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class=\"wp-block-paragraph\">\u5728\u672c\u7814\u7a76\u4e2d\uff0c\u7814\u7a76\u4eba\u5458\u57fa\u4e8e\u73b0\u6709\u4e34\u5e8a\u6570\u636e\uff0c\u5f00\u53d1\u4e86\u4e00\u79cd\u65b0\u578b\u7684\u5c3c\u62c9\u5e15\u5229PBPK\u6a21\u578b\uff0c\u4ee5\u63a2\u7a76\u8be5\u836f\u7269\u5728\u7279\u6b8a\u4eba\u7fa4\u4e2d\u7684\u836f\u4ee3\u52a8\u529b\u5b66\u7279\u5f81\u3002PBPK\u5efa\u6a21\u80fd\u591f\u9884\u6d4b\u836f\u7269\u5728\u5404\u5668\u5b98\u548c\u7ec4\u7ec7\u4e2d\u7684\u5206\u5e03\u53ca\u66b4\u9732\u91cf\uff0c\u53ef\u7528\u4e8e\u8bc4\u4f30\u836f\u7269\u7684\u7597\u6548\u548c\u6bd2\u6027\u76f8\u5173\u95ee\u9898\u3002\u9274\u4e8e\u5c3c\u62c9\u5e15\u5229\u5b58\u5728\u8840\u6db2\u5b66\u6bd2\u6027\u98ce\u9669\uff0c\u8be5\u6a21\u578b\u5bf9\u5176\u5728\u9aa8\u7ec4\u7ec7\u4e2d\u6d53\u5ea6\u7684\u6a21\u578b\u5316\u4f30\u7b97\u5c24\u4e3a\u91cd\u8981\u3002\u5728\u6784\u5efa\u7684PBPK\u6a21\u578b\u4e2d\uff0c\u7814\u7a76\u4eba\u5458\u660e\u786e\u4e86\u4ee5\u8840\u6d46\u603b\u80c6\u7ea2\u7d20\uff08TBIL\uff09\u8868\u793a\u7684\u809d\u529f\u80fd\u4e0e\u5c3c\u62c9\u5e15\u5229\u7ecfCES1\u4ee3\u8c22\u7684\u7279\u5f02\u6027\u6e05\u9664\u7387\u4e4b\u95f4\u7684\u76f8\u5173\u6027\u3002\u57fa\u4e8e\u8fd9\u4e00\u5173\u8054\uff0c\u7814\u7a76\u4eba\u5458\u4e3a\u4e0d\u540c\u809d\u635f\u4f24\u7a0b\u5ea6\u7684\u60a3\u8005\u5236\u5b9a\u4e86\u7ed9\u836f\u5efa\u8bae\uff0c\u76ee\u6807\u662f\u4f7f\u8fd9\u4e9b\u60a3\u8005\u7684\u836f\u7269\u66b4\u9732\u91cf\u4e0e\u809d\u529f\u80fd\u6b63\u5e38\u60a3\u8005\u7684\u66b4\u9732\u91cf\u76f8\u5f53\u3002<\/p>\n\n\n\n<h5 class=\"wp-block-heading\"><strong>2 \u57fa\u4e8e\u751f\u7406\u7684\u836f\u4ee3\u52a8\u529b\u5b66\u5efa\u6a21<\/strong><\/h5>\n\n\n\n<p class=\"wp-block-paragraph\">2.1 \u5c3c\u62c9\u5e15\u5229PBPK\u6a21\u578b\u6784\u5efa<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5b8c\u6574\u7684\u57fa\u4e8e\u751f\u7406\u5b66\u7684\u836f\u4ee3\u52a8\u529b\u5b66\u6a21\u578b\u7531\u591a\u5ba4\u7ed3\u6784\u6784\u6210\uff0c\u8be5\u7ed3\u6784\u901a\u8fc7\u7cfb\u7edf\u548c\u836f\u7269\u76f8\u5173\u53c2\u6570\u8fdb\u884c\u63cf\u8ff0\u3002\u9488\u5bf9\u5c3c\u62c9\u5e15\u5229\u5f00\u53d1\u4e86\u4e00\u79cd\u201c\u7531\u5185\u800c\u5916\u201d\u7684\u9002\u914dPBPK\u6a21\u578b(Shebley\u7b49\u4eba\uff0c2018)\uff1b\u6a21\u578b\u7ed3\u6784\u548c\u7cfb\u7edf\u53c2\u6570\u91c7\u7528PK-Sim\u4e2d\u7684\u65e2\u5b9a\u5b9e\u73b0\u65b9\u5f0f\uff0c\u800c\u836f\u7269\u7279\u5f02\u6027\u53c2\u6570\u5219\u6765\u6e90\u4e8e\u5df2\u53d1\u8868\u7684\u6587\u732e\uff0c\u6216\u57fa\u4e8e\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u80f6\u56ca\u7ed9\u836f\u540e\u5c3c\u62c9\u5e15\u5229\u7684\u73b0\u6709\u4e34\u5e8a\u66b4\u9732\u6570\u636e\u8fdb\u884c\u4f30\u7b97\u3002\u5c3c\u62c9\u5e15\u5229\u662f\u4e00\u79cd\u5c0f\u5206\u5b50\u5316\u5408\u7269\uff0c\u5206\u5b50\u91cf\u4e3a320.4 g\/mol\uff1b\u4eba\u8840\u6d46\u4e2d\u7684\u672a\u7ed3\u5408\u5206\u6570\uff08fu\uff09\u4e3a0.17\uff08\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40FDA\uff0c2017\u5e74\uff1b\u6b27\u6d32\u836f\u54c1\u7ba1\u7406\u5c40EMA\uff0c2020\u5e74\uff09\u3002\u5206\u914d\u7cfb\u6570\u548c\u7ec6\u80de\u901a\u900f\u6027\u5206\u522b\u91c7\u7528PK-Sim\u4e2d\u5185\u7f6e\u7684Schmitt\u65b9\u6cd5\u548c\u7535\u8377\u4f9d\u8d56\u6027Schmitt\u65b9\u6cd5\u8fdb\u884c\u8ba1\u7b97\u3002\u4e3a\u7b80\u5316\u6a21\u578b\u6821\u51c6\u6d41\u7a0b\uff0c\u5bf9\u5438\u6536\u53c2\u6570\u505a\u51fa\u4e86\u5982\u4e0b\u5047\u8bbe\uff1a\u57fa\u4e8e\u7fa4\u4f53\u836f\u4ee3\u52a8\u529b\u5b66\u6a21\u578b\u4e2d\u7981\u98df\u6761\u4ef6\u4e0b\u96f6\u7ea7\u836f\u7269\u91ca\u653e\u7684\u4f30\u7b97\u65f6\u957f\uff080.235\u5c0f\u65f6\u53ca\u4ee5\u4e0a\uff09\uff0c\u91c7\u7528Weibull\u51fd\u6570\u63cf\u8ff0\u5c3c\u62c9\u5e15\u5229\u80f6\u56ca\u5728\u80c3\u80a0\u9053\u4e2d\u7684\u6eb6\u51fa\u8fc7\u7a0b\uff0c\u5176\u4e2d\u6eb6\u51fa\u65f6\u95f4\u4e3a0.5\u5c0f\u65f6\uff0c\u6eb6\u51fa\u5f62\u72b6\u53c2\u6570\u4e3a2.0\u3002\u6839\u636e\uff08Basit\u7b49\u4eba\uff0c2020\u5e74\uff09\u7684\u7814\u7a76\u6570\u636e\uff0c\u8ba1\u7b97\u51fa\u5c3c\u62c9\u5e15\u5229\u4ee3\u8c22\u9176\u540c\u5de5\u578bCES1\u5728\u809d\u810f\u3001\u80a0\u9053\u3001\u80be\u810f\u3001\u5fc3\u810f\u548c\u80ba\u90e8\u4e2d\u7684\u76f8\u5bf9\u4e30\u5ea6\uff0c\u5e76\u5c06\u5176\u7eb3\u5165\u6a21\u578b\u3002\u5bf9\u4e8e\u6240\u6709\u5176\u4ed6\u7cfb\u7edf\u53c2\u6570\uff0c\u5747\u91c7\u7528\u5b8c\u6574PBPK\u6a21\u578b\u62a5\u544a\u7684\u9ed8\u8ba4\u503c\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">2.2 \u6a21\u578b\u53c2\u6570\u6821\u51c6<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e94\u4e2a\u836f\u7269\u7279\u5f02\u6027\u53c2\u6570\uff0c\u5206\u522b\u4e3aLogP\u3001pKa\u3001P<sub>int<\/sub>\uff08dm\/min\uff09\u3001CL<sub>ren<\/sub>\uff08ml\/min\/kg\uff09\u4ee5\u53caCL<sub>spec<\/sub>\uff08L\/min\/umol\uff09\u7528\u4e8e\u6821\u51c6\u3002\u91c7\u7528\u4e86\u8fed\u4ee3\u8fd1\u4f3c\u8d1d\u53f6\u65af\u8ba1\u7b97\u5e8f\u8d2f\u8499\u7279\u5361\u6d1b\uff08ABC-SMC\uff09\u65b9\u6cd5\u3002ABC-SMC\u7b97\u6cd5\u4f1a\u4f9d\u6b21\u4f18\u5316\u6240\u4f7f\u7528\u7684\u53c2\u6570\u540e\u9a8c\u5206\u5e03\u8fd1\u4f3c\u503c\uff0c\u4e3a\u540e\u7eed\u6b65\u9aa4\u751f\u6210\u53c2\u6570\u96c6\u3002\u5728\u4ee5t\u4e3a\u7d22\u5f15\u7684\u6bcf\u6b21\u8fed\u4ee3\u4e2d\uff0c\u8be5\u7b97\u6cd5\u65e8\u5728\u4ecep(\u03b8|\u03c1\uff08Y, Y<sub>obs<\/sub>\uff09&lt; \u025b<sub>t<\/sub>)\u4e2d\u62bd\u6837\uff0c\u5176\u4e2d&nbsp;\u025b<sub>t<\/sub><sub>&nbsp;<\/sub>\u5b9a\u4e49\u4e86\u4e00\u7cfb\u5217\u9012\u51cf\u7684\u9608\u503c\u3002\u03c1(Y, Y<sub>obs<\/sub>)\u662f\u6a21\u578b\u9884\u6d4b\u7684\u836f\u7269\u6d53\u5ea6\uff08Y\uff09\u4e0e\u5b9e\u6d4b\u836f\u7269\u6d53\u5ea6Y<sub>obs<\/sub>\u4e4b\u95f4\u5dee\u5f02\u7684\u9009\u5b9a\u8861\u91cf\u6307\u6807\uff0c\u5373\u76ee\u6807\u51fd\u6570\u3002\u5728\u9996\u6b21\u8fed\u4ee3\u4e2d\uff0c\u53c2\u6570\u503c\u4ece\u5148\u9a8c\u5206\u5e03\u4e2d\u62bd\u6837\uff0c\u5148\u9a8c\u5206\u5e03\u5047\u8bbe\u4e3a\u6b63\u6001\u5206\u5e03\u4e14\u8303\u56f4\u76f8\u5bf9\u8f83\u5bbd\u3002P<sub>int<\/sub>\u3001CL<sub>ren<\/sub>\u548cCL<sub>spec<\/sub>\u5148\u9a8c\u5206\u5e03\u7684\u5e73\u5747\u503c\u4e3b\u8981\u5728PK-Sim\u56fe\u5f62\u7528\u6237\u754c\u9762\u4e2d\u9009\u53d6\uff0c\u5c3c\u62c9\u5e15\u5229\u7684\u7406\u8bba\u4f30\u8ba1\u503c\uff08logP=2.45\uff0cpKa=10\uff09\u53d6\u81eaDrugBank\u6570\u636e\u5e93\u3002\u5bf9\u4e8eP<sub>int<\/sub>\u3001CL<sub>ren<\/sub>\u548cCL<sub>spec<\/sub>\u7684\u5148\u9a8c\u5206\u5e03\uff0c\u4f7f\u7528\u4e86\u76f8\u5bf9\u8f83\u5927\u7684CV=100 %\uff0c\u800clogP\u548cpKa\u7684\u5148\u9a8c\u5206\u5e03\u5219\u4f7f\u7528\u4e86\u8f83\u5c0f\u7684CV=20 %\u3002\u4ece\u7b2c\u4e8c\u6b21\u8fed\u4ee3\u5f00\u59cb\uff0c\u901a\u8fc7\u5bf9\u524d\u4e00\u6b21\u8fed\u4ee3\u5f97\u5230\u7684\u7ed3\u679c\u5e94\u7528\u591a\u5143\u6b63\u6001\uff08MVN\uff09\u6270\u52a8\u6838\uff0c\u751f\u6210\u53c2\u6570\u7a7a\u95f4\u5185\u7684\u65b0\u53c2\u6570\u96c6\u3002\u591a\u5143\u6b63\u6001\u5206\u5e03\u7684\u53c2\u6570\uff08\u5747\u503c\u548c\u534f\u65b9\u5dee\u77e9\u9635\uff09\u57fa\u4e8e\u524d\u4e00\u6b21\u8fed\u4ee3\u5f97\u5230\u7684\u540e\u9a8c\u5206\u5e03\u96c6\u8fdb\u884c\u4f30\u8ba1\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e3a\u4e86\u83b7\u5f97\u89c2\u6d4b\u503c\u76f8\u5bf9\u8f83\u4f4e\u548c\u8f83\u9ad8\u65f6\u7684\u53ef\u6bd4\u5f71\u54cd\uff0c\u91c7\u7528\u4e86\u5982\u4e0b\u5f62\u5f0f\u7684\u76ee\u6807\u51fd\u6570\uff1a<img decoding=\"async\" width=\"275\" height=\"72\" src=\"blob:https:\/\/www.millibuff.com\/d1a83ff9-47c5-44f5-a5d6-20e0f9d11993\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5c3c\u62c9\u5e15\u5229\u539f\u5f62\u836f\u7269\u7ecf\u5c3f\u6db2\u6392\u6cc4\u7684\u76f8\u5173\u4fe1\u606f\u88ab\u6574\u5408\u5230\u5254\u9664\u6d41\u7a0b\u4e2d\uff0c\u4ee5\u964d\u4f4e\u62df\u5408\u53c2\u6570\u7684\u4e0d\u786e\u5b9a\u6027\uff0c\u5e76\u786e\u4fdd\u6a21\u578b\u4e0e\u5df2\u53d1\u8868\u7684\u73b0\u6709\u836f\u4ee3\u52a8\u529b\u5b66\u6570\u636e\u76f8\u517c\u5bb9\u3002\u82e5\u9884\u6d4b\u7684\u5c3f\u6db2\u4e2d\u836f\u7269\u5242\u91cf\u5904\u4e8e\u9884\u671f\u503c&nbsp;\u00b140%&nbsp;\u7684\u533a\u95f4\u5185\uff0c\u5219\u76f8\u5173\u63d0\u8bae\u5c06\u88ab\u91c7\u7eb3\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5728\u6bcf\u6b21\u8fed\u4ee3\u4e2d\uff0c\u9488\u5bf9\u4e0d\u540c\u5242\u91cf\u5c3c\u62c9\u5e15\u5229\u8ba1\u7b97\u51fa\u7684 \u03c1(Y, Y<sub>obs<\/sub>) \u503c\uff08\u82e5\u8003\u8651\u591a\u79cd\u5242\u91cf\uff09\uff0c\u5747\u91c7\u7528\u76f8\u540c\u7684\u9608\u503c \u03b5<sub>t<\/sub>\u3002\u56e0\u6b64\uff0c\u53ea\u6709\u5f53\u67d0\u4e00\u65b9\u6848\u80fd\u540c\u65f6\u51c6\u786e\u63cf\u8ff0\u4e0d\u540c\u5242\u91cf\u7684\u76f8\u5173\u6570\u636e\u65f6\uff0c\u624d\u4f1a\u88ab\u63a5\u53d7\u3002\u7b97\u6cd5\u5b9e\u73b0\u7684\u5177\u4f53\u7ec6\u8282\u8be6\u89c1\u4e0b\u8868\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-full is-resized\"><img fetchpriority=\"high\" decoding=\"async\" width=\"408\" height=\"339\" src=\"https:\/\/www.millibuff.com\/wp-content\/uploads\/2026\/10\/image.png\" alt=\"\" class=\"wp-image-2204\" style=\"aspect-ratio:1.2035585987414712;width:544px;height:auto\" srcset=\"https:\/\/www.millibuff.com\/wp-content\/uploads\/2026\/10\/image.png 408w, https:\/\/www.millibuff.com\/wp-content\/uploads\/2026\/10\/image-300x249.png 300w\" sizes=\"(max-width: 408px) 100vw, 408px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">\u88681 \u8fd1\u4f3c\u8d1d\u53f6\u65af\u8ba1\u7b97\u5e8f\u5217\u8499\u7279\u5361\u6d1b\uff08ABC-SMC\uff09\u7b97\u6cd5\u53c2\u6570\u6458\u8981<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">2.3 \u809d\u529f\u80fd\u4f9d\u8d56\u6574\u5408<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u60a3\u8005\u7684\u809d\u529f\u80fd\u4f9d\u636e\u7f8e\u56fd\u56fd\u5bb6\u764c\u75c7\u7814\u7a76\u6240-\u5668\u5b98\u529f\u80fd\u969c\u788d\u5de5\u4f5c\u7ec4\uff08NCI-ODWG\uff09\u6807\u51c6\u8fdb\u884c\u5206\u7ea7\uff0c\u8be5\u6807\u51c6\u88ab\u7528\u4e8e\u5c3c\u62c9\u5e15\u5229\u836f\u4ee3\u52a8\u529b\u5b66\u552f\u4e00\u4e00\u9879\u7eb3\u5165\u809d\u529f\u80fd\u6b63\u5e38\uff08NHF\uff09\u548c\u4e2d\u5ea6\u809d\u529f\u80fd\u635f\u5bb3\uff08MHI\uff09\u60a3\u8005\u7684\u4e34\u5e8a\u8bd5\u9a8c\u3002\u6839\u636e\u8fd9\u4e9b\u6807\u51c6\uff0c\u809d\u529f\u80fd\u969c\u788d\u7684\u4e25\u91cd\u7a0b\u5ea6\u901a\u8fc7\u8840\u6d46\u4e2d\u603b\u80c6\u7ea2\u7d20\uff08TBIL\uff09\u548c\u5929\u95e8\u51ac\u6c28\u9178\u6c28\u57fa\u8f6c\u79fb\u9176\uff08AST\uff09\u6c34\u5e73\u7684\u7ec4\u5408\u6765\u786e\u5b9a\u3002\u4ee5\u4e0b\u9650\u503c\u88ab\u7528\u4e8e\u5b9a\u4e49\u809d\u529f\u80fd\u635f\u5bb3\u8bc4\u4f30\u7684\u53c2\u8003\u503c\uff1a\u809d\u529f\u80fd\u6b63\u5e38\u7ec4\u548c\u4e2d\u5ea6\u809d\u529f\u80fd\u635f\u5bb3\u7ec4\u5206\u522b\u6ee1\u8db3TBIL\u6b63\u5e38\u4e0a\u9650\uff08ULN\uff09\u4ee5\u53caTBIL\u5904\u4e8e1.5\u500dULN\u81f33\u500dULN\u7684\u6761\u4ef6\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e3a\u6574\u5408\u5c3c\u62c9\u5e15\u5229\u6e05\u9664\u7387\u5bf9\u809d\u635f\u4f24\u4e25\u91cd\u7a0b\u5ea6\u7684\u4f9d\u8d56\u6027\uff0c\u4f5c\u51fa\u5982\u4e0b\u5047\u8bbe\uff1a\u5c06CES1\u4ee3\u8c22\u7684CL<sub>spec<\/sub>\u53c2\u6570\u8bbe\u4e3a\u603b\u80c6\u7ea2\u7d20\uff08TBIL\uff09\u7684\u51fd\u6570\uff1a<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img decoding=\"async\" width=\"246\" height=\"47\" src=\"https:\/\/www.millibuff.com\/wp-content\/uploads\/2026\/10\/image-1.png\" alt=\"\" class=\"wp-image-2205\"\/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">\u5176\u4e2dCL<sub>spec<\/sub><sub>; median<\/sub>\u4ee3\u8868\u809d\u529f\u80fd\u6b63\u5e38\u60a3\u8005\u7684\u6821\u51c6\u53c2\u6570\u503c\uff0cTBIL<sub>media<\/sub><sub>n<\/sub>\u5bf9\u5e94\u4e8e\u4ece\u7814\u7a76\u961f\u5217\u7279\u5f81\u5f97\u51fa\u7684\u603b\u80c6\u7ea2\u7d20\u4e2d\u4f4d\u6570\u6d53\u5ea6\uff086.8&nbsp;\u03bcM\uff09\u3002\u4e3a\u4f30\u7b97\u4e2d\u5ea6\u809d\u635f\u4f24\uff08MHI\uff09\u7ec4\u4e2d\u7684CL<sub>spec<\/sub>\uff0c\u91c7\u7528\u76f8\u540c\u7684\u6821\u51c6\u7b97\u6cd5\uff0c\u5c06\u4e2d\u5ea6\u809d\u635f\u4f24\u7ec4\u7684\u603b\u80c6\u7ea2\u7d20\u4e2d\u4f4d\u6570\uff0841.9&nbsp;\u03bcM\uff09\u4ee3\u5165\u65b9\u7a0b\u3002\u968f\u540e\u901a\u8fc7\u5229\u7528\u4e2d\u5ea6\u809d\u635f\u4f24\u7ec4\u4e0e\u6b63\u5e38\u809d\u529f\u80fd\uff08NHF\uff09\u7ec4\u7684\u603b\u80c6\u7ea2\u7d20\u4e2d\u4f4d\u6570\u4e4b\u6bd4\u6c42\u89e3\u65b9\u7a0b\uff0c\u786e\u5b9a\u53c2\u6570\u03b1\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e3a\u9a8c\u8bc1\u6a21\u578b\u9884\u6d4b\u7ed3\u679c\uff0c\u7814\u7a76\u4eba\u5458\u4f9d\u636eChild-Pugh\u6807\u51c6\u5bf9\u8f7b\u5ea6\u3001\u4e2d\u5ea6\u6216\u91cd\u5ea6\u809d\u529f\u80fd\u4e0d\u5168\u7684\u7279\u5b9a\u4e2a\u4f53\u5f00\u5c55\u4e86\u989d\u5916\u6a21\u62df\u3002\u57fa\u4e8eEdginton\u4e0eWillmann\uff082008\uff09\u4ee5\u53caJohnson\u7b49\uff082010\uff09\u7684\u7814\u7a76\uff0c\u9488\u5bf9\u8fd9\u4e9b\u4e2a\u4f53\uff0c\u5c06\u591a\u9879\u751f\u7406\u5b66\u53c2\u6570\uff08\u5982\u809d\u7ec6\u80de\u529f\u80fd\u5bb9\u79ef\u3001\u76f8\u5173\u5668\u5b98\u7684\u8840\u6d41\u91cf\u3001\u57fa\u4e8e\u4f4e\u767d\u86cb\u767d\u6c34\u5e73\u8ba1\u7b97\u7684\u8840\u6d46\u4e2d\u672a\u7ed3\u5408\u5206\u6570\u7b49\uff09\u4e0e\u6b63\u5e38\u503c\u8fdb\u884c\u4e86\u5bf9\u6bd4\u5206\u6790\uff0c\u8be6\u89c1\u4e0b\u8868\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"399\" height=\"263\" src=\"https:\/\/www.millibuff.com\/wp-content\/uploads\/2026\/10\/image-2.png\" alt=\"\" class=\"wp-image-2206\" style=\"aspect-ratio:1.5172087894778294;width:575px;height:auto\" srcset=\"https:\/\/www.millibuff.com\/wp-content\/uploads\/2026\/10\/image-2.png 399w, https:\/\/www.millibuff.com\/wp-content\/uploads\/2026\/10\/image-2-300x198.png 300w\" sizes=\"(max-width: 399px) 100vw, 399px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">\u88682 \u809d\u529f\u80fd\u4e0d\u5168\u60a3\u8005\u7684\u751f\u7406\u5b66\u53c2\u6570\u503c<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u989d\u5916\u7684\u6a21\u62df\u7eb3\u5165\u4e86\u91cd\u5ea6\u809d\u635f\u4f24\u60a3\u8005\u4e2d\u89c2\u5bdf\u5230\u7684\u809d\u7ec4\u7ec7CES1\u4e30\u5ea6\u964d\u4f4e\u60c5\u51b5\uff0c\u89c1\u4e0b\u8868\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"413\" height=\"234\" src=\"https:\/\/www.millibuff.com\/wp-content\/uploads\/2026\/10\/image-4.png\" alt=\"\" class=\"wp-image-2208\" style=\"width:571px;height:auto\" srcset=\"https:\/\/www.millibuff.com\/wp-content\/uploads\/2026\/10\/image-4.png 413w, https:\/\/www.millibuff.com\/wp-content\/uploads\/2026\/10\/image-4-300x170.png 300w\" sizes=\"(max-width: 413px) 100vw, 413px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">\u88683 \u5404\u7ec4\u7ec7\u4e2d CES1 \u7684\u76f8\u5bf9\u4e30\u5ea6<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">2.4 \u6700\u7ec8\u6a21\u578b\u5206\u6790<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u901a\u8fc7\u8ba1\u7b97\u673a\u6a21\u62df\u9884\u6d4b\u4e0d\u540c\u809d\u529f\u80fd\u635f\u5bb3\u4e25\u91cd\u7a0b\u5ea6\u60a3\u8005\u7684\u5c3c\u62c9\u5e15\u5229\u8840\u6d46\u66b4\u9732\u91cf\u53d8\u5316\uff0c\u5e76\u63a2\u7d22\u80fd\u591f\u4f7fAUC\u843d\u5728\u6b63\u5e38\u809d\u529f\u80fd\u60a3\u8005\u6240\u9884\u6d4b\u76ee\u6807\u8303\u56f4\u5185\u7684\u5242\u91cf\u8c03\u6574\u65b9\u6848\u3002\u5728\u5b9e\u65bd\u62df\u8bae\u7684\u5242\u91cf\u8c03\u6574\u540e\uff0c\u5bf9\u5c3c\u62c9\u5e15\u5229\u7684\u7ec4\u7ec7\u5206\u5e03\u8fdb\u884c\u4e86\u9884\u6d4b\uff0c\u5e76\u4e0e\u63a5\u53d7\u5168\u5242\u91cf\u7ed9\u836f\u7684\u5bf9\u7167\u7ec4\uff08NHF \u7ec4\uff09\u8fdb\u884c\u4e86\u6bd4\u8f83\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u672c\u7814\u7a76\u5f00\u5c55\u4e86\u5c40\u90e8\u654f\u611f\u6027\u5206\u6790\uff0c\u65e8\u5728\u8bc6\u522b\u90a3\u4e9b\u53ef\u80fd\u5bf9\u836f\u7269\u5728\u751f\u7406\u5b66\u76f8\u5173\u6548\u5e94\u9694\u5ba4\uff08\u5305\u62ec\u9aa8\u9ad3\u2014\u2014\u4f5c\u4e3a\u8840\u6db2\u5b66\u6bd2\u6027\u7684\u66ff\u4ee3\u6307\u6807\uff0c\u4ee5\u53ca\u6027\u817a\u2014\u2014\u5728\u5375\u5de2\u764c\u53d7\u8bd5\u8005\u4e2d\u4f5c\u4e3a\u7597\u6548\u8bc4\u4f30\u7684\u4ee3\u8868\u6027\u90e8\u4f4d\uff09\u4e2d\u7684\u66b4\u9732\u91cf\u4ea7\u751f\u66f4\u5927\u5f71\u54cd\u7684\u6a21\u578b\u53c2\u6570\u3002\u7531\u4e8e\u5c3c\u62c9\u5e15\u5229\u6240\u81f4\u7684\u5242\u91cf\u9650\u5236\u6027\u8840\u6db2\u5b66\u6bd2\u6027\uff08\u5982\u8840\u5c0f\u677f\u51cf\u5c11\u75c7\u3001\u8d2b\u8840\uff09\u5728\u673a\u5236\u4e0a\u4e0e\u836f\u7269\u5728\u9020\u8840\u7ec4\u7ec7\u4e2d\u7684\u84c4\u79ef\u76f8\u5173\uff0c\u56e0\u6b64\u786e\u5b9a\u9aa8\u9ad3\u4e2d\u7684\u836f\u7269\u66b4\u9732\u91cf\u88ab\u5217\u4e3a\u4f18\u5148\u7814\u7a76\u5bf9\u8c61\u3002\u672c\u7814\u7a76\u63a2\u8ba8\u4e86\u6b27\u6d32\u5973\u6027\u60a3\u8005\u5728\u91c7\u7528\u63a8\u8350\u5242\u91cf\u4e3a 300 mg \u7684\u6bcf\u65e5\u4e00\u6b21\uff08QD\uff09\u7ed9\u836f\u65b9\u6848\u65f6\u7684\u5c3c\u62c9\u5e15\u5229\u66b4\u9732\u91cf\u3002\u4f7f\u7528\u5b8c\u6574 PBPK \u6a21\u578b\uff0c\u5728\u7b2c 28 \u6b21\u6bcf\u65e5\u7ed9\u836f\u540e\uff0c\u8ba1\u7b97\u4e86 24 \u5c0f\u65f6\u5185\u5c3c\u62c9\u5e15\u5229\u5728\u5404\u5668\u5b98\u548c\u7ec4\u7ec7\u4e2d\u7ec6\u80de\u5185\u6e38\u79bb\u6d53\u5ea6\u7684\u7a33\u6001 AUC \u503c\uff0c\u5e76\u9488\u5bf9\u67d0\u4e00\u7279\u5b9a\u53c2\u6570\u503c\u7684\u53d8\u5316\u8fdb\u884c\u4e86\u5206\u6790\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">2.5 \u8f6f\u4ef6<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4f7f\u7528WebPlotDigitizer\u5bf9\u6d53\u5ea6-\u65f6\u95f4\u66f2\u7ebf\u8fdb\u884c\u6570\u5b57\u5316\u5904\u7406\u3002\u5c3c\u62c9\u5e15\u5229\u751f\u7406\u836f\u4ee3\u52a8\u529b\u5b66\u6a21\u578b\u7684\u6838\u5fc3\u90e8\u5206\u57fa\u4e8ePK-Sim<sup>\u00ae<\/sup>\u6784\u5efa\u3002\u6570\u636e\u5904\u7406\u3001\u6a21\u578b\u5f00\u53d1\u3001\u5206\u6790\u53ca\u6b63\u5411\u6a21\u62df\u5747\u901a\u8fc7R\u8f6f\u4ef6\u5b8c\u6210\u3002<\/p>\n\n\n\n<h5 class=\"wp-block-heading\">3 \u7ed3\u679c<\/h5>\n\n\n\n<p class=\"wp-block-paragraph\">3.1 \u73b0\u6709PK\u6570\u636e\u7cfb\u7edf\u7efc\u8ff0<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u652f\u6301\u672c\u9879 PBPK \u6a21\u578b\u5f00\u53d1\u7684\u7cfb\u7edf\u6027\u6587\u732e\u7efc\u8ff0\u7ed3\u679c\u6c47\u603b\u8be6\u89c1\u4e0b\u56fe\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"353\" height=\"213\" src=\"https:\/\/www.millibuff.com\/wp-content\/uploads\/2026\/10\/image-5.png\" alt=\"\" class=\"wp-image-2209\" style=\"aspect-ratio:1.6573274822780537;width:565px;height:auto\" srcset=\"https:\/\/www.millibuff.com\/wp-content\/uploads\/2026\/10\/image-5.png 353w, https:\/\/www.millibuff.com\/wp-content\/uploads\/2026\/10\/image-5-300x181.png 300w\" sizes=\"(max-width: 353px) 100vw, 353px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">\u56fe1 \u68c0\u7d22\u53ca\u7b5b\u9009\u6d41\u7a0b\u56fe<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u7528\u4e8e\u6a21\u578b\u5f00\u53d1\u7684\u516b\u9879\u7814\u7a76\u5747\u5305\u542b\u6765\u81ea\u9ad8\u52a0\u7d22\u88d4\u60a3\u8005\u7684\u76f8\u5173\u836f\u4ee3\u52a8\u529b\u5b66\uff08PK\uff09\u6570\u636e\u3002\u603b\u4f53\u800c\u8a00\uff0c\u672c\u7814\u7a76\u7eb3\u5165\u4e86\u6765\u81ea26\u9879\u4e34\u5e8a\u8bd5\u9a8c\u961f\u5217\u4e2d220\u4f8b\u60a3\u8005\u7684\u6c47\u603b\u6570\u636e\uff0c\u6db5\u76d613\u79cd\u4e0d\u540c\u7ed9\u836f\u65b9\u6848\uff0830\u300140\u300160\u300180\u3001110\u3001150\u3001210\u3001290\u3001300\u3001400 mg QD\uff0c\u4ee5\u53ca100\u3001200\u3001300 mg SD\uff09\u3002\u7528\u4e8e\u6a21\u578b\u6821\u51c6\u7684\u6570\u636e\u5305\u62ec\u4e00\u9879 \u2160&nbsp;\u671f\u591a\u5242\u91cf\u9012\u589e\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u7684\u5c3c\u62c9\u5e15\u5229\u8840\u6d46\u6d53\u5ea6\u6d4b\u5b9a\u7ed3\u679c\u4ee5\u53ca\u4e00\u9879\u4eba\u4f53\u8d28\u91cf\u5e73\u8861\u7814\u7a76\u4e2d\u7684\u5c3f\u6392\u6cc4\u6570\u636e\u3002\u6a21\u578b\u9a8c\u8bc1\u57fa\u4e8e\u5176\u4f59\u516d\u9879\u4e34\u5e8a\u7814\u7a76\u4e2d\u7684\u4e34\u5e8a\u6570\u636e\u5f00\u5c55\uff0c\u8fd9\u4e9b\u7814\u7a76\u6db5\u76d6\u4e86\u4e0d\u540c\u7ed9\u836f\u65b9\u6848\u4e0b\u7684\u5b9e\u6d4b\u8840\u6d46\u6d53\u5ea6-\u65f6\u95f4\u66f2\u7ebf\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">3.2 \u6a21\u578b\u5f00\u53d1<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u6a21\u578b\u7ed3\u6784\u548c\u521d\u59cb\u53c2\u6570\u503c\u57fa\u4e8e\u5c3c\u62c9\u5e15\u5229\u836f\u7406\u5b66\u7684\u73b0\u6709\u5148\u9a8c\u4fe1\u606f\u786e\u5b9a\u3002\u6a21\u578b\u6821\u51c6\u7684\u7b2c\u4e00\u6b65\u662f\u4f18\u5316\u4e94\u4e2a\u836f\u7269\u7279\u5f02\u6027\u53c2\u6570\u7684\u503c\uff0c\u4ee5\u63cf\u8ff0210 mg\u6bcf\u65e5\u4e00\u6b21\u7ed9\u836f\u540e\u5c3c\u62c9\u5e15\u5229\u5728I\u671f\u5242\u91cf\u9012\u589e\u7814\u7a76\u4e2d\u7684\u8840\u6d46\u603b\u6d53\u5ea6-\u65f6\u95f4\u66f2\u7ebf\u3002\u8be5\u6821\u51c6\u6b65\u9aa4\u8fd8\u91c7\u7528\u4e86\u989d\u5916\u6807\u51c6\uff1a\u57fa\u4e8e\u5c3c\u62c9\u5e15\u5229\u4eba\u4f53\u8d28\u91cf\u5e73\u8861\u7814\u7a76\uff0c\u5c3f\u6db2\u4e2d\u539f\u5f62\u836f\u7269\u7684\u6c34\u5e73\u4e0e\u4f30\u7b97\u503c\u7684\u504f\u5dee\u4e0d\u5f97\u8d85\u8fc740%\u3002\u4e3a\u907f\u514d\u540e\u9a8c\u5206\u5e03\u4e2d\u53c2\u6570\u95f4\u5b58\u5728\u9ad8\u5ea6\u4e92\u76f8\u5173\uff0c\u968f\u540e\u5c06\u4e94\u4e2a\u53c2\u6570\u4e2d\u7684\u4e24\u4e2a\uff08LogP\u548cCL<sub>spec<\/sub>\uff09\u56fa\u5b9a\u4e3a\u6240\u5f97\u540e\u9a8c\u5206\u5e03\u7684\u4e2d\u4f4d\u6570\u3002\u7b2c\u4e8c\u6b65\uff0c\u5bf9\u5269\u4f59\u4e09\u4e2a\u53c2\u6570\uff08P<sub>int<\/sub>\u3001CL<sub>ren<\/sub>\u548cpKa\uff09\u91c7\u7528ABC-SMC\u6d41\u7a0b\u8fdb\u884c\u6821\u51c6\u3002\u6a21\u578b\u7684\u6700\u7ec8\u53c2\u6570\u503c\u89c1\u4e0b\u8868\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"443\" height=\"160\" src=\"https:\/\/www.millibuff.com\/wp-content\/uploads\/2026\/10\/image-3.png\" alt=\"\" class=\"wp-image-2207\" style=\"width:566px;height:auto\" srcset=\"https:\/\/www.millibuff.com\/wp-content\/uploads\/2026\/10\/image-3.png 443w, https:\/\/www.millibuff.com\/wp-content\/uploads\/2026\/10\/image-3-300x108.png 300w\" sizes=\"(max-width: 443px) 100vw, 443px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">\u88684 \u6700\u7ec8\u53c2\u6570\u503c<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">3.3 \u6a21\u578b\u8bca\u65ad\u4e0e\u9a8c\u8bc1<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u516c\u5f00\u53ef\u7528\u7684\u6570\u636e\u672a\u5305\u542b\u4e2a\u4f53\u836f\u4ee3\u52a8\u529b\u5b66\u7279\u5f81\uff0c\u56e0\u6b64\u65e0\u6cd5\u8003\u8651\u4e2a\u4f53\u95f4\u5dee\u5f02\u3002\u56e0\u6b64\uff0c\u5c06\u6240\u83b7\u5f97\u7684\u540e\u9a8c\u53c2\u6570\u5206\u5e03\u7684\u5178\u578b\u8840\u6d46\u6d53\u5ea6\u6a21\u578b\u9884\u6d4b\u503c\u7528\u4e8e\u8bca\u65ad\u548c\u9a8c\u8bc1\u6b65\u9aa4\u3002\u8be5\u6a21\u578b\u5145\u5206\u63cf\u8ff0\u4e86\u6821\u51c6\u6570\u636e\uff1b\u6b8b\u5dee\u672a\u8868\u73b0\u51fa\u4efb\u4f55\u529f\u80fd\u6027\u7cfb\u7edf\u4e0b\u964d\u6a21\u5f0f\uff0c\u89c1\u4e0b\u56fe\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"346\" height=\"271\" src=\"https:\/\/www.millibuff.com\/wp-content\/uploads\/2026\/10\/image-6.png\" alt=\"\" class=\"wp-image-2210\" style=\"width:566px;height:auto\" srcset=\"https:\/\/www.millibuff.com\/wp-content\/uploads\/2026\/10\/image-6.png 346w, https:\/\/www.millibuff.com\/wp-content\/uploads\/2026\/10\/image-6-300x235.png 300w\" sizes=\"(max-width: 346px) 100vw, 346px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">\u56fe2 Niraparib PBPK \u6a21\u578b\u7684\u8bca\u65ad\u56fe\u3002\u4e0d\u540c\u7ed9\u836f\u65b9\u6848\u91c7\u7528\u989c\u8272\u7f16\u7801\u8868\u793a\uff1a\u7ea2\u8272\uff0860 mg\/\u65e5\uff09\u3001\u7eff\u8272\uff0880 mg\/\u65e5\uff09\u53ca\u84dd\u8272\uff08210 mg\/\u65e5\uff09\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u7814\u7a76\u9884\u6d4b\u4e86\u6b27\u6d32\u5973\u6027\u60a3\u8005\u5355\u6b21\u7ed9\u836f\u6216\u6bcf\u65e5\u7ed9\u836f\u65b9\u6848\u4e0b\u5c3c\u62c9\u5e15\u5229\u7684\u8840\u6d46\u603b\u6d53\u5ea6\u66f2\u7ebf\uff0c\u4ee5\u8003\u8651\u53c2\u6570\u53d8\u5f02\u6027\u5e76\u5c06\u5176\u4e0e\u73b0\u6709\u89c2\u6d4b\u6570\u636e\u8fdb\u884c\u6bd4\u8f83\u3002\u5982\u56fe3\u6240\u793a\uff0c\u65e0\u8bba\u91c7\u7528SD\u8fd8\u662fQD\uff0c\u8be5\u6a21\u578b\u5747\u5145\u5206\u63cf\u8ff0\u4e86\u5c3c\u62c9\u5e15\u5229\u7684\u5e73\u5747\u6d53\u5ea6-\u65f6\u95f4\u66f2\u7ebf\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"352\" height=\"315\" src=\"https:\/\/www.millibuff.com\/wp-content\/uploads\/2026\/10\/image-7.png\" alt=\"\" class=\"wp-image-2211\" style=\"width:556px;height:auto\" srcset=\"https:\/\/www.millibuff.com\/wp-content\/uploads\/2026\/10\/image-7.png 352w, https:\/\/www.millibuff.com\/wp-content\/uploads\/2026\/10\/image-7-300x268.png 300w\" sizes=\"(max-width: 352px) 100vw, 352px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">\u56fe3 Niraparib PBPK\u6a21\u578b\u7684\u9884\u6d4b\u7ed3\u679c\u4e0e\u5b9e\u9645\u89c2\u5bdf\u5230\u7684\u4e34\u5e8a\u6570\u636e\uff08\u6570\u636e\u70b9\uff09\u8fdb\u884c\u9a8c\u8bc1\uff0c\u9a8c\u8bc1\u5bf9\u8c61\u5305\u62ec\uff1a(A) 300 mg SD \u7ed9\u836f\u65b9\u6848\u3001(B) 300 mg QD \u7ed9\u836f\u65b9\u6848\u4ee5\u53ca (C) 200 mg QD \u7ed9\u836f\u65b9\u6848\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">3.4 \u5c3c\u62c9\u5e15\u5229\u5728\u809d\u529f\u80fd\u4e0d\u5168\u60a3\u8005\u4f53\u5185\u66b4\u9732\u91cf\u7684PBPK\u6a21\u578b\u6a21\u62df<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u7814\u7a76\u57fa\u4e8e\u809d\u529f\u80fd\u969c\u788d\u7684\u4e25\u91cd\u7a0b\u5ea6\u5212\u5206\u4e86\u4e94\u7ec4\uff0c\u4ee5\u63a2\u7a76\u809d\u529f\u80fd\u635f\u4f24\u5bf9\u5c3c\u62c9\u5e15\u5229\u66b4\u9732\u91cf\u7684\u6f5c\u5728\u5f71\u54cd\uff1a(i) \u809d\u529f\u80fd\u6b63\u5e38\u7ec4\uff08NHF\uff0cTBIL=6.8 \u03bcM\uff09\uff1b(ii) \u8f7b\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u7ec4\uff08TBIL=21.25 \u03bcM\uff09\uff1b(iii) \u4e2d\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u7ec4\uff08MHI\uff0cTBIL=41.9 \u03bcM\uff09\uff1b(iv) \u91cd\u5ea6\u809d\u529f\u80fd\u635f\u4f2460\u7ec4\uff08SHI60\uff0cTBIL=60&nbsp;\u03bcM\uff09\uff1b\u4ee5\u53ca (v) \u91cd\u5ea6\u809d\u529f\u80fd\u635f\u4f24120\u7ec4\uff08SHI120\uff0cTBIL=120&nbsp;\u03bcM\uff09\u3002\u57fa\u4e8e\u4e2d\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u7ec4\u7684\u836f\u4ee3\u52a8\u529b\u5b66\u6570\u636e\uff0c\u5bf9CES1\u4ee3\u8c22\u9176\u6d53\u5ea6\u5f52\u4e00\u5316\u7684\u5c3c\u62c9\u5e15\u5229\u56fa\u6709\u6e05\u9664\u7387\u8fdb\u884c\u4e86\u6821\u51c6\u3002\u6700\u7ec8\u4e0eTBIL\u4f9d\u8d56\u6027\u76f8\u5173\u7684\u53c2\u6570&nbsp;\u03b1&nbsp;\u8ba1\u7b97\u503c\u4e3a0.316\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u7814\u7a76\u6a21\u62df\u4e86QD\u7ed9\u836f\u65b9\u6848\u4e0b\u5c3c\u62c9\u5e15\u5229\u7684\u8840\u6d46\u66b4\u9732\u60c5\u51b5\uff0c\u7ed9\u836f\u5242\u91cf\u8303\u56f4\u4e3a100mg\u81f3300mg\uff0c\u7ed9\u836f\u6b65\u957f\u4e3a50mg\uff0c\u65e8\u5728\u5bf9\u6bd4\u4e94\u4e2a\u7ec4\u522b\u4e2d\u5c3c\u62c9\u5e15\u5229\u7684\u8840\u6d46\u66b4\u9732\u6c34\u5e73\uff0c\u5e76\u63d0\u51fa\u6a21\u578b\u63a8\u5bfc\u7684\u5242\u91cf\u8c03\u6574\u65b9\u6848\uff0c\u4ee5\u660e\u786e\u4e0d\u540c\u809d\u529f\u80fd\u635f\u5bb3\u7ec4\u4e0e\u6b63\u5e38\u809d\u529f\u80fd\uff08NHF\uff09\u7ec4\u60a3\u8005\u5728\u7a33\u6001\u4e0b\u9884\u6d4b\u8840\u6d46\u6d53\u5ea6\u66f2\u7ebf\u4e0b\u9762\u79efAUC<sub>ss<\/sub>\u503c\u7684\u53d8\u5316\u60c5\u51b5\u63a5\u53d7\u63a8\u8350\u7684300mg\u5242\u91cf\u7684\u6bd4\u4f8b\u4e0d\u4f1a\u8d85\u8fc720%\u3002\u6a21\u62df\u7ed3\u679c\u5982\u56fe4\u6240\u793a\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"391\" height=\"343\" src=\"https:\/\/www.millibuff.com\/wp-content\/uploads\/2026\/10\/image-9.png\" alt=\"\" class=\"wp-image-2212\" style=\"width:545px;height:auto\" srcset=\"https:\/\/www.millibuff.com\/wp-content\/uploads\/2026\/10\/image-9.png 391w, https:\/\/www.millibuff.com\/wp-content\/uploads\/2026\/10\/image-9-300x263.png 300w\" sizes=\"(max-width: 391px) 100vw, 391px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">\u56fe4 \u809d\u529f\u80fd\u4e0d\u5168\u5bf9\u5c3c\u62c9\u5e15\u5229\u8840\u836f\u6d53\u5ea6\u53ca\u6a21\u578b\u63a8\u5bfc\u7684\u7ed9\u836f\u5242\u91cf\u8c03\u6574\u7684\u5f71\u54cd<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u8be5\u6a21\u578b\u9884\u6d4b\uff0c\u809d\u529f\u80fd\u6b63\u5e38\u7684\u60a3\u8005\u91c7\u7528300mg\u6bcf\u65e5\u4e00\u6b21\u7684\u7ed9\u836f\u65b9\u6848\u65f6\uff0c\u5c3c\u62c9\u5e15\u5229\u7684\u8840\u6d46\u6d53\u5ea6\u4e3a4.51&nbsp;\u03bcM\u3002\u5bf9\u4e8e\u809d\u529f\u80fd\u53d7\u635f\u7ec4\uff0cC<sub>max<\/sub>\u6570\u503c\u968f\u809d\u529f\u80fd\u969c\u788d\u4e25\u91cd\u7a0b\u5ea6\u589e\u52a0\u800c\u5347\u9ad8\uff0c\u5206\u522b\u4e3a5.44&nbsp;\u03bcM\u30016.12&nbsp;\u03bcM\u30016.52&nbsp;\u03bcM\u548c7.38&nbsp;\u03bcM\uff08\u56fe4A\uff09\u3002\u540c\u6837\uff0c\u8840\u6d46AUC<sub>ss<\/sub>\u76f8\u8f83\u4e8e\u9884\u6d4b\u76844155&nbsp;\u03bcM\u00b7min\u7684\u201c\u6b63\u5e38\u201d\u503c\uff0c\u5206\u522b\u589e\u52a0\u4e8633%\u300157%\u300171%\u548c101%\u3002\u5bf9\u8f7b\u5ea6\u809d\u529f\u80fd\u635f\u5bb3\u7ec4\u8c03\u6574\u5242\u91cf\u81f3250mg\u3001\u4e2d\u5ea6\u809d\u529f\u80fd\u635f\u5bb3\u7ec4\u81f3200mg\uff0c\u4e24\u4e2a\u91cd\u5ea6\u809d\u529f\u80fd\u635f\u5bb3\u7ec4\u8c03\u6574\u81f3150mg\u540e\uff0c\u6a21\u62df\u7ed3\u679c\u663e\u793aAUC<sub>ss<\/sub>\u6570\u503c\u4ecd\u5904\u4e8e\u63a5\u53d7300mg\u5168\u5242\u91cf\u7684\u809d\u529f\u80fd\u6b63\u5e38\u60a3\u8005\u201c\u6b63\u5e38\u201d\u66b4\u9732\u6c34\u5e73\u7684\u00b120%\u8303\u56f4\u5185\uff08\u56fe4B\uff09\u3002\u5177\u4f53\u800c\u8a00\uff0c\u4e2d\u5ea6\u809d\u529f\u80fd\u635f\u5bb3\u7ec4\u7684\u8840\u6d46&nbsp;AUC&nbsp;\u4e0e\u809d\u529f\u80fd\u6b63\u5e38\u7ec4\u76f8\u6bd4\u4ec5\u504f\u5dee4.4%\uff0c\u8fd9\u652f\u6301\u4e86\u4e3a\u8be5\u4e2d\u5ea6\u809d\u529f\u80fd\u635f\u5bb3\u4eba\u7fa4\u63a8\u8350200mg\u7684\u5242\u91cf\u8c03\u6574\u65b9\u6848\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">3.5 \u5c3c\u62c9\u5e15\u5229PBPK\u6a21\u578b\u5728\u4e0d\u540cChild-Pugh\u809d\u529f\u80fd\u635f\u4f24\u5206\u7ea7\u4e2a\u4f53\u4e2d\u7684\u5e94\u7528<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e3a\u9a8c\u8bc1\u4e0a\u8ff0\u809d\u635f\u4f24\u5916\u63a8\u7684\u5b9e\u8bc1\u65b9\u6cd5\uff0c\u7814\u7a76\u4eba\u5458\u5f00\u5c55\u4e86\u989d\u5916\u7684PBPK\u6a21\u62df\uff08\u56fe5\uff09\u3002\u8bc4\u4f30\u809d\u635f\u4f24\u5bf9\u836f\u7269\u66b4\u9732\u5f71\u54cd\u7684\u4e00\u79cd\u76f4\u63a5\u65b9\u6cd5\uff0c\u662f\u53c2\u8003\u5065\u5eb7\u4eba\u7fa4\u4e0e\u809d\u635f\u4f24\u4eba\u7fa4\u76f8\u5173\u4eba\u4f53\u751f\u7406\u53c2\u6570\u53d8\u5316\u7684\u5148\u9a8c\u77e5\u8bc6\u3002\u7814\u7a76\u4eba\u5458\u5728PK-Sim\u8f6f\u4ef6\u4e2d\u5f00\u5c55\u6a21\u578b\u6a21\u62df\uff0c\u901a\u8fc7\u7eb3\u5165\u5177\u6709\u4e0d\u540c Child-Pugh\uff08CP\uff09\u5206\u7ea7\u7279\u5f02\u6027\u751f\u7406\u53c2\u6570\u4fee\u6539\u7684\u7279\u5b9a\u5185\u7f6e\u4e2a\u4f53\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"445\" height=\"215\" src=\"https:\/\/www.millibuff.com\/wp-content\/uploads\/2026\/10\/image-8.png\" alt=\"\" class=\"wp-image-2213\" style=\"width:571px;height:auto\" srcset=\"https:\/\/www.millibuff.com\/wp-content\/uploads\/2026\/10\/image-8.png 445w, https:\/\/www.millibuff.com\/wp-content\/uploads\/2026\/10\/image-8-300x145.png 300w\" sizes=\"(max-width: 445px) 100vw, 445px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">\u56fe5 \u6839\u636e\u4e0d\u540c\u809d\u529f\u80fd\u4e0d\u5168\u5206\u7ea7\uff08\u4f9d\u636e NCI-ODWG \u6807\u51c6\uff0c\u5de6\u56fe\uff1b\u4f9d\u636e Child-Pugh \u6807\u51c6\uff0c\u53f3\u56fe\uff09\u5212\u5206\u7684\u5404\u7ec4\u60a3\u8005\uff0c\u5176\u6a21\u578b\u9884\u6d4b\u7684\u5c3c\u62c9\u5e15\u5229\u8840\u6d46\u66b4\u9732\u91cf\uff08300 mg\/\u65e5\uff0cAUC<sub>ss<\/sub>\uff09\u4e0e\u809d\u529f\u80fd\u6b63\u5e38\u7ec4\u7684\u9884\u6d4b\u503c\u4e4b\u6bd4\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u603b\u4f53\u800c\u8a00\uff0c\u5f53\u8003\u8651\u5230\u6839\u636e CP \u6807\u51c6\u4e0e NCI-ODWG \u6807\u51c6\u5bf9\u60a3\u8005\u8fdb\u884c\u809d\u529f\u80fd\u4e0d\u5168\u5206\u7ea7\u65f6\u6240\u89c2\u5bdf\u5230\u7684\u60a3\u8005\u5206\u5e03\u5dee\u5f02\u65f6\uff0c\u901a\u8fc7\u4e0d\u540c\u65b9\u6cd5\u83b7\u5f97\u7684\u6a21\u578b\u9884\u6d4b\u7ed3\u679c\u5177\u6709\u4e00\u81f4\u6027\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">3.6 \u5c3c\u62c9\u5e15\u5229\u66b4\u9732\u6307\u6807\u7684\u63a2\u7d22\u4e0e\u654f\u611f\u6027\u5206\u6790<\/p>\n\n\n\n<p 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