{"id":2228,"date":"2026-10-15T11:17:37","date_gmt":"2026-10-15T03:17:37","guid":{"rendered":"https:\/\/www.millibuff.com\/?p=2228"},"modified":"2026-10-15T11:29:55","modified_gmt":"2026-10-15T03:29:55","slug":"%e5%b0%8f%e7%89%9b%e6%b4%9e%e5%af%9f-science-%e9%87%8d%e7%a3%85%e7%bb%bc%e8%bf%b0%ef%bd%9c%e5%91%8a%e5%88%ab%e5%8a%a8%e7%89%a9%e5%ae%9e%e9%aa%8c%e4%be%9d%e8%b5%96%ef%bc%81%e4%bb%a5%e4%ba%ba%e4%b8%ba","status":"publish","type":"post","link":"https:\/\/www.millibuff.com\/?p=2228","title":{"rendered":"\u5c0f\u725b\u6d1e\u5bdf | Science \u91cd\u78c5\u7efc\u8ff0\uff5c\u544a\u522b\u52a8\u7269\u5b9e\u9a8c\u4f9d\u8d56\uff01\u4ee5\u4eba\u4e3a\u4e2d\u5fc3\u7684\u836f\u7269\u7814\u53d1\u65b0\u8303\u5f0f\u6765\u4e86"},"content":{"rendered":"\n

\u4f20\u7edf\u65b0\u836f\u7814\u53d1\u9ad8\u5ea6\u4f9d\u8d56\u52a8\u7269\u6a21\u578b\uff0c\u4f46\u7269\u79cd\u5dee\u5f02\u5e26\u6765\u96be\u4ee5\u903e\u8d8a\u7684\u8f6c\u5316\u9e3f\u6c9f\uff1a\u8d85\u8fc7 90% \u5728\u4e34\u5e8a\u524d\u8868\u73b0\u4f18\u5f02\u7684\u5019\u9009\u836f\u7269\uff0c\u6700\u7ec8\u5012\u5728\u4eba\u4f53\u4e34\u5e8a\u8bd5\u9a8c\u3002\u968f\u7740\u5be1\u6838\u82f7\u9178\u3001\u6297\u4f53\u5076\u8054\u836f\u7269\u3001\u86cb\u767d\u964d\u89e3\u5242\u7b49\u65b0\u5174\u7597\u6cd5\u6d8c\u73b0\uff0c\u5f88\u591a\u4f5c\u7528\u9776\u70b9\u5728\u52a8\u7269\u4f53\u5185\u5e76\u4e0d\u5b58\u5728\uff0c\u8fdb\u4e00\u6b65\u653e\u5927\u7814\u53d1\u98ce\u9669\u3002<\/p>\n\n\n\n

2026\u5e744\u6708\uff0c\u65af\u5766\u798f Joseph C. Wu \u56e2\u961f\u5728\u300aScience\u300b\uff08IF 45.8\uff09\u53d1\u8868\u91cd\u78c5\u7efc\u8ff0Reimagining human<\/em>-centric drug development with new approach methodologies<\/em>\uff0c\u5168\u9762\u89e3\u6790NAMs <\/strong>\u65b0\u65b9\u6cd5\u5b66\uff08<\/strong>New Approach Methodologies<\/strong>\uff09<\/strong>\u5982\u4f55\u63a8\u52a8\u836f\u7269\u7814\u53d1\u4ece\u52a8\u7269\u6a21\u578b\u8f6c\u5411\u4ee5\u4eba\u4e3a\u4e2d\u5fc3<\/strong>\u7684\u5168\u65b0\u4f53\u7cfb\u3002<\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

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    \n
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  • \u5fae\u751f\u7406\u7cfb\u7edf<\/strong> MPS<\/strong>\uff1a\u7c7b\u5668\u5b98\u8fd8\u539f\u7ec4\u7ec7\u4e09\u7ef4\u7a7a\u95f4\u5f02\u8d28\u6027\uff1b\u5668\u5b98\u82af\u7247\u5f15\u5165\u6d41\u4f53\u529b\u5b66\u3001\u673a\u68b0\u523a\u6fc0\uff1b\u4e8c\u8005\u878d\u5408\u7684\u6df7\u5408\u82af\u7247\u7cfb\u7edf\uff0c\u53ef\u642d\u5efa\u591a\u5668\u5b98\u4e92\u8054\u56de\u8def\uff0c\u4f53\u5916\u590d\u523b\u4eba\u4f53\u836f\u4ee3\u52a8\u529b\u5b66\u4e0e\u5668\u5b98\u4e92\u4f5c\u3002<\/li>\n\n\n\n
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    \ud83d\udd39\u4eba\u4f53\u591a\u5668\u5b98\u82af\u7247\u8bc4\u4f30<\/strong>\uff1a\u6a21\u62df\u836f\u7269 ADME \u8fc7\u7a0b\uff0c\u8bc4\u4f30\u7cfb\u7edf\u6bd2\u6027\uff1b\u5546\u4e1a\u5316\u809d\u82af\u7247\u5df2\u8fdb\u5165 FDA ISTAND \u76d1\u7ba1\u8d44\u8d28\u901a\u9053\u3002 <\/p>\n\n\n\n

    \ud83d\udd39\u57f9\u517b\u76bf\u4e2d\u7684\u4e34\u5e8a\u8bd5\u9a8c<\/strong>\uff08<\/strong>Clinical<\/strong>-trial<\/strong>-in<\/strong>-a<\/strong>-dish<\/strong>\uff09<\/strong>\uff1a\u4f9d\u6258\u5927\u89c4\u6a21\u60a3\u8005\u6765\u6e90\u751f\u7269\u5e93\uff0c\u4f53\u5916\u6a21\u62df\u591a\u6837\u5316\u60a3\u8005\u961f\u5217\uff0c\u63d0\u524d\u9884\u5224\u836f\u6548\u5dee\u5f02\uff0c\u7b5b\u9009\u836f\u7269\u83b7\u76ca\u4eba\u7fa4\u3002 <\/p>\n\n\n\n

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    \"\"<\/figure>\n\n\n\n

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    \u6587\u672b\u5c0f\u7ed3\uff1a\u7c7b\u5668\u5b98\u3001\u5668\u5b98\u82af\u7247\u4e0e AI \u7684\u878d\u5408\uff0c\u4e0d\u53ea\u662f\u5355\u4e00\u6280\u672f\u7684\u8fed\u4ee3\uff0c\u66f4\u662f\u65b0\u836f\u7814\u53d1\u5e95\u5c42\u8303\u5f0f\u7684\u53d8\u9769\u3002\u4f46\u6807\u51c6\u5316\u3001\u53ef\u91cd\u590d\u6027\u3001\u76d1\u7ba1\u843d\u5730\u3001\u590d\u5408\u578b\u4eba\u624d\u57f9\u517b\uff0c\u4ecd\u662f\u884c\u4e1a\u9700\u8981\u5171\u540c\u653b\u514b\u7684\u73b0\u5b9e\u6311\u6218\u3002<\/h5>\n\n\n\n

    <\/p>\n\n\n\n

    \u64b0\u6587\uff1a\u5bab\u96ea<\/p>\n\n\n\n

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