{"id":2242,"date":"2026-10-20T11:34:20","date_gmt":"2026-10-20T03:34:20","guid":{"rendered":"https:\/\/www.millibuff.com\/?p=2242"},"modified":"2026-10-20T11:36:28","modified_gmt":"2026-10-20T03:36:28","slug":"%e5%b0%8f%e7%89%9b%e6%b4%9e%e5%af%9f-%e4%bb%a3%e8%b0%a2%e9%85%b6%e4%bb%8b%e5%af%bc%e7%9a%84%e8%8d%af%e7%89%a9%e7%9b%b8%e4%ba%92%e4%bd%9c%e7%94%a8%ef%bc%9a%e4%bb%8e%e6%b8%85%e9%99%a4%e7%8e%87","status":"publish","type":"post","link":"https:\/\/www.millibuff.com\/?p=2242","title":{"rendered":"\u5c0f\u725b\u6d1e\u5bdf | \u4ee3\u8c22\u9176\u4ecb\u5bfc\u7684\u836f\u7269\u76f8\u4e92\u4f5c\u7528\uff1a\u4ece\u6e05\u9664\u7387\u672c\u8d28\u5230\u4e34\u5e8a\u98ce\u9669\u5168\u666f\u89e3\u6790"},"content":{"rendered":"\n<h5 class=\"wp-block-heading\">\u4e00\u3001<strong>\u6e05\u9664\u7387\uff1a\u4ee3\u8c22\u9176 DDI \u7684\u751f\u7406\u5b66\u5e95\u5c42\u903b\u8f91<\/strong><\/h5>\n\n\n\n<p class=\"wp-block-paragraph\">1\u3001<strong>\u6e05\u9664\u7387\u7684\u6838\u5fc3\u5b9a\u4e49\u4e0e\u5b9a\u91cf\u5173\u7cfb<\/strong><\/p>\n\n\n\n<ol class=\"wp-block-list\"><\/ol>\n\n\n\n<p class=\"wp-block-paragraph\">\u6e05\u9664\u7387\uff08Clearance, CL\uff09\u662f\u6307\u5355\u4f4d\u65f6\u95f4\u5185\u6709\u591a\u5c11\u4f53\u79ef\u8840\u6d46\u4e2d\u7684\u836f\u7269\u88ab\u5b8c\u5168\u6e05\u9664\uff0c\u5355\u4f4d\u901a\u5e38\u4e3a L\/h\uff0c\u662f\u673a\u4f53\u6d88\u9664\u836f\u7269\u80fd\u529b\u7684\u76f4\u63a5\u91cf\u5316\u6307\u6807\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4ece\u836f\u4ee3\u52a8\u529b\u5b66\u57fa\u672c\u5173\u7cfb\u770b\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u66b4\u9732\u91cf\u4e0e\u6e05\u9664\u7387\u6210\u53cd\u6bd4<\/strong>\uff1a\u5728\u7ebf\u6027\u836f\u4ee3\u52a8\u529b\u5b66\u8303\u7574\u5185\uff0c\u5355\u6b21\u9759\u8109\u7ed9\u836f\u4e14\u7b26\u5408\u5355\u5ba4\u6a21\u578b\u7684\u8840\u836f\u6d53\u5ea6-\u65f6\u95f4\u66f2\u7ebf\u4e0b\u9762\u79ef\u6ee1\u8db3<img decoding=\"async\" width=\"91\" height=\"37\" src=\"blob:https:\/\/www.millibuff.com\/97a65ce6-1895-45f0-80e1-ef470aeafe3a\">\uff0c\u6e05\u9664\u7387\u4e0b\u964d\u5219\u66b4\u9732\u91cf\u7b49\u6bd4\u4f8b\u5347\u9ad8\uff0c\u6e05\u9664\u7387\u5347\u9ad8\u5219\u66b4\u9732\u91cf\u4e0b\u964d\u3002\u8fd9\u662f\u4ee3\u8c22\u9176 DDI \u6700\u6838\u5fc3\u7684\u5b9a\u91cf\u57fa\u7840\uff1a\u9176\u6291\u5236\u2192\u6e05\u9664\u7387\u4e0b\u964d\u2192AUC \u5347\u9ad8\u2192\u6bd2\u6027\u98ce\u9669\u589e\u52a0\uff1b\u9176\u8bf1\u5bfc\u2192\u6e05\u9664\u7387\u5347\u9ad8\u2192AUC \u4e0b\u964d\u2192\u6cbb\u7597\u5931\u8d25\u3002<\/li>\n\n\n\n<li><strong>\u534a\u8870\u671f\u7531\u6e05\u9664\u7387\u548c\u5206\u5e03\u5bb9\u79ef\u5171\u540c\u51b3\u5b9a<\/strong>\uff1a<img decoding=\"async\" width=\"90\" height=\"39\" src=\"blob:https:\/\/www.millibuff.com\/8623fd79-bb89-498b-b38f-adaeaf5451a7\">\uff0c\u6e05\u9664\u7387\u964d\u4f4e\u4f1a\u540c\u65f6\u5ef6\u957f\u836f\u7269\u4f5c\u7528\u65f6\u95f4\uff0c\u8fdb\u4e00\u6b65\u653e\u5927\u66b4\u9732\u5dee\u5f02\u3002<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u836f\u7269\u7684\u603b\u6e05\u9664\u7387\u662f\u5404\u5668\u5b98\u6e05\u9664\u80fd\u529b\u7684\u603b\u548c\uff1a<em>CL<\/em><sub><em>total<\/em><\/sub><em>=CL<\/em><sub><em>H<\/em><\/sub><em>+CL<\/em><sub><em>R<\/em><\/sub><em>+CL<\/em><sub><em>other<\/em><\/sub><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5176\u4e2d\u809d\u6e05\u9664\u7387CL<sub>H<\/sub>\u662f\u7edd\u5927\u591a\u6570\u5c0f\u5206\u5b50\u836f\u7269\u7684\u4e3b\u8981\u6e05\u9664\u9014\u5f84\uff0c\u4e5f\u662f\u4ee3\u8c22\u9176\u4ecb\u5bfc DDI \u7684\u6838\u5fc3\u4f5c\u7528\u4f4d\u70b9\u3002\u636e\u7edf\u8ba1\uff0c\u7ea6 70% \u7684\u4e34\u5e8a\u5e38\u7528\u836f\u7269\u4e3b\u8981\u7ecf\u809d\u810f\u4ee3\u8c22\u6e05\u9664\uff0c\u809d\u810f\u4ee3\u8c22\u80fd\u529b\u7684\u6539\u53d8\u662f\u4ea7\u751f\u4e34\u5e8a\u663e\u8457 DDI \u7684\u6700\u4e3b\u8981\u6765\u6e90\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">2\u3001<strong>\u809d\u6e05\u9664\u7387\u7684\u53cc\u91cd\u5efa\u6a21\uff1a\u704c\u6ce8\u9650\u5236\u4e0e\u4ee3\u8c22\u9650\u5236<\/strong><\/p>\n\n\n\n<ol class=\"wp-block-list\"><\/ol>\n\n\n\n<p class=\"wp-block-paragraph\">\u809d\u810f\u6e05\u9664\u836f\u7269\u9700\u8981\u4e24\u4e2a\u8fde\u7eed\u6b65\u9aa4\uff1a\u836f\u7269\u968f\u8840\u6d41\u8fdb\u5165\u809d\u810f \u2192 \u88ab\u809d\u7ec6\u80de\u6444\u53d6\u5e76\u4ee3\u8c22\/\u6392\u6cc4\u3002\u8fd9\u4e24\u4e2a\u73af\u8282\u7684\u76f8\u5bf9\u9650\u901f\u5730\u4f4d\uff0c\u51b3\u5b9a\u4e86\u836f\u7269\u5bf9\u4ee3\u8c22\u9176\u53d8\u5316\u7684\u654f\u611f\u7a0b\u5ea6\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u7ecf\u5178\u7684\u5145\u5206\u6405\u62cc\u6a21\u578b\uff08Well-stirred model\uff09\u5b9a\u91cf\u63cf\u8ff0\u4e86\u809d\u6e05\u9664\u7387\u7684\u51b3\u5b9a\u56e0\u7d20\uff1a<img decoding=\"async\" width=\"180\" height=\"39\" src=\"blob:https:\/\/www.millibuff.com\/1c1f81b0-fecf-4d65-8e2e-06681ed6456f\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5176\u4e2d\uff0c<em>Q<\/em><sub><em>H<\/em><\/sub>\u8868\u793a\u809d\u8840\u6d41\u91cf\uff0c<em>fu<\/em>\u8868\u793a\u8840\u6d46\u6e38\u79bb\u836f\u7269\u5206\u6570\uff0cCL<sub>int<\/sub>\u8868\u793a\u5185\u5728\u6e05\u9664\u7387\uff0c\u5373\u4e0d\u53d7\u8840\u6d41\u548c\u86cb\u767d\u7ed3\u5408\u9650\u5236\u65f6\uff0c\u809d\u7ec6\u80de\u9176\u5bf9\u836f\u7269\u7684\u56fa\u6709\u4ee3\u8c22\u6e05\u9664\u80fd\u529b\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u6839\u636e\u5185\u5728\u6e05\u9664\u7387\u4e0e\u809d\u8840\u6d41\u91cf\u7684\u76f8\u5bf9\u5927\u5c0f\uff0c\u53ef\u5c06\u836f\u7269\u5206\u4e3a\u4e24\u7c7b\uff0c\u5176 DDI \u98ce\u9669\u5b58\u5728\u672c\u8d28\u5dee\u5f02\uff1a<\/p>\n\n\n\n<figure class=\"wp-block-image size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"553\" height=\"90\" src=\"https:\/\/www.millibuff.com\/wp-content\/uploads\/2026\/10\/image-13.png\" alt=\"\" class=\"wp-image-2243\" style=\"width:762px;height:auto\" srcset=\"https:\/\/www.millibuff.com\/wp-content\/uploads\/2026\/10\/image-13.png 553w, https:\/\/www.millibuff.com\/wp-content\/uploads\/2026\/10\/image-13-300x49.png 300w\" sizes=\"(max-width: 553px) 100vw, 553px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">\u53ea\u6709\u4ee3\u8c22\u9650\u5236\u6027\u6e05\u9664\u7684\u836f\u7269\uff0c\u624d\u4f1a\u56e0\u4ee3\u8c22\u9176\u7684\u6291\u5236\u6216\u8bf1\u5bfc\u4ea7\u751f\u663e\u8457\u7684\u6e05\u9664\u7387\u53d8\u5316\u548c\u4e34\u5e8a DDI \u98ce\u9669\u3002\u8fd9\u4e5f\u662f\u4e3a\u4ec0\u4e48\u540c\u6837\u662f CYP3A4 \u5e95\u7269\uff0c\u6709\u7684\u836f\u7269\u8054\u7528\u5f3a\u6291\u5236\u5242\u540e AUC \u5347\u9ad8\u5341\u51e0\u500d\uff0c\u6709\u7684\u5374\u51e0\u4e4e\u65e0\u53d8\u5316\u2014\u2014\u5e95\u5c42\u539f\u56e0\u5728\u4e8e\u6e05\u9664\u7684\u9650\u901f\u73af\u8282\u4e0d\u540c\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">3\u3001<strong>\u5185\u5728\u6e05\u9664\u7387\uff1a\u8fde\u63a5\u9176\u6d3b\u6027\u4e0e DDI \u7684\u6838\u5fc3\u6865\u6881<\/strong><\/p>\n\n\n\n<ol class=\"wp-block-list\"><\/ol>\n\n\n\n<p class=\"wp-block-paragraph\">\u5185\u5728\u6e05\u9664\u7387CL<sub>int<\/sub>\u76f4\u63a5\u53cd\u6620\u4e86\u4ee3\u8c22\u9176\u5bf9\u6e38\u79bb\u836f\u7269\u7684\u6700\u5927\u4ee3\u8c22\u80fd\u529b\u3002\u5728\u7ebf\u6027\u52a8\u529b\u5b66\u8303\u56f4\uff08\u5373\u5e95\u7269\u6d53\u5ea6\u8fdc\u4f4e\u4e8e\u7c73\u6c0f\u5e38\u6570&nbsp;K<sub>m<\/sub>\u65f6\uff09\uff0cCL<sub>int<\/sub>&nbsp;\u53ef\u8868\u793a\u4e3a\u9176\u52a8\u529b\u5b66\u53c2\u6570\u7684\u6bd4\u503c\uff1a<img loading=\"lazy\" decoding=\"async\" width=\"80\" height=\"37\" src=\"blob:https:\/\/www.millibuff.com\/d851ca13-4a12-4e67-a766-3a1e2a480c78\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5176\u4e2d\uff0cV<sub>max<\/sub>\u8868\u793a\u6700\u5927\u53cd\u5e94\u901f\u7387\uff0c\u4e0e\u9176\u7684\u8868\u8fbe\u603b\u91cf\u6b63\u76f8\u5173\uff0c&nbsp;K<sub>m<\/sub>\u4e3a\u7c73\u6c0f\u5e38\u6570\uff0c\u53cd\u6620\u9176\u4e0e\u5e95\u7269\u7684\u4eb2\u548c\u529b\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5f53\u53d1\u751f\u4ee3\u8c22\u6027\u76f8\u4e92\u4f5c\u7528\u65f6\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u9176\u6291\u5236\u5242\u901a\u8fc7\u5360\u636e\u6216\u7834\u574f\u9176\u6d3b\u6027\u4f4d\u70b9\u6765\u964d\u4f4e\u50ac\u5316\u6548\u7387\uff1a\u7ade\u4e89\u6027\u6291\u5236\u5242\u4e3b\u8981\u5347\u9ad8\u8868\u89c2K<sub>m<\/sub>\uff08\u4eb2\u548c\u529b\u4e0b\u964d\uff09\uff0c\u800c\u975e\u7ade\u4e89\u6027\u6216\u4e0d\u53ef\u9006\u6291\u5236\u5242\u5219\u4e3b\u8981\u964d\u4f4e\u8868\u89c2V<sub>max<\/sub>\uff08\u6709\u6548\u9176\u91cf\u51cf\u5c11\uff09\uff0c\u6700\u7ec8\u5747\u5bfc\u81f4CL<sub>int<\/sub>\u4e0b\u964d\uff1b<\/li>\n\n\n\n<li>\u9176\u8bf1\u5bfc\u5242\u901a\u8fc7\u4e0a\u8c03\u9176\u86cb\u767d\u7684\u8868\u8fbe\uff0c\u76f4\u63a5\u589e\u52a0V<sub>max<\/sub>\uff0c\u5bfc\u81f4CL<sub>int<\/sub>\u5347\u9ad8\u3002<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u53ef\u4ee5\u8bf4\uff0c\u6240\u6709\u4ee3\u8c22\u9176\u4ecb\u5bfc\u7684 DDI\uff0c\u5728\u673a\u5236\u4e0a\u6700\u7ec8\u90fd\u843d\u811a\u4e8e\u5bf9&nbsp;CL<sub>int<\/sub>\u7684\u6539\u5199\u3002\u4f46\u9700\u7279\u522b\u8b66\u60d5\uff1aCL<sub>int<\/sub>\u7684\u6539\u53d8\u80fd\u5426\u7275\u52a8\u5168\u8eab\u6e05\u9664\u7387\uff0c\u53d6\u51b3\u4e8e\u836f\u7269\u7684\u809d\u63d0\u53d6\u7387\uff08E\uff09\u3002\u5bf9\u4e8e\u4f4e\u63d0\u53d6\u7387\u836f\u7269\uff08E&lt;0.3\uff09\uff0cCL<sub>H<\/sub>\u968fCL<sub>int<\/sub>\u7ebf\u6027\u53d8\u5316\uff1b\u800c\u5bf9\u4e8e\u9ad8\u63d0\u53d6\u7387\u836f\u7269\uff08E&gt;0.7\uff09\uff0cCL<sub>H<\/sub>\u53d7\u8840\u6d41\u9650\u901f\u800c\u201c\u5cbf\u7136\u4e0d\u52a8\u201d\uff0c\u6b64\u65f6\u53e3\u670d\u66b4\u9732\u91cf\u7684\u5267\u53d8\u6e90\u4e8e\u9996\u8fc7\u751f\u7269\u5229\u7528\u5ea6\uff08F\uff09\u7684\u6ce2\u52a8\uff0c\u800c\u975eCL<sub>H<\/sub>\u672c\u8eab\u7684\u6539\u53d8\u3002\u56e0\u6b64\uff0c\u4f53\u5916\u6d4b\u5b9a\u7684&nbsp;CL<sub>int<\/sub>\u53d8\u5316\uff0c\u5fc5\u987b\u7ed3\u5408\u6070\u5f53\u7684\u751f\u7406\u6a21\u578b\uff08\u5982\u5145\u5206\u6405\u62cc\u6a21\u578b\uff09\u5916\u63a8\uff0c\u65b9\u80fd\u7cbe\u51c6\u9884\u6d4b\u4f53\u5185 AUC \u7684\u6700\u7ec8\u8d70\u5411\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">4\u3001<strong>\u53e3\u670d\u9996\u8fc7\u6e05\u9664\uff1a\u80a0\u9053\u4ee3\u8c22\u7684\u7279\u6b8a\u6743\u91cd<\/strong><\/p>\n\n\n\n<ol class=\"wp-block-list\"><\/ol>\n\n\n\n<p class=\"wp-block-paragraph\">\u53e3\u670d\u836f\u7269\u5728\u8fdb\u5165\u4f53\u5faa\u73af\u524d\uff0c\u4f1a\u5148\u540e\u7ecf\u8fc7\u80a0\u9053\u58c1\u4ee3\u8c22\u548c\u809d\u810f\u4ee3\u8c22\uff0c\u5373\u9996\u8fc7\u6548\u5e94\uff0c\u5176\u4e2d\u80a0\u9053 CYP3A4 \u4ecb\u5bfc\u7684\u4ee3\u8c22\u662f\u8bb8\u591a\u53e3\u670d\u836f\u7269\u751f\u7269\u5229\u7528\u5ea6\u4f4e\u7684\u4e3b\u8981\u539f\u56e0\u3002\u80a0\u9053\u4ee3\u8c22\u6e05\u9664\u7684\u7279\u70b9\uff1a<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u2460. \u80a0\u8154\u836f\u7269\u6d53\u5ea6\u8fdc\u9ad8\u4e8e\u8840\u6d46\u6d53\u5ea6\uff0c\u80a0\u9053 CYP3A4 \u66f4\u5bb9\u6613\u88ab\u9971\u548c\u6216\u6291\u5236\uff1b<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u2461. \u80a0\u9053 P -\u7cd6\u86cb\u767d\u4e0e CYP3A4 \u534f\u540c\u4f5c\u7528\uff0c\u8fdb\u4e00\u6b65\u964d\u4f4e\u836f\u7269\u5438\u6536\uff1b<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u2462. \u8461\u8404\u67da\u6c41\u7b49\u80a0\u9053 CYP3A4 \u6291\u5236\u5242\u51e0\u4e4e\u4e0d\u5f71\u54cd\u809d\u810f\u9176\u6d3b\u6027\uff0c\u4f46\u53ef\u663e\u8457\u6291\u5236\u80a0\u9053\u9996\u8fc7\u4ee3\u8c22\uff0c\u4f7f\u53e3\u670d\u836f\u7269 AUC \u5347\u9ad8\u6570\u500d\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u8fd9\u4e5f\u89e3\u91ca\u4e86\u4e3a\u4ec0\u4e48\u540c\u6837\u662f CYP3A4 \u6291\u5236\u5242\uff0c\u6709\u4e9b\u5bf9\u53e3\u670d\u836f\u7269\u7684\u5f71\u54cd\u8fdc\u5927\u4e8e\u9759\u8109\u836f\u7269\u2014\u2014\u56e0\u4e3a\u5b83\u4eec\u540c\u65f6\u4f5c\u7528\u4e8e\u80a0\u9053\u548c\u809d\u810f\u4e24\u4e2a\u6e05\u9664\u4f4d\u70b9\u3002<\/p>\n\n\n\n<h5 class=\"wp-block-heading\">\u4e8c\u3001<strong>\u4ee3\u8c22\u9176\u8c31\u7cfb\u4e0e DDI \u98ce\u9669\u5206\u7ea7<\/strong><\/h5>\n\n\n\n<p class=\"wp-block-paragraph\">\u836f\u7269\u4ee3\u8c22\u9176\u5206\u4e3a \u2160 \u76f8\u4ee3\u8c22\u9176\u548c \u2161 \u76f8\u4ee3\u8c22\u9176\u4e24\u5927\u7c7b\uff0c\u5171\u540c\u5b8c\u6210\u836f\u7269\u7684\u751f\u7269\u8f6c\u5316\u3002\u5176\u4e2d \u2160 \u76f8\u7684 CYP \u9176\u7cfb\u662f DDI \u7684\u7edd\u5bf9\u6838\u5fc3\uff0c\u2161 \u76f8\u9176\u7684\u4e34\u5e8a\u610f\u4e49\u4e5f\u5728\u9010\u6b65\u88ab\u91cd\u89c6\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">1\u3001<strong>\u2160 \u76f8\u4ee3\u8c22\uff1aCYP \u9176\u7cfb\u7684\u7edd\u5bf9\u4e3b\u5bfc\u5730\u4f4d<\/strong><\/p>\n\n\n\n<ol class=\"wp-block-list\"><\/ol>\n\n\n\n<p class=\"wp-block-paragraph\">\u7ec6\u80de\u8272\u7d20 P450\uff08CYP\uff09\u8d85\u5bb6\u65cf\u53c2\u4e0e 90% \u4ee5\u4e0a\u4e34\u5e8a\u836f\u7269\u7684\u6c27\u5316\u4ee3\u8c22\uff0c\u4eba\u7c7b\u57fa\u56e0\u7ec4\u5171\u7f16\u7801\u81f3\u5c11 57 \u79cd\u6709\u529f\u80fd\u7684 CYP\uff0c\u5206\u5c5e 18 \u4e2a\u5bb6\u65cf 43 \u4e2a\u4e9a\u5bb6\u65cf\uff0c\u5176\u4e2dCYP1\u3001CYP2\u3001CYP3 \u5bb6\u65cf\u8d1f\u8d23\u7ea6 80% \u4e34\u5e8a\u836f\u7269\u7684\u4ee3\u8c22\uff0c\u662f\u836f\u7269\u76f8\u4e92\u4f5c\u7528\u3001\u4e2a\u4f53\u5dee\u5f02\u7684\u6838\u5fc3\u9776\u70b9\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">2\u3001<strong>\u6838\u5fc3 CYP \u4e9a\u578b\u7684 DDI \u98ce\u9669\u8c31<\/strong><\/p>\n\n\n\n<ol class=\"wp-block-list\"><\/ol>\n\n\n\n<p class=\"wp-block-paragraph\">7 \u79cd\u6838\u5fc3 CYP \u4e9a\u578b\u627f\u62c5\u4e86\u7edd\u5927\u591a\u6570\u836f\u7269\u4ee3\u8c22\u4efb\u52a1\uff0c\u5176\u5e95\u7269\u7279\u5f81\u3001\u591a\u6001\u6027\u548c DDI \u98ce\u9669\u5dee\u5f02\u663e\u8457\uff1a<\/p>\n\n\n\n<div class=\"wp-block-group is-layout-constrained wp-block-group-is-layout-constrained\">\n<p class=\"has-text-align-left wp-block-paragraph\"><img loading=\"lazy\" decoding=\"async\" width=\"553\" height=\"252\" src=\"blob:https:\/\/www.millibuff.com\/f1bff39b-150d-4db1-9913-7b11775a1481\"><\/p>\n<\/div>\n\n\n\n<ul class=\"wp-block-list\">\n<li>CYP3A4\/5\uff1a\u6700\u91cd\u8981\u7684 DDI \u9776\u70b9\uff0c\u4e0d\u4ec5\u5e95\u7269\u591a\uff0c\u4e14\u591a\u6570\u5e95\u7269\u5c5e\u4e8e\u4ee3\u8c22\u9650\u5236\u6027\u6e05\u9664\uff0c\u540c\u65f6\u5b58\u5728\u80a0\u9053\u9996\u8fc7\u4ee3\u8c22\u548c\u673a\u5236\u6027\u6291\u5236\u98ce\u9669\uff0c\u5f3a\u6291\u5236\u5242\u53ef\u4f7f\u5e95\u7269 AUC \u5347\u9ad8 5~20 \u500d\u3002<\/li>\n\n\n\n<li>CYP2D6\uff1a\u4e2a\u4f53\u5dee\u5f02\u4e3b\u8981\u6765\u81ea\u57fa\u56e0\u591a\u6001\u6027\uff0c\u6162\u4ee3\u8c22\u578b\u60a3\u8005\u672c\u8eab\u9176\u6d3b\u6027\u6781\u4f4e\uff0c\u6291\u5236\u5242\u51e0\u4e4e\u65e0\u989d\u5916\u4f5c\u7528\uff1b\u8d85\u5feb\u4ee3\u8c22\u578b\u5219\u5bf9\u6291\u5236\u5242\u66f4\u654f\u611f\u3002<\/li>\n\n\n\n<li>CYP2C9\uff1a\u5e95\u7269\u4e2d\u534e\u6cd5\u6797\u7b49\u6cbb\u7597\u7a97\u6781\u7a84\uff0c\u5373\u4f7f\u5f31\u76f8\u4e92\u4f5c\u7528\u4e5f\u53ef\u80fd\u5bfc\u81f4\u4e25\u91cd\u4e0d\u826f\u53cd\u5e94\uff0c\u662f\u4e34\u5e8a\u98ce\u9669\u7ba1\u63a7\u7684\u91cd\u70b9\u3002<\/li>\n\n\n\n<li>CYP2C19\uff1a\u4e1c\u4e9a\u4eba\u7fa4\u6162\u4ee3\u8c22\u578b\u6bd4\u4f8b\uff0815%~20%\uff09\u663e\u8457\u9ad8\u4e8e\u9ad8\u52a0\u7d22\u4eba\u7fa4\uff083%~5%\uff09\uff0c\u662f\u4e2d\u56fd\u4eba\u7fa4 DDI \u8bc4\u4f30\u9700\u7279\u522b\u5173\u6ce8\u7684\u4e9a\u578b\u3002<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u6b64\u5916\uff0c\u9ec4\u7d20\u5355\u52a0\u6c27\u9176\uff08FMO\uff09\u3001\u7fa7\u9178\u916f\u9176\uff08CES\uff09\u7b49\u975e CYP\u2160 \u76f8\u9176\u4ecb\u5bfc\u7684\u836f\u7269\u4ee3\u8c22\u5360\u6bd4\u8f83\u4f4e\uff0c\u901a\u5e38\u4e0d\u4f1a\u4ea7\u751f\u4e34\u5e8a\u663e\u8457\u7684 DDI\uff0c\u4f46\u90e8\u5206\u524d\u836f\uff08\u5982\u4f0a\u7acb\u66ff\u5eb7\u3001\u6c2f\u5421\u683c\u96f7\uff09\u7684\u6d3b\u5316\u4f9d\u8d56 CES\uff0c\u5176\u6291\u5236\u53ef\u80fd\u5f71\u54cd\u836f\u6548\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">3\u3001<strong>\u2161 \u76f8\u4ee3\u8c22\uff1a\u4ece \u201c\u6b21\u8981\u901a\u8def\u201d \u5230\u4e34\u5e8a\u4e0d\u53ef\u5ffd\u89c6<\/strong><\/p>\n\n\n\n<ol class=\"wp-block-list\"><\/ol>\n\n\n\n<p class=\"wp-block-paragraph\">\u4f20\u7edf\u89c2\u70b9\u8ba4\u4e3a \u2161 \u76f8\u7ed3\u5408\u53cd\u5e94\u4ee3\u8c22\u80fd\u529b\u5f3a\u3001\u4e0d\u6613\u9971\u548c\uff0cDDI \u98ce\u9669\u4f4e\uff0c\u4f46\u8fd1\u5e74\u7814\u7a76\u8bc1\u5b9e\u90e8\u5206\u4e9a\u578b\u4ecb\u5bfc\u7684\u76f8\u4e92\u4f5c\u7528\u53ef\u4ea7\u751f\u663e\u8457\u4e34\u5e8a\u540e\u679c\uff0c\u5176\u4e2d UDP -\u8461\u8404\u7cd6\u919b\u9178\u8f6c\u79fb\u9176\uff08UGT\uff09\u6700\u4e3a\u91cd\u8981\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>UGT1A1\uff1a\u4ee3\u8c22\u4f0a\u7acb\u66ff\u5eb7\u6d3b\u6027\u4ea7\u7269 SN-38\u3001\u80c6\u7ea2\u7d20\u3001\u4f9d\u6298\u9ea6\u5e03\u3002\u963f\u624e\u90a3\u97e6\u3001\u5409\u975e\u66ff\u5c3c\u7b49\u5f3a\u6291\u5236\u5242\u53ef\u4f7f SN-38 \u7684 AUC \u5347\u9ad8\u7ea6 2 \u500d\uff0c\u663e\u8457\u589e\u52a0\u8179\u6cfb\u548c\u9aa8\u9ad3\u6291\u5236\u98ce\u9669\u3002<\/li>\n\n\n\n<li>UGT2B7\uff1a\u4ee3\u8c22\u5417\u5561\u3001\u9f50\u591a\u592b\u5b9a\u3001\u5361\u9a6c\u897f\u5e73\u3002\u4e19\u78fa\u8212\u53ef\u6291\u5236 UGT2B7\uff0c\u4f7f\u5417\u5561\u9547\u75db\u4f5c\u7528\u589e\u5f3a\u5e76\u5ef6\u957f\u3002<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u5176\u4ed6 \u2161 \u76f8\u9176\u5982\u78fa\u57fa\u8f6c\u79fb\u9176\uff08SULT\uff09\u3001\u8c37\u80f1\u7518\u80bd S &#8211; \u8f6c\u79fb\u9176\uff08GST\uff09\u7b49\u4ecb\u5bfc\u7684 DDI \u62a5\u9053\u8f83\u5c11\uff0c\u4e34\u5e8a\u98ce\u9669\u603b\u4f53\u8f83\u4f4e\u3002<\/p>\n\n\n\n<h5 class=\"wp-block-heading\">\u4e09\u3001<strong>\u4ee3\u8c22\u9176 DDI \u7684\u6838\u5fc3\u4f5c\u7528\u673a\u5236<\/strong><\/h5>\n\n\n\n<p class=\"wp-block-paragraph\">\u4ee3\u8c22\u9176\u4ecb\u5bfc\u7684 DDI \u5206\u4e3a\u6291\u5236\u4f5c\u7528\u548c\u8bf1\u5bfc\u4f5c\u7528\u4e24\u5927\u7c7b\uff0c\u524d\u8005\u964d\u4f4e\u5185\u5728\u6e05\u9664\u7387\u3001\u5347\u9ad8\u836f\u7269\u66b4\u9732\uff0c\u540e\u8005\u5347\u9ad8\u5185\u5728\u6e05\u9664\u7387\u3001\u964d\u4f4e\u836f\u7269\u66b4\u9732\u3002\u4e24\u7c7b\u4f5c\u7528\u7684\u5206\u5b50\u673a\u5236\u3001\u52a8\u529b\u5b66\u7279\u5f81\u548c\u4e34\u5e8a\u98ce\u9669\u5dee\u5f02\u6781\u5927\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">1\u3001<strong>\u9176\u6291\u5236\u4f5c\u7528\uff1a\u964d\u4f4e\u6e05\u9664\u7387\u7684\u4e3b\u8981\u8def\u5f84<\/strong><\/p>\n\n\n\n<ol class=\"wp-block-list\"><\/ol>\n\n\n\n<p class=\"wp-block-paragraph\">\u6291\u5236\u5242\u901a\u8fc7\u964d\u4f4e\u9176\u7684\u50ac\u5316\u6d3b\u6027\u4f7fCL<sub>int<\/sub>\u4e0b\u964d\uff0c\u6839\u636e\u7ed3\u5408\u65b9\u5f0f\u5206\u4e3a\u53ef\u9006\u6027\u6291\u5236\u4e0e\u4e0d\u53ef\u9006\u6027\u6291\u5236\u4e24\u7c7b\u3002<\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li>1<strong>\u53ef\u9006\u6027\u6291\u5236<\/strong><\/li>\n<\/ol>\n\n\n\n<p class=\"wp-block-paragraph\">\u6291\u5236\u5242\u4e0e\u9176\u901a\u8fc7\u6c22\u952e\u3001\u758f\u6c34\u952e\u7b49\u975e\u5171\u4ef7\u952e\u7ed3\u5408\uff0c\u7ed3\u5408\u8fc7\u7a0b\u53ef\u9006\uff0c\u6291\u5236\u7a0b\u5ea6\u53d6\u51b3\u4e8e\u6291\u5236\u5242\u6d53\u5ea6\u4e0e\u4eb2\u548c\u529b\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u7ade\u4e89\u6027\u6291\u5236\uff1a\u6700\u5e38\u89c1\u7c7b\u578b\uff0c\u6291\u5236\u5242\u4e0e\u5e95\u7269\u7ade\u4e89\u9176\u7684\u6d3b\u6027\u4f4d\u70b9\uff0c\u8868\u89c2K<sub>m<\/sub>\u5347\u9ad8\uff0cV<sub>max<\/sub>\u4e0d\u53d8\u3002\u589e\u52a0\u5e95\u7269\u6d53\u5ea6\u53ef\u90e8\u5206\u9006\u8f6c\u6291\u5236\uff0c\u5982\u6c1f\u5eb7\u5511\u7ade\u4e89\u6027\u6291\u5236 CYP2C9\u3002<\/li>\n\n\n\n<li>\u975e\u7ade\u4e89\u6027\u6291\u5236\uff1a\u6291\u5236\u5242\u7ed3\u5408\u9176\u7684\u522b\u6784\u4f4d\u70b9\uff0c\u4e0d\u5f71\u54cd\u5e95\u7269\u7ed3\u5408\u4f46\u964d\u4f4e\u50ac\u5316\u6548\u7387\uff0cV<sub>max<\/sub>\u4e0b\u964d\uff0cK<sub>m<\/sub>\u4e0d\u53d8\u3002\u6291\u5236\u7a0b\u5ea6\u4ec5\u4e0e\u6291\u5236\u5242\u6d53\u5ea6\u6709\u5173\uff0c\u589e\u52a0\u5e95\u7269\u65e0\u6cd5\u9006\u8f6c\u3002<\/li>\n\n\n\n<li>\u53cd\u7ade\u4e89\u6027\u6291\u5236\uff1a\u6291\u5236\u5242\u4ec5\u4e0e\u9176-\u5e95\u7269\u590d\u5408\u7269\u7ed3\u5408\uff0c\u4e34\u5e8a\u5c11\u89c1\u3002<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u5bf9\u4e8e\u4ee3\u8c22\u9650\u5236\u6027\u836f\u7269\uff0c\u5728\u7ebf\u6027\u52a8\u529b\u5b66\u8303\u56f4\u5185\uff0c\u82e5\u67d0\u4ee3\u8c22\u901a\u8def\u7684\u4ee3\u8c22\u5206\u6570\u4e3a<em>f<\/em><sub><em>m<\/em><\/sub>\uff0c\u5b8c\u5168\u6291\u5236\u8be5\u901a\u8def\u540e\uff0c\u5185\u5728\u6e05\u9664\u7387\u53d8\u4e3a\u539f\u6765\u76841-<em>f<\/em><sub><em>m<\/em><\/sub>\uff0cAUC \u53d8\u4e3a\u539f\u6765\u7684<img loading=\"lazy\" decoding=\"async\" width=\"30\" height=\"38\" src=\"blob:https:\/\/www.millibuff.com\/9e6befc8-c46f-47cf-987b-5d7ee08b457d\">\u3002\u4f8b\u5982\u67d0\u836f\u7269 CYP3A4 \u4ee3\u8c22\u5206\u6570<em>f<\/em><sub><em>m<\/em><\/sub>&nbsp;=&nbsp;0.8\uff0c\u5b8c\u5168\u6291\u5236\u540e AUC \u5347\u9ad8\u81f3\u539f\u6765\u7684 5 \u500d\u3002<\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li>2<strong>\u4e0d\u53ef\u9006\u6027\u6291\u5236\uff08\u673a\u5236\u6027\u6291\u5236\/ MBI\uff09\uff1a\u88ab\u4f4e\u4f30\u7684\u4e34\u5e8a\u9ad8\u98ce\u9669<\/strong><\/li>\n<\/ol>\n\n\n\n<p class=\"wp-block-paragraph\">\u6291\u5236\u5242\u672c\u8eab\u662f\u9176\u7684\u5e95\u7269\uff0c\u5728\u88ab\u50ac\u5316\u4ee3\u8c22\u7684\u8fc7\u7a0b\u4e2d\u4ea7\u751f\u6d3b\u6027\u4e2d\u95f4\u4f53\uff0c\u4e0e\u9176\u6d3b\u6027\u4f4d\u70b9\u5f62\u6210\u5171\u4ef7\u952e\uff0c\u5bfc\u81f4\u9176\u6c38\u4e45\u5931\u6d3b\u3002\u9176\u6d3b\u6027\u7684\u6062\u590d\u5fc5\u987b\u4f9d\u8d56\u65b0\u86cb\u767d\u7684\u5408\u6210\uff0c\u56e0\u6b64\u6291\u5236\u4f5c\u7528\u6781\u5176\u6301\u4e45\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5176\u5bf9\u6e05\u9664\u7387\u7684\u5f71\u54cd\u7279\u70b9\uff1a<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\uff081\uff09\u65f6\u95f4\u4f9d\u8d56\u6027\uff1a\u6291\u5236\u4f5c\u7528\u968f\u7ed9\u836f\u65f6\u95f4\u9010\u6e10\u589e\u5f3a\uff0c\u591a\u6b21\u7ed9\u836f\u8fbe\u7a33\u6001\u540e\u624d\u51fa\u73b0\u6700\u5927\u6291\u5236\uff0c\u5355\u6b21\u7ed9\u836f\u5f80\u5f80\u4e25\u91cd\u4f4e\u4f30\u98ce\u9669\uff1b<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\uff082\uff09\u6062\u590d\u6781\u6162\uff1a\u505c\u836f\u540e\u9176\u6d3b\u6027\u6062\u590d\u53d6\u51b3\u4e8e\u9176\u7684\u534a\u8870\u671f\uff08CYP3A4 \u7ea6 24~36\u00a0h\uff0cCYP2C9 \u7ea6 104\u00a0h\uff09\uff0c\u6e05\u9664\u7387\u6062\u590d\u6ede\u540e\u4e8e\u6291\u5236\u5242\u6e05\u9664\uff1b<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\uff083\uff09\u6291\u5236\u5f3a\u5ea6\u5927\uff1a\u5bf9\u9176\u7684\u706d\u6d3b\u662f\u4e0d\u53ef\u9006\u7684\uff0c\u5373\u4f7f\u8840\u4e2d\u6291\u5236\u5242\u6d53\u5ea6\u5f88\u4f4e\uff0c\u5df2\u7ed3\u5408\u7684\u9176\u4ecd\u5904\u4e8e\u5931\u6d3b\u72b6\u6001\u3002<\/p>\n\n\n\n<ol class=\"wp-block-list\"><\/ol>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>2 \u3001\u9176\u8bf1\u5bfc\u4f5c\u7528\uff1a\u5347\u9ad8\u6e05\u9664\u7387\u7684\u9690\u533f\u98ce\u9669<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u8bf1\u5bfc\u5242\u901a\u8fc7\u6fc0\u6d3b\u6838\u53d7\u4f53\uff0c\u4fc3\u8fdb\u9176\u7684\u57fa\u56e0\u8f6c\u5f55\u548c\u86cb\u767d\u5408\u6210\uff0c\u4ece\u603b\u91cf\u4e0a\u589e\u52a0\u9176\u7684\u8868\u8fbe\uff0c\u4f7fCL<sub>int<\/sub>\u5347\u9ad8\u3002<\/p>\n\n\n\n<h6 class=\"wp-block-heading\">\u6838\u53d7\u4f53\u4ecb\u5bfc\u7684\u8bf1\u5bfc\u901a\u8def\uff1a<\/h6>\n\n\n\n<ul class=\"wp-block-list\">\n<li>PXR\uff08\u5b55\u70f7 X \u53d7\u4f53\uff09\uff1a\u6700\u4e3b\u8981\u7684\u8bf1\u5bfc\u901a\u8def\uff0c\u4ecb\u5bfc CYP3A4\u3001CYP2C9\u3001CYP2C19 \u7684\u8f6c\u5f55\u4e0a\u8c03\uff0c\u5229\u798f\u5e73\u662f\u5176\u5f3a\u6fc0\u52a8\u5242\uff1b<\/li>\n\n\n\n<li>CAR\uff08\u7ec4\u6210\u578b\u96c4\u70f7\u53d7\u4f53\uff09\uff1a\u4e3b\u8981\u4ecb\u5bfcCYP2B6\u3001 CYP2C9\u3001CYP3A4 \u53ca\u90e8\u5206 UGT \u7684\u8bf1\u5bfc\uff0c\u4e0e PXR \u5b58\u5728\u4ea4\u53c9\u8c03\u63a7\uff1b<\/li>\n\n\n\n<li>AhR\uff08\u82b3\u9999\u70c3\u53d7\u4f53\uff09\uff1a\u4ecb\u5bfc CYP1A1\/2 \u7684\u8bf1\u5bfc\uff0c\u5438\u70df\u4ea7\u751f\u7684\u591a\u73af\u82b3\u70c3\u662f\u5176\u5929\u7136\u914d\u4f53\u3002<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u5176\u5bf9\u6e05\u9664\u7387\u7684\u5f71\u54cd\u7279\u70b9\uff1a<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\uff081\uff09\u8d77\u6548\u6162\uff1a\u9176\u7684\u5408\u6210\u4e0e\u6210\u719f\u9700\u8981\u65f6\u95f4\uff0c\u901a\u5e38\u7ed9\u836f\u00a03~7 \u5929\u540e\u6e05\u9664\u7387\u5f00\u59cb\u5347\u9ad8\uff0c2~4 \u5468\u8fbe\u5230\u7a33\u6001\uff1b<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\uff082\uff09\u6d88\u9000\u6162\uff1a\u505c\u836f\u540e\u9176\u86cb\u767d\u9010\u6e10\u964d\u89e3\uff0c\u6e05\u9664\u7387\u6062\u590d\u81f3\u57fa\u7ebf\u9700 1~2 \u5468\u751a\u81f3\u66f4\u4e45\uff1b<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\uff083\uff09\u5929\u82b1\u677f\u6548\u5e94\uff1a\u9176\u7684\u5408\u6210\u80fd\u529b\u6709\u4e0a\u9650\uff0c\u5b58\u5728\u6700\u5927\u8bf1\u5bfc\u6548\u5e94\uff0c\u5242\u91cf\u8d85\u8fc7\u9608\u503c\u540e\u8bf1\u5bfc\u6548\u5e94\u4e0d\u518d\u589e\u5f3a\u3002<\/p>\n\n\n\n<ol class=\"wp-block-list\"><\/ol>\n\n\n\n<p class=\"wp-block-paragraph\">\u9176\u8bf1\u5bfc\u5bfc\u81f4\u7684\u6e05\u9664\u7387\u5347\u9ad8\u4f1a\u4f7f\u836f\u7269\u66b4\u9732\u91cf\u4e0b\u964d\uff0c\u5e38\u5bfc\u81f4\u6cbb\u7597\u5931\u8d25\u3002\u4f8b\u5982\u5229\u798f\u5e73\u53ef\u4f7f CYP3A4 \u5e95\u7269\u7684\u5185\u5728\u6e05\u9664\u7387\u5347\u9ad8 2~5 \u500d\uff0cAUC \u964d\u4f4e 50%~80%\uff0c\u6d89\u53ca\u6297\u771f\u83cc\u836f\u3001\u9776\u5411\u836f\u3001\u907f\u5b55\u836f\u3001\u6297\u51dd\u836f\u7b49\u591a\u4e2a\u6cbb\u7597\u9886\u57df\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>3<\/strong><strong> \u3001\u51b3\u5b9a\u76f8\u4e92\u4f5c\u7528\u5f3a\u5ea6\u7684<\/strong><strong>\u76f8\u5173<\/strong><strong>\u5b9a\u91cf\u5173\u952e\u56e0\u7d20<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4ee3\u8c22\u9176 DDI \u5e76\u975e\u201c\u6709\u6216\u65e0\u201d\u7684\u5b9a\u6027\u5173\u7cfb\uff0c\u5176\u5f3a\u5ea6\u7531\u591a\u4e2a\u5b9a\u91cf\u53c2\u6570\u5171\u540c\u51b3\u5b9a\uff1a<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\uff081\uff09\u5e95\u7269\u7684\u4ee3\u8c22\u5206\u6570\uff08<em>f<\/em><sub><em>m<\/em><\/sub>\uff09<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u6700\u6838\u5fc3\u53c2\u6570\uff0c\u6307\u67d0\u6761\u4ee3\u8c22\u901a\u8def\u6e05\u9664\u7684\u836f\u7269\u5360\u603b\u6e05\u9664\u7684\u6bd4\u4f8b\u3002<em>f<\/em><sub><em>m<\/em><\/sub>\u8d8a\u9ad8\uff0c\u6291\u5236\u8be5\u901a\u8def\u540e\u7684\u6e05\u9664\u7387\u53d8\u5316\u8d8a\u5927\u3002ICH M12 \u6307\u5357\u660e\u786e\u5c06<em>f<\/em><sub><em>m<\/em><\/sub> \u2265 25%\u4f5c\u4e3a\u89e6\u53d1\u8fdb\u4e00\u6b65\u4e34\u5e8aDDI\u7814\u7a76\u7684\u9608\u503c\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\uff082\uff09\u6291\u5236\u5242\u7684\u66b4\u9732\u91cf\u4e0e\u4eb2\u548c\u529b\uff08[I]\/K<sub>i<\/sub>\u6bd4\u503c\uff09<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u6291\u5236\u5242\u5728\u4f5c\u7528\u90e8\u4f4d\u7684\u6d53\u5ea6&nbsp;[I]&nbsp;\u4e0e\u89e3\u79bb\u5e38\u6570 K<sub>i <\/sub>\u7684\u6bd4\u503c\uff0c\u76f4\u63a5\u51b3\u5b9a\u9176\u6d3b\u6027\u7684\u6291\u5236\u7a0b\u5ea6\u3002\u8bc4\u4f30\u809d\u810f\u4ee3\u8c22\u65f6\u901a\u5e38\u91c7\u7528\u8840\u6d46\u6e38\u79bb\u836f\u7269\u6d53\u5ea6\uff1b\u8bc4\u4f30\u80a0\u9053\u4ee3\u8c22\u65f6\u91c7\u7528\u80a0\u8154\u836f\u7269\u6d53\u5ea6\uff0c\u5176\u6570\u503c\u8fdc\u9ad8\u4e8e\u8840\u6d46\u6d53\u5ea6\uff0c\u56e0\u6b64\u80a0\u9053 CYP3A4 \u6291\u5236\u5f80\u5f80\u6bd4\u809d\u810f\u6291\u5236\u66f4\u663e\u8457\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\uff083\uff09 \u57fa\u56e0\u591a\u6001\u6027<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5bf9\u4e8e CYP2D6\u3001CYP2C19 \u7b49\u591a\u6001\u6027\u9176\uff0c\u57fa\u7840\u9176\u6d3b\u6027\u7684\u4e2a\u4f53\u5dee\u5f02\u751a\u81f3\u53ef\u80fd\u5927\u4e8e\u6291\u5236\u5242\u7684\u5f71\u54cd\u3002\u6162\u4ee3\u8c22\u578b\u60a3\u8005\u672c\u8eab\u9176\u6d3b\u6027\u6781\u4f4e\uff0c\u6291\u5236\u5242\u53ef\u8fdb\u4e00\u6b65\u964d\u4f4e\u7684\u7a7a\u95f4\u6709\u9650\uff1b\u8d85\u5feb\u4ee3\u8c22\u578b\u60a3\u8005\u57fa\u7840\u9176\u6d3b\u6027\u9ad8\uff0c\u6291\u5236\u5242\u7684\u7edd\u5bf9\u6291\u5236\u6548\u679c\u53ef\u80fd\u66f4\u663e\u8457\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\uff084\uff09\u80a0\u9053\u4e0e\u809d\u810f\u4ee3\u8c22\u7684\u76f8\u5bf9\u8d21\u732e<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u80a0\u9053\u4ee3\u8c22\u5360\u6bd4\u9ad8\u7684\u836f\u7269\uff08\u5982\u8f9b\u4f10\u4ed6\u6c40\u3001\u6d1b\u4f10\u4ed6\u6c40\uff09\uff0c\u80a0\u9053 CYP3A4 \u6291\u5236\u5242\u53ef\u4f7f AUC \u4ea7\u751f\u6570\u500d\u7684\u663e\u8457\u5347\u9ad8\uff1b\u809d\u810f\u4ee3\u8c22\u5360\u6bd4\u9ad8\u7684\u836f\u7269\uff0c\u5219\u53d7\u5168\u8eab\u5faa\u73af\u7684\u6291\u5236\u5242\u5f71\u54cd\u66f4\u663e\u8457\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>4<\/strong><strong> \u3001\u4ee3\u8c22\u9176 DDI \u7684\u9636\u68af\u5f0f\u8bc4\u4f30\u6846\u67b6<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4ee3\u8c22\u9176 DDI \u8bc4\u4f30\u9075\u5faa \u201c\u4f53\u5916\u7b5b\u9009\u2192\u98ce\u9669\u5206\u5c42\u2192\u4f53\u5185\u9a8c\u8bc1 \/ \u5efa\u6a21\u9884\u6d4b\u201d \u7684\u9636\u68af\u5f0f\u8def\u5f84\uff0c\u8fd9\u4e5f\u662f ICH M12 \u6307\u5357\u786e\u7acb\u7684\u5168\u7403\u7edf\u4e00\u7814\u7a76\u903b\u8f91\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\uff081\uff09\u6574\u4f53\u903b\u8f91\uff1a\u4ece\u4f53\u5916\u7b5b\u9009\u5230\u98ce\u9669\u5206\u5c42<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Step 1\uff1a\u4f53\u5916\u9ad8\u901a\u91cf\u7b5b\u9009<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5728\u65b0\u836f\u7814\u53d1\u65e9\u671f\uff0c\u91c7\u7528\u91cd\u7ec4\u9176\u3001\u4eba\u809d\u5fae\u7c92\u4f53\u7b49\u4f53\u7cfb\uff0c\u5feb\u901f\u8bc4\u4f30\u836f\u7269\u5bf9 7 \u79cd\u6838\u5fc3 CYP \u9176\u7684\u5e95\u7269\u3001\u6291\u5236\u3001\u8bf1\u5bfc\u6f5c\u80fd\uff0c\u8bc6\u522b\u6f5c\u5728\u9776\u70b9\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Step 2\uff1a\u98ce\u9669\u5206\u5c42\u51b3\u7b56<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u57fa\u4e8e\u4f53\u5916\u83b7\u5f97\u7684<em>f<\/em><sub><em>m<\/em><\/sub>\u3001[I]\/<em>K<\/em><sub><em>i<\/em><\/sub>\u7b49\u53c2\u6570\uff0c\u7ed3\u5408\u51b3\u7b56\u6811\u8fdb\u884c\u98ce\u9669\u5206\u5c42\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u4f4e\u98ce\u9669\uff1a\u76f4\u63a5\u8c41\u514d\u4f53\u5185\u7814\u7a76\uff1b<\/li>\n\n\n\n<li>\u4e2d\u98ce\u9669\uff1a\u53ef\u91c7\u7528 PBPK \u5efa\u6a21\u9884\u6d4b\uff1b<\/li>\n\n\n\n<li>\u9ad8\u98ce\u9669\uff1a\u9700\u5f00\u5c55\u4e34\u5e8a DDI \u7814\u7a76\u9a8c\u8bc1\u3002<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Step 3\uff1a\u4f53\u5185\u786e\u8bc1\u6216\u5efa\u6a21\u652f\u6301<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u9ad8\u98ce\u9669\u5316\u5408\u7269\u901a\u8fc7\u4e34\u5e8a\u4ea4\u53c9\u8bd5\u9a8c\u9a8c\u8bc1 DDI \u5e45\u5ea6\uff1b\u90e8\u5206\u573a\u666f\u53ef\u91c7\u7528\u7ecf\u8fc7\u9a8c\u8bc1\u7684 PBPK \u6a21\u578b\u66ff\u4ee3\u4e34\u5e8a\u7814\u7a76\uff0c\u652f\u6301\u8bf4\u660e\u4e66\u64b0\u5199\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\uff082\uff09\u4f53\u5916\u7814\u7a76\u4f53\u7cfb\u4e0e\u6838\u5fc3\u5b9e\u9a8c<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5e38\u7528\u7684\u4f53\u5916\u7814\u7a76\u4f53\u7cfb\u5404\u6709\u4fa7\u91cd\uff0c\u5171\u540c\u6784\u6210 DDI \u8bc4\u4f30\u7684\u57fa\u7840\uff1a<\/p>\n\n\n\n<figure class=\"wp-block-image size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"535\" height=\"219\" src=\"https:\/\/www.millibuff.com\/wp-content\/uploads\/2026\/10\/image-14.png\" alt=\"\" class=\"wp-image-2244\" style=\"width:758px;height:auto\" srcset=\"https:\/\/www.millibuff.com\/wp-content\/uploads\/2026\/10\/image-14.png 535w, https:\/\/www.millibuff.com\/wp-content\/uploads\/2026\/10\/image-14-300x123.png 300w\" sizes=\"(max-width: 535px) 100vw, 535px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">\uff083\uff09\u4f53\u5916-\u4f53\u5185\u5916\u63a8\uff1a\u4ece\u9759\u6001\u4f30\u7b97\u5230\u52a8\u6001\u5efa\u6a21<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u9759\u6001\u9884\u6d4b\u6cd5<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u57fa\u4e8e[I]\/<em>K<\/em><sub><em>i<\/em><\/sub>\u548c<em>f<\/em><sub><em>m<\/em><\/sub>\uff0c\u901a\u8fc7\u516c\u5f0f\u76f4\u63a5\u8ba1\u7b97 AUC \u53d8\u5316\u500d\u6570\u3002\u4f18\u70b9\u662f\u7b80\u5355\u5feb\u901f\uff0c\u9002\u5408\u65e9\u671f\u9ad8\u901a\u91cf\u7b5b\u9009\uff1b\u7f3a\u70b9\u662f\u5ffd\u7565\u65f6\u95f4\u52a8\u529b\u5b66\u3001\u80a0\u9053\u4ee3\u8c22\u3001\u591a\u6001\u6027\u7b49\u56e0\u7d20\uff0c\u5bf9\u673a\u5236\u6027\u6291\u5236\u548c\u8bf1\u5bfc\u7684\u9884\u6d4b\u51c6\u786e\u6027\u5dee\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u751f\u7406\u836f\u4ee3\u52a8\u529b\u5b66\uff08PBPK\uff09\u5efa\u6a21<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u6574\u5408\u836f\u7269\u7406\u5316\u6027\u8d28\u3001\u4f53\u5916\u9176\u52a8\u529b\u5b66\u53c2\u6570\u3001\u4eba\u4f53\u751f\u7406\u53c2\u6570\uff0c\u6a21\u62df\u836f\u7269\u5728\u4f53\u5185\u7684 ADME \u5168\u8fc7\u7a0b\uff0c\u5b9a\u91cf\u9884\u6d4b\u4e0d\u540c\u8054\u7528\u65b9\u6848\u4e0b\u809d\u6e05\u9664\u7387\u548c AUC \u7684\u53d8\u5316\uff1a<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\uff083.1\uff09\u53ef\u7cbe\u51c6\u533a\u5206\u80a0\u9053\u4e0e\u809d\u810f\u4ee3\u8c22\u7684\u72ec\u7acb\u8d21\u732e\uff1b<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\uff083.2\uff09\u53ef\u8fd8\u539f\u673a\u5236\u6027\u6291\u5236\u548c\u9176\u8bf1\u5bfc\u7684\u65f6\u95f4\u52a8\u529b\u5b66\u7279\u5f81\uff1b<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\uff083.3\uff09\u53ef\u6a21\u62df\u4e0d\u540c\u57fa\u56e0\u578b\u3001\u4e0d\u540c\u809d\u80be\u529f\u80fd\u4eba\u7fa4\u7684 DDI \u98ce\u9669\u3002<\/p>\n\n\n\n<ol class=\"wp-block-list\"><\/ol>\n\n\n\n<h5 class=\"wp-block-heading\"><strong>\u603b\u7ed3<\/strong><\/h5>\n\n\n\n<p class=\"wp-block-paragraph\">\u4ee3\u8c22\u9176\u4ecb\u5bfc\u7684 DDI\uff0c\u5176\u672c\u8d28\u662f\u9176\u6d3b\u6027\u6539\u53d8\u901a\u8fc7\u5185\u5728\u6e05\u9664\u7387\uff08CL<sub>int<\/sub>\uff09\u4f20\u5bfc\u81f3\u809d\u810f\u6e05\u9664\u7387\uff08CL<sub>H<\/sub>\uff09\uff0c\u8fdb\u800c\u7275\u52a8\u5168\u8eab\u6e05\u9664\u7387\uff08CL\uff09\u4e0e\u8840\u836f\u66b4\u9732\u91cf\u53d8\u5316\u7684\u751f\u7406\u8fc7\u7a0b\u3002\u7406\u89e3CL<sub>int<\/sub>\u4e0eCL<sub>H<\/sub>\u7684\u201c\u751f\u7406\u5206\u79bb\u201d\u3001\u533a\u5206\u53ef\u9006\u4e0e\u4e0d\u53ef\u9006\u6291\u5236\u7684\u65f6\u7a0b\u5dee\u5f02\uff0c\u5e76\u59cb\u7ec8\u5c06\u809d\u63d0\u53d6\u7387\uff08E\uff09\u4e0e&nbsp;\u7ed9\u836f\u9014\u5f84\u7eb3\u5165\u98ce\u9669\u5224\u65ad\u6846\u67b6\uff0c\u662f\u7cbe\u51c6\u8bc4\u4f30 DDI \u7684\u6838\u5fc3\u652f\u70b9\u3002\u5398\u6e05\u8fd9\u4e09\u91cd\u903b\u8f91\uff0c\u4e34\u5e8a\u7528\u836f\u51b3\u7b56\u65b9\u80fd\u4ece\u201c\u88ab\u52a8\u5e94\u5bf9\u5df2\u77e5\u98ce\u9669\u201d\u8d70\u5411\u201c\u4e3b\u52a8\u9884\u5224\u8054\u5408\u7528\u836f\u7ed3\u5c40\u201d\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u53c2\u8003\u6587\u732e<\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li>Mingzhe Z,\u00a0Jingsong M,\u00a0Mo L, et al.\u00a0Cytochrome P450 Enzymes and Drug Metabolism in Humans[J].\u00a0International Journal of Molecular Sciences,\u00a02021,\u00a022(23):\u00a012808-12808.<\/li>\n\n\n\n<li>ICH M12 Guideline on drug interaction studies. 2024.<\/li>\n<\/ol>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u64b0\u6587\uff1a\u8042\u8339\u4f73<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5ba1\u6838\uff1a\u5bab\u96ea<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u5927\u591a\u6570\u7ecf\u4ee3\u8c22\u9176\u4ecb\u5bfc\u7684\u836f\u7269\u76f8\u4e92\u4f5c\u7528\uff0c\u6838\u5fc3\u673a\u5236\u662f\u8054\u7528\u836f\u7269\u6539\u53d8\u4ee3\u8c22\u9176\u6d3b\u6027\u6216\u5360\u636e\u7ed3\u5408\u4f4d\u70b9\uff0c\u8fdb\u800c\u6539\u53d8\u836f\u7269\u7684\u5185\u5728\u6e05\u9664\u7387\uff08CLint\uff09\u3002\u8fd9\u79cd\u53d8\u5316\u6700\u7ec8\u4f1a\u53cd\u6620\u5728\u8840\u836f\u6d53\u5ea6-\u65f6\u95f4\u66f2\u7ebf\u4e0b\u9762\u79ef\uff08AUC\uff09\u7684\u53d8\u5316\u4e0a\uff0c\u4f46\u5177\u4f53\u662f\u901a\u8fc7\u5f71\u54cd\u5168\u8eab\u6e05\u9664\u7387\uff08CL\uff09\u8fd8\u662f\u53e3\u670d\u751f\u7269\u5229\u7528\u5ea6\uff08F\uff09\uff0c\u53d6\u51b3\u4e8e\u836f\u7269\u7684\u809d\u810f\u63d0\u53d6\u7387\u53ca\u7ed9\u836f\u9014\u5f84\uff08\u9759\u8109\u8fd8\u662f\u53e3\u670d\uff09\u3002<br \/>\n\u672c\u6587\u5148\u7cfb\u7edf\u68b3\u7406\u6e05\u9664\u7387\u7684\u6838\u5fc3\u6982\u5ff5\u3001\u809d\u810f\u6e05\u9664\u6a21\u578b\u4e0e\u5185\u5728\u4ee3\u8c22\u6e05\u9664\u7684\u672c\u8d28\uff0c\u518d\u4ee5\u6b64\u4e3a\u57fa\u7840\u6df1\u5165\u89e3\u6790\u4ee3\u8c22\u9176\u4ecb\u5bfc\u7684\u836f\u7269\u76f8\u4e92\u4f5c\u7528\u673a\u5236\u4e0e\u8bc4\u4f30\u65b9\u6cd5\u3002<\/p>\n","protected":false},"author":1,"featured_media":2245,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[147],"tags":[35,86,15,32,34,29],"class_list":["post-2242","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-147","tag-35","tag-86","tag-15","tag-32","tag-34","tag-29"],"_links":{"self":[{"href":"https:\/\/www.millibuff.com\/index.php?rest_route=\/wp\/v2\/posts\/2242","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.millibuff.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.millibuff.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.millibuff.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.millibuff.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2242"}],"version-history":[{"count":3,"href":"https:\/\/www.millibuff.com\/index.php?rest_route=\/wp\/v2\/posts\/2242\/revisions"}],"predecessor-version":[{"id":2248,"href":"https:\/\/www.millibuff.com\/index.php?rest_route=\/wp\/v2\/posts\/2242\/revisions\/2248"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.millibuff.com\/index.php?rest_route=\/wp\/v2\/media\/2245"}],"wp:attachment":[{"href":"https:\/\/www.millibuff.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2242"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.millibuff.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2242"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.millibuff.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2242"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}