b62\u63a2\u7d22\uff0c\u5242\u91cf\u4f18\u5316\u4ecd\u5728\u8fdb\u884c\u4e2d<sup><strong>[10]<\/strong><\/sup>\u3002ABBV-969 \u4e3a\u53cc\u53ef\u53d8\u57df IgG1 \u836f\u7269\u5076\u8054\u7269\uff0c\u540c\u65f6\u9776\u5411 PSMA \u548c STEAP1\u2014\u2014\u5176\u8bbe\u8ba1\u903b\u8f91\u6b63\u662f\u57fa\u4e8e\u4e0a\u8ff0\u5171\u8868\u8fbe\u6570\u636e\uff1a\u901a\u8fc7\u53cc\u9776\u70b9\u534f\u540c\u8986\u76d6\u80bf\u7624\u5185\u8868\u8fbe\u5f02\u8d28\u6027\uff0c\u51cf\u5c11\u56e0\u5355\u4e00\u6297\u539f\u4e0b\u8c03\u5bfc\u81f4\u7684\u80bf\u7624\u9003\u9038<sup><strong>[10]<\/strong><\/sup>\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>ABBV-969 I <\/strong><strong>\u671f\u5173\u952e<\/strong><strong>\u6570\u636e<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u5165\u7ec4\u4eba\u7fa4\uff5c<\/strong>49 \u4f8b&nbsp;mCRPC\uff0c\u4e2d\u4f4d 5 \u7ebf\u65e2\u5f80\u6cbb\u7597\uff081\u20139 \u7ebf\uff09\uff0c47% \u65e2\u5f80\u63a5\u53d7\u8fc7 \u00b9\u2077\u2077Lu-PSMA<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u7597\u6548\uff08<\/strong><strong>\u22653 mg\/kg<\/strong><strong>\uff09\uff5c<\/strong>\u786e\u8ba4 PSA50 67% \uff0f PSA90 28%<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u5ba2\u89c2\u7f13\u89e3\uff5c<\/strong>29 \u4f8b RECIST \u53ef\u8bc4\u4f30\u8005\u786e\u8ba4 ORR 45%\uff0895% CI 26\u201364\uff09<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>rPFS<\/strong><strong>\uff5c<\/strong>\u4e2d\u4f4d 15.3 \u4e2a\u6708\uff1b\u6570\u636e\u622a\u6b62\u65f6 26 \u4f8b\u4ecd\u5728\u6cbb\u7597\u4e2d<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u5b89\u5168\u6027\uff5c<\/strong>\u22653 \u7ea7 TEAE 63%\uff1b3 \u7ea7\u8d2b\u8840 49%\uff0824\/49\uff09\uff1b12.5 mg\/kg \u56e0\u95f4\u8d28\u6027\u80ba\u75c5\u4fe1\u53f7\u505c\u6b62\u63a2\u7d22<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u968f\u8bbf\uff5c<\/strong>\u4e2d\u4f4d\u968f\u8bbf 11.1 \u4e2a\u6708\uff08\u7f13\u89e3\u6301\u7eed\u65f6\u95f4\u6570\u636e\u5c1a\u672a\u6210\u719f\uff09<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">DXC-008 \u7531\u676d\u5dde\u591a\u79a7\u751f\u7269\u5f00\u53d1\uff0c\u662f\u4e2d\u56fd\u4f01\u4e1a\u4e2d\u8f83\u65e9\u8fdb\u5165\u4e34\u5e8a\u7684 PSMA\u00d7STEAP1 \u53cc\u9776\u70b9 ADC\u3002\u4e34\u5e8a\u524d\u7814\u7a76\u663e\u793a\uff0cDXC-008 \u5bf9 STEAP1 \u548c PSMA \u5747\u5177\u6709\u9ad8\u4eb2\u548c\u529b\uff0c\u53ef\u6709\u6548\u5185\u5316\u8fdb\u5165\u80bf\u7624\u7ec6\u80de\uff0c\u4f53\u5185\u5916\u5448\u5242\u91cf\u4f9d\u8d56\u6027\u6297\u80bf\u7624\u6d3b\u6027\u4e14\u4f18\u4e8e\u5bf9\u5e94\u7684\u5355\u9776\u70b9 ADC\uff1b\u6052\u6cb3\u7334 2 \u4e2a\u6708\u91cd\u590d\u7ed9\u836f\u6bd2\u6027\u7814\u7a76\u4e2d\uff0c\u6700\u9ad8\u975e\u4e25\u91cd\u6bd2\u6027\u5242\u91cf\uff08HNSTD\uff09\u4e3a 40 mg\/kg<sup><strong>[11]<\/strong><\/sup>\u3002\u5176 I \u671f\u8bd5\u9a8c\uff08NCT06926283\uff09\u8ba1\u5212\u5165\u7ec4 110 \u4f8b\u524d\u5217\u817a\u764c\u3001\u5c24\u6587\u8089\u7624\u7b49\u5b9e\u4f53\u7624\u60a3\u8005\uff0c\u4eba\u4f53\u7597\u6548\u6570\u636e\u5c1a\u672a\u62ab\u9732<sup><strong>[11]<\/strong><\/sup>\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e2d\u56fd\u8fdb\u5c55\uff1a\u8bfa\u8bda\u5065\u534e\u7684 ICP-B381\u30022026 \u5e74 9 \u6708\uff0c\u8bfa\u8bda\u5065\u534e\u5ba3\u5e03\u5176\u81ea\u4e3b\u7814\u53d1\u7684\u9776\u5411 PSMA \u548c STEAP1 \u7684\u53cc\u6297 ADC \u65b0\u836f ICP-B381 \u83b7 NMPA \u4e34\u5e8a\u8bd5\u9a8c\u8bb8\u53ef\uff0c\u7528\u4e8e\u524d\u5217\u817a\u764c\u7b49\u5b9e\u4f53\u7624\u6cbb\u7597\u2014\u2014\u8fd9\u662f\u56fd\u5185\u9996\u6b3e\u83b7\u6279\u4e34\u5e8a\u7684 PSMA\/STEAP1 \u53cc\u6297 ADC<sup><strong>[12]<\/strong><\/sup>\u3002\u4e34\u5e8a\u524d 22Rv1 \u4eba\u524d\u5217\u817a\u764c\u5f02\u79cd\u79fb\u690d\u6a21\u578b\u4e2d\uff0cICP-B381 \u5448\u73b0\u5f3a\u6548\u3001\u5242\u91cf\u4f9d\u8d56\u6027\u7684\u6297\u80bf\u7624\u6d3b\u6027\uff0c\u540c\u7b49\u7ed9\u836f\u5242\u91cf\u4e0b\u836f\u6548\u4f18\u4e8e\u5bf9\u5e94\u7684\u5355\u9776\u70b9 PSMA-ADC \u548c STEAP1-ADC<sup><strong>[12]<\/strong><\/sup>\u3002\u81f3\u6b64\uff0c\u5168\u7403\u5c1a\u65e0 PSMA\u00d7STEAP1 \u53cc\u6297 ADC \u83b7\u6279\u4e0a\u5e02\uff0c\u8fd9\u4e00\u8d5b\u9053\u7684\u4e34\u5e8a\u7ade\u4e89\u624d\u521a\u521a\u5f00\u59cb<sup><strong>[10-12]<\/strong><\/sup>\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4ece\u5355\u9776\u70b9\u5230\u53cc\u9776\u70b9\uff0c\u662f STEAP1 ADC \u5f00\u53d1\u7684\u6838\u5fc3\u903b\u8f91\uff1aPSMA \u4e0e STEAP1 \u5728 AR \u9633\u6027\u80bf\u7624\u4e2d\u5171\u8868\u8fbe\uff0c\u8054\u5408\u9776\u5411\u4efb\u610f\u4e24\u4e2a\u6297\u539f\u53ef\u63d0\u9ad8\u6574\u4f53\u80bf\u7624\u8986\u76d6\u3001\u51cf\u5c11\u5355\u4e00\u6297\u539f\u5f02\u8d28\u6027\u5bfc\u81f4\u7684\u9003\u9038<sup><strong>[3]<\/strong><\/sup>\u3002\u4f46\u9700\u6ce8\u610f\u5176\u9002\u7528\u8fb9\u754c\u2014\u2014\u795e\u7ecf\u5185\u5206\u6ccc\u8f6c\u5316\u540e STEAP1 \u548c PSMA \u8868\u8fbe\u5747\u4e0b\u964d\uff0c\u53cc\u9776\u70b9 ADC \u65e0\u6cd5\u89e3\u51b3\u8c31\u7cfb\u8f6c\u5316\u540e\u7684\u9776\u70b9\u4e22\u5931\u95ee\u9898<sup><strong>[3]<\/strong><\/sup>\u3002\u8fd9\u4e5f\u662f\u524d\u8ff0 ZIC4 \/ MYC \/ SWI\/SNF \u8c03\u63a7\u7814\u7a76\u7684\u4ef7\u503c\u6240\u5728\uff1a\u82e5\u80fd\u901a\u8fc7\u8054\u5408\u7528\u836f\u5728\u6cbb\u7597\u8fc7\u7a0b\u4e2d\u7ef4\u6301\u6216\u4e0a\u8c03 STEAP1 \u8868\u8fbe\uff0c\u9776\u70b9\u7684\u9002\u7528\u8fb9\u754c\u6709\u671b\u88ab\u5916\u63a8<sup><strong>[2]<\/strong><\/sup>\u3002<\/p>\n\n\n\n<h5 class=\"wp-block-heading\"><strong>\u4e09\u3001<\/strong><strong>CAR-T <\/strong><strong>\u4e0e\u75ab\u82d7\uff1a\u65e9\u671f\u63a2\u7d22<\/strong><\/h5>\n\n\n\n<p class=\"wp-block-paragraph\">CAR-T \u65b9\u5411\uff0c\u4e24\u9879 I \u671f\u8bd5\u9a8c\u6b63\u5728\u63a8\u8fdb\u3002\u5176\u4e00\u4e3a STEAP1 CAR-T \u8054\u5408\u6069\u624e\u5362\u80fa\u7684 I\/II \u671f\u8bd5\u9a8c\uff08Fred Hutchinson \u764c\u75c7\u4e2d\u5fc3\u4e3b\u5bfc\uff0c2024 \u5e74 11 \u6708\u542f\u52a8\uff09\uff1a\u5229\u7528\u6069\u624e\u5362\u80fa\u5728\u4e34\u5e8a\u524d\u6a21\u578b\u4e2d\u89c2\u5bdf\u5230\u7684\u4e0a\u8c03 STEAP1 \u8868\u8fbe\u7279\u6027\u589e\u5f3a CAR-T \u7597\u6548\uff0c\u60a3\u8005\u7ecf\u73af\u78f7\u9170\u80fa + \u6c1f\u8fbe\u62c9\u6ee8\u6e05\u6dcb\u540e\u8f93\u6ce8 STEAP1 CAR-T\uff0c\u5e76\u81ea\u8f93\u6ce8\u65e5\u8d77\u6bcf\u65e5\u53e3\u670d\u6069\u624e\u5362\u80fa<sup><strong>[14]<\/strong><\/sup>\u3002\u5176\u4e8c\u4e3a\u300cIL-18 \u88c5\u7532\u300dSTEAP1 CAR-T \u7684 I \u671f\u8bd5\u9a8c\uff08NCT07803653\uff0cFred Hutchinson \u764c\u75c7\u4e2d\u5fc3\uff09\uff1a\u5728\u6807\u51c6 CAR-T \u57fa\u7840\u4e0a\u5171\u8868\u8fbe IL-18\uff0c\u65e8\u5728\u589e\u5f3a T \u7ec6\u80de\u6d3b\u5316\u3001\u4fc3\u8fdb Th1 \u578b\u708e\u75c7\u53cd\u5e94\uff1b\u8ba1\u5212\u5165\u7ec4&nbsp;20 \u4f8b&nbsp;mCRPC\uff0c\u9884\u8ba1 2026 \u5e74 10 \u6708\u5e95\u542f\u52a8\uff0c\u968f\u8bbf\u957f\u8fbe 15 \u5e74<sup><strong>[15]<\/strong><\/sup>\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u75ab\u82d7\u65b9\u5411\uff0cVTP-850\uff08Barinthus Bio\uff0c\u539f&nbsp;Vaccitech\uff09\u662f\u6700\u5177\u4ee3\u8868\u6027\u7684\u591a\u6297\u539f\u8bbe\u8ba1\uff1a\u4ee5 ChAdOx1 \u521d\u514d \/ MVA \u52a0\u5f3a\u7684 prime-boost \u7b56\u7565\uff0c\u7f16\u7801 PSA\u3001PAP\u3001STEAP1 \u548c 5T4 \u56db\u79cd\u524d\u5217\u817a\u76f8\u5173\u6297\u539f\uff0c\u901a\u8fc7\u591a\u6297\u539f\u8986\u76d6\u964d\u4f4e\u514d\u75ab\u9003\u9038\u98ce\u9669\u3002\u4f46\u5176 I\/II \u671f\u8bd5\u9a8c\uff08NCT05617040\uff0c\u751f\u5316\u590d\u53d1\u4eba\u7fa4\uff09\u5728\u5b8c\u6210 I \u671f\u90e8\u5206\u540e\u5df2\u4e8e 2025 \u5e74 2 \u6708\u7ec8\u6b62\uff08\u975e\u5b89\u5168\u6027\u539f\u56e0\uff0c\u5b9e\u9645\u5165\u7ec4 22 \u4f8b\uff09\uff0cII \u671f\u6269\u5c55\u672a\u542f\u52a8<sup><strong>[16]<\/strong><\/sup>\u3002\u66f4\u65e9\u4e4b\u524d\uff0cCureVac&nbsp;\u7684 CV9104\uff08\u540c\u6837\u9776\u5411 STEAP1 \u7b49\u591a\u79cd\u6297\u539f\uff09\u5728 197 \u4f8b&nbsp;mCRPC&nbsp;\u7684&nbsp;IIb&nbsp;\u671f\u8bd5\u9a8c\u4e2d\u672a\u80fd\u6539\u5584 OS\uff0c\u5f00\u53d1\u5c31\u6b64\u7ec8\u6b62<sup><strong>[17]<\/strong><\/sup>\u3002\u4e24\u6761\u632b\u6298\u7ebf\u7d22\u53e0\u52a0\uff0c\u63d0\u793a STEAP1 \u75ab\u82d7\u8def\u7ebf\u7684\u53ef\u884c\u6027\u4ecd\u9700\u66f4\u957f\u65f6\u95f4\u9a8c\u8bc1\u3002<\/p>\n\n\n\n<h5 class=\"wp-block-heading\"><strong>\u56db\u3001\u7406\u6027\u5224\u65ad\uff1a<\/strong><strong>STEAP1 <\/strong><strong>\u9776<\/strong><strong>\u5411\u6cbb\u7597<\/strong><strong>\u7684\u56db\u4e2a\u5c42\u6b21<\/strong><\/h5>\n\n\n\n<p class=\"wp-block-paragraph\">STEAP1 \u9776\u5411\u6cbb\u7597\u6b63\u5728\u591a\u6761\u6280\u672f\u8def\u7ebf\u4e0a\u540c\u65f6\u63a8\u8fdb\uff0c\u4f46\u4ece\u6570\u636e\u6210\u719f\u5ea6\u770b\uff0c\u5f53\u524d\u5448\u73b0\u5982\u4e0b\u56db\u4e2a\u5c42\u6b21\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>STEAP1 <\/strong><strong>\u9776<\/strong><strong>\u5411\u6cbb\u7597<\/strong><strong>\u7684\u56db\u4e2a\u5c42\u6b21<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u7b2c\u4e00\u5c42\uff1a\u786e\u8bc1\u6027<\/strong><strong> III <\/strong><strong>\u671f\uff5c<\/strong>Xaluritamig&nbsp;\u4e24\u9879 III \u671f\uff08XALute&nbsp;\u5df2\u5165\u7ec4 707 \u4f8b\u3001XALience&nbsp;\u8ba1\u5212\u7ea6 750 \u4f8b\uff09\u5747\u4ee5 OS \u4e3a\u4e3b\u8981\u7ec8\u70b9\uff0c\u662f\u672c\u9776\u70b9\u6700\u63a5\u8fd1\u4e34\u5e8a\u8f6c\u5316\u7684\u65b9\u5411[5,6]<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u7b2c\u4e8c\u5c42\uff1a\u65e9\u671f\u4e34\u5e8a\u9a8c\u8bc1\uff5c<\/strong>ABBV-969 I \u671f ORR 45%\u3001PSA50 67%\u3001\u4e2d\u4f4d&nbsp;rPFS 15.3 \u4e2a\u6708\uff1bDXC-008 \u5df2\u8fdb\u5165 I \u671f\uff1bICP-B381 \u83b7\u6279\u4e34\u5e8a[10-12]<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u7b2c\u4e09\u5c42\uff1a\u9996\u6b21\u4eba\u4f53\u95e8\u69db\uff5c<\/strong>HLX3902 \u83b7\u6fb3\u6d32 + \u4e2d\u56fd\u4e34\u5e8a\u8bb8\u53ef\u3001I \u671f\u5373\u5c06\u542f\u52a8\uff1b\u4e24\u9879 STEAP1 CAR-T I \u671f\u8bd5\u9a8c\u5728\u63a8\u8fdb\u4e2d[7,14,15]<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u7b2c\u56db\u5c42\uff1a\u9700\u8c28\u614e\u5bf9\u5f85\uff5c<\/strong>\u75ab\u82d7\u8def\u7ebf\u5df2\u6709\u4e24\u6b21\u632b\u6298\u2014\u2014CV9104 IIb&nbsp;\u671f\u672a\u8fbe OS \u4e3b\u8981\u7ec8\u70b9\uff1bVTP-850 I\/II \u671f\u5728 I \u671f\u90e8\u5206\u5b8c\u6210\u540e\u7ec8\u6b62[16,17]<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5173\u952e\u6311\u6218\u4ecd\u5728\u9776\u70b9\u672c\u8eab\u3002STEAP1 \u5728 AR \u9633\u6027\u80bf\u7624\u4e2d\u9ad8\u8868\u8fbe\u3001\u5728\u795e\u7ecf\u5185\u5206\u6ccc\u8f6c\u5316\u540e\u8868\u8fbe\u4e0b\u964d\u2014\u2014\u5b83\u8986\u76d6\u4e86 AR \u9633\u6027\u817a\u764c\u7684\u4e3b\u4f53\u4eba\u7fa4\uff0c\u4f46\u65e0\u6cd5\u8986\u76d6 AR \u9634\u6027 \/ \u795e\u7ecf\u5185\u5206\u6ccc\u8f6c\u5316\u7684\u60a3\u8005\uff1bPSMA\u00d7STEAP1 \u53cc\u9776\u70b9\u8bbe\u8ba1\u89e3\u51b3\u7684\u662f\u80bf\u7624\u5185\u4e0e\u80bf\u7624\u95f4\u7684\u6297\u539f\u5f02\u8d28\u6027\uff0c\u89e3\u51b3\u4e0d\u4e86\u8c31\u7cfb\u8f6c\u5316\u540e\u7684\u9776\u70b9\u4e22\u5931<sup><strong>[3]<\/strong><\/sup>\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4ece\u6570\u636e\u6210\u719f\u5ea6\u770b\uff0cXaluritamig&nbsp;\u7684 III \u671f OS \u6570\u636e\u5c06\u51b3\u5b9a STEAP1 \u80fd\u5426\u6210\u4e3a\u7ee7 PSMA \u4e4b\u540e\u7b2c\u4e8c\u4e2a\u83b7\u5f97\u786e\u8bc1\u6027\u9a8c\u8bc1\u7684\u524d\u5217\u817a\u764c\u8868\u9762\u9776\u70b9\uff1bABBV-969 \u4e0e DXC-008 \u4ee3\u8868\u7684 PSMA\u00d7STEAP1 \u53cc\u9776\u70b9 ADC\uff0c\u5219\u662f\u5bf9\u4ed8\u6297\u539f\u5f02\u8d28\u6027\u7684\u7ec4\u5408\u7b56\u7565\u5347\u7ea7\u2014\u2014\u6709\u671b\u7f13\u89e3\u6297\u539f\u5f02\u8d28\u6027\u5e26\u6765\u7684\u8010\u836f\u95ee\u9898\uff0c\u4f46\u65e0\u6cd5\u5916\u63a8\u81f3\u8c31\u7cfb\u8f6c\u5316\u573a\u666f\u3002STEAP1 \u9776\u5411\u6cbb\u7597\u7684\u6700\u7ec8\u4ef7\u503c\uff0c\u53d6\u51b3\u4e8e\u8fd9\u4e24\u6761\u8def\u7ebf\u5728\u786e\u8bc1\u6027\u4e34\u5e8a\u4e2d\u7684\u8868\u73b0\u3002<\/p>\n\n\n\n<h5 class=\"wp-block-heading\"><strong>\u4e00\u53e5\u8bdd\u603b\u7ed3<\/strong><\/h5>\n\n\n\n<p class=\"wp-block-paragraph\">\u9776\u70b9\u751f\u7269\u5b66\u51b3\u5b9a\u5929\u82b1\u677f\uff0c\u4e34\u5e8a\u7b56\u7565\u51b3\u5b9a\u5151\u73b0\u901f\u5ea6\u2014\u2014STEAP1 \u7684\u7ade\u901f\uff0c\u672c\u8d28\u4e0a\u662f\u300c\u9776\u70b9\u8868\u8fbe\u8fb9\u754c \u00d7 \u6280\u672f\u8def\u7ebf\u8fed\u4ee3\u300d\u7684\u53cc\u91cd\u535a\u5f08\u3002<\/p>\n\n\n\n<h5 class=\"wp-block-heading\"><strong>\u53c2\u8003\u6587\u732e<\/strong><\/h5>\n\n\n\n<p class=\"wp-block-paragraph\">[1] Dang K, Ma W, Coleman R, et al. Targeting advanced prostate cancer with STEAP1 chimeric antigen receptor T cell and tumor-localized IL-12 immunotherapy. <em>Nat <\/em><em>Commun<\/em>. 2023;14:3396.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">[2] Zhu S, et al. Study identifies mechanisms controlling STEAP1 expression, opportunities for combination therapy in PCa. <em>J <\/em><em>Clin<\/em><em>Oncol<\/em>. 2025;43(16 suppl):e17084. \u53c2\u89c1 GU Oncology Now \u76f8\u5173\u62a5\u9053\uff082025 PCF Scientific Retreat\uff09\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">[3] Sayar E, Richards HM, Gulati R, et al. Integrative Surface Antigen Profiling of KLK2 and STEAP1 in Advanced Prostate Cancer. <em>Mol<\/em><em> Cancer Res<\/em>. 2026;24(9):754-769.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">[4] Kelly WK, Danila DC, Lin CC, et al. Xaluritamig, a STEAP1 \u00d7 CD3 XmAb 2+1 Immune Therapy for Metastatic Castration-Resistant Prostate Cancer: Results from Dose Exploration in a First-in-Human Study. <em>Cancer <\/em><em>Discov<\/em>. 2024;14(1):76-89.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">[5] Amgen. Phase 3 Study of Xaluritamig vs Cabazitaxel or Second Androgen Receptor-Directed Therapy in Subjects With Metastatic Castration-Resistant Prostate Cancer (XALute). NCT06691984. ClinicalTrials.gov.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">[6] Dorff TB, Appleman LJ, Lin CC, et al. XALience: A phase 3, open-label, multicenter, randomized study of xaluritamig plus abiraterone vs investigator&#8217;s choice in patients with chemotherapy-na\u00efve metastatic castration-resistant prostate cancer. <em>J <\/em><em>Clin<\/em><em>Oncol<\/em>. 2026;44(16 suppl):TPS5144. \u53c2\u89c1 NCT07213674, ClinicalTrials.gov.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">[7] \u590d\u5b8f\u6c49\u9716. HLX3902\uff08STEAP1\u00d7CD3\u00d7CD28 \u4e09\u7279\u5f02\u6027\u6297\u4f53\uff09\u83b7\u6fb3\u5927\u5229\u4e9a\u4e34\u5e8a\u8bd5\u9a8c\u6279\u51c6. 2026-05-21\uff1b\u53e6\u89c1\u6e2f\u4ea4\u6240\u516c\u544a\uff082026-07-30\uff09\u53ca\u4e2d\u56fd\u4e34\u5e8a\u8bd5\u9a8c\u8bb8\u53ef\u516c\u544a\uff082026-06-17\uff09\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">[8] Raychaudhuri R, Schweizer MT, Hawley JE, et al. Xaluritamig: a first step towards a new target, new mechanism for metastatic prostate cancer. <em>AME <\/em><em>Clin<\/em><em> Trials Rev<\/em>. 2024;2:44&nbsp;\u53ca\u7814\u7a76\u56e2\u961f\u56de\u590d\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">[9] Danila DC, Szmulewitz RZ, Vaishampayan U, et al. Phase I Study of DSTP3086S, an Antibody-Drug Conjugate Targeting Six-Transmembrane Epithelial Antigen of Prostate 1, in Metastatic Castration-Resistant Prostate Cancer. <em>J <\/em><em>Clin<\/em><em>Oncol<\/em>. 2019;37(36):3518-3527.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">[10] Dorff TB, et al. A phase 1, first-in-human study evaluating the safety, pharmacokinetics, and efficacy of ABBV-969 in patients with metastatic castration-resistant prostate cancer. <em>J <\/em><em>Clin<\/em><em>Oncol<\/em>. 2026;44(16 suppl):5014. \u53c2\u89c1 AbbVie \u5b98\u65b9\u65b0\u95fb\u7a3f\uff082026-05-21\uff09\u53ca&nbsp;ApexOnco&nbsp;\u4f1a\u8bae\u62a5\u9053\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">[11] Yu J, Guo H, Jia J, et al. The anti-STEAP1\/PSMA ADC, DXC008: Assessment of anti-tumor efficacy, pharmacokinetic, and toxicity properties. <em>J <\/em><em>Clin<\/em><em>Oncol<\/em>. 2025;43(16 suppl):e17161. \u53c2\u89c1 NCT06926283, ClinicalTrials.gov.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">[12] \u8bfa\u8bda\u5065\u534e. \u8bfa\u8bda\u5065\u534e PSMA\/STEAP1 \u53cc\u6297 ADC ICP-B381 \u83b7\u6279\u4e34\u5e8a. 2026-09-09.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">[13] Adcentrx Therapeutics. China NMPA Grants IND Clearance to ADRX-0405 STEAP1 ADC. 2026-06-08\uff1b\u53e6\u89c1 U.S. FDA Grants Orphan Drug Designation to ADRX-0405 for Gastric Cancer. 2025-07-08.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">[14] Fred Hutchinson Cancer Center. Phase 1\/2 Dose-Escalation and Cohort Study of STEAP1 CART With Enzalutamide in Participants With mCRPC. NCT06236139. ClinicalTrials.gov.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">[15] Fred Hutchinson Cancer Center. Phase 1 Dose-Escalation and Expansion Study of IL-18 Armored STEAP1 CAR T in Participants With&nbsp;mCRPC. NCT07803653. ClinicalTrials.gov.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">[16] Barinthus&nbsp;Biotherapeutics. Prime-boost Immunotherapeutic Trial (VTP-850) in Men With Biochemical Recurrence After Definitive Local Therapy for Prostate Cancer. NCT05617040. ClinicalTrials.gov\uff08\u8bd5\u9a8c\u5728 I \u671f\u90e8\u5206\u5b8c\u6210\u540e\u7ec8\u6b62\uff09.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">[17] CureVac prostate cancer vaccine candidate CV9104 fails Phase IIb trial. <em>Genet <\/em><em>Eng<\/em><em>Biotechnol<\/em><em> News<\/em>. 2017-01-12.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u64b0\u6587\uff1a\u90d1\u53f6\u654f<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u5f15\u8a00\uff1a\u4e3a\u4ec0\u4e48\u662f STEAP1\uff1f \u5728\u524d\u5217\u817a\u764c\u9776\u5411\u6cbb\u7597\u9886\u57df\uff0cPSMA \u4ecd\u662f\u6700\u6210\u719f\u7684\u9776\u70b9\u3002\u4f46 PSMA \u5e76\u975e\u5b8c\u7f8e\u2014\u2014 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":2170,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[147],"tags":[86,15,32,34,29],"class_list":["post-2169","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-147","tag-86","tag-15","tag-32","tag-34","tag-29"],"_links":{"self":[{"href":"https:\/\/www.millibuff.com\/index.php?rest_route=\/wp\/v2\/posts\/2169","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.millibuff.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.millibuff.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.millibuff.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.millibuff.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2169"}],"version-history":[{"count":3,"href":"https:\/\/www.millibuff.com\/index.php?rest_route=\/wp\/v2\/posts\/2169\/revisions"}],"predecessor-version":[{"id":2173,"href":"https:\/\/www.millibuff.com\/index.php?rest_route=\/wp\/v2\/posts\/2169\/revisions\/2173"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.millibuff.com\/index.php?rest_route=\/wp\/v2\/media\/2170"}],"wp:attachment":[{"href":"https:\/\/www.millibuff.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2169"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.millibuff.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2169"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.millibuff.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2169"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}