{"id":2265,"date":"2026-10-29T14:47:55","date_gmt":"2026-10-29T06:47:55","guid":{"rendered":"https:\/\/www.millibuff.com\/?p=2265"},"modified":"2026-10-29T15:05:33","modified_gmt":"2026-10-29T07:05:33","slug":"%e5%90%8c%e6%a0%b7%e5%8f%abiii%e6%9c%9f%e9%98%b3%e6%80%a7%ef%bc%8c%e5%90%ab%e9%87%91%e9%87%8f%e5%b7%ae%e5%9c%a8%e5%93%aa%ef%bc%9aesmo-2026%e7%bb%99%e4%b8%b4%e5%ba%8a%e5%bc%80","status":"publish","type":"post","link":"https:\/\/www.millibuff.com\/?p=2265","title":{"rendered":"\u5c0f\u725b\u6d1e\u5bdf | \u540c\u6837\u53eb\u201cIII\u671f\u9633\u6027\u201d\uff0c\u542b\u91d1\u91cf\u5dee\u5728\u54ea\uff1aESMO 2026\u7ed9\u4e34\u5e8a\u5f00\u53d1\u8005\u7684\u56db\u5802\u9a8c\u8bc1\u8bfe"},"content":{"rendered":"\n<h5 class=\"wp-block-heading\"><strong>\u7b2c\u4e00\u8bfe\uff1a\u5934\u5bf9\u5934\u8d62\u4e0b<\/strong><strong>\u201c<\/strong><strong>\u5168\u7403\u6700\u4f18\u6807\u51c6<\/strong><strong>\u201d<\/strong><strong>\uff0c<\/strong><strong>\u5168\u7403\u9a8c\u8bc1<\/strong><strong>\u88ab\u671f\u5f85<\/strong><\/h5>\n\n\n\n<p class=\"wp-block-paragraph\">\u5eb7\u65b9\u751f\u7269\u7684\u4f9d\u6c83\u897f\uff08PD-1\/VEGF\u53cc\u6297\uff09\u8054\u5408\u5316\u7597\uff0c\u5728\u665a\u671f\u80c6\u9053\u764c\u4e00\u7ebf\u5934\u5bf9\u5934\u51fb\u8d25\u5ea6\u4f10\u5229\u5c24\u5355\u6297\u8054\u5408\u5316\u7597\u2014\u2014\u540e\u8005\u662fTOPAZ-1\u786e\u7acb\u7684\u56fd\u9645\u4e00\u7ebf\u6807\u51c6&nbsp;[2]\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">HARMONi-GI1\u5165\u7ec4682\u4f8b\uff1aITT\u4eba\u7fa4\u4e2d\u4f4dOS 14.9 vs 12.1\u4e2a\u6708\uff0cHR 0.75\uff0895% CI 0.61\u20130.92\uff09\uff0cP=0.0031\uff0c\u6b7b\u4ea1\u98ce\u9669\u964d\u4f4e25%\uff1b\u4e2d\u4f4dPFS 8.4 vs 5.8\u4e2a\u6708\uff0cHR 0.61\uff0895% CI 0.51\u20130.72\uff09\uff1bORR 53.8% vs 32.5%\uff0cDCR 91.5% vs 77.8%\u300212\u4e2a\u6708OS\u738759.7% vs 50.7%\u300118\u4e2a\u670844.0% vs 32.5%\uff0c\u83b7\u76ca\u968f\u65f6\u95f4\u6269\u5927\uff1b\u4f9d\u6c83\u897f\u7ec4\u51fa\u7ec4\u540e\u63a5\u53d7\u540e\u7eed\u6297\u80bf\u7624\u6cbb\u7597\u7684\u6bd4\u4f8b31.8%\uff0c\u4f4e\u4e8e\u5bf9\u7167\u7ec4\u768445.9%\u2014\u2014\u5bf9\u7167\u7ec4\u7528\u4e86\u66f4\u591a\u540e\u7ebf\u6cbb\u7597\u4ecd\u8f93\u6389OS\uff0c\u53cd\u5411\u652f\u6301\u83b7\u76ca\u771f\u5b9e\u6027[2]\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u7136\u8fd9\u4e2a\u7ed3\u679c\u5f97\u8fde\u7740\u4ee5\u4e0b\u4fe1\u606f\u4e00\u8d77\u770b\uff0c\u907f\u514d\u8bfb\u504f\uff1a\u8fd9\u662fIDMC\u9884\u8bbe\u671f\u4e2d\u5206\u6790\uff0c\u4e2d\u4f4d\u968f\u8bbf\u4ec514.3\u4e2a\u6708\uff1b\u8fd9\u662f\u7eaf\u4e2d\u56fd\u7814\u7a76\uff0cESMO\u8ba8\u8bba\u8005\u660e\u786e\u201c\u5373\u4f7fKM\u66f2\u7ebf\u4e4b\u95f4\u80fd\u5f00\u8fdb\u4e09\u8f86\u5361\u8f66\uff0c\u5168\u7403\u9a8c\u8bc1\u4ecd\u5c06\u88ab\u671f\u5f85\u201d[3]\uff0c\u5168\u7403\u6ce8\u518c\u6027EA2251\u76f4\u523010\u670821\u65e5\u624d\u7531Summit\u4e0eECOG-ACRIN\u5ba3\u5e03\u542f\u52a8\uff1b\u5bf9\u7167\u81c2\u4e2d\u4f4dOS 12.1\u4e2a\u6708\u4f4e\u4e8eTOPAZ-1\u5f53\u5e74\u768412.8\u4e2a\u6708\uff0c\u8de8\u7814\u7a76\u53ef\u6bd4\u6027\u9700\u8c28\u614e[2]\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e34\u5e8a\u5f00\u53d1\u542b\u4e49\uff1a\u80c6\u9053\u764c\u662f\u201c\u51b7\u80bf\u7624\u201d\u4ee3\u8868\uff0cTOPAZ-1\u7684OS HR\u4ec50.80\uff08\u5ea6\u4f10\u5229\u5c24+\u5316\u759712.8 vs \u5316\u759711.5\u4e2a\u6708\uff09\u5c31\u662f\u6ce8\u811a\uff1b\u4f9d\u6c83\u897f\u4ee5\u6700\u4f18SOC\u4e3a\u5bf9\u7167\u53d6\u5f97OS\u9633\u6027\uff0c\u9a8c\u8bc1\u7684\u662fVEGF\u901a\u8def\u5bf9\u514d\u75ab\u6392\u65a5\u7684\u9006\u8f6c\u53ef\u8de8\u7624\u79cd\u8fc1\u79fb\u3002\u843d\u5230\u65b9\u6848\u4e0a\uff0c\u5c31\u662f\u4e09\u4ef6\u4e8b\uff1a\u5bf9\u7167\u5047\u8bbe\u987b\u951a\u5b9a\u5f53\u524d\u6700\u4f18\u6807\u51c6\uff0c\u5e76\u4e3a\u5bf9\u7167\u81c2\u8868\u73b0\u4f4e\u4e8e\u5386\u53f2\u6570\u636e\u9884\u7559\u654f\u611f\u6027\u5206\u6790\uff1b\u4e9a\u7ec4\u5206\u6790\u8981\u9884\u5148\u533a\u5206\u201c\u4e00\u81f4\u6027\u68c0\u9a8c\u201d\u4e0e\u201c\u83b7\u76ca\u4fee\u9970\u68c0\u9a8c\u201d\u4e24\u79cd\u76ee\u7684\u2014\u2014HARMONi-GI1\u62ab\u9732\u7684ECOG PS 1\u4e0e\u5e74\u9f84\u226565\u5c81\u4e9a\u7ec4\u5c5e\u4e8e\u524d\u8005\uff08\u65b9\u5411\u4e00\u81f4\u3001\u7f6e\u4fe1\u533a\u95f4\u5927\u5e45\u91cd\u53e0\uff09\uff0c\u4e0d\u6784\u6210\u83b7\u76ca\u4fee\u9970\u8bc1\u636e\uff1b\u540e\u8005\u9700\u8981\u9884\u8bbe\u4ea4\u4e92\u68c0\u9a8c\u5e76\u63a7\u5236\u2160\u7c7b\u9519\u8bef\uff08\u6211\u4eec\u5e38\u8bf4\u7684\u5047\u9633\u6027\uff09\uff1b\u4e2d\u56fd\u5355\u56fdIII\u671f\u7684\u5168\u7403\u6ce8\u518c\u8def\u5f84\u8981\u4e0eNDA\u540c\u6b65\u89c4\u5212[2]\u3002<\/p>\n\n\n\n<h5 class=\"wp-block-heading\"><strong>\u7b2c\u4e8c\u8bfe\uff1a\u628a<\/strong><strong>\u201c<\/strong><strong>\u672b\u7ebf\u633d\u6551<\/strong><strong>\u201d<\/strong><strong>\u505a\u6210<\/strong><strong>\u201c<\/strong><strong>\u4e00\u7ebf\u7ef4\u6301<\/strong><strong>\u201d<\/strong><strong>\uff0c\u4f46<\/strong><strong>OS<\/strong><strong>\u540c\u6837\u5c1a\u672a\u6210\u719f<\/strong><\/h5>\n\n\n\n<p class=\"wp-block-paragraph\">\u5b89\u8fdb\u4e3b\u5bfc\u7684III\u671fDeLLphi-305\uff0c\u5728\u5e7f\u6cdb\u671f\u5c0f\u7ec6\u80de\u80ba\u764c\u4e00\u7ebf\u7ef4\u6301\u4e2d\u5c06\u5854\u62c9\u59a5\u5355\u6297\uff08Imdelltra\u00ae\uff0cDLL3\u00d7CD3\u53cc\u7279\u5f02\u6027T\u7ec6\u80de\u8854\u63a5\u5668\uff1b\u4e2d\u56fd\u533a\u7531\u767e\u6d4e\u795e\u5dde\u8d1f\u8d23\uff09\u52a0\u5165\u5ea6\u4f10\u5229\u5c24\u5355\u6297\u7ef4\u6301\uff0c563\u4f8b\u8bf1\u5bfc\u540e\u672a\u8fdb\u5c55\u60a3\u80051:1\u968f\u673a[4]\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e2d\u4f4d\u968f\u8bbf\u7ea616\u4e2a\u6708\u65f6\uff1a\u4e2d\u4f4dOS 21.1 vs 12.7\u4e2a\u6708\uff0cHR 0.42\uff0895% CI 0.32\u20130.54\uff09\uff0cP&lt;0.001\uff0c\u6b7b\u4ea1\u98ce\u9669\u964d\u4f4e58%\uff0c\u7edd\u5bf9\u83b7\u76ca8.4\u4e2a\u6708\uff1b12\u4e2a\u6708OS\u738779.4% vs 53.3%\uff1b\u7814\u7a76\u8005\u8bc4\u4f30\u7684\u4e2d\u4f4dPFS 7.4 vs 1.9\u4e2a\u6708\uff0cHR 0.34\uff0895% CI 0.28\u20130.42\uff09\uff1bORR 26.4% vs 4.1%\u3002\u83b7\u76ca\u5728\u6240\u6709\u9884\u8bbe\u4e9a\u7ec4\u4e00\u81f4\uff0c\u542b\u8111\u8f6c\u79fb\uff08HR 0.49\uff09\u4e0e\u809d\u8f6c\u79fb\uff08HR 0.41\uff09\u60a3\u8005[4]\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4f46\u62a5\u544a\u4ebaJacob Sands\u73b0\u573a\u660e\u786e\u8868\u793a\u201c\u8fd9\u4e0d\u662f\u6700\u7ec8\u7684\u4e2d\u4f4dOS\u201d\u2014\u2014\u7814\u7a76\u4e3a\u9884\u8bbe\u671f\u4e2d\u5206\u6790\uff0cOS\u5206\u6790\u5728243\u4e2a\u4e8b\u4ef6\u300161%\u4fe1\u606f\u5206\u6570\u65f6\u8fdb\u884c\uff0c\u8054\u5408\u7ec4mOS\u768495% CI\u4e0a\u754c\u4e3a\u201c\u4e0d\u53ef\u4f30\u8ba1\u201d[4]\u3002\u5bf9\u7167\u81c2\u5f3a\u5ea6\u4e5f\u987b\u6446\u4e0a\u53f0\u9762\uff1a\u5ea6\u4f10\u5229\u5c24\u5355\u836f\u7ef4\u6301\u7ec4\u4e2d\u4f4dPFS\u4ec51.9\u4e2a\u6708\uff0c\u63a5\u8fd1\u8be5\u4eba\u7fa4\u81ea\u7136\u75c5\u7a0b\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u66f4\u5173\u952e\u7684\u662f\uff0c\u82a6\u6bd4\u66ff\u5b9a\u8054\u5408\u963f\u66ff\u5229\u73e0\u5355\u6297\uff08IMforte\uff09\u5728\u540c\u4e00\u7ef4\u6301\u573a\u666f\u5df2\u83b7\u9633\u6027\u7ed3\u679c\uff08OS 13.2 vs 10.6\u4e2a\u6708\uff09[5]\uff0cESMO\u8ba8\u8bba\u8005\u636e\u6b64\u79f0\u5854\u62c9\u59a5\u5355\u6297\u201c\u662f\u53c8\u4e00\u4e2a\u6f5c\u5728\u7684\u7ef4\u6301\u9009\u62e9\uff0c\u5176\u4f4d\u7f6e\u4ecd\u6709\u5f85\u754c\u5b9a\u201d[3]\u3002\u6545\u201cSCLC\u7ef4\u6301\u6cbb\u7597\u59cb\u7ec8\u7f3a\u4e4f\u6709\u6548\u624b\u6bb5\u201d\u5e94\u4fee\u6b63\u4e3a\uff1aES-SCLC\u4e00\u7ebf\u7ef4\u6301\u5df2\u8fdb\u5165\u201c\u6709\u591a\u4e2a\u9633\u6027\u65b9\u6848\u3001\u4f46\u5f7c\u6b64\u7f3a\u4e4f\u5934\u5bf9\u5934\u6bd4\u8f83\u201d\u7684\u9636\u6bb5\u3002\u5b89\u5168\u6027\u53ef\u843d\u5730\uff1aCRS 49.6% vs 1.4%\uff0c\u4f46\u22653\u7ea7\u4ec50.4%\u3001\u65e0\u81f4\u6b7b\u4e8b\u4ef6\uff0cICANS 1.1%\u4e14\u65e0\u22653\u7ea7[4]\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e34\u5e8a\u5f00\u53d1\u542b\u4e49\uff1a\u672c\u7814\u7a76\u628aT\u7ec6\u80de\u8854\u63a5\u5668\u4ece\u201c\u672b\u7ebf\u633d\u6551\u201d\u63a8\u5230\u201c\u4e00\u7ebf\u7ef4\u6301\u201d\u3002&nbsp;\u4f46\u540e\u7eed\u540c\u7c7bIII\u671f\u4e0d\u80fd\u53ea\u76ef\u7740\u7597\u6548\u6570\u5b57\uff0c\u65b9\u6848\u91cc\u5f97\u63d0\u524d\u628a\u51e0\u4ef6\u4e8b\u5b9a\u4e0b\u6765\uff1aCRS\u548c\u5ef6\u8fdf\u795e\u7ecf\u6bd2\u6027\u600e\u4e48\u957f\u671f\u76ef\u3001\u524d\u4e24\u5242\u8981\u4e0d\u8981\u4f4f\u9662\u76d1\u6d4b\u3001\u8ddfPD-L1\u6291\u5236\u5242\u8c01\u5148\u8c01\u540e\u3001\u7ef4\u6301\u671f\u60a3\u8005\u611f\u53d7\u600e\u4e48\u8861\u91cf\u3002<\/p>\n\n\n\n<h5 class=\"wp-block-heading\"><strong>\u7b2c\u4e09\u8bfe\uff1a<\/strong><strong>RFS<\/strong><strong>\u8fbe\u6807\u4e0d\u7b49\u4e8e<\/strong><strong>\u201c<\/strong><strong>\u8db3\u591f\u597d<\/strong><strong>\u201d<\/strong><strong>\uff0c\u9897\u7c92\u5ea6\u51b3\u5b9a\u542b\u91d1\u91cf<\/strong><\/h5>\n\n\n\n<p class=\"wp-block-paragraph\">\u9ed8\u6c99\u4e1c\u4e0eModerna\u7684\u4e2a\u4f53\u5316mRNA\u65b0\u6297\u539f\u7597\u6cd5intismeran&nbsp;autogene\u8054\u5408\u5e15\u535a\u5229\u73e0\u5355\u6297\uff0c\u7528\u4e8e\u5b8c\u5168\u5207\u9664\u7684IIB\u2013IV\u671f\u9ed1\u8272\u7d20\u7624\u672f\u540e\u8f85\u52a9\u3002III\u671fINTerPath-001\u662f\u5168\u7403\u9996\u4e2a\u9633\u6027\u7684\u4e2a\u4f53\u5316mRNA\u80bf\u7624\u75ab\u82d7III\u671f\u7814\u7a76\uff0c1137\u4f8b\u63092:1\u968f\u673a\uff08757 vs 380\uff09\uff0c\u7ec8\u70b9\u6309RFS\u2192DMFS\u2192OS\u5c42\u7ea7\u68c0\u9a8c[6]\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e2d\u4f4d\u968f\u8bbf24.6\u4e2a\u6708\u65f6\uff1a24\u4e2a\u6708RFS\u738782.2% vs 70.0%\uff0cHR 0.58\uff0895% CI 0.45\u20130.75\uff09\uff0c\u53cc\u4fa7P&lt;0.001\uff1b24\u4e2a\u6708DMFS\u738788.5% vs 80.2%\uff0cHR 0.62\uff0895% CI 0.45\u20130.85\uff09\uff0cP=0.002\u3002OS\u672a\u8fbe\u9884\u8bbe\u754c\u503c\uff1aHR 0.77\uff0895% CI 0.45\u20131.31\uff09\uff0cP=0.33[6]\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5b89\u5168\u6027\u9700\u533a\u5206\u53e3\u5f84\uff1a23.6% vs 20.3%\u662f\u5168\u56e03\u20135\u7ea7\u4e0d\u826f\u4e8b\u4ef6\uff0c\u6cbb\u7597\u76f8\u5173\u76843\u20135\u7ea7TRAE\u4ec514.2% vs 13.4%\uff1b\u5dee\u5f02\u4e3b\u8981\u662f\u4f4e\u7ea7\u522b\u6ce8\u5c04\u53cd\u5e94\uff08\u53d1\u70ed52.2% vs 8.2%\u3001\u6ce8\u5c04\u90e8\u4f4d\u75bc\u75db51.0% vs 9.5%\u3001\u6d41\u611f\u6837\u75be\u75c525.4% vs 9.2%\uff09\uff0c\u800c\u5e15\u535a\u5229\u73e0\u5355\u6297\u76f8\u5173\u514d\u75ab\u4ecb\u5bfc\u4e0d\u826f\u4e8b\u4ef636.0% vs 34.7%\u2014\u2014intismeran\u672a\u653e\u5927PD-1\u6bd2\u6027[6]\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e24\u4e2a\u51b3\u5b9a\u542b\u91d1\u91cf\u7684\u7ec6\u8282\u3002<strong>\u5176\u4e00\uff0c\u83b7\u76ca\u5b8c\u5168\u51fa\u73b0\u5728\u514d\u75ab\u7a0b\u5e8f\u4e4b\u540e\uff1a<\/strong>\u9884\u8bbe\u5206\u6bb5\u5206\u6790\u663e\u793a0\u20136\u4e2a\u6708RFS HR\u4e3a0.99\uff0895% CI 0.66\u20131.49\uff09\uff0c6\u4e2a\u6708\u540e\u964d\u81f30.42\uff0895% CI 0.30\u20130.58\uff09\u2014\u2014\u56e0\u75ab\u82d7\u9700\u4e2a\u4f53\u5316\u5236\u5907\u3001\u4e2d\u4f4d\u9996\u6b21\u7ed9\u836f\u4e3a\u968f\u673a\u540e64\u5929\uff0c\u603b\u4f53HR 0.58\u56e0\u6b64\u88ab\u7a00\u91ca\uff0cmITT\u4eba\u7fa4\u6539\u5584\u81f30.51\uff0895% CI 0.39\u20130.67\uff0c2\u5e74RFS\u738784.2% vs 70.4%\uff09[6]\u3002\u51e1\u4f9d\u8d56\u4e2a\u4f53\u5316\u5236\u5907\u7684\u7597\u6cd5\uff0c\u82e5\u4e0d\u9884\u8bbe\u5206\u6bb5\u5206\u6790\u4e0emITT\u654f\u611f\u6027\u5206\u6790\uff0c\u8bfb\u51fa\u65f60.58\u5c31\u4f1a\u88ab\u8bef\u8bfb\u4e3a\u7597\u6548\u4e0a\u9650\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u5176\u4e8c\uff0c\u5bf9\u7167\u6807\u51c6\u6b63\u88ab\u66f4\u65e9\u7ebf\u7684\u5e72\u9884\u62ac\u9ad8\uff1a<\/strong>SWOG S1801\uff08II\u671f\uff0cn=313\uff0c\u65b0\u8f85\u52a9+\u8f85\u52a9 vs \u8f85\u52a9\uff09\u76842\u5e74EFS\u4e3a72% vs 49%\uff08HR 0.58\uff09\uff1bNADINA\uff08III\u671f\uff0cn=423\uff0c\u65b0\u8f85\u52a9\u53cc\u514d vs \u8f85\u52a9\u7eb3\u6b66\u5229\u5c24\uff09\u768412\u4e2a\u6708EFS\u4e3a83.7% vs 57.2%\uff08HR 0.32\uff09[7]\u3002\u4e24\u8005\u5747\u672a\u7eb3\u5165IIB\/IIC\u671f\uff0c\u4e14EFS\u4e0eRFS\u5b9a\u4e49\u4e0d\u540c\u30012\u5e74\u4e0e12\u4e2a\u6708\u65f6\u70b9\u4e0d\u540c\uff0c\u4e0e\u672c\u7814\u7a76\u5e76\u975e\u4e25\u683c\u5934\u5bf9\u5934\uff0c\u4f46\u5df2\u628a\u8f85\u52a9\u6cbb\u7597\u7684\u589e\u91cf\u83b7\u76ca\u95e8\u69db\u63a8\u9ad8\u4e00\u6863\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e34\u5e8a\u5f00\u53d1\u542b\u4e49\uff1a\u8f85\u52a9\u6cbb\u7597III\u671f\u987b\u5728\u5b9a\u7a3f\u65f6\u9884\u8bbe\u6807\u51c6\u6cbb\u7597\u6f14\u53d8\u7684\u60c5\u666f\u5206\u6790\uff0c\u5bf9\u7167\u5047\u8bbe\u4e0d\u80fd\u951a\u5b9a\u5728\u8bd5\u9a8c\u542f\u52a8\u65f6\u70b9\uff1b\u5206\u6bb5\u5206\u6790\u4e0emITT\u654f\u611f\u6027\u5206\u6790\u5bf9\u5b58\u5728\u5236\u5907\u5ef6\u8fdf\u7684\u7597\u6cd5\u5e94\u4e3a\u6807\u914d\u3002\u8be5\u8d44\u4ea7\u7684\u5b9a\u4f4d\u6700\u7ec8\u53d6\u51b3\u4e8eOS\u80fd\u5426\u8f6c\u5316\u3001\u76f8\u5bf9\u65b0\u8f85\u52a9\u514d\u75ab\u7684\u4ef7\u503c\u3001\u5236\u5907\u6210\u672c\u7684\u53ef\u652f\u4ed8\u6027\uff0c\u4ee5\u53ca\u80fd\u5426\u8df3\u51fa\u9ed1\u8272\u7d20\u7624\u3002<\/p>\n\n\n\n<h5 class=\"wp-block-heading\"><strong>\u7b2c\u56db\u8bfe\uff1a<\/strong><strong>OS<\/strong><strong>\u9634\u6027\u4e4b\u5916\uff0c\u6cbb\u7597\u7ebf\u6570\u7684\u4ea4\u4e92\u4f5c\u7528\u624d\u662f\u771f\u6b63\u7684<\/strong><strong>\u8b66\u544a<\/strong><\/h5>\n\n\n\n<p class=\"wp-block-paragraph\">\u8f89\u745e\u7684SigVie-002\u672a\u8fbe\u5230OS\u4e3b\u8981\u7ec8\u70b9\u3002sigvotatug&nbsp;vedotin\u662f\u6f5c\u5728\u9996\u521b\u7684\u6574\u5408\u7d20\u03b26\uff08IB6\uff09\u9776\u5411ADC\uff0c\u6765\u81ea\u5176430\u4ebf\u7f8e\u5143\u6536\u8d2dSeagen\u6240\u5f97\u8d44\u4ea7\u3002703\u4f8b\u7ecf\u6cbb\u975e\u9cdeNSCLC\u5934\u5bf9\u5934\u591a\u897f\u4ed6\u8d5b\uff1a\u603b\u4f53\u4e2d\u4f4dOS 11.9 vs 11.5\u4e2a\u6708\uff0cHR 0.929\uff0895% CI 0.767\u20131.126\uff09\uff0c\u5355\u4fa7P=0.226\uff1bBICR\u4e2d\u4f4dPFS 4.7 vs 4.2\u4e2a\u6708\uff0cHR 0.844[8]\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u771f\u6b63\u7684\u8b66\u544a\u5728\u6cbb\u7597\u7ebf\u6570\u7684\u53cd\u8f6c\uff1a\u4e8c\u7ebf\u4e9a\u7ec4\uff08\u7ea6\u5360\u4e09\u5206\u4e4b\u4e8c\uff09\u4e2d\u4f4dOS 13.6 vs 11.1\u4e2a\u6708\uff0cHR 0.831\uff0c95% CI 0.658\u20131.049\u8de81\uff1b\u4e09\u7ebf\u53ca\u4ee5\u4e0a\u4e0d\u4ec5\u65e0\u83b7\u76ca\uff0c\u4e2d\u4f4dOS\u53cd\u800c\u4e3a10.0 vs 11.9\u4e2a\u6708\uff08HR 1.187\uff09\u3002\u8fd9\u662f\u4e8b\u540e\uff08post hoc\uff09\u5206\u6790\uff0c\u7814\u7a76\u8005\u5b9a\u6027\u4e3a\u201c\u5047\u8bbe\u751f\u6210\u6027\u201d[8]\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u60a3\u8005\u5bcc\u96c6\u7b56\u7565\u540c\u6837\u5931\u6548\uff1a\u8f89\u745e\u5b98\u65b9\u53e3\u5f84\u4e3a\u201cIB6\u5728\u7ea690%\u7684NSCLC\u80bf\u7624\u4e2d\u8868\u8fbe\u201d\u3002\u63a2\u7d22\u6027\u5206\u6790\u672a\u53d1\u73b0IB6\u8868\u8fbe\u6c34\u5e73\u4e0e\u5e94\u7b54\u5e45\u5ea6\u4e4b\u95f4\u5b58\u5728\u660e\u786e\u5173\u7cfb\uff1b\u66ff\u6362\u8bc4\u5206\u9608\u503c\u4ea6\u65e0\u8d8b\u52bf\u3002\u8fd9\u4e0e\u201c\u9ad8\u8868\u8fbe\u5373\u5bcc\u96c6\u201d\u7684\u9884\u8bbe\u76f4\u63a5\u51b2\u7a81[8]\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u540e\u7eed\u5f00\u53d1\u5df2\u8f6c\u5411SigVie-003\uff08NCT06758401\uff0c\u8054\u5408\u5e15\u535a\u5229\u73e0\u5355\u6297\u4e00\u7ebf\u6cbb\u7597PD-L1 TPS\u226550%\uff0c\u7ea6714\u4f8b1:1\u968f\u673a\uff0c\u53cc\u4e3b\u8981\u7ec8\u70b9\u4e3aOS\u4e0eBICR-PFS\uff09\uff0c\u5373\u4ece\u201c\u66ff\u4ee3\u5316\u7597\u201d\u8f6c\u4e3a\u201c\u8054\u5408\u589e\u6548\u201d[9]\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u4e24\u9879\u5fc5\u987b\u533a\u5206\u5f00\u7684\u5bf9\u7167\u6848\u4f8b<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>CLARITY-Gastric01<\/strong><strong>\uff1a\u8fd9\u662f<\/strong><strong>\u201cPFS<\/strong><strong>\u9634\u6027<\/strong><strong>\/OS<\/strong><strong>\u5f3a\u9633\u6027<\/strong><strong>\u201d<\/strong><strong>\uff0c\u4e0d\u662f<\/strong><strong>\u201cOS<\/strong><strong>\u9634\u6027<\/strong><strong>\u201d<\/strong><strong>\u3002<\/strong>\u963f\u65af\u5229\u5eb7\u7684Claudin 18.2 ADC sonesitatug&nbsp;vedotin\uff08CMG901\/AZD0901\uff0c\u6e90\u81ea\u5eb7\u8bfa\u4e9a\u4e0e\u4e50\u666e\u751f\u7269\uff09\u7528\u4e8e\u4e8c\u7ebf\u53ca\u540e\u7ebfCLDN18.2\u9633\u6027\u80c3\u98df\u7ba1\u764c\uff0c\u53cc\u4e3b\u8981\u7ec8\u70b9\u4e3a3L+\u4eba\u7fa4OS\u4e0eITT\u4eba\u7fa4BICR\u8bc4\u4f30PFS\uff0c\u4e2d\u4f4d\u968f\u8bbf\u4ec58.6\u4e2a\u6708\u7684\u8ba1\u5212\u5185\u671f\u4e2d\u5206\u6790\uff08LBA7\uff0c\u4e3b\u5e2d\u8bba\u575bII\uff0c\u5f90\u745e\u534e\u9662\u58eb\uff0cNCT06346392\uff09[10]\u30023L+ OS\u8fd9\u4e00\u5171\u540c\u4e3b\u8981\u7ec8\u70b9\u8fbe\u6210\uff1a\u4e2d\u4f4dOS 10.0 vs 5.0\u4e2a\u6708\uff0cHR 0.47\uff0895% CI 0.36\u20130.62\uff09\uff0cP&lt;0.000001\uff1bITT\u4eba\u7fa4OS\u4ea6\u663e\u8457\uff0810.6 vs 6.4\u4e2a\u6708\uff0cHR 0.58\uff0c\u4e3a\u5df2\u8fbe\u6807\u7684\u5173\u952e\u6b21\u8981\u7ec8\u70b9\uff09\u3002\u672a\u8fbe\u6210\u7684\u662fITT\u4eba\u7fa4BICR PFS\uff1a4.2 vs 3.8\u4e2a\u6708\uff0cHR 0.77\uff0895% CI 0.62\u20130.96\uff09\uff0cP=0.053193[10]\u3002\u800c\u201c\u8179\u819c\u64ad\u6563\u4f7fPFS\u8bc4\u4f30\u66f4\u56f0\u96be\u201d\u6700\u76f4\u63a5\u7684\u91cf\u5316\u8bc1\u636e\u6070\u5728\u540c\u4e00\u6458\u8981\u4e2d\uff1a\u7814\u7a76\u8005\u8bc4\u4f30\u7684\u63a2\u7d22\u6027PFS\u4e3a4.4 vs 3.0\u4e2a\u6708\uff08HR 0.59\uff0c95% CI 0.48\u20130.73\uff09\uff0c\u4e0eBICR\u76840.77\u5dee\u8ddd\u663e\u8457[10]\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>OptiTROP-Lung06<\/strong><strong>\uff1a\u540c\u6837\u9002\u7528<\/strong><strong>\u201cOS<\/strong><strong>\u6210\u719f\u5ea6<\/strong><strong>\u201d<\/strong><strong>\u6807\u5c3a\u3002<\/strong>\u79d1\u4f26\u535a\u6cf0\u4e0e\u9ed8\u6c99\u4e1c\u5171\u540c\u5f00\u53d1\u7684TROP2 ADC\u82a6\u5eb7\u6c99\u59a5\u73e0\u5355\u6297\u4e00\u7ebf\u6cbb\u7597PD-L1 TPS&lt;1%\u3001EGFR\/ALK\u9634\u6027\u975e\u9cdeNSCLC\uff0c455\u4f8b1:1\u968f\u673a\uff0c\u5bf9\u7167\u7ec4\u662f\u5e15\u535a\u5229\u73e0\u5355\u6297\u8054\u5408\u57f9\u7f8e\u66f2\u585e+\u94c2\u7c7b\u5316\u7597\uff08\u73b0\u884c\u4e00\u7ebf\u6807\u51c6\uff0c\u800c\u975e\u5e15\u535a\u5229\u73e0\u5355\u836f\uff09\uff0c\u9884\u8bbe\u4e2d\u671f\u5206\u6790\u4e2d\u4f4d\u968f\u8bbf\u4ec59.7\u4e2a\u6708\uff08LBA66\uff0c\u5468\u5f69\u5b58\u6559\u6388\uff0cNCT06711900\uff0cNEJM\u540c\u6b65\uff09[11]\u3002BICR\u4e2d\u4f4dPFS 15.0 vs 5.7\u4e2a\u6708\uff0cHR 0.49\uff0895% CI 0.36\u20130.65\uff09\uff0cP&lt;0.0001\uff1b\u800cORR\u4e24\u7ec4\u51e0\u4e4e\u76f8\u540c\uff0850.2% vs 47.3%\uff09\u2014\u2014\u83b7\u76ca\u6765\u81ea\u7f13\u89e3\u6301\u4e45\u6027\uff08\u4e2d\u4f4dDoR&nbsp;13.6 vs 6.8\u4e2a\u6708\uff0cHR 0.47\uff09\u4e0e\u6df1\u5ea6\u7f13\u89e3\u7387\uff0828.8% vs 17.3%\uff09\u800c\u975e\u5e94\u7b54\u7387\u3002\u4f46OS\u5c1a\u672a\u6210\u719f\uff1aHR 0.58\uff0895% CI 0.38\u20130.88\uff09\uff0c\u4e24\u7ec4\u4e2d\u4f4dOS\u5747\u672a\u8fbe\u5230[11]\u3002\u5b83\u4e0eINTerPath-001\u9762\u5bf9\u7684\u662f\u540c\u4e00\u4e2a\u95ee\u9898\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e34\u5e8a\u5f00\u53d1\u542b\u4e49\uff1aADC\u9886\u57df\u6b63\u540c\u65f6\u7ecf\u5386\u4e09\u79cd\u5206\u5316\u2014\u2014\u66ff\u4ee3\u7ec8\u70b9\u5411\u751f\u5b58\u7ec8\u70b9\u8f6c\u5316\u7684\u4e0d\u786e\u5b9a\u6027\u3001\u6cbb\u7597\u7ebf\u6570\u5bf9\u83b7\u76ca\u65b9\u5411\u7684\u53cd\u8f6c\uff08\u4e8c\u7ebfHR 0.831 vs \u4e09\u7ebfHR 1.187\uff09\u3001\u4ee5\u53ca\u9776\u70b9\u8868\u8fbe\u4f5c\u4e3a\u5bcc\u96c6\u6807\u5fd7\u7269\u7684\u80fd\u529b\u5dee\u5f02\u3002<strong>\u4e09\u8005\u8981\u5206\u5f00\u8bf4\uff1a<\/strong>IB6\u5c5e\u4e8e\u5b8c\u5168\u65e0\u6cd5\u8bc6\u522b\u83b7\u76ca\u4eba\u7fa4\uff1bCLDN18.2\u5219\u76f8\u53cd\u2014\u2014\u226525%\u4f5c\u4e3a\u5165\u7ec4\u95e8\u69db\u662f\u6709\u6548\u7684\uff08\u226575% HR 0.59\u300125\u2013&lt;75% HR 0.63\uff0c\u4e24\u4e2a\u8868\u8fbe\u4e9a\u7ec4\u5747\u4e00\u81f4\u83b7\u76ca\uff09\uff0c\u4f46\u5b83\u65e0\u6cd5\u8fdb\u4e00\u6b65\u7ec6\u5206\u51fa\u66f4\u4f18\u4eba\u7fa4[10]\u3002\u56db\u70b9\u53ef\u5728\u65b9\u6848\u4e2d\u4f53\u73b0\uff1a\u4ee5PFS\u4e3a\u4e3b\u8981\u7ec8\u70b9\u7684\u6ce8\u518c\u6027\u8bd5\u9a8c\u987b\u9884\u8bbeOS\u671f\u4e2d\u754c\u503c\uff0c\u5e76\u660e\u786eOS\u4e0d\u5229\u65f6\u7684\u51b3\u7b56\u89c4\u5219\uff1b\u53cc\u4e3b\u8981\u7ec8\u70b9\u662f\u53ef\u884c\u7684\u98ce\u9669\u5bf9\u51b2\uff0c\u4f46\u987b\u9884\u8bbe\u4e24\u9879\u7ec8\u70b9\u65b9\u5411\u4e0d\u4e00\u81f4\u65f6\u7684\u6ce8\u518c\u8bba\u8bc1\u8def\u5f84\uff1b\u6cbb\u7597\u7ebf\u6570\u4e0e\u8010\u836f\u673a\u5236\u5e94\u8fdb\u5165\u968f\u673a\u5316\u5206\u5c42\u800c\u975e\u7559\u4f5c\u4e8b\u540e\u5206\u6790\uff1b\u4e8b\u540e\u4e9a\u7ec4\u5fc5\u987b\u968f\u9644\u7f6e\u4fe1\u533a\u95f4\u4e0e\u201c\u5047\u8bbe\u751f\u6210\u6027\u201d\u5b9a\u6027\u3002<\/p>\n\n\n\n<h5 class=\"wp-block-heading\"><strong>\u5199\u5728\u6700\u540e\uff1a<\/strong><strong>ESMO 2026<\/strong><strong>\u7684<\/strong><strong>\u201c<\/strong><strong>\u9a8c\u8bc1\u9897\u7c92\u5ea6<\/strong><strong>\u201d<\/strong><strong>\u6b63\u5728\u53d8\u7ec6<\/strong><\/h5>\n\n\n\n<p class=\"wp-block-paragraph\">\u201c\u8fbe\u5230\u4e3b\u8981\u7ec8\u70b9\u201d\u6b63\u5728\u88ab\u62c6\u89e3\u4e3a\u516d\u4e2a\u53ef\u72ec\u7acb\u68c0\u9a8c\u7684\u7ef4\u5ea6\uff1a\u83b7\u76ca\u5e45\u5ea6\u3001\u83b7\u76ca\u6301\u4e45\u6027\u3001\u4e9a\u7ec4\u4e00\u81f4\u6027\u3001\u6570\u636e\u6210\u719f\u5ea6\u3001\u5bf9\u7167\u6807\u51c6\u7684\u65f6\u70b9\u6f14\u53d8\u3001\u66ff\u4ee3\u7ec8\u70b9\u5411\u751f\u5b58\u7ec8\u70b9\u8f6c\u5316\u7684\u786e\u5b9a\u6027\u3002\u56db\u5802\u8bfe\u5206\u522b\u6f14\u793a\u4e86\u5176\u4e2d\u67d0\u4e00\u7ef4\u5ea6\u7684\u5931\u5b88\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">III\u671f\u65b9\u6848\u7684\u8bbe\u8ba1\u8d28\u91cf\uff0c\u8d8a\u6765\u8d8a\u53d6\u51b3\u4e8e\u5b9a\u7a3f\u65f6\u662f\u5426\u5df2\u4e3a\u201c\u4e3b\u8981\u7ec8\u70b9\u8fbe\u6807\u3001\u4f46\u67d0\u4e2a\u5173\u952e\u7ef4\u5ea6\u4e0d\u8fbe\u6807\u201d\u9884\u8bbe\u4e86\u51b3\u7b56\u6846\u67b6\u3002\u5bf9\u7167\u5047\u8bbe\u6821\u51c6\u3001OS\u968f\u8bbf\u65f6\u957f\u4e0e\u671f\u4e2d\u754c\u503c\u524d\u7f6e\u3001\u7ec8\u70b9\u7ec4\u5408\u7684\u98ce\u9669\u5bf9\u51b2\u3001\u7ecf\u9884\u8bbe\u4ea4\u4e92\u68c0\u9a8c\u786e\u8ba4\u7684\u83b7\u76ca\u4fee\u9970\u53d8\u91cf\u8fdb\u5165\u968f\u673a\u5316\u5206\u5c42\u3001\u66ff\u4ee3\u7ec8\u70b9\u7684\u6865\u63a5\u5047\u8bbe\u3001\u4e2a\u4f53\u5316\u7597\u6cd5\u7684\u8fd0\u8425\u4e0e\u5236\u5907\u6307\u6807\u2014\u2014\u8fd9\u4e9b\u6b63\u5728\u4ece\u201c\u7edf\u8ba1\u5206\u6790\u8ba1\u5212\u201d\u7684\u9644\u5c5e\u9879\uff0c\u53d8\u6210\u51b3\u5b9a\u8d44\u4ea7\u80fd\u5426\u8d70\u5411\u6ce8\u518c\u4e0e\u5546\u4e1a\u5316\u7684\u6838\u5fc3\u53d8\u91cf\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u5bf9\u4e34\u5e8a\u7814\u7a76\u670d\u52a1\u65b9\u800c\u8a00\uff0c\u5728\u65b9\u6848\u8bbe\u8ba1\u9636\u6bb5\u4e0e\u7533\u529e\u65b9\u5171\u540c\u56de\u7b54\u8fd9\u4e9b\u95ee\u9898\uff0c\u6bd4\u5728\u6570\u636e\u8bfb\u51fa\u540e\u89e3\u91ca\u6570\u636e\u66f4\u6709\u4ef7\u503c\u3002<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u672c\u6587\u6570\u636e\u591a\u6765\u81ea\u4f1a\u8bae\u6458\u8981\u3001\u4f01\u4e1a\u65b0\u95fb\u7a3f\u4e0e\u5a92\u4f53\u62a5\u9053\uff0c\u4e14\u591a\u4e3a\u671f\u4e2d\u5206\u6790\u7ed3\u679c\uff0c\u6700\u7ec8\u4ee5\u540c\u884c\u8bc4\u8bae\u5168\u6587\u53ca\u76d1\u7ba1\u673a\u6784\u5ba1\u8bc4\u7ed3\u8bba\u4e3a\u51c6\u3002<\/p>\n\n\n\n<h5 class=\"wp-block-heading\"><strong>\u53c2\u8003\u6587\u732e<\/strong><\/h5>\n\n\n\n<p class=\"wp-block-paragraph\">[1] ESMO 2026 \u5927\u4f1aLBA\u6536\u5f55\u7edf\u8ba1\u4e0e\u4e3b\u5e2d\u8bba\u575b\u6784\u6210\uff08\u4e2d\u56fd\u6765\u6e90\u7814\u7a76\u7ea629\u9879\u3001\u4e3b\u5e2d\u8bba\u575b5\u9879\uff09\uff1a\u836f\u667a\u7f512026-10-26\uff1b\u817e\u8baf\u65b0\u95fb\u300aESMO 2026\u7b80\u62a5\u300b2026-10-25\uff1b\u533b\u836f\u9b54\u65b9\u300a5\u9879\u4e2d\u56fdIII\u671f\u767b\u9876ESMO 2026\u4e3b\u5e2d\u7814\u8ba8\u4f1a\u300b2026-10-19.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">[2] Zhou J, et al. HARMONi-GI1\uff08AK112-309\uff1bNCT06591520 \/ CTR20243164\uff09\uff1aESMO 2026 LBA8\uff0c\u4e3b\u5e2d\u8bba\u575bII\u3002\u6570\u636e\u51fa\u5904\uff1a\u5eb7\u65b9\u751f\u7269\u6e2f\u4ea4\u6240\u81ea\u613f\u516c\u544a2026-10-26\uff1bAkeso\/Summit \u8054\u5408\u65b0\u95fb\u7a3f\uff08\u542bTOPAZ-1\u53c2\u7167\u6570\u636e12.8 vs 11.5\u4e2a\u6708\u3001HR 0.80\uff0c\u53caECOG PS1\u3001\u226565\u5c81\u4e9a\u7ec4HR\uff09\uff1bOncLive 2026-10-25\uff08\u7814\u7a76\u8bbe\u8ba1\u4e0e\u5165\u7ec4\u6807\u51c6\uff09\uff1b\u4e2d\u4fe1\u5efa\u6295\u533b\u836f\u70b9\u8bc42026-10-25\uff08682\u4f8b\u5206\u7ec4\u3001\u4e2d\u4f4d\u968f\u8bbf14.3\u4e2a\u6708\uff09\u3002\u5168\u7403EA2251\uff1aSummit\u4e0eECOG-ACRIN\u5408\u4f5c\u516c\u544a2026-10-21\u3002CDE\u62df\u4f18\u5148\u5ba1\u8bc4\u516c\u793a2026-10-23.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">[3] ESMO 2026 \u73b0\u573a\u53ca\u4f1a\u524d\u4e13\u5bb6\u8bc4\u8bba\uff1aYakup&nbsp;Erg\u00fcn\uff08Bower Hospital\uff09\u5bf9HARMONi-GI1&#8243;global validation will still be expected because the trial was conducted exclusively in China&#8221;\u4e0eDeLLphi-305&#8243;another potential maintenance option; its place remains to be defined&#8221;\u7684\u8bc4\u8bba\uff0cOncoDaily 2026-10-19.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">[4] Sands J, et al. DeLLphi-305\uff08NCT06211036\uff09\uff1aESMO 2026 LBA3\uff0c\u4e3b\u5e2d\u8bba\u575bI\uff0c\u9884\u8bbe\u671f\u4e2d\u5206\u6790\uff0c\u6570\u636e\u622a\u6b622026-07-07\uff1b\u540c\u6b65\u53d1\u8868 N Engl J Med 2026-10-24, doi:10.1056\/NEJMoa2609482\u3002\u6570\u636e\u51fa\u5904\uff1aTargetedOnc\u300aKey Takeaways From DeLLphi-305 at ESMO 2026\u300b\uff08\u4e2d\u4f4d\u968f\u8bbf15.9 vs 16.1\u4e2a\u6708\u300161%\u4fe1\u606f\u5206\u6570\u3001\u7814\u7a76\u8005\u8bc4\u4f30PFS\u3001\u8111\/\u809d\u8f6c\u79fb\u4e9a\u7ec4HR\uff09\uff1bOncoDaily\uff0812\u4e2a\u6708OS\u738779.4% vs 53.3%\u3001CRS 49.6% \/ \u22653\u7ea70.4%\uff09\uff1bMedscape 2026-10-24\uff08\u542bIMforte\u5bf9\u7167\u53e3\u5f84\uff09\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">[5] IMforte\uff08\u82a6\u6bd4\u66ff\u5b9a+\u963f\u66ff\u5229\u73e0\u5355\u6297\u4e00\u7ebf\u7ef4\u6301\uff09\uff1aESMO\u5b98\u65b9\u58f0\u660e\u8f6c\u8ff0\uff08\u6b64\u524dES-SCLC\u4e00\u7ebf\u6700\u957f\u4e2d\u4f4dOS\u4e3a13.2\u4e2a\u6708\uff09\uff0c\u89c1Medscape 2026-10-24\uff1bFierce Biotech\u53ca\u52a8\u8109\u7f51\u8f6c\u8ff02026-10-25.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">[6] Long GV, et al. INTerPath-001\uff08NCT05933577\uff09\uff1aESMO 2026 LBA1\uff0c\u4e3b\u5e2d\u8bba\u575bI\uff0c\u6570\u636e\u622a\u6b622026-06-30\uff0c\u4e2d\u4f4d\u968f\u8bbf24.6\u4e2a\u6708\u3002\u6570\u636e\u51fa\u5904\uff1aCancerNetwork\u300aINTerpath-001 Data Detail Survival, Subgroup, and Safety Findings in Melanoma\u300b2026-10-24\uff08\u5206\u6bb5\u5206\u67900\u20136\u4e2a\u6708HR 0.99 \/ 6\u4e2a\u6708\u540e0.42\u3001\u4e2d\u4f4d\u9996\u6b21\u7ed9\u836f64\u5929\u3001mITT HR 0.51\u3001\u5168\u56e03\u20135\u7ea7AE 23.6% vs 20.3%\u3001TRAE 3\u20135\u7ea714.2% vs 13.4%\u3001\u5e15\u535a\u5229\u73e0\u76f8\u5173\u514d\u75ab\u4ecb\u5bfcAE 36.0% vs 34.7%\uff09\uff1bOncLive 2026-10-24\uff1bESMO\u5b98\u65b9\u65b0\u95fb\u7a3f2026-10-24\u3002\u5168\u6587\u5df2\u88abNEJM\u63a5\u6536\uff0c\u5b9a\u4e8e2026-11-11\u520a\u51fa.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">[7] Patel SP, et al. SWOG S1801\uff08II\u671f\uff0cn=313\uff09. N Engl J Med 2023\uff1bBlank CU, et al. NADINA\uff08III\u671f\uff0cn=423\uff09. N Engl J Med 2024. \u6570\u503c\u5f15\u81ea ASCO Educational Book\u300aStepping on the Gas or Hitting the Brakes: Response-Driven Therapy for Melanoma\u300b(doi:10.1200\/EDBK-26-520562).<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">[8] Peters S, et al. SigVie-002\uff08NCT06012435\uff09\uff1aESMO 2026 LBA68\uff0c2026-10-25\u8be6\u7ec6\u6570\u636e\uff1b\u8f89\u745e\u9876\u7ebf\u7ed3\u679c\u516c\u544a\uff08Business Wire\uff092026-06-22\uff08IB6\u5728\u7ea690%\u7684NSCLC\u80bf\u7624\u4e2d\u8868\u8fbe\u3001\u63a2\u7d22\u6027\u5206\u6790\u672a\u53d1\u73b0IB6\u8868\u8fbe-\u5e94\u7b54\u5173\u7cfb\uff09\uff1bOncLive\u3001TargetedOnc 2026-06\/10\uff08703\u4f8b\u3001\u4e8c\u7ebf\u7ea6\u4e09\u5206\u4e4b\u4e8c\u3001\u7814\u7a76\u8bbe\u8ba1\u4e0e\u5165\u6392\uff09\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">[9] Reck M, Lu S, O Byrne KJ, et al. Frontline sigvotatug&nbsp;vedotin plus pembrolizumab vs pembrolizumab for NSCLC with PD-L1 TPS \u226550%: phase III study design (SigVie-003, NCT06758401). Future Oncol. 2025;21(30):3891-3901. doi:10.1080\/14796694.2025.2596228. PMID: 41388832. \u53e6\u89c1 ASCO Abstract TPS8660 (J Clin&nbsp;Oncol 44, 2026).<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">[10] Xu RH, et al. CLARITY-Gastric 01\uff08NCT06346392\uff09\uff1aESMO 2026 LBA7\uff0c\u4e3b\u5e2d\u8bba\u575bII\uff0c\u8ba1\u5212\u5185\u671f\u4e2d\u5206\u6790\uff0c\u6570\u636e\u622a\u6b622026-05-31\uff0c\u4e2d\u4f4d\u968f\u8bbf8.6\u4e2a\u6708\u3002\u6570\u636e\u51fa\u5904\uff1aAstraZeneca\u5b98\u65b9\u7ed3\u679c\u88682026-10-25\uff083L+ OS 10.0 vs 5.0\u3001HR 0.47\u3001P&lt;0.000001\uff1bITT OS HR 0.58\uff1bBICR-PFS HR 0.77\u3001P=0.053193\uff1b\u63a2\u7d22\u6027\u7814\u7a76\u8005\u8bc4\u4f30PFS 4.4 vs 3.0\u3001HR 0.59\uff1bCLDN18.2\u226575% HR 0.59\u3001\u226525\u2013&lt;75% HR 0.63\uff1b\u22653\u7ea7TRAE 36.4% vs 44.8%\uff09\uff1b\u4e50\u666e\u751f\u7269\u6e2f\u4ea4\u6240\u81ea\u613f\u516c\u544a2026-10-26\uff08CMG901\/AZD0901\u300119\u56fd175\u4e2d\u5fc3\u3001594\u4f8b\u3001\u5206\u5c42\u56e0\u7d20\uff09\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">[11] Zhou C, et al. OptiTROP-Lung06\uff08NCT06711900\uff09\uff1aESMO 2026 LBA66\uff0c\u4f18\u9009\u53e3\u5934\u62a5\u544a\uff0c\u540c\u6d4e\u5927\u5b66\u9644\u5c5e\u4e1c\u65b9\u533b\u9662\u5468\u5f69\u5b58\u6559\u6388\u62a5\u544a\uff1b\u540c\u6b65\u53d1\u8868\u4e8e N Engl J Med\uff0c\u6570\u636e\u622a\u6b622026-06-09\uff0c\u4e2d\u4f4d\u968f\u8bbf9.7\u4e2a\u6708\u3002\u6570\u636e\u51fa\u5904\uff1a\u56db\u5ddd\u79d1\u4f26\u836f\u4e1a\u516c\u544a2026-10-27\uff1b\u79d1\u4f26\u535a\u6cf0\/\u7f8e\u901a\u793e\u65b0\u95fb\u7a3f2026-10-25\uff1bOncoDaily 2026-10-26.[12] INTerPath-001\u6570\u636e\u63d0\u524d\u6d41\u51fa\u4e0e\u5f53\u65e5\u5e02\u573a\u53cd\u5e94\uff1aESMO\u65b0\u95fb\u529e\u516c\u5ba4\u7981\u8fd0\u4ee4\u58f0\u660e\uff1bReuters\/Bloomberg\u7ecfThe Globe and Mail\u3001\u53f0\u6e7e\u4ea7\u7ecf\u65b0\u95fb\u7f51\u8f6c\u8ff0\uff08Moderna\u76d8\u4e2d\u4e00\u5ea6\u8dcc\u7ea625%\u3001\u5e02\u503c\u4e00\u5ea6\u84b8\u53d1\u7ea6240\u4ebf\u7f8e\u5143\uff1bWilliam Blair\u4e0eTD Cowen\u5b9a\u6027\u4e3asell-the-news\uff09\uff1b\u7ea2\u661f\u8d44\u672c\u5c402026-10-25\uff08MRNA 2026-10-22\u6536\u8dcc17.57%\u3001\u9ed8\u6c99\u4e1c\u6536\u8dcc1.76%\uff09\uff1bFinancial News\uff08Moderna\u76d8\u4e2d\u4e00\u5ea6\u8dcc\u7ea625%\uff1b\u8be5\u6e90\u6536\u76d8\u8dcc\u5e45\u4e0e\u884c\u60c5\u8868\u4e0d\u4e00\u81f4\uff0c\u672c\u6587\u4e0d\u4e88\u91c7\u7528\uff09\u3002IIb\u671fKEYNOTE-942\u4e94\u5e74\u968f\u8bbf\uff1a\u590d\u53d1\u6216\u6b7b\u4ea1\u98ce\u9669\u964d\u4f4e49%\uff08HR 0.51\uff09\u3001\u8fdc\u5904\u8f6c\u79fb\u6216\u6b7b\u4ea1\u98ce\u9669\u964d\u4f4e59%\uff08HR 0.411\uff09\u30015\u5e74OS\u738792.2% vs 71.3%\uff1b\u516c\u5e03\u65f6\u70b9\u5404\u4e2d\u6587\u6e90\u5b58\u5728&#8221;2026\u5e741\u6708&#8221;\u4e0e&#8221;ASCO 2026&#8243;\u4e24\u79cd\u8bf4\u6cd5\uff0c\u672c\u6587\u4e0d\u9501\u5b9a\u5177\u4f53\u65e5\u671f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u64b0\u6587\uff1a\u90d1\u53f6\u654f<\/p>\n","protected":false},"excerpt":{"rendered":"<p>2026\u5e74ESMO\u5e74\u4f1a\uff0810\u670823~27\u65e5\uff0c\u9a6c\u5fb7\u91cc\uff09\u516c\u5e03\u4e86\u4e00\u6279\u8db3\u4ee5\u6539\u5199\u6cbb\u7597\u683c\u5c40\u7684\u6570\u636e\uff0c\u4e5f\u516c\u5e03\u4e86\u4e00\u6279\u201c\u8fbe\u5230\u7ec8\u70b9\u4f46\u4e0d\u591f\u597d\u201d\u7684\u6570\u636e\u3002\u672c\u5c4a\u4e2d\u56fd\u836f\u4f01\u76f8\u5173\u7814\u7a76\u5165\u9009LBA\u7ea629\u9879\uff0c\u5360\u5927\u4f1aLBA\u603b\u6570\uff08\u903e90\u9879\uff09\u7ea6\u4e09\u5206\u4e4b\u4e00\uff0c\u5176\u4e2d5\u9879\u4e2d\u56fd\u539f\u7814\u5206\u5b50\u7814\u7a76\u8fdb\u5165\u4e3b\u5e2d\u8bba\u575b[1]\u3002<br \/>\n\u540c\u6837\u53eb\u201cIII\u671f\u9633\u6027\u201d\uff0c\u6709\u7684\u6539\u53d8\u4e86\u6807\u51c6\u6cbb\u7597\uff0c\u6709\u7684\u53ea\u662f\u52c9\u5f3a\u8de8\u8fc7\u7edf\u8ba1\u95e8\u69db\uff0c\u8fd8\u6709\u7684\u4ece\u4e00\u5f00\u59cb\u5c31\u628a\u98ce\u9669\u57cb\u5728\u4e86\u7ec8\u70b9\u9009\u62e9\u3001\u5bf9\u7167\u8bbe\u5b9a\u6216\u968f\u8bbf\u6210\u719f\u5ea6\u91cc\u3002<\/p>\n","protected":false},"author":1,"featured_media":2272,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[147],"tags":[35,86,15,32,29],"class_list":["post-2265","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-147","tag-35","tag-86","tag-15","tag-32","tag-29"],"_links":{"self":[{"href":"https:\/\/www.millibuff.com\/index.php?rest_route=\/wp\/v2\/posts\/2265","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.millibuff.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.millibuff.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.millibuff.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.millibuff.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2265"}],"version-history":[{"count":4,"href":"https:\/\/www.millibuff.com\/index.php?rest_route=\/wp\/v2\/posts\/2265\/revisions"}],"predecessor-version":[{"id":2273,"href":"https:\/\/www.millibuff.com\/index.php?rest_route=\/wp\/v2\/posts\/2265\/revisions\/2273"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.millibuff.com\/index.php?rest_route=\/wp\/v2\/media\/2272"}],"wp:attachment":[{"href":"https:\/\/www.millibuff.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2265"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.millibuff.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2265"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.millibuff.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2265"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}