{"id":2222,"date":"2026-10-13T15:36:25","date_gmt":"2026-10-13T07:36:25","guid":{"rendered":"https:\/\/www.millibuff.com\/?p=2222"},"modified":"2026-10-13T15:41:32","modified_gmt":"2026-10-13T07:41:32","slug":"%e5%b0%8f%e7%89%9b%e6%b4%9e%e5%af%9f%ef%bd%9c2026-fierce-15-%e6%b7%b1%e5%ba%a6%e6%8b%86%e8%a7%a3%ef%bc%9aai%e5%b7%b2%e6%b2%89%e5%85%a5%e5%b9%b3%e5%8f%b0%e5%ba%95%e5%b1%82%ef%bc%8c%e4%b8%ad%e5%9b%bd","status":"publish","type":"post","link":"https:\/\/www.millibuff.com\/?p=2222","title":{"rendered":"\u5c0f\u725b\u6d1e\u5bdf\uff5c2026 Fierce 15 \u6df1\u5ea6\u62c6\u89e3\uff1aAI\u5df2\u6c89\u5165\u5e73\u53f0\u5e95\u5c42\uff0c\u4e2d\u56fd\u6210\u4e3a\u65e9\u671f\u521b\u65b0\u7684\u300c\u79bb\u5cb8\u652f\u70b9\u300d"},"content":{"rendered":"\n<h5 class=\"wp-block-heading\"><strong>\u5f15\u8a00\uff1a<\/strong><strong>Fierce 15 <\/strong><strong>\u7684\u4e09\u4e2a\u7ed3\u6784\u6027\u4fe1\u53f7<\/strong><\/h5>\n\n\n\n<p class=\"wp-block-paragraph\">2026 \u5e74 10 \u6708 5 \u65e5\uff0cFierce Biotech \u6b63\u5f0f\u53d1\u5e03\u7b2c 24 \u5c4a\u300cFierce 15\u300d\u699c\u5355\u3002\u9ad8\u7ea7\u7f16\u8f91 James Waldron \u5e26\u9886\u56e2\u961f\u4ece\u8d85\u8fc7 150 \u5bb6\u88ab\u63d0\u540d\u7684\u65e9\u671f\u751f\u7269\u6280\u672f\u516c\u53f8\u4e2d\uff0c\u7ecf\u8fc7\u591a\u8f6e\u8ba8\u8bba\u9009\u51fa 15 \u5bb6\u6700\u5177\u521b\u65b0\u529b\u7684\u79c1\u8425 Biotech<sup><strong>[1]<\/strong><\/sup>\u3002Waldron \u6709\u4e00\u53e5\u8bc4\u8bed\u8ba9\u4eba\u5370\u8c61\u6df1\u523b\u2014\u2014\u300cThe willingness to proceed anyway is the risk appetite we keep seeing each year\u300d\u3002\u601d\u7d22\u826f\u4e45\uff0c\u8fd9\u91cc\u7ffb\u8bd1\u4e3a\u300c\u83b7\u5956\u8005\u7684\u91ce\u5fc3\u4ece\u672a\u5982\u6b64\u9ad8\u6da8\uff1a\u5b83\u4eec\u6562\u4e8e\u505a\u5927\u836f\u4f01\u4e0d\u6562\u505a\u7684\u4e8b\u300d\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4eca\u5e74\u7684\u699c\u5355\u8986\u76d6\u4e86\u81ea\u590d\u5236 RNA\u3001\u8868\u89c2\u9057\u4f20\u7f16\u8f91\u3001\u8d85\u58f0\u4ecb\u5bfc\u7684\u975e\u75c5\u6bd2\u9012\u9001\u3001\u653e\u5c04\u540c\u4f4d\u7d20\u751f\u4ea7\u3001\u53cc\u7279\u5f02\u6027\u6297\u4f53\u964d\u89e3\u3001\u5206\u5b50\u80f6\u3001\u53d8\u6784\u6291\u5236\u5242\u3001AAV \u57fa\u56e0\u6cbb\u7597\u3001Th2 \u901a\u8def\u6297\u4f53\u7b49\u51e0\u4e4e\u6240\u6709\u5f53\u4e0b\u6700\u524d\u6cbf\u7684\u5206\u5b50\u6a21\u5f0f\u4e0e\u9012\u9001\u7cfb\u7edf<sup><strong>[1]<\/strong><\/sup>\u3002\u4f46\u5bf9\u4e34\u5e8a\u5f00\u53d1\u4ece\u4e1a\u8005\u800c\u8a00\uff0c\u6bd4\u300c\u6709\u54ea\u4e9b\u6280\u672f\u300d\u66f4\u91cd\u8981\u7684\u662f\u2014\u2014\u8fd9\u4e9b\u516c\u53f8\u7684\u4e34\u5e8a\u8282\u70b9\u5982\u4f55\u8bbe\u8ba1\u3001\u8d44\u672c\u5982\u4f55\u4e0e\u4e34\u5e8a\u6570\u636e\u6302\u94a9\u3001\u4ee5\u53ca\u4e2d\u56fd\u5728\u8fd9\u4e00\u8f6e\u521b\u65b0\u4e2d\u626e\u6f14\u4ec0\u4e48\u89d2\u8272\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u6211\u4eec\u628a 15 \u5bb6\u516c\u53f8\u91cd\u65b0\u644a\u5f00\u5bf9\u6bd4\uff0c\u770b\u5230\u4e09\u4e2a\u6e05\u6670\u7684\u7ed3\u6784\u6027\u4fe1\u53f7\u3002<\/p>\n\n\n\n<h5 class=\"wp-block-heading\"><strong>\u4e00\u3001\u4e09\u4e2a\u7ed3\u6784\u6027\u4fe1\u53f7<\/strong><\/h5>\n\n\n\n<h6 class=\"wp-block-heading\"><strong>\u4fe1\u53f7<\/strong><strong> 1<\/strong><strong>\uff1a<\/strong><strong>AI <\/strong><strong>\u4ece\u300c\u8f85\u52a9\u5de5\u5177\u300d\u6c89\u5165\u300c\u5e73\u53f0\u5e95\u5c42\u300d<\/strong><\/h6>\n\n\n\n<p class=\"wp-block-paragraph\">Waldron \u7684\u8bc4\u8bed\u70b9\u51fa\u4e86\u5173\u952e\u4e8b\u5b9e\uff1aAI \u4e0d\u518d\u53ea\u662f\u300c\u7b5b\u9009-\u6392\u5e8f\u300d\u73af\u8282\u7684\u4f18\u5316\u5668\u2014\u2014\u7528\u673a\u5668\u5b66\u4e60\u4ece\u5316\u5408\u7269\u5e93\u4e2d\u6311\u51fa\u66f4\u6709\u5e0c\u671b\u7684\u5019\u9009\u5206\u5b50\u2014\u2014\u800c\u662f\u627f\u62c5\u300c\u5728\u8f83\u4e3a\u5e73\u5766\u7684\u86cb\u767d\u8868\u9762\u5bfb\u627e\u5171\u4ef7\u7ed3\u5408\u4f4d\u70b9\u300d\u8fd9\u79cd\u8fc7\u53bb\u5b8c\u5168\u4f9d\u8d56\u5316\u5b66\u5bb6\u7ecf\u9a8c\u7684\u4e8b\u60c5<sup><strong>[1]<\/strong><\/sup>\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Expedition Medicines \u662f\u8fd9\u4e00\u8d8b\u52bf\u7684\u5178\u578b\u4ee3\u8868\u3002\u5176\u5e73\u53f0\u7528 AI \u76f4\u63a5\u5b66\u4e60\u5c0f\u5206\u5b50\u4e0e\u86cb\u767d\u7684\u539f\u5b50\u7ed3\u6784\u3001\u7535\u5b50\u5bc6\u5ea6\u548c\u7535\u5b50\u7ed3\u6784\uff0c\u4e0e\u8f89\u745e\u5408\u4f5c\u5728\u524d\u5217\u817a\u764c\u7b49\u96be\u6210\u836f\u9776\u70b9\u4e0a\u63a8\u8fdb\u5019\u9009\u836f\u7269\uff0c\u76ee\u6807\u662f\u5728 6\u20139 \u4e2a\u6708\u5185\u63d0\u540d\u5019\u9009\u836f<sup><strong>[1]<\/strong><\/sup>\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Soley Therapeutics \u9009\u62e9\u4e86\u53e6\u4e00\u6761\u8def\u5f84\u2014\u2014\u4e0e Oracle \u5408\u4f5c\u4f7f\u7528 NVIDIA AI \u57fa\u7840\u8bbe\u65bd\uff0c\u5c06\u7ec6\u80de\u538b\u529b\u751f\u7269\u5b66\u5e73\u53f0\u4e0e\u5927\u89c4\u6a21\u8ba1\u7b97\u80fd\u529b\u7ed3\u5408\u3002\u5176 SOL-001\/002\/STX-6398 \u8ba1\u5212 2027 \u5e74\u8fdb\u5165\u4e34\u5e8a<sup><strong>[1]<\/strong><\/sup>\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Infinimmune&nbsp;\u5219\u5c55\u793a\u4e86 AI \u5d4c\u5165\u6297\u4f53\u53d1\u73b0\u6d41\u7a0b\u7684\u5b8c\u6574\u5f62\u6001\uff1a\u5176&nbsp;Anthrobody&nbsp;\u5e73\u53f0\u7b5b\u9009\u6570\u767e\u4e07\u4e2a\u5355\u8bb0\u5fc6 B \u7ec6\u80de\uff0c\u5e76\u884c\u53d1\u73b0\u9488\u5bf9\u6570\u767e\u4e2a\u9776\u70b9\u7684\u5168\u4eba\u6e90\u6297\u4f53\uff0c\u518d\u5229\u7528 GLIMPSE \u6297\u4f53\u8bed\u8a00\u6a21\u578b\u5feb\u901f\u9009\u62e9\u548c\u5de5\u7a0b\u5316\u6297\u4f53<sup><strong>[1]<\/strong><\/sup>\u30022026 \u5e74 3 \u6708\uff0cInfinimmune&nbsp;\u4e0e\u9ed8\u6c99\u4e1c\u8fbe\u6210\u591a\u9776\u70b9\u6297\u4f53\u53d1\u73b0\u5408\u4f5c\uff0c\u91cc\u7a0b\u7891\u603b\u989d\u7ea6 8.38 \u4ebf\u7f8e\u5143\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e34\u5e8a\u5f00\u53d1\u542b\u4e49\uff1a\u5f53 AI \u5c06\u5019\u9009\u836f\u7269\u53d1\u73b0\u6548\u7387\u63d0\u5347\u4e00\u4e2a\u6570\u91cf\u7ea7\u65f6\uff0c\u4e34\u5e8a\u9636\u6bb5\u7684\u5242\u91cf\u63a2\u7d22\u548c PK\/PD \u8282\u70b9\u8bbe\u8ba1\u6210\u4e3a\u65b0\u7684\u74f6\u9888<sup><strong>[1]<\/strong><\/sup>\u3002Fierce 15 \u4e2d\u591a\u5bb6\u516c\u53f8\u8ba1\u5212\u5728 2027 \u5e74\u8fdb\u5165\u4e34\u5e8a\uff0c\u8fd9\u610f\u5473\u7740\u672a\u6765 12\u201318 \u4e2a\u6708\u662f\u8fd9\u4e9b\u516c\u53f8\u7684 FIH \u7a97\u53e3\uff0c\u5bf9\u5177\u5907\u5feb\u901f\u542f\u52a8\u548c\u5242\u91cf\u63a2\u7d22\u65b9\u6cd5\u5b66\u80fd\u529b\u7684\u4e34\u5e8a\u670d\u52a1\u65b9\u6709\u96c6\u4e2d\u9700\u6c42\u3002<\/p>\n\n\n\n<h6 class=\"wp-block-heading\"><strong>\u4fe1\u53f7<\/strong><strong> 2<\/strong><strong>\uff1a\u5168\u7403\u79bb\u5cb8\u7814\u53d1\u6210\u4e3a\u5e38\u6001\uff0c\u4e2d\u56fd\u662f\u6838\u5fc3\u652f\u70b9<\/strong><\/h6>\n\n\n\n<p class=\"wp-block-paragraph\">Waldron \u7684\u53e6\u4e00\u8bc4\u8bed\u63aa\u8f9e\u514b\u5236\u53c8\u660e\u786e\uff1a\u300c\u867d\u7136 Fierce 15 \u83b7\u5956\u8005\u957f\u671f\u4ee5\u6765\u4e00\u76f4\u62e5\u6709\u8de8\u5927\u897f\u6d0b\u8db3\u8ff9\uff0c\u4f46\u6211\u4eec\u770b\u5230\u8d8a\u6765\u8d8a\u591a\u7684\u521d\u521b\u516c\u53f8\u5f00\u59cb\u5728\u4e2d\u56fd\u3001\u5370\u5ea6\u7b49\u5730\u8bbe\u7acb\u836f\u7269\u5f00\u53d1\u524d\u54e8\u3002\u8fd9\u53cd\u6620\u4e86\u751f\u7269\u5236\u836f\u65e5\u76ca\u5168\u7403\u5316\u7684\u672c\u8d28\uff0c\u4ee5\u53ca\u5c0f\u516c\u53f8\u5728\u83b7\u53d6\u521b\u65b0\u548c\u4e13\u4e1a\u80fd\u529b\u65b9\u9762\u7684\u5f00\u653e\u6001\u5ea6\u300d<sup><strong>[1]<\/strong><\/sup>\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Alveus Therapeutics \u662f\u8fd9\u4e00\u8d8b\u52bf\u7684\u76f4\u63a5\u4f8b\u8bc1\u3002\u5176\u6838\u5fc3\u7ba1\u7ebf ALV-100 \u662f\u4e00\u6b3e\u53cc\u529f\u80fd GIP \u53d7\u4f53\u62ee\u6297\u5242\/GLP-1 \u53d7\u4f53\u6fc0\u52a8\u5242\u878d\u5408\u86cb\u767d\uff0c\u4ece\u4e2d\u56fd&nbsp;Gmax&nbsp;Biopharm\uff08\u9e3f\u8fd0\u534e\u5b81\u751f\u7269\uff09&nbsp;\u5f15\u8fdb<sup><strong>[1]<\/strong><\/sup>\u3002ALV-100 \u7684&nbsp;Ib&nbsp;\u671f\u8bd5\u9a8c\u6b63\u5728\u8bc4\u4f30\u5176\u5728\u8d85\u91cd\/\u80a5\u80d6\u53c2\u4e0e\u8005\u4e2d\u7684\u5b89\u5168\u6027\u3001\u8010\u53d7\u6027\u4e0e PK\/PD\uff0c\u8ba1\u5212\u5165\u7ec4 180 \u4eba\uff1b2 \u671f\u8bd5\u9a8c\u7684\u8bbe\u8ba1\u5219\u4e13\u95e8\u9488\u5bf9\u300c\u65e2\u5f80\u63a5\u53d7\u53f8\u7f8e\u683c\u9c81\u80bd\u6cbb\u7597\u540e\u7ef4\u6301\u4f53\u91cd\u300d\u7684\u573a\u666f\u3002CEO Raj Kannan \u8868\u793a\uff0c\u516c\u53f8\u7684\u5dee\u5f02\u5316\u903b\u8f91\u5728\u4e8e\u89e3\u51b3\u73b0\u6709\u80a5\u80d6\u836f\u7269\u7684\u4e09\u5927\u75db\u70b9\u2014\u2014\u7ed9\u836f\u9891\u7387\u9ad8\u3001\u8010\u53d7\u6027\u95ee\u9898\u3001\u51cf\u91cd\u540e\u7684\u957f\u671f\u7ef4\u6301\u56f0\u96be<sup><strong>[1]<\/strong><\/sup>\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u8fd9\u610f\u5473\u7740\uff0c\u4e2d\u56fd\u4e0d\u4ec5\u662f\u5168\u7403\u4e34\u5e8a\u5f00\u53d1\u7684\u6267\u884c\u5730\uff0c\u66f4\u6b63\u5728\u6210\u4e3a\u521b\u65b0\u8d44\u4ea7\u7684\u7b56\u6e90\u5730<sup><strong>[1]<\/strong><\/sup>\u3002\u5bf9\u4e8e\u56fd\u5185\u4e34\u5e8a\u7814\u7a76\u670d\u52a1\u65b9\u800c\u8a00\uff0cFierce 15 \u4e2d\u300c\u4ece\u4e2d\u56fd\u5f15\u8fdb\u8d44\u4ea7\u300d\u7684\u516c\u53f8\uff0c\u5728\u6388\u6743\u4ea4\u6613\u540e\u7684\u6570\u636e\u6865\u63a5\u3001\u4e2d\u7f8e\u53cc\u62a5\u548c\u76d1\u7ba1\u6c9f\u901a\u9700\u6c42\u5c06\u6301\u7eed\u589e\u957f\u3002<\/p>\n\n\n\n<h6 class=\"wp-block-heading\"><strong>\u4fe1\u53f7<\/strong><strong> 3<\/strong><strong>\uff1a\u8d44\u672c\u56de\u6765\u4e86\uff0c\u4f46\u53ea\u4e3a\u300c\u673a\u5236\u5dee\u5f02\u5316<\/strong><strong> + <\/strong><strong>\u5e73\u53f0\u53ef\u590d\u7528<\/strong><strong> + <\/strong><strong>\u4e34\u5e8a\u8282\u70b9\u660e\u786e\u300d\u4e70\u5355<\/strong><\/h6>\n\n\n\n<p class=\"wp-block-paragraph\">6 \u5bb6\u4e0a\u699c\u516c\u53f8\u5728 2025\u20132026 \u5e74\u5b8c\u6210\u4e86\u65b0\u4e00\u8f6e\u878d\u8d44\uff1a<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Alveus Therapeutics\uff081.97 \u4ebf\u7f8e\u5143 A \u8f6e\uff09<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">SonoThera\uff08A \u8f6e 6070 \u4e07\u7f8e\u5143 + B \u8f6e 1.25 \u4ebf\u7f8e\u5143\uff0c\u5408\u8ba1\u7ea6 1.86 \u4ebf\u7f8e\u5143\uff09<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Pelage Pharmaceuticals\uff081.2 \u4ebf\u7f8e\u5143 B \u8f6e\uff0c2025-10\uff09<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Infinimmune\uff087500 \u4e07\u7f8e\u5143 A \u8f6e\uff0c2026-08\uff09<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Nuclidium\uff08B \u8f6e 1.15 \u4ebf\u6b27\u5143\uff0c\u7ea6 1.27 \u4ebf\u7f8e\u5143\uff09<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Tune Therapeutics\uff081.75 \u4ebf\u7f8e\u5143 B \u8f6e\uff09<sup><strong>[1]<\/strong><\/sup>\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Pelage\u3001Alveus\u3001SonoThera&nbsp;\u4e09\u5bb6\u516c\u53f8\u672c\u5e74\u5ea6\u878d\u8d44\u989d\u5747\u8d85\u8fc7 1 \u4ebf\u7f8e\u5143\u2014\u2014\u8fd9\u4e0e 2023 \u5e74\u65e9\u671f\u9636\u6bb5\u300c\u780d\u4f30\u503c\u3001\u780d\u89c4\u6a21\u3001\u780d\u7ba1\u7ebf\u300d\u7684\u666f\u8c61\u5f62\u6210\u9c9c\u660e\u5bf9\u6bd4\u3002\u4f46\u8d44\u91d1\u7684\u96c6\u4e2d\u65b9\u5411\u975e\u5e38\u660e\u786e\uff1a\u8fd9\u4e9b\u516c\u53f8\u90fd\u6709\u6e05\u6670\u7684\u4e34\u5e8a\u8282\u70b9<sup><strong>[1]<\/strong><\/sup>\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Beacon Therapeutics \u662f\u8fd9\u4e00\u903b\u8f91\u7684\u6700\u4f73\u4f8b\u8bc1\u3002\u5176\u6838\u5fc3\u7ba1\u7ebf&nbsp;laru-zova&nbsp;\u5728\u5173\u952e\u6027 III \u671f VISTA \u8bd5\u9a8c\u4e2d\u8fbe\u5230\u4e3b\u8981\u7ec8\u70b9\uff1a12 \u4e2a\u6708\u65f6\uff0c\u9ad8\u5242\u91cf\u7ec4 31%\u3001\u4f4e\u5242\u91cf\u7ec4 24.1% \u7684\u60a3\u8005\u5728\u4f4e\u7167\u5ea6\u89c6\u529b\u4e2d\u6539\u5584 \u226515 \u4e2a\u5b57\u6bcd\uff0c\u800c\u672a\u6cbb\u7597\u5bf9\u7167\u7ec4\u65e0\u60a3\u8005\u8fbe\u5230\u8fd9\u4e00\u6807\u51c6<sup><strong>[1]<\/strong><\/sup>\u3002CEO Lance Baldo&nbsp;\u8868\u793a\uff1a\u300c\u6211\u4eec\u662f\u76ee\u524d\u552f\u4e00\u4e00\u5bb6\u5728\u5173\u952e\u6027 III \u671f\u7814\u7a76\u4e2d\u4e3b\u8981\u7ec8\u70b9\u8bfb\u51fa\u9633\u6027\u7684\u516c\u53f8\uff0c\u8fd9\u7ed9\u4e86\u6211\u4eec\u65f6\u95f4\u4e0a\u7684\u4f18\u52bf\u300d<sup><strong>[1]<\/strong><\/sup>\u3002Beacon \u8ba1\u5212 2026 \u5e74\u665a\u4e9b\u65f6\u5019\u542f\u52a8\u6eda\u52a8 FDA \u7533\u62a5\u2014\u2014\u8fd9\u4e2a\u65f6\u95f4\u8868\u672c\u8eab\uff0c\u5c31\u662f\u8d44\u672c\u613f\u610f\u4e3a\u300c\u8282\u70b9\u660e\u786e\u300d\u7684\u516c\u53f8\u7ee7\u7eed\u4e70\u5355\u7684\u6700\u597d\u8bc1\u636e\u3002<\/p>\n\n\n\n<h5 class=\"wp-block-heading\"><strong>\u4e8c\u3001\u6309\u300c\u5206\u5b50\u6a21\u5f0f<\/strong><strong> \u00d7 <\/strong><strong>\u9012\u9001\u7cfb\u7edf\u300d\u770b<\/strong><strong> 15 <\/strong><strong>\u5bb6\u516c\u53f8<\/strong><\/h5>\n\n\n\n<p class=\"wp-block-paragraph\">\u628a 15 \u5bb6\u516c\u53f8\u6309\u6838\u5fc3\u6280\u672f\u5e73\u53f0\u91cd\u65b0\u5f52\u7c7b\uff0c\u53ef\u4ee5\u770b\u5230\u4e00\u4e2a\u6e05\u6670\u7684\u7248\u56fe\u2014\u2014\u6bcf\u4e2a\u5e73\u53f0\u80cc\u540e\u90fd\u5bf9\u5e94\u7740\u4e0d\u540c\u7684\u4e34\u5e8a\u5f00\u53d1\u6311\u6218\u3002<\/p>\n\n\n\n<h6 class=\"wp-block-heading\"><strong>\u8868<\/strong><strong> 1&nbsp; 2026 Fierce 15 <\/strong><strong>\u6309\u6280\u672f\u5e73\u53f0\u5206\u7c7b<\/strong><\/h6>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><tbody><tr><td><strong>\u6280\u672f\u5e73\u53f0<\/strong><\/td><td><strong>\u516c\u53f8<\/strong><\/td><td><strong>\u4e3b\u8981\u9002\u5e94\u75c7<\/strong><\/td><td><strong>\u5173\u952e\u8282\u70b9<\/strong><\/td><\/tr><tr><td><strong>\u81ea\u590d\u5236<\/strong><strong> RNA<\/strong><strong>\uff08<\/strong><strong>srRNA<\/strong><strong>\uff09<\/strong><\/td><td>Replicate Bioscience<\/td><td>\u72c2\u72ac\u75c5\u3001\u547c\u5438\u9053\u5408\u80de\u75c5\u6bd2\u3001EB \u75c5\u6bd2<\/td><td>RBI-4000\uff08\u72c2\u72ac\u75c5\uff09\u5b8c\u6210 I \u671f\uff0c0.1\u03bcg \u5373\u8fbe WHO \u72c2\u72ac\u75c5\u8840\u6e05\u4fdd\u62a4\u9608\u503c\uff1b2025 \u5e74\u4e0e\u8bfa\u548c\u7b7e\u6700\u9ad8 5.5 \u4ebf\u7f8e\u5143\u5408\u4f5c[1]<\/td><\/tr><tr><td><strong>\u8868\u89c2\u9057\u4f20\u7f16\u8f91\uff08<\/strong><strong>LNP <\/strong><strong>\u9012\u9001\uff09<\/strong><\/td><td>Tune Therapeutics<\/td><td>\u6162\u6027\u4e59\u578b\u809d\u708e<\/td><td>TUNE-401 Ib\/IIa&nbsp;\u671f\uff1a\u76f4\u63a5\u9776\u5411\u5e76\u7532\u57fa\u5316\u6c89\u9ed8 HBV cccDNA\uff0c\u66f4\u9ad8\u5242\u91cf\u7ec4 100% \u751f\u6807\u5e94\u7b54\uff1b\u5355\u6b21\u7ed9\u836f\u540e\u6297\u75c5\u6bd2\u6548\u679c\u6301\u7eed 17 \u4e2a\u6708\u4ee5\u4e0a\uff08ongoing\uff09[1]<\/td><\/tr><tr><td><strong>\u8d85\u58f0<\/strong><strong> + <\/strong><strong>\u5fae\u6c14\u6ce1\u57fa\u56e0\u9012\u9001\uff08<\/strong><strong>RIPPLE\u2122 <\/strong><strong>\u5e73\u53f0\uff09<\/strong><\/td><td>SonoThera<\/td><td>\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7\uff08DMD\uff09\u3001\u5e38\u67d3\u8272\u4f53\u663e\u6027\u591a\u56ca\u80be\u75c5\uff08ADPKD\uff09<\/td><td>RIPPLE\u2122 \u5e73\u53f0\u8d85\u58f0\u4ecb\u5bfc\u975e\u75c5\u6bd2\u9012\u9001\uff1b\u9996\u4e2a DMD \u9879\u76ee\u8ba1\u5212 2027 \u5e74\u8fdb\u4e34\u5e8a[1]<\/td><\/tr><tr><td><strong>AAV <\/strong><strong>\u89c6\u7f51\u819c\u57fa\u56e0\u6cbb\u7597<\/strong><\/td><td>Beacon Therapeutics<\/td><td>X \u8fde\u9501\u89c6\u7f51\u819c\u8272\u7d20\u53d8\u6027\uff08XLRP\uff0cRPGR \u57fa\u56e0\u7a81\u53d8\uff09<\/td><td>laru-zova&nbsp;\u5173\u952e\u6027 II\/III \u671f VISTA \u8bd5\u9a8c 2026-09-21 \u8bfb\u51fa\u4e3b\u8981\u7ec8\u70b9\u9633\u6027[1]<\/td><\/tr><tr><td><strong>\u653e\u5c04\u540c\u4f4d\u7d20\uff08\u94dc\u57fa\u8bca\u7597\u4e00\u4f53\u5316\uff09<\/strong><\/td><td>Nuclidium<\/td><td>\u524d\u5217\u817a\u764c\u3001\u8f6c\u79fb\u6027\u4e73\u817a\u764c<\/td><td>\u5229\u7528\u533b\u7528\u56de\u65cb\u52a0\u901f\u5668\u8f70\u51fb\u5bcc\u96c6\u950c\u9776\u6750\uff08\u2077\u2070Zn\/\u2076\u2078Zn\uff09\u751f\u4ea7 \u2076\u2077Cu\uff0c\u5e76\u901a\u8fc7\u5168\u7403\u751f\u4ea7\u7f51\u7edc\u5b9e\u73b0\u5206\u5e03\u5f0f\u5236\u9020\uff1b\u2076\u00b9Cu-NuriPro \u5904\u4e8e 1 \u671f\uff0c\u2076\u2077Cu-NuriPro&nbsp;\u5904\u4e8e\u4e34\u5e8a\u524d[1]\u3002<\/td><\/tr><tr><td><strong>\u53cc\u7279\u5f02\u6027\u6297\u4f53\u964d\u89e3\uff08<\/strong><strong>EpiTAC<\/strong><strong>\uff09<\/strong><\/td><td>EpiBiologics<\/td><td>EGFR \u7a81\u53d8\u578b NSCLC\u3001HNSCC\uff08\u8ba1\u5212\u6269\u5c55 CRC\uff09<\/td><td>EpiTAC&nbsp;\u5e73\u53f0\u8986\u76d6 270+ \u964d\u89e3\u53d7\u4f53\uff1bEPI-326 \u5168\u7403 I \u671f 2026-04 \u542f\u52a8\uff1b2026-01 \u5b8c\u6210 1.07 \u4ebf\u7f8e\u5143 B \u8f6e[1]<\/td><\/tr><tr><td><strong>\u5206\u5b50\u80f6\u86cb\u767d\u964d\u89e3<\/strong><\/td><td>Neomorph<\/td><td>\u900f\u660e\u7ec6\u80de\u80be\u7ec6\u80de\u764c\uff08ccRCC\uff0c\u4e0e AbbVie\/Biogen\/Novo \u5408\u4f5c\uff09<\/td><td>NEO-811 \u5df2\u8fdb I\/II \u671f\uff1b2026-02 \u9996\u6b21\u7ed9\u836f\uff1b2026-04 \u5b8c\u6210 1 \u4ebf\u7f8e\u5143 B \u8f6e[1]<\/td><\/tr><tr><td><strong>GIPR <\/strong><strong>\u62ee\u6297<\/strong><strong> + GLP-1R <\/strong><strong>\u6fc0\u52a8\u878d\u5408\u86cb\u767d<\/strong><\/td><td>Alveus Therapeutics<\/td><td>\u80a5\u80d6\u4e0e\u957f\u671f\u4f53\u91cd\u7ba1\u7406<\/td><td>ALV-100 \u7f8e\u56fd 1b \u671f 2026-01-23 \u542f\u52a8\uff0c\u8ba1\u5212\u5165\u7ec4 180 \u4eba[1]<\/td><\/tr><tr><td><strong>\u8111\u9012\u9001\u5e73\u53f0<\/strong><strong> + <\/strong><strong>\u53d8\u6784\u6291\u5236\u5242\uff08<\/strong><strong>SARM1 \/ NAMPT \/ RIPK1<\/strong><strong>\uff09<\/strong><\/td><td>Sironax<\/td><td>ALS\u3001CIPN\uff08FDA \u5feb\u901f\u901a\u9053\u8d44\u683c\uff09\u3001\u4ee3\u8c22\u529f\u80fd\u969c\u788d\u3001\u708e\u75c7\u4e0e\u514d\u75ab\u6027\u75be\u75c5<\/td><td>SIR2501\uff08\u5168\u7403\u9996\u521b SARM1 \u53d8\u6784\uff0cCIPN \u83b7\u5feb\u901f\u901a\u9053\uff09+ SIR4156\uff08NAMPT \u589e NAD\uff09+ SIR9900\uff08\u8111\u6e17\u900f\u6027 RIPK1 \u53d8\u6784\uff09\uff1b2026-09-16 \u8bfa\u534e\u4ee5 1.25 \u4ebf\u7f8e\u5143\u884c\u4f7f\u9009\u62e9\u6743\u6536\u8d2d\u5176\u8111\u9012\u9001\u5e73\u53f0\uff08Sironax&nbsp;\u4fdd\u7559\u90e8\u5206\u8d44\u4ea7\uff09[1]<\/td><\/tr><tr><td><strong>\u751f\u6210\u5f0f<\/strong><strong> AI + <\/strong><strong>\u53cd\u5e94\u4f18\u5148\uff08<\/strong><strong>reaction-first<\/strong><strong>\uff09\u5171\u4ef7\u5316\u5b66<\/strong><\/td><td>Expedition Medicines<\/td><td>\u524d\u5217\u817a\u764c\u7b49\u96be\u6210\u836f\u9776\u70b9\uff08\u4e0e Pfizer \u5408\u4f5c\uff09<\/td><td>Flagship Pioneering 2025-10 \u63ed\u5e55\u5e76\u627f\u8bfa 5000 \u4e07\u7f8e\u5143\uff1b\u4e0e Pfizer \u591a\u9776\u70b9\u5408\u4f5c\u8bc6\u522b\u524d\u5217\u817a\u764c\u521b\u65b0\u5019\u9009[1]<\/td><\/tr><tr><td><strong>\u5fae\u751f\u7269\u7ec4\u8c03\u63a7\uff08<\/strong><strong>IVF <\/strong><strong>\u80da\u80ce\u7740\u5e8a<\/strong><strong> \/ <\/strong><strong>\u65e9\u4ea7\u9884\u9632\uff09<\/strong><\/td><td>Freya Biosciences<\/td><td>IVF \u80da\u80ce\u7740\u5e8a\u5931\u8d25\u3001\u65e9\u4ea7\u9884\u9632<\/td><td>Dyscover&nbsp;\u5e73\u53f0\uff08\u5bab\u9888\u9634\u9053\u5fae\u751f\u7269\u7ec4\u591a\u7ec4\u5b66\uff09\uff1bFB301\uff08IVF \u9002\u5e94\u75c7\uff092026-04 \u62a5\u9633\u6027 I \u671f\u6570\u636e\uff0c\u5df2\u8fdb 2 \u671f\uff1bFB401 \u8ba1\u5212 2027 Q3 \u8fdb 2 \u671f[1]<\/td><\/tr><tr><td><strong>\u7ec6\u80de\u538b\u529b\u751f\u7269\u5b66\uff08<\/strong><strong>integrated cell stress biology<\/strong><strong>\uff09<\/strong><\/td><td>Soley Therapeutics<\/td><td>\u6025\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\uff08AML\uff09\u3001\u5934\u9888\u9cde\u764c\u3001\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\uff08\u5e15\u91d1\u68ee\uff09<\/td><td>\u4e0e Oracle \u5408\u4f5c\u4f7f\u7528 NVIDIA Blackwell GPU \u7684 AI \u57fa\u7840\u8bbe\u65bd\uff1bSOL-001\/002\/STX-6398\uff08CKAP2 \u8c03\u8282\u5242\uff0c2026-04 AACR \u516c\u5e03\u4e34\u5e8a\u524d\u6570\u636e\uff09\u8ba1\u5212 2026 \u5e74\u5e95\u8d77\u9646\u7eed\u8fdb 1 \u671f[1]<\/td><\/tr><tr><td><strong>Th2 <\/strong><strong>\u901a\u8def\u6297\u4f53\uff08<\/strong><strong>IL-22 \/ IL-13<\/strong><strong>\uff09<\/strong><\/td><td>Infinimmune<\/td><td>\u4e2d\u91cd\u5ea6\u7279\u5e94\u6027\u76ae\u708e\uff08atopic dermatitis\uff09<\/td><td>IFX-101\uff08IL-22\uff09+ IFX-201\uff08IL-13\uff09\uff0c\u8ba1\u5212 2027 \u6fb3\u6d32\u542f 1 \u671f\uff1b2026-03 \u4e0e\u9ed8\u6c99\u4e1c\u7b7e\u8ba2\u6297\u4f53\u53d1\u73b0\u5408\u4f5c\uff08\u91cc\u7a0b\u7891\u603b\u989d\u6700\u9ad8 8.38 \u4ebf\u7f8e\u5143\uff09[1]<\/td><\/tr><tr><td><strong>\u5916\u7528\u6bdb\u56ca\u5e72\u7ec6\u80de\u6fc0\u6d3b\uff08\u5c40\u90e8\u7ebf\u7c92\u4f53\u4e19\u916e\u9178\u8f7d\u4f53<\/strong><strong> MPC <\/strong><strong>\u6291\u5236\uff09<\/strong><\/td><td>Pelage Pharmaceuticals<\/td><td>\u96c4\u6fc0\u7d20\u6027\u8131\u53d1\uff08\u7537\u6027\u4e0e\u5973\u6027\uff09<\/td><td>PP405 2a \u671f 78 \u4f8b\u5b8c\u6210\uff0c\u4e3b\u8981\u5b89\u5168\u7ec8\u70b9\u8fbe\u6210\uff0c4 \u5468\u6cbb\u7597\u540e\u7b2c 8 \u5468\u53d1\u5bc6\u5ea6\u5e94\u7b54 31% vs \u5b89\u6170\u5242 0%\uff1b2025-10 \u5b8c\u6210 1.2 \u4ebf\u7f8e\u5143 B \u8f6e[1]<\/td><\/tr><tr><td><strong>\u751f\u6b96\u533b\u5b66\u53e3\u670d\u5c0f\u5206\u5b50<\/strong><\/td><td>ReproNovo<\/td><td>\u7537\u6027\u4f4e\u777e\u916e\u4e0d\u80b2\u3001IVF \u80da\u80ce\u7740\u5e8a\u3001\u5b50\u5bab\u817a\u808c\u75c5<\/td><td>RPN-001\uff08leflutrozole\uff0c\u975e\u753e\u4f53\u82b3\u9999\u5316\u9176\u6291\u5236\u5242\uff09\u7f8e\u56fd 2 \u671f + RPN-002\uff08nolasiban\uff0c\u53e3\u670d\u50ac\u4ea7\u7d20\u53d7\u4f53\u62ee\u6297\u5242\uff09\u6b27\u76df 2 \u671f[1]<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">\u6ce8\uff1a15 \u5bb6\u516c\u53f8\u6309 Fierce Biotech \u539f\u6587\u9996\u5b57\u6bcd\u987a\u5e8f\u5448\u73b0\uff1b\u6280\u672f\u5e73\u53f0\u4e0e\u516c\u53f8\u5e76\u975e\u4e00\u5bf9\u4e00\uff0c\u90e8\u5206\u516c\u53f8\u5e73\u53f0\u53ef\u6a2a\u8de8\u591a\u4e2a\u5206\u5b50\u6a21\u5f0f[1]\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u53ef\u4ee5\u770b\u5230\u4e00\u4e2a\u6709\u8da3\u7684\u7ed3\u6784\uff1a15 \u5bb6\u516c\u53f8\u91cc\uff0c\u9488\u5bf9\u96be\u6210\u836f\u9776\u70b9\u6216\u5168\u65b0\u5206\u5b50\u6a21\u5f0f\u505a\u5e95\u5c42\u5e73\u53f0\u5316\u653b\u5173\u7684\u5360\u5927\u591a\u6570\u2014\u2014EpiTAC\uff08\u53cc\u7279\u5f02\u6027\u964d\u89e3\uff09\u3001\u5206\u5b50\u80f6\u3001\u8868\u89c2\u9057\u4f20\u7f16\u8f91\u3001srRNA\u3001\u8d85\u58f0\u9012\u9001\u3001AI \u5171\u4ef7\u5316\u5b66\u2014\u2014\u8fd9\u4e9b\u4e0d\u662f\u300c\u5728\u5df2\u6709\u9776\u70b9\u4e0a\u6362\u5206\u5b50\u300d\uff0c\u800c\u662f\u300c\u5728\u672a\u88ab\u8bc1\u660e\u7684\u673a\u5236\u6216\u9012\u9001\u4e0a\u5148\u8bc1\u4f2a\u300d<sup><strong>[1]<\/strong><\/sup>\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u8fd9\u610f\u5473\u7740\u5bf9\u4e34\u5e8a\u5f00\u53d1\u65b9\u7684\u6311\u6218\u4ece\u300c\u8dd1 BE\u3001\u8bbe\u8ba1\u5165\u6392\u6807\u51c6\u300d\u5347\u7ea7\u4e3a\u300c\u4e3a\u65b0\u578b\u673a\u5236\u8bbe\u8ba1\u5168\u65b0\u7684\u5b89\u5168\u6027\u76d1\u6d4b\u3001\u5242\u91cf\u63a2\u7d22\u3001PK\/PD \u6846\u67b6\u300d\u3002\u4ee5 Tune Therapeutics \u7684 TUNE-401 \u4e3a\u4f8b\u2014\u2014\u5355\u6b21\u7ed9\u836f\u5373\u5bf9 HBV cccDNA&nbsp;\u4e0e\u6574\u5408\u578b HBV DNA \u8fdb\u884c\u7532\u57fa\u5316\uff0c\u6297\u75c5\u6bd2\u6548\u679c\u6301\u7eed 17 \u4e2a\u6708\u4ee5\u4e0a\u2014\u2014\u8fd9\u79cd\u300c\u4e00\u6b21\u7ed9\u836f\u3001\u957f\u671f\u6c89\u9ed8\u300d\u7684\u65b0\u6a21\u5f0f\u5bf9\u4f20\u7edf I \u671f\u8bbe\u8ba1\u6846\u67b6\u63d0\u51fa\u4e86\u76f4\u63a5\u6311\u6218<sup><strong>[1]<\/strong><\/sup>\u3002<\/p>\n\n\n\n<h5 class=\"wp-block-heading\"><strong>\u4e09\u3001\u4e09\u5bb6\u5bf9\u4e34\u5e8a\u8bbe\u8ba1\u6709\u76f4\u63a5\u51b2\u51fb\u7684\u516c\u53f8<\/strong><\/h5>\n\n\n\n<p class=\"wp-block-paragraph\">\u628a 15 \u5bb6\u516c\u53f8\u4e2d\u51e0\u5bb6\u300c\u5bf9\u4e34\u5e8a\u8bbe\u8ba1\u672c\u8eab\u6709\u76f4\u63a5\u51b2\u51fb\u300d\u7684\u516c\u53f8\u5355\u72ec\u63d0\u51fa\u6765\u770b\uff0c\u66f4\u80fd\u770b\u51fa\u65b0\u673a\u5236\u5bf9 I \u671f\u3001II \u671f\u6846\u67b6\u7684\u771f\u5b9e\u6311\u6218\u3002<\/p>\n\n\n\n<h6 class=\"wp-block-heading\"><strong>Tune Therapeutics<\/strong><strong>\uff1a\u4e00\u6b21\u7ed9\u836f\uff0c<\/strong><strong>17 <\/strong><strong>\u4e2a\u6708\u6301\u7eed\u6c89\u9ed8<\/strong><\/h6>\n\n\n\n<p class=\"wp-block-paragraph\">TUNE-401 \u662f\u5168\u7403\u9996\u4e2a\u8fdb\u5165\u4e34\u5e8a\u7684\u8868\u89c2\u9057\u4f20\u6c89\u9ed8\u7597\u6cd5<sup><strong>[1]<\/strong><\/sup>\u3002\u5728 2026 \u5e74\u6b27\u6d32\u809d\u810f\u7814\u7a76\u534f\u4f1a\uff08EASL\uff09\u5e74\u4f1a\u4e0a\u516c\u5e03\u7684&nbsp;Ib\/IIa&nbsp;\u671f\u6570\u636e\u663e\u793a\uff1aTUNE-401 \u901a\u8fc7LNP\u9012\u9001dCas9-\u8868\u89c2\u6291\u5236\u57df\u878d\u5408\u86cb\u767d\uff0c\u76f4\u63a5\u9776\u5411\u5e76\u7532\u57fa\u5316 HBV cccDNA&nbsp;\u4e0e\u6574\u5408\u578b HBV DNA\uff0c\u5728\u66f4\u9ad8\u5242\u91cf\u6c34\u5e73\u5b9e\u73b0 100% \u751f\u7269\u6807\u5fd7\u7269\u5e94\u7b54\uff0c\u6297\u75c5\u6bd2\u6548\u679c\u5728\u5355\u6b21\u7ed9\u836f\u540e\u6301\u7eed 17 \u4e2a\u6708\u4ee5\u4e0a\uff08\u4ecd\u5728\u8fdb\u884c\u4e2d\uff09<sup><strong>[1]<\/strong><\/sup>\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u6162\u6027\u4e59\u578b\u809d\u708e\u73b0\u6709\u7597\u6cd5\u51e0\u4e4e\u65e0\u6cd5\u5b9e\u73b0\u529f\u80fd\u6027\u6cbb\u6108\uff08\u5e74\u6cbb\u6108\u7387\u7ea6 1%\uff09\uff0c\u6838\u5fc3\u969c\u788d\u6b63\u662f&nbsp;cccDNA&nbsp;\u7684\u6301\u7eed\u5b58\u5728<sup><strong>[1]<\/strong><\/sup>\u3002TUNE-401 \u662f\u9996\u4e2a\u5728\u4e34\u5e8a\u4e0a\u8bc1\u660e\u53ef\u8868\u89c2\u9057\u4f20\u6c89\u9ed8&nbsp;cccDNA&nbsp;\u7684\u7597\u6cd5\u2014\u2014\u5b83\u4e0d\u53ea\u662f\u300c\u53c8\u4e00\u4e2a\u6297\u75c5\u6bd2\u836f\u300d\uff0c\u800c\u662f\u4e3a\u300c\u4e00\u6b21\u7ed9\u836f\u3001\u957f\u671f\u6c89\u9ed8\u300d\u7684\u65b0\u8303\u5f0f\u63d0\u4f9b\u4e86\u4e34\u5e8a\u8bc1\u636e\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e34\u5e8a\u5f00\u53d1\u542f\u793a\uff1a\u300c\u4e00\u6b21\u7ed9\u836f\u3001\u957f\u671f\u6c89\u9ed8\u300d\u6a21\u5f0f\u5bf9\u4f20\u7edf I \u671f\u8bbe\u8ba1\u6846\u67b6\u63d0\u51fa\u76f4\u63a5\u6311\u6218\u2014\u2014\u5b89\u5168\u6027\u76d1\u6d4b\u7684\u65f6\u957f\u3001PD \u6807\u5fd7\u7269\u7684\u9009\u62e9\u3001\u4ee5\u53ca\u300c\u6c89\u9ed8\u6df1\u5ea6\u300d\u7684\u91cf\u5316\u6807\u51c6\u90fd\u9700\u8981\u4e0e\u76d1\u7ba1\u673a\u6784\u91cd\u65b0\u534f\u5546\u3002\u5982\u679c TUNE-401 \u7684\u957f\u671f\u6570\u636e\u6301\u7eed\u79ef\u6781\uff0c\u5b83\u5c06\u4e3a\u8868\u89c2\u9057\u4f20\u7f16\u8f91\u7c7b\u7597\u6cd5\u7684\u76d1\u7ba1\u8def\u5f84\u5efa\u7acb\u4e00\u4e2a\u5148\u4f8b\u3002<\/p>\n\n\n\n<h6 class=\"wp-block-heading\"><strong>EpiBiologics<\/strong><strong>\uff1a\u7ec4\u7ec7\u9009\u62e9\u6027\u964d\u89e3\uff0c\u8bd5\u56fe\u7ed5\u5f00<\/strong><strong> EGFR <\/strong><strong>\u6bd2\u6027<\/strong><\/h6>\n\n\n\n<p class=\"wp-block-paragraph\">EPI-326 \u662f\u4e00\u79cd\u7ec4\u7ec7\u9009\u62e9\u6027\u53cc\u7279\u5f02\u6027\u6297\u4f53\u964d\u89e3\u5242\uff0c\u964d\u89e3\u6240\u6709\u81f4\u764c\u7a81\u53d8\u578b\u548c\u91ce\u751f\u578b EGFR\uff0c\u4f46\u5c06\u964d\u89e3\u5b9a\u4f4d\u5728\u80bf\u7624\u90e8\u4f4d\uff0c\u907f\u514d\u635f\u4f24\u5065\u5eb7\u7ec4\u7ec7<sup><strong>[1]<\/strong><\/sup>\u3002\u5176\u5168\u7403 I \u671f\u8bd5\u9a8c\u4e8e 2026 \u5e74 4 \u6708\u542f\u52a8\uff0c\u9488\u5bf9 EGFR \u7a81\u53d8\u578b\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u4e0e\u5934\u9888\u9cde\u764c\uff08HNSCC\uff09\uff0c\u8ba1\u5212\u6269\u5c55\u81f3\u7ed3\u76f4\u80a0\u764c\uff08CRC\uff09<sup><strong>[1]<\/strong><\/sup>\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e34\u5e8a\u524d\u6570\u636e\u663e\u793a\uff0cEPI-326 \u5728 EGFR \u7a81\u53d8 NSCLC \u6a21\u578b\u4e2d\u9a71\u52a8\u4e86\u9ad8\u5b8c\u5168\u7f13\u89e3\u7387\uff0c\u4e14\u5f3a\u4e8e EGFR \u6291\u5236\u5242<sup><strong>[1]<\/strong><\/sup>\u3002\u5728\u975e\u4eba\u7075\u957f\u7c7b\uff08NHP\uff09\u6bd2\u7406\u5b66\u7814\u7a76\u4e2d\uff0c\u6700\u5927\u53ef\u884c\u5242\u91cf 204 mg\/kg \u4e0b\u8010\u53d7\u826f\u597d\uff0c\u672a\u89c2\u5bdf\u5230\u5178\u578b\u7684 EGFR \u76f8\u5173\u6bd2\u6027\uff08\u76ae\u75b9\u3001\u8179\u6cfb\u7b49\uff09<sup><strong>[1]<\/strong><\/sup>\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e34\u5e8a\u5f00\u53d1\u542f\u793a\uff1aEGFR \u6291\u5236\u5242\u7684\u5242\u91cf\u9650\u5236\u6027\u6bd2\u6027\uff08\u76ae\u75b9\u3001\u8179\u6cfb\uff09\u662f\u4e34\u5e8a\u4e0a\u957f\u671f\u5b58\u5728\u7684\u95ee\u9898\u3002\u5982\u679c&nbsp;EPI-326 \u7684\u7ec4\u7ec7\u9009\u62e9\u6027\u964d\u89e3\u7b56\u7565\u5728\u4eba\u4f53\u4e2d\u80fd\u591f\u7ef4\u6301\u4e34\u5e8a\u524d\u5c55\u793a\u7684\u5bbd\u6cbb\u7597\u7a97\u53e3\uff0c\u5b83\u5c06\u652f\u6301\u66f4\u65e9\u7ebf\u6cbb\u7597\u548c\u8054\u5408\u7528\u836f\u2014\u2014\u8fd9\u5bf9 EGFR \u7a81\u53d8 NSCLC \u7684\u4e34\u5e8a\u5f00\u53d1\u683c\u5c40\u6709\u5b9e\u8d28\u6027\u5f71\u54cd\u3002I \u671f\u8bd5\u9a8c\u7684\u5242\u91cf\u9012\u589e\u8bbe\u8ba1\u548c\u5b89\u5168\u6027\u76d1\u6d4b\u65b9\u6848\u5c06\u662f\u5173\u952e\u9a8c\u8bc1\u8282\u70b9\u3002<\/p>\n\n\n\n<h6 class=\"wp-block-heading\"><strong>Sironax<\/strong><strong>\uff1a\u8bfa\u534e<\/strong><strong> 1.25 <\/strong><strong>\u4ebf\u7f8e\u5143\u62bc\u6ce8\u7684\u662f\u300c\u8111\u9012\u9001\u300d\u672c\u8eab<\/strong><\/h6>\n\n\n\n<p class=\"wp-block-paragraph\">2026 \u5e74 9 \u6708 16 \u65e5\uff0c\u8bfa\u534e\u4ee5 1.25 \u4ebf\u7f8e\u5143\u6536\u8d2d&nbsp;Sironax&nbsp;\u7684\u8111\u9012\u9001\u5e73\u53f0\uff0c\u540c\u65f6&nbsp;Sironax&nbsp;\u4fdd\u7559\u90e8\u5206\u8d44\u4ea7\u7684\u4f7f\u7528\u6743<sup><strong>[1]<\/strong><\/sup>\u3002\u8be5\u5e73\u53f0\u65e8\u5728\u514b\u670d\u8840\u8111\u5c4f\u969c\u8fd9\u4e00 CNS \u836f\u7269\u5f00\u53d1\u7684\u6838\u5fc3\u969c\u788d\uff0c\u53ef\u9012\u9001\u5355\u514b\u9686\u6297\u4f53\u3001\u80bd\u3001\u86cb\u767d\u3001\u57fa\u56e0\u7597\u6cd5\u548c\u5176\u4ed6\u5927\u5206\u5b50\u81f3\u8111\u90e8\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Sironax&nbsp;\u81ea\u8eab\u6709\u4e09\u6b3e\u4e34\u5e8a\u9636\u6bb5\u8d44\u4ea7\uff1aSIR2501\uff08\u5168\u7403\u9996\u521b SARM1 \u53d8\u6784\u6291\u5236\u5242\uff0c\u7528\u4e8e ALS \u548c\u5316\u7597\u8bf1\u5bfc\u7684\u5468\u56f4\u795e\u7ecf\u75c5\u53d8\uff0cCIPN \u9002\u5e94\u75c7\u5df2\u83b7 FDA \u5feb\u901f\u901a\u9053\u8d44\u683c\uff09\u3001SIR4156\uff08\u5168\u7403\u9996\u521b NAMPT \u53d8\u6784\u6fc0\u6d3b\u5242\uff0c\u7528\u4e8e\u4ee3\u8c22\u529f\u80fd\u969c\u788d\uff09\u3001SIR9900\uff08\u8111\u6e17\u900f\u6027 RIPK1 \u53d8\u6784\u6291\u5236\u5242\uff09<sup><strong>[1]<\/strong><\/sup>\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e34\u5e8a\u5f00\u53d1\u542f\u793a\uff1a\u8bfa\u534e\u4ee5 1.25 \u4ebf\u7f8e\u5143\u6536\u8d2d\u4e00\u4e2a\u5e73\u53f0\u800c\u975e\u5355\u4e00\u8d44\u4ea7\u2014\u2014\u8bf4\u660e\u9012\u9001\u80fd\u529b\u672c\u8eab\u6b63\u5728\u6210\u4e3a\u53ef\u72ec\u7acb\u4f30\u503c\u7684\u8d44\u4ea7\u3002\u5bf9\u4e34\u5e8a\u5f00\u53d1\u56e2\u961f\u800c\u8a00\uff0c\u8fd9\u610f\u5473\u7740\u5728 CNS \u836f\u7269\u8bd5\u9a8c\u7684\u65b9\u6848\u8bbe\u8ba1\u4e2d\uff0c\u9012\u9001\u7cfb\u7edf\u7684\u9a8c\u8bc1\uff08\u8111\u66b4\u9732\u91cf\u3001\u9776\u70b9\u5360\u6709\u7387\uff09\u9700\u8981\u4f5c\u4e3a\u72ec\u7acb\u7684\u65e9\u671f\u4e34\u5e8a\u7ec8\u70b9\u6765\u8bbe\u8ba1\uff0c\u800c\u4e0d\u4ec5\u4ec5\u662f\u8f85\u52a9\u6027 PK \u53c2\u6570\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e09\u5bb6\u516c\u53f8\u7684\u5171\u6027\u542f\u793a\uff1a\u65b0\u578b\u5206\u5b50\u6a21\u5f0f\u6b63\u5728\u8feb\u4f7f\u4e34\u5e8a\u56e2\u961f\u91cd\u65b0\u5b9a\u4e49\u300c\u5b89\u5168\u6027\u76d1\u6d4b\u65f6\u957f\u300d\u300c\u5242\u91cf\u63a2\u7d22\u65b9\u6cd5\u300d\u300c\u9012\u9001\u9a8c\u8bc1\u7ec8\u70b9\u300d\u3002\u4f20\u7edf\u7684 I \u671f\u8bbe\u8ba1\u6846\u67b6\u2014\u2014\u56fa\u5b9a\u968f\u8bbf\u671f\u3001\u6807\u51c6 PK\/PD \u91c7\u6837\u3001\u5e38\u89c4\u5b89\u5168\u6027\u76d1\u6d4b\u2014\u2014\u5728\u9762\u5bf9\u8868\u89c2\u9057\u4f20\u7f16\u8f91\u3001\u7ec4\u7ec7\u9009\u62e9\u6027\u964d\u89e3\u3001\u8111\u9012\u9001\u5e73\u53f0\u7b49\u65b0\u673a\u5236\u65f6\uff0c\u9700\u8981\u66f4\u65e9\u5730\u4e0e\u76d1\u7ba1\u673a\u6784\u6c9f\u901a\uff0c\u5e76\u8bbe\u8ba1\u66f4\u7075\u6d3b\u7684\u9002\u5e94\u6027\u65b9\u6848\u3002<\/p>\n\n\n\n<h5 class=\"wp-block-heading\"><strong>\u4e00\u53e5\u8bdd\u603b\u7ed3\uff1a<\/strong><strong>Fierce 1<\/strong><strong>5 <\/strong><strong>\u4e0d\u662f\u4e00\u4e2a\u7b80\u5355\u7684\u300c\u6700\u6709\u610f\u601d\u7684\u516c\u53f8\u540d\u5355\u300d<\/strong><strong>\u2014\u2014<\/strong><strong>\u5b83\u662f\u65e9\u671f\u521b\u65b0\u751f\u6001\u5728<\/strong><strong> 2026 <\/strong><strong>\u5e74\u7684\u4f53\u68c0\u62a5\u544a\uff1a\u8d44\u672c\u53d8\u6311\u5254\u4e86\u3001<\/strong><strong>AI <\/strong><strong>\u53d8\u5e95\u5c42\u4e86\u3001<\/strong><strong>\u5168\u7403\u79bb\u5cb8\u53d8\u5e38\u6001\u4e86<\/strong><strong>\u3002<\/strong><\/h5>\n\n\n\n<h5 class=\"wp-block-heading\"><strong>\u53c2\u8003\u6587\u732e<\/strong><\/h5>\n\n\n\n<p class=\"wp-block-paragraph\">[1] Waldron J. Introducing Fierce Biotech&#8217;s 2026 Fierce 15. <em>Fierce Biotech<\/em>. 2026-10-05. https:\/\/www.fiercebiotech.com\/biotech\/introducing-fierce-biotechs-2026-fierce-15<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">[2] Alveus Therapeutics. ALV-100 Phase 1b Clinical Trial (NCT07399678). ICHGCP. https:\/\/ichgcp.net\/clinical-trials-registry\/NCT07399678<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">[3] Tune Therapeutics. TUNE-401 Phase 1b\/2a Proof-of-Concept Data at EASL 2026. 2026-05-30. https:\/\/tunetx.com\/tune-therapeutics-presents-positive-phase-1b-2a-proof-of-concept-data-on-tune-401-a-first-in-class-epigenetic-silencer-for-patients-with-hepatitis-b-at-easl-2026\/<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">[4] EpiBiologics. EPI-326 Global Phase 1 First Patient Dosed. 2026-04-19. https:\/\/www.epibiologics.com\/news-publications\/epibiologics-doses-first-patient-with-epi-326-bispecific-antibody-in-global-phase-1-study-for-egfr-driven-solid-tumors<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">[5] Sironax. Novartis Exercises Option to Acquire Brain Delivery Platform. 2026-09-16. https:\/\/www.sironax.com\/sironax-announces-option-exercise-and-asset-purchase\/<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u64b0\u6587\uff1a\u90d1\u53f6\u654f<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u2014\u2014Fierce Biotech \u7b2c 24 \u5c4a\u699c\u5355\u80cc\u540e\u7684\u4e09\u4e2a\u7ed3\u6784\u6027\u4fe1\u53f7\u4e0e\u4e34\u5e8a\u5f00\u53d1\u542f\u793a<\/p>\n","protected":false},"author":1,"featured_media":2227,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[147],"tags":[86,15,32,34,29],"class_list":["post-2222","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-147","tag-86","tag-15","tag-32","tag-34","tag-29"],"_links":{"self":[{"href":"https:\/\/www.millibuff.com\/index.php?rest_route=\/wp\/v2\/posts\/2222","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.millibuff.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.millibuff.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.millibuff.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.millibuff.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2222"}],"version-history":[{"count":2,"href":"https:\/\/www.millibuff.com\/index.php?rest_route=\/wp\/v2\/posts\/2222\/revisions"}],"predecessor-version":[{"id":2226,"href":"https:\/\/www.millibuff.com\/index.php?rest_route=\/wp\/v2\/posts\/2222\/revisions\/2226"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.millibuff.com\/index.php?rest_route=\/wp\/v2\/media\/2227"}],"wp:attachment":[{"href":"https:\/\/www.millibuff.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2222"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.millibuff.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2222"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.millibuff.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2222"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}